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Green Energy & Environment 2022年第6期7卷 1241-1252页

作者： Zhe Hong Guoqing Zhao Fangtao Huang Xiaoxia Wang Zhirong Zhu School of Chemical Science and Engineering Tongji UniversityShanghai200092China

Side-chain alkylation of toluene with methanol is a green pathway to realize the one-step production of styrene under mild conditions,but the low selectivity of styrene is difficult to be improved with by-products of ethylbenzene and xylene.In this study,a new way is introduced to improve the catalytic performance by means of assisting basic compounds as co-catalysts during the toluene side-chain alkylation with methanol to styrene.As a result,high activity of side-chain alkylation appears over the basic Cs-modified zeolite catalysts prepared by ion exchange and impregnation methods.This high performance should be mainly attributed to two co-catalysis actions:(1)the promotion of basic compounds for methanol dehydrogenation to formaldehyde as the intermediate for side-chain alkylation;(2)the suppression of the styrene transfer hydrogenation on basic Cs-modified zeolites to avoid the formation of ethylbenzene.Especially for Cs_(2)O/CsX-ex catalyst,the addition of 2%mol/mol 2-picoline in reaction mixture could achieve both 12.3%toluene conversion and 84.1%styrene selectivity.Whereas the higher concentration of 2-picoline(>6%mol/mol)caused an inhibition to the catalytic activity because the excessive basic compound poisoned the combined acid-base pathway required for the side-chain alkylation process.In addition,two possible side-chain alkylation reaction routes on Cs-modified zeolite under the different 2-picoline absorption were described.

关键词： Basic co-catalysis Toluene Side-chain alkylation Zeolite Styrene

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Trapping endoplasmic reticulum with amphiphilic AIE-active sensor via specific interaction of ATP-sensitive potassium(KATP)

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National Science Review 2021年第6期8卷 34-45页

作者： Zhirong Zhu Qi Wang Hongze Liao Ming Liu Zhenxing Liu Youheng Zhang Wei-Hong zhu Shanghai Key Laboratory of Functional Materials Chemistry Key Laboratory for Advanced Materials and Institute of Fine ChemicalsJoint International Research Laboratory of Precision Chemistry and Molecular EngineeringFeringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Chemistry and Molecular EngineeringEast China University of Science and Technology Research Center for Marine Drugs State Key Laboratory of Oncogene and Related GenesDepartment of PharmacyRen Ji HospitalSchool of MedicineShanghai Jiao Tong University

The current aggregation-induced emission luminogens(AIEgens) sometimes suffer from poor targeting selectivity due to undesirable aggregation in the hydrophilic biosystem with ‘always-on’ fluorescence or unspecific aggregation in the lipophilic organelle with prematurely activated fluorescence. Herein, we report an unprecedented ‘amphiphilic AIEgen’ sensor QM-SO3-ER based on the AIE building block of quinoline-malononitrile(QM). The introduced hydrophilic sulfonate group can well control the specific solubility in a hydrophilic system with desirable initial ‘fluorescence-off’ state. Moreover, the incorporated p-toluenesulfonamide group plays two roles: enhancing the lipophilic dispersity, and behaving as binding receptor to the adenosine triphosphate(ATP)-sensitive potassium(KATP) on the endoplasmic reticulum(ER) membrane to generate the docking assay confinement effect with targetable AIE signal. The amphiphilic AIEgen has for the first time settled down the predicament of unexpected ‘always-on’fluorescence in the aqueous system and the untargetable aggregation signal in the lipophilic organelle before binding to ER, thus successfully overcoming the bottleneck of AIEgens’ targetability.

关键词： aggregation-induced emission amphiphilic AIEgens endoplasmic reticulum targeting specificity high-fidelity tracking

Inhibition of proliferation,migration,and invasiveness of bladder cancer cells through SAPCD2 knockdown

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BIOCELL 2024年第1期48卷 97-109页

作者： CHONG SHEN JIAJUN YAN YU REN Zhirong Zhu XIAOLONG ZHANG SHUIXIANG TAO Department of Urology Shaoxing People’s HospitalShaoxing HospitalZhejiang University School of MedicineShaoxingChina

