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Early assessment of responsive neurostimulation for drug-resistant epilepsy in China: A multicenter, self-controlled study

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中华医学杂志(英文版) 2025年第04期

作者： Yang Yanfeng Wei Penghu Shi Jianwei Mao Ying Zhang Jianmin Lei Ding Yang zhiquan song Shiwei Qian Ruobing Li Wenling Shan Yongzhi Zhao Guoguang Department of Neurosurgery Xuanwu Hospital Capital Medical University Beijing China Department of Neurosurgery Huashan Hospital Fudan University Shanghai China Department of Neurosurgery The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China Department of Neurosurgery West China Hospital of Sichuan University Chengdu Sichuan China Department of Neurosurgery Xiangya Hospital Central South University Changsha Hunan China Department of Neurosurgery Fujian Medical University Union Hospital Fuzhou Fujian China Department of Neurosurgery The First Affiliated Hospital of University of Science and Technology of China Anhui Provincial Hospital Hefei Anhui China Department of Neurosurgery The Second Hospital of Hebei Medical University Shijiazhuang Hebei China

Background: To evaluate the efficacy and safety of the first cohort of people in China treated with a responsive neurostimulation system (EpilcureTM, GenLight MedTech, Hangzhou, China) for focal drug-resistant epilepsy in this ***: This multicenter, before-and-after self-controlled study was conducted across 8 centers from March 2022 to June 2023, involving patients with drug-resistant epilepsy who were undergoing responsive neurostimulation (RNS). The study was based on an ongoing multi-center, single-blind, randomized controlled study. Efficacy was assessed through metrics including median seizure count, seizure frequency reduction (SFR), and response rate. Multivariable linear regression analysis was conducted to explore the relationships of basic clinical factors and intracranial electrophysiological characteristics with SFR. The postoperative quality of life, cognitive function, depression, and anxiety were evaluated as ***: The follow-up period for the 19 participants was 10.7 ± 3.4 months. Seizure counts decreased significantly 6 months after device activation, with median SFR of 48% at the 6th month (M6) and 58% at M12 (P <0.05). The average response rate after 13 months of treatment was 42%, with 21% (n = 4) of the participants achieving seizure freedom. Patients who have previously undergone resective surgery appear to achieve better therapeutic outcomes at M11, M12 and M13 (β <0,P <0.05). No statistically significant differences were observed in patients’ scores of quality of life, cognition, depression and anxiety following stimulation when compared to baseline measurements. No serious adverse events related to the devices were ***: The preliminary findings suggest that EpilcureTM exhibits promising therapeutic potential in reducing the frequency of epileptic seizures. However, to further validate its efficacy, larger-scale randomized controlled trials are ***: Chinese Clinical Trial Registry (No. Chi

关键词： Neuromodulation EpilcureTM Focal epilepsy Seizure control Responsive neurostimulation

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直接饲喂微生物和发酵制品生产菌株鉴定概述

食品与发酵工业 2023年第13期49卷 328-333页

作者：曹艳花程坤刘艺茹丁健白飞荣张欣王荃宋智泉张娜谢九艳李婷姚粟胡广东中国食品发酵工业研究院有限公司中国工业微生物菌种保藏管理中心北京100015 全国畜牧总站北京100125

我国生物发酵类饲料添加剂主要涉及两类,即直接饲喂微生物和发酵制品(如酶制剂、氨基酸等)。对微生物进行科学准确的鉴定是开展生物发酵类饲料添加剂安全性评价的基础,也是此类产品研发和产业化发展的必要前提。文章介绍了欧盟和我国直... 详细信息

我国生物发酵类饲料添加剂主要涉及两类,即直接饲喂微生物和发酵制品(如酶制剂、氨基酸等)。对微生物进行科学准确的鉴定是开展生物发酵类饲料添加剂安全性评价的基础,也是此类产品研发和产业化发展的必要前提。文章介绍了欧盟和我国直接饲喂微生物和发酵制品生产菌株鉴定要求,分析了形态学、生理生化和分子生物学鉴定技术,并系统阐述了微生物鉴定技术的应用,为开展直接饲喂微生物和发酵制品生产菌株鉴定提供参考。

关键词：直接饲喂微生物发酵制品生产菌株鉴定技术

Conversion of magnetron-sputtered sacrificial intermediate layer into a stable FeCo-LDH catalyst for oxygen evolution reaction

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Nano Research 2024年第5期17卷 4307-4313页

