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多能蛋白聚糖在恶性肿瘤中的表达及生物学作用的研究进展

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上海交通大学学报（医学版） 2024年第4期44卷 525-530页

作者：刘林楠冯莉王龙刘嘉寅范志松河北医科大学第四医院肿瘤内科石家庄050011

恶性肿瘤严重威胁着人类健康,是全球人类死亡的主要原因之一。为了进一步提高对于恶性肿瘤的治疗效果,延长患者生存时间,明确恶性肿瘤的发病机制以及寻找新的诊断和治疗靶点变得尤为重要。研究发现,恶性肿瘤的发生发展是肿瘤细胞与肿瘤... 详细信息

恶性肿瘤严重威胁着人类健康,是全球人类死亡的主要原因之一。为了进一步提高对于恶性肿瘤的治疗效果,延长患者生存时间,明确恶性肿瘤的发病机制以及寻找新的诊断和治疗靶点变得尤为重要。研究发现,恶性肿瘤的发生发展是肿瘤细胞与肿瘤微环境(tumor microenvironment,TME)相互作用的结果。多能蛋白聚糖(versican)是一种硫酸软骨素蛋白聚糖,属于外源凝集素蛋白聚糖家族,由VCAN基因编码,是细胞外基质的主要成分,在胚胎发育和炎症反应过程中均发挥重要作用。作为TME的重要组成部分,versican在肾细胞癌、肝细胞癌、胃癌等多种肿瘤组织中异常表达,且与患者的临床病理特征及预后密切相关,是肿瘤早期诊断和预后评估的潜在生物标志物。进一步的研究显示,versican可通过促进肿瘤细胞增殖、侵袭和转移,抑制肿瘤细胞凋亡,促进肿瘤血管生成和抑制抗肿瘤免疫反应等多种方式促进肿瘤的发展。该文就versican在恶性肿瘤中的表达及生物学作用的研究现状进行综述,旨在为肿瘤的后续研究及临床诊治提供参考依据。

关键词：多能蛋白聚糖恶性肿瘤肿瘤微环境细胞外基质

Simulation model of SAR remote sensing of turbulent wake of semi-elliptical submerged body

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Acta Oceanologica Sinica 2005年第5期24卷 50-60页

作者： fan zhisong Marine Environment College Ocean University of China Qingdao 266003 China

In terms of the 2-dimensional hydrodynamic simplified model of a semi-elliptical submerged body moving horizontally at high speed, by using the full-spectrum model of SAR（synthetic aperture radar） remote sensing and taking the effect of oceanic interior turbulence on surface gravity capillary waves into account, applying the k-ε model of turbulence with internal wave mixing, and adopthag the Nasmyth spectrum of oceanic turbulence, the 2-dimensional simulation model of SAR remote sensing of this semi-elliptical submerged body is built up. Simulation by using this model at X band and C band is made in the northeastern South China Sea （21°00＇ N, 119°00＇ E）. Satisfactory results of the delay time and delay distance of turbulent surface wake of this semi-elliptical submerged body, as well as the minimum submerged depth at which this submerged body which cannot be discovered by SAR, are obtained through simulation.

关键词： semi-elliptical submerged body SAR remote sensing wake turbulence lee waves

The host microbiota is associated with the occurrence and development of esophageal squamous cell carcinoma

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Protein & Cell 2023年第4期14卷 294-298页

作者： Jing Zuo Yanjun Liu Wenjing Lv Yudong Wang zhisong fan Long Wang Li Feng Xue Zhang Jing Hani Zhiyu Ni Department of Oncology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011China The Affliated Hospital of Hebei University Baoding 071000China School of Basic Medical Science Hebei UniversityBaoding 071000China

DearEditor,Microecology is an emerging research area,particularly that of the digestive system(Marchesi et al.,2016;Wang et al.,2018).The intestinal microbiota contains a rich and complex microbial ecosystem that is in dynamic balance,the disruption of which can result in disease(Yatsunenko et al.,2012;Li et al.,2017;He et al.,2018).For example,studies have found that the esophagus has a variety of colonizing bacteria that may be related to esophageal cancer.