Introduction:Bladder cancer(BC)has a high incidence and mortality rate worldwide.Suppressor anaphasepromoting complex domain containing 2(SAPCDC2)is over-expressed in a variety of tumors.Objectives:This study investigated the effects of SAPCD2 knockdown on BC cells.Methods:T24 and UMUC3 cell models and the xenografted BC tumor model with SAPCD2 knockdown were established to observe the malignant phenotype of BC cells by cell counting kit-8 assay,colony formation test,wound healing,and Transwell assay,mRNA and proteins expressions were measured with quantitative real-time polymerase chain reaction,western blotting,and tissue immunohistochemistry.Lithium chloride agonist on the Wnt/β-catenin pathway was used to clarify the molecular mechanism of SAPCD2 knockdown.Results:SAPCD2 expression was significantly higher in BC cell lines than in SVHUC-1 cells.SAPCD2 knockdown inhibited viability and cloning,hindered the G0/G1 phase of the cell cycle in UMUC3 and T24 cells,and decreased the migration and invasiveness of BC cells.SAPCD2 knockdown inhibited expression levels of cyclin D1,cyclin B1,N-cadherin,vimentin,Snail,β-catenin,c-Myc,and cyclin-dependent kinase 4,while the P21 and E-cadherin were raised by SAPCD2 knockdown.Furthermore,lithium chloride reversed the effects of SAPCD2 knockdown on the expression levels of the above proteins in UMUC3 and T24 cells.In vivo,SAPCD2 knockdown inhibited the volume,weight,and expression of Ki-67 andβ-catenin in tumors and increased the E-cadherin expression.Conclusion:SAPCD2 knockdown inhibits the malignant phenotype of BC via a pathway involvingβ-catenin.

关键词： Bladder cancer SAPCD2 β-catenin c-Myc CDK4 Lithium chloride

An AIE-based enzyme-activatable fluorescence indicator for Western blot assay:Quantitative expression of proteins with reproducible stable signal and wide linear range

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Aggregate

Aggregate 2021年第2期2卷 136-144页

作者： Tijian Zhou Qi Wang Ming Liu Zhenxing Liu Zhirong Zhu Xiaolei Zhao Wei-Hong zhu Shanghai Key Laboratory of Functional Materials Chemistry Key Laboratory for Advanced Materials and Institute of Fine ChemicalsJoint International Research Laboratory of Precision Chemistry and Molecular EngineeringFeringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China

Western blot is a commonly used experimental method to analyze the protein expression.However,the most commonly used chromogenic indicator based on chemiluminescence is limited by narrow linear range and unstable quantitative reproducibility,whereas the recently developed fluorescent indicator suffers from poor detection limit.Herein,we report an enzyme-activatable fluorescence indicator to quantify proteins with reproducible stable signal and wide linear range,through introducing the hydrophilic alkaline phosphatase(ALP)-triggered phosphoric acid moiety into our established aggregation-induced emission(AIE)building block of quinoline-malononitrile(QM).In this strategy,the indicator DQM-ALP disperses well in both aqueous and lipid environments to exhibit initial“off”fluorescence,but when exposing to the ALP-coupled secondary antibody on the PVDF membrane,the specific enzymatic turnover would liberate hydrophobic AIE luminogen(AIEgen)QM-OH to emit strong luminescence,thereby achieving an ideal“off-on”state for sensitively imaging proteins with high signal-to-noise(S/N)ratio.Moreover,benefiting from the excellent signal stability of AIE fluorophore,DQM-ALP indicator exhibits superior quantitative analysis of protein expression with high reproducibility.Upon taking advantage of the AIEgens to reduce high concentration-induced luminance quenching,the linear quantification range is extremely expanded.In contrast with the traditional chemiluminescent indicator,the AIE-based enzymeactivatable indicator DQM-ALP not only greatly improves the signal stability for quantitative reproducibility,but also expands the linear quantification range,and further provides a practical alternative reagent for fluorescence Western blot assay.

关键词： aggregation-induced emission amphiphilic fluorescence indicator Western blot assay

Shape-selective alkylation of benzene with ethylene over a core–shell ZSM-5@MCM-41 composite material

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Chinese Journal of Chemical Engineering 2021年第9期34卷 64-71页

作者： Zhenhao Shen Chongwei Ma Darui Wang Junlin He Hongmin Sun Zhirong Zhu Weimin Yang Shanghai Key Lab of Chemical Assessment and Sustainability School of Chemical Science and EngineeringTongji UniversityShanghai 200092China Shanghai Research Institute of Petrochemical Technology SinopecShanghai 201208China School of Chemical Engineering East China University of Science and TechnologyShanghai 200237China

A series of ZSM-5@MCM-41 core-shell composite materials prepared via a multi-cycle-sol-gel coating strategy is investigated as the catalyst for benzene alkylation with ethylene,in which both ethylbenzene and para-diethylbenzene(p-DEB)are aimed as the target products.With multi-cycle-sol-gel coating,the external acid sites on the samples are gradually passivated by the inert MCM-41 shell.As a result,the shape selectivity to p-DEB is greatly enhanced.Nevertheless,the coating of mesoporous MCM-41 shell on ZSM-5 accelerates deactivation of the catalyst only due to the dilution effect of ZSM-5 content in the catalyst at the same space velocity,which is a reason that core-shell ZSM-5@MCM-41 will potentially be a practical catalyst in shape selective alkylation of benzene.In order to enhance the yield of p-DEB on ZSM-5@MCM-41,the reaction conditions at the fixed bed reactor including temperature,the molar rate of benzene to ethylene and GHSV,are also optimized.