作者： zhiquan Lang Guang-Ling song Xingpeng Liao Wenzhong Huang Yixing Zhu Haipeng Wang Dajiang Zheng Center for Marine Materials Corrosion and Protection College of MaterialsXiamen UniversityXiamen 361005China Department of Ocean Science and Engineering Southern University of Science and TechnologyShenzhen 518055China State Key Laboratory of Physical Chemistry of Solid Surfaces Xiamen UniversityXiamen 361005China The University of Queensland St.LuciaOLD 4072Australia State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China

Controllable and scalable preparation of electrocatalyst materials holds significant importance for their practical *** sputtering is a highly effective synthesis method,known for its producing uniform films and allowing easy control of component *** this paper,we propose an in-situ synthesis method for layered double hydroxide(LDH)electrocatalysts through sacrificing magnetron sputtered *** resulting FeCo-LDH catalyst demonstrated a low overpotential of only 300 mV at 10 mA·cm^(-2).Furthermore,we conducted spectroscopic analysis to investigate the surface changes of the catalysts during the oxygen evolution reaction(OER)*** findings indicated that the formation of Co oxyhydroxides plays a beneficial role in enhancing the catalytical performance of the FeCo-LDH for OER *** restructuring strategy of converting a magnetron-sputtered sacrificial film into a catalytical LDH introduces a new avenue to the synthesis of transition metal-based electrocatalysts.

关键词： magnetron co-sputtering surface reconstruction electrocatalyst oxygen evolution reaction

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基于系统辨识的轴向磁悬浮轴承建模研究

电机与控制学报 2024年第10期28卷 76-84页

作者：宋学涛邓智泉南京航空航天大学自动化学院江苏南京211106

磁悬浮轴承可有效地提升高速电机的临界转速,然而轴向磁悬浮轴承在转子高转速和材料实心的情况下涡流效应显著。针对该情况下实心轴向磁悬浮轴承的建模问题,使用等效磁路法建立轴向磁悬浮轴承模型时常会忽略涡流效应,导致理论模型与实... 详细信息

磁悬浮轴承可有效地提升高速电机的临界转速,然而轴向磁悬浮轴承在转子高转速和材料实心的情况下涡流效应显著。针对该情况下实心轴向磁悬浮轴承的建模问题,使用等效磁路法建立轴向磁悬浮轴承模型时常会忽略涡流效应,导致理论模型与实际模型存在较大误差。为了得到更贴近实际的轴向磁悬浮轴承精确模型,针对一种混合型三自由度磁悬浮轴承的轴向部分采用系统辨识的方法进行了闭环辨识,研究了分数阶模型阶次的确定流程和误差准则,得到了轴向磁悬浮轴承的数学模型。结果表明,分数阶系统模型能够弥补整数阶模型在高频段上的相位特性误差,在整个频域上有着更高的精确度。

关键词：高速电机磁悬浮轴承三自由度混合型磁悬浮轴承数学模型系统辨识分数阶系统

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Oat avenanthramide B alleviates high-fat diet-induced obesity via regulating fatty acid metabolism involved in gut bacteria and fungi remodeling

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Food Science and Human Wellness 2024年

作者： Yongyong Liu Kai Huang Xiao Guan Sen Li Hongdong song Ying Zhang Yu Zhang Zhu Sun zhiquan Yu School of Health Science and Engineering， University of Shanghai for Science and Technology National Grain Industry (Urban Grain and Oil Security) Technology Innovation Center Inner Mongolia Yangufang Whole Grain Industry Development Co.， Ltd.

Oat avenanthramides (AVNs) have been found to exhibit novel lipid-lowering effects. However， the mechanism remains unclear. In this study， the effect of avenanthramide B (AVN B)， as one of the major AVNs， on high-fat diet (HFD)-induced mice was investigated. Results showed that AVN B significantly inhibited weight gain and improved hepatic and serum lipid biochemical indices. Hepatic RNA-Sequencing analysis suggested that AVN B significantly modulates fatty acid (FA) metabolism. Hepatic real-time qualitative polymerase chain reaction (RT-qPCR) and Western blot results indicated that AVN B could alleviate FA synthesis by activating the AMPK- SREBP1c-FAS， and increase FA oxidation by activating the AMPK/CPT1A and PPARα. Additionally， AVN B had a regulating effect on ileum lipid metabolism by inhibiting intestinal cell differentiation and down-regulating the expression levels of FA absorption-related protein and gene. Moreover， AVN B promoted the growth of beneficial bacteria and fungi such as Coriobacteriaceae＿UCG-002， Parvibacter， Enterococcus， and Aspergillus， while decreasing the abundance of Roseburia， unclassified＿f＿Lachnospiraceae Cladosporium， Eurotium， unclassified＿f＿Aspergillaceae and unclassified＿f＿Ceratocystidaceae. All these results provided new points of the lipid-lowing mechanism of AVNs and oats via the gut-liver axis.