关键词： al. esophageal esophagus

Is the small-scale turbulence an exclusive breaking product of oceanic internal waves

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Acta Oceanologica Sinica 2011年第6期30卷 1-11页

作者： fan zhisong College of Physical and Environmental Oceanography Ocean University of China Qingdao 266100 China

On the basis of the theoretical research results by the author and the literature published up to date, the analysis and the justification presented in this paper show that the breaking products of oceanic internal waves are not only turbulence, but also the fine-scale near-inertial internal waves （the oceanic reversible finestructure） for inertial waves and the internal solitary waves for internal tides respectively. It was found that the oceanic reversible finestructure may be induced by the effect of the horizontal component f （f = 2Ωcosφ） of the rotation vector on inertial waves. And a new instability of the theoretical shear and strain spectra due to the effect of f occurs at critical vertical wavenumber β c ≈ 0.1 cpm. It happens when the levels of shear and strain of the reversible finestructure are higher than those of inertial waves, which is induced by the effect of f along an ＂iso-potential-pycnal＂ of internal wave. If all breaking products of internal waves are taken into account, the average kinetic energy dissipation rate is an order of magnitude larger than the values of turbulence observed by microstructure measurements. The author’s theoretical research results are basically in agreement with those observed in IWEX, DRIFTER and PATCHEX experiments. An important impersonal fact is that on the mean temporal scale of thermohaline circulation these breaking products of internal waves exist simultaneously with turbulence. Because inertial waves are generated by winds at the surface, and internal tides are generated by strong tide-topography interactions, the analysis and justification in this paper support in principle the abyssal recipes Ⅱ：energetics of tidal and wind mixing by Munk Wunsch in 1998, in despite of the results of microstructure measurements for the turbulent kinetic energy dissipation rate and the diapycnal turbulent eddy diffusivity.

关键词： internal waves inertial waves internal tides turbulence oceanic interior mixing

A study of SAR remote sensing of internal solitary waves in the north of the South China Sea:Ⅱ.Simulation of SAR signatures of internal solitary waves

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Acta Oceanologica Sinica 2008年第4期27卷 36-48页

作者： fan zhisong ZHANG Yuanling SONG Mei College of Physical and Environmental Oceanography Ocean University of China Qingdao 266100 China

A new model developed from the full-spectrum model of Lyzenga and Bennett （ 1988 ） is built up by us preliminarily through considering the impact of the ocean surface mixed layer turbulence on SAR remote sensing of internal solitary waves. In the partial differential equation of the action spectral density of the surface gravity-capillary waves the source function representing the contribution of the turbulence is added besides the usual source function representing the contribution of the wind. The source function is determined by applying the κ - ε model and adopting the Nasmyth spectrum of oceanic turbulence （ Nasmyth, 1970; Oakey, 1982; fan, 2002） on the basis of the previous simulation results of internal tide transformation obtained in the companion paper （fan et al. ,2008）. Either under relatively high wind speed, or under low wind speed, our model predicts significant large modulations of radar backscatter at all three bands （ L, C and X bands） for both VV and HH polarization. These results prove that considering the impact of ocean surface mixed layer turbulence on SAR remote sensing of internal solitary waves is reasonable and appropriate for settlement of the well-known problem of contemporary radar imaging models.

关键词： internal tide internal solitary waves turbulence SAR remote sensing

Distribution of Vertical Turbulent Mixing Parameter Caused by Internal Tidal Waves and Solitary Waves in the South Yellow Sea

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Journal of Ocean University of China 2012年第3期11卷 279-289页

作者： SI Zongshang fan zhisong DU Ling College of Physical and Environmental Oceanography Ocean University of ChinaQingdao 266100P.R.China

Many observations show that in the Yellow Sea internal tidal waves (ITWs) possess the remarkable characteristics of internal Kelvin wave, and in the South Yellow Sea (SYS) the nonlinear evolution of internal tidal waves is one of the mechanisms producing internal solitary waves (ISWs), which is different from the generation mechanism in the case where the semidiurnal tidal current flows over topographic drops. In this paper, the model of internal Kelvin wave with continuous stratification is given, and an elementary numerical study of nonlinear evolution of ITWs is made for the SYS, using the generalized KdV model (GKdV model for short) for a continuous stratified ocean, in which the different effects of background barotropic ebb and flood currents are considered. Moreover, the parameterization of vertical turbulent mixing caused by ITWs and ISWs in the SYS is studied, using a parameterization scheme which was applied to numerical experiments on the breaking of ISWs by Vlasenko and Hutter in 2002. It is found that the vertical turbulent mixing caused by internal waves is very strong within the upper layer with depth less than about 30m, and the vertical turbulent mixing caused by ISWs is stronger than that by ITWs.