关键词： Core-shell ZSM-5@MCM-41 Coating Ethylbenzene Para-diethylbenzene Shape selectivity Deactivation

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Catalytic Performance of Modified HMCM-22 Catalysts in Xylene Isomerization

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Chinese Journal of Chemistry 2016年第12期34卷 1291-1296页

作者： Xiang Wu Chao Hu Guoqing Zhao Ying Yuan Zhirong Zhu Shanghai Key Lab of Chemical Assessment and Substainability School of Chemical Science and Engineering Tongji University Shanghai 200092 China

HMCM-22 catalysts modified with La203 （5% La） and MgO （≈0.87% Mg） were prepared respectively by impregnation method, and were characterized by scanning electron microscopy, X-ray diffraction, N2 physical ad- sorption-desorption and temperature-programmed desorption of NH3. The effect of supported metallic oxides （La203, MgO） on catalytic performance in xylene isomerization of C8 aromatics （ethylbenzene, m-xylene and o-xylene） was investigated in detail. The experimental results showed that 5% LaJHMCM-22 catalyst had higher isomerization activity and stronger shape-selectivity than 0.87% Mg/HMCM-22 catalyst, owing to its more acid sites and smaller pore size. And the loading amount of La was optimized to be about 7%. Moreover, supporting metal over 7% La/HMCM-22, respectively with 0.3% Pt, 3% Ni and 3% Mo, was carried out to prepare bifunction- al isomerization catalysts. In comparison, 3% Mo/7% La/HMCM-22 showed the best catalytic performance with both high activity and high selectivity, with the low hydrocracking of m-xylene and o-xylene. Besides, the op- timal reaction conditions were found： 340℃, 1.5 MPa H2, WHSV 4 h^-1 and H2/C8 4 mol/mol. Under the above conditions, ethylbenzene conversion was up to 20%, para-selectivity was over 23% with low xylene loss of 2.9%.

关键词： xylene isomerization HMCM-22 catalyst metallic oxide modification bifunctional catalyst

Structural and temporal dynamics analysis on drug-eluting stents: History, research hotspots and emerging trends

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Bioactive Materials 2023年第5期23卷 170-186页

作者： Lili Tan Xiangxiu Wang Kungshan Yuan Tieying Yin Ruolin Du Li Shen Zhirong Zhu Suhua Yu Haijun Zhang Guixue Wang Key Laboratory of Biorheological and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsModern Life Science Experiment Teaching Center at Bioengineering College of Chongqing UniversityChongqing400030China National United Engineering Laboratory for Biomedical Material Modification Shandong Rientech Medical Tech Co.LtdDezhouShandong251100China Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghaiNational Clinical Research Center for Interventional MedicineShanghai200032China Shanghai Key Lab of Chemical Assessment and Sustainability School of Chemical Science and EngineeringTongji UniversityShanghai200092China Blue Sail Pioneer Lab JW Medical SystemsJiwei Shandong264200China JinFeng Laboratory Chongqing401329China

Purpose:This review aims to explore the history,research hotspots,and emerging trends of drug-eluting stents(DES)in the last two decades from the perspective of structural and temporal dynamics.Methods:Publications on DES were retrieved from WoSCC.The bibliometric tools including CiteSpace and HistCite were used to identify the historical features,the evolution of active topics,and emerging trends on the DES field.Results:In the last 20 years,the field of DES is still in the hot phase and there is a wide range of extensive scientific collaborations.In addition,active topics emerge in different periods,as evidenced by a total of 41 disciplines,511 keywords,and 1377 papers with citation bursts.Keyword clustering anchored five emerging research subfields,namely#0 dual antiplatelet therapy,#3 drug-coated balloon,#4 bifurcation,5#rotational atherectomy,and 6#quantitative flow ratio.The keyword alluvial map shows that the most persistent research concepts in this field are thrombosis,restenosis,etc.,and the emerging keywords are paclitaxel eluting balloon,coated balloon,drug-eluting balloon,etc.There are 7 recent research subfields anchored by reference clustering,namely#2 dual antiplatelet therapy,#4 drug-coated balloon,#5 peripheral artery disease,#8 fractional flow reserve,#10 bioresorbable vascular scaffold,#13 intravascular ultrasound,#14 biodegradable polymer.Conclusion:The findings based on the bibliometric studies provide the current status and trends in DES research and may help researchers to identify hot topics and explore new research directions in this field.