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电枢绕组开路式混合励磁电机发电系统

中国电机工程学报 2014年第9期34卷 1392-1403页

作者：宋路程邓智泉王宇南京航空航天大学自动化学院江苏省南京市210016

针对绕组开路式永磁电机发电系统蓄电池电流控制困难的问题,研究了一种适用于混合动力电动汽车的绕组开路式混合励磁电机发电系统,并提出相应的蓄电池电流控制策略。通过采用绕组开路式电机结构,减少了发电系统有功功率回路中全控器件... 详细信息

针对绕组开路式永磁电机发电系统蓄电池电流控制困难的问题,研究了一种适用于混合动力电动汽车的绕组开路式混合励磁电机发电系统,并提出相应的蓄电池电流控制策略。通过采用绕组开路式电机结构,减少了发电系统有功功率回路中全控器件的数量。根据推导所得蓄电池电流与励磁电流的线性关系,将蓄电池电流环输出量作为励磁电流给定值,调节励磁电流,控制发电机输出功率,从而实现控制蓄电池电流的目的,克服了绕组开路永磁电机发电系统中蓄电池电流控制困难的缺点。该文分析了系统发电调压原理,给出了通过调节励磁电流控制蓄电池电流的控制策略。仿真和实验结果表明,该系统具有控制蓄电池电流的功能,为实现混合动力电动汽车电驱动系统中蓄电池与发电机之间功率协调控制创造条件。

关键词：绕组开路混合励磁电机蓄电池电流励磁电流

Porous Carbon Derived from Poplar Catkins and Its High-performance CO_(2)Capture

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Journal of Wuhan University of Technology(Materials Science) 2023年第4期38卷 789-795页

作者：李重阳 TIAN Shujian 宋小勇 ZOU Bing 陈志权 ZHANG Zhen College of Energy and Power Engineering North China University of Water Resources and Electric PowerZhengzhou450045China Department of Oncology The Second Affiliated Hospital of Nanchang UniversityNanchang360000China School of Physical Science and Technology Wuhan UniversityWuhan430072China

In order to deal with the increasingly serious environmental problems,it is important and necessary to lower the concentration of greenhouse gases,especially the CO_(2)***_(2)capture and storage are the relative suitable options for the reduction of these harmful gas *** the variation of mass ratio of KOH to bio-char,the as prepared active carbon PC-4 exhibits a higher specific surface area of 2491.57 cm^(3)·g^(−1),with the ultra-micropores of 0.5 and 1.2 *** 298 K/1 bar,the CO_(2)adsorption capacity of PC-4 also represents the highest value of 5.81 mmol/*** work demonstrates that the both the pore size and the specific surface area are equally important to enhance the CO_(2)*** work provides a sustainable method to develop high efficiency waste-based adsorbents to deal with environmental issues of CO_(2)gas.

关键词： porous carbon biomass microporous CO_(2)adsorption

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耦合系统中时空混沌的神经网络控制方法

控制理论与应用 1999年第2期16卷 283-287页

作者：汪小帆王执铨宋文忠南京理工大学自控系南京210094 东南大学自动化所南京210096

以耦合映象链模型为例 ,利用神经网络的学习能力 ,提出了一种控制耦合系统的时空混沌行为的方法。

关键词：耦合系统时空混沌神经网络自动控制

12/10极永磁磁通切换电机转子初始位置检测

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中国电机工程学报 2013年第9期33卷 104-114页

作者：许培林邓智泉王宇宋路程南京航空航天大学自动化学院

电机转子初始位置检测的精度直接决定其启动运行时的性能。针对12/10极永磁磁通切换型电机,在验证其凸极性的基础上,采用注入脉振高频信号实现转子初始位置估计。通过对传统高频脉振正弦电压信号注入的分析,研究了基于高频方波或三角波... 详细信息

电机转子初始位置检测的精度直接决定其启动运行时的性能。针对12/10极永磁磁通切换型电机,在验证其凸极性的基础上,采用注入脉振高频信号实现转子初始位置估计。通过对传统高频脉振正弦电压信号注入的分析,研究了基于高频方波或三角波的注入方法,再利用电流差值调制或直接信号调制方法得到位置误差信号,同时根据磁路的饱和效应,通过对d轴电流过零点时间差值的累加,实现了磁极方向辨识。分析了位置误差信号的系数与初始位置检测收敛性的关系。通过实验验证了所提方法的正确性和可行性。

关键词：永磁磁通切换电机初始位置检测方波三角波