关键词：湍流混合内孤立波南黄海垂直混合参数内潮波非线性演化参数化方案

A parameterization scheme of vertical mixing due to inertial internal wave breaking in the ocean general circulation model

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Acta Oceanologica Sinica 2015年第1期34卷 11-22页

作者： fan zhisong SHANG Zhenqi ZHANG Shanwu HU Ruijin LIU Hailong College of Physical and Environmental Oceanography Ocean University of China The Third Institute of Oceanography State Oceanic Administration State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of Sciences

Based on the theoretical spectral model of inertial internal wave breaking （fine structure） proposed previ- ously, in which the effects of the horizontal Coriolis frequency component f-tilde on a potential isopycnal are taken into account, a parameterization scheme of vertical mixing in the stably stratified interior be- low the surface mixed layer in the ocean general circulation model （OGCM） is put forward preliminarily in this paper. Besides turbulence, the impact of sub-mesoscale oceanic processes （including inertial internal wave breaking product） on oceanic interior mixing is emphasized. We suggest that adding the inertial inter- hal wave breaking mixing scheme （F-scheme for short） put forward in this paper to the turbulence mixing scheme of Canuto et al. （T-scheme for short） in the OGCM, except the region from 15°S to 15°N. The numeri- cal results ofF-scheme by usingWOA09 data and an OGCM （LICOM, LASG/IAP climate system ocean model） over the global ocean are given. A notable improvement in the simulation of salinity and temperature over the global ocean is attained by using T-scheme adding F-scheme, especially in the mid- and high-latitude regions in the simulation of the intermediate water and deep water. We conjecture that the inertial internal wave breaking mixing and inertial forcing of wind might be one of important mechanisms maintaining the ventilation process. The modeling strength of the Atlantic meridional overturning circulation （AMOC） by using T-scheme adding F-scheme may be more reasonable than that by using T-scheme alone, though the physical processes need to be further studied, and the overflow parameterization needs to be incorporated. A shortcoming in F-scheme is that in this paper the error of simulated salinity and temperature by using T-scheme adding F-scheme is larger than that by using T-scheme alone in the subsurface layer.

关键词： vertical mixing inertial internal wave fine structure horizontal Coriolis frequency component,ocean general circulation model

Infragravity waves with internal wave characteristics in the south of the Bohai Sea of China

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Acta Oceanologica Sinica 2003年第2期22卷 171-178页

作者： fan zhisong, Gao Guoping, Yin Xunqiang, fan Yu, Wu Wei Marine Environment College,Ocean University of China,Qingdao 266003, China Marine Environment College Ocean University of China Qingdao 266003 China

The measurements by using ADCP (500 KH) and CTD were made during August 2000in the south (37?5'N, 120?5'E) of the Bohai Sea, where the water depth was about 16.5 m. The data of horizontal velocity with sampling interval of 2 min in 7 layers were obtained. The power spectrum analysis of these data indicates that there are very energetic infragravity waves with a period of about 6 min. The coherence spectrum analysis and the analysis of temporal variation of shear show that these infragravity waves are mainly the free wave model (properties of edge waves), in the meantime they possess some characteristics of internal waves, which are likely due to the distinctive marine environment in this area. It is speculated on that the instability processes (chiefly shear instability) of sheared stratified tidal flow owing to the effect of sea-floor slope in the coastal area might be the main mechanism generating these infragravity waves.

关键词： Infragravity waves edge waves internal waves vertical shear of horizontal velocity internal mixing

Effects of Tidal Currents on Nonlinear Internal Solitary Waves in the South China Sea

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Journal of Ocean University of China 2013年第1期12卷 13-22页

作者： fan zhisong SHI Xingang Antony K. Liu LIU Hailong LI Peiliang College of Physical and Environmental Oceanography Ocean University of China Beijing Branch of CNOOC Energy Technology and Services Limited Ocean Sciences Branch NASA Goddard Space Flight Center State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric Physics Chinese Academy of Sciences

The propagation and fission process of internal solitary waves (ISWs) with amplitudes of about 170 m are simulated in the northeast of the South China Sea (NSCS) by using the generalized Korteweg-de Vries (KdV) equation under continuous stratification. More attention is paid to the effects of the ebb and flood background currents on the fission process of ISWs. This kind of background current is provided by the composed results simulated in terms of monthly mean baroclinic circulation and barotropic tidal current. It is found that the obtained relation of the number of fission solitons to the water depth and stratification is roughly in accordance with the fission law derived by Djordjevic and Redekopp in 1978; however, there exists obvious difference between the effects of the ebb and flood background currents on the wave-lengths of fission solitons (defined as the distance between two neighboring peaks of ISWs). The difference in nonlinearity coefficient α between the ebb and flood background currents is a main cause for the different wave-lengths of fission solitons.

关键词：非线性系数中国南海内孤立波潮流孤子波德弗里斯 NSCS 裂变