关键词： Drug-eluting stents Dual antiplatelet therapy Drug-coated balloon Bioresorbable scaffold Bibliometric

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论“中国美学”的学科特质

哲学动态 2024年第5期 35-45,127页

作者：朱志荣华东师范大学中文系

狭义的“中国美学”是指中国古代美学思想及其在当代的研究和继承发展。它是中国人数千年来审美实践和思想概括的产物。中国古代只是没有“美学”这一学科名称,但是早已有了丰富的美学思想。中国美学不仅包含在美学思想中,更感性地存留... 详细信息

狭义的“中国美学”是指中国古代美学思想及其在当代的研究和继承发展。它是中国人数千年来审美实践和思想概括的产物。中国古代只是没有“美学”这一学科名称,但是早已有了丰富的美学思想。中国美学不仅包含在美学思想中,更感性地存留在体现审美意识的器物和历代文学艺术作品中。审美意识是中国美学的源头活水。中国美学元范畴围绕一个核心不断衍生,形成了独特的以意象为中心的范畴系统。佛学思想的融入有力地开拓了中国美学的发展。中国美学重体验、重视主体的直觉思维等特点,将自然规律与社会法则贯通起来,体现了生命意识。中国古代美学思想中有着潜在的体系,需要我们借鉴西方,面向当代的审美实践进行理论建构,以彰显中国美学的独特性。中国美学通过与西方美学的对话融合,走向现代,走向世界,最终成为多元一体的世界美学的有机组成部分。

关键词：美学思想审美意识意象生命意识多元一体

Spatiotemporal Visualization of Cell Membrane with Amphiphilic Aggregation-Induced Emission-Active Sensor

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CCS Chemistry 2022年第5期4卷 1619-1632页

作者： Youheng Zhang Qi Wang Zhirong Zhu Weijun Zhao Chenxu Yan Zhenxing Liu Ming Liu Xiaolei Zhao He Tian Wei-Hong zhu Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterShanghai Key Laboratory of Functional Materials ChemistryInstitute of Fine ChemicalsFrontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Chemistry and Molecular EngineeringEast China University of Science&TechnologyShanghai 200237

High-fidelity spatiotemporal monitoring of the cell membrane is critically important.However,commercial fluorescence probes are stalked by the aggregation-caused quenching(ACQ)effect,and the reported aggregation-induced emission(AIE)-active probes are always limited by nonspecific aggregations in the biological environment.Herein,we report the rational molecular design of a stateof-the-art amphiphilic AIE luminogen(AIEgen),membrane tracker QMC12,using a core quinolinemalononitrile(QM)structure to suppress the ACQ effect,incorporate a positively charged pyridinium to regulate dispersity and strengthen the binding affinity to the negatively charged cell membrane,and extend the alky chain to improve the anchoring ability to the cell membrane.The membrane tracker QMC12,which disperses well in both hydrophilic and lipophilic environments,not only achieves minimal background interference and high signal-to-noise(S/N)ratio in the“ultrafast”visualization of the cell membrane,but also endows a“wash-free”characteristic.Furthermore,it realizes a spatial three dimensional(3D)view in a multicellular spheroid model and morphology changes over time.Moreover,QMC12 avoids false staining and signal loss and unprecedentedly achieves the direct observation of the cell membrane’s microstructure,which could elucidate spatiotemporal 3D model studies of the intercellular information exchange.

关键词： aggregation-induced emission amphiphilicity cell membrane imaging high-fidelity spatiotemporal dimensions

建构一种通向未来的创新美学——论蒋孔阳美学思想的杰出贡献

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复旦学报（社会科学版） 2024年第1期66卷 34-57,101页

作者：朱立元朱志荣复旦大学中文系上海200433 华东师范大学中文系上海200241

本文为纪念蒋孔阳先生诞辰100周年而作。全文主要包含两大部分:第一部分为美学理论,主要论述其从美的实体论走向关系论、从现成论走向创造生成论、从单纯认识论走向存在论的理论发展过程,以及美感论和方法论等方面的理论创新;第二部分... 详细信息

本文为纪念蒋孔阳先生诞辰100周年而作。全文主要包含两大部分:第一部分为美学理论,主要论述其从美的实体论走向关系论、从现成论走向创造生成论、从单纯认识论走向存在论的理论发展过程,以及美感论和方法论等方面的理论创新;第二部分着重论述其中外美学史和文学理论研究的杰出贡献,包括从《德国古典美学》到《西方美学通史》的经典性研究,对中国古典美学尤其是先秦音乐美学、中国诗画美学等的开拓性研究,以及比较美学和文学理论的开创性研究。

关键词：蒋孔阳美学思想通向未来理论创新杰出贡献

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