检索结果-南通市图书馆

Equivalent efficacy assessment of QL1101 and bevacizumab in nonsquamous non-small cell lung cancer patients:A two-year follow-up data update

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2022年第1期34卷 28-39页

作者： Jun Lu Tianqing Chu Hongyu Liu Minjuan Hu Yuqing Lou Yanwei Zhang zhiqiang gao Wei Zhang Xueyan Zhang Huimin Wang Hua Zhong Baohui Han Department of Pulmonary Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China Shanghai Institute of Thoracic Oncology Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China Translational Medical Research Platform for Thoracic Oncology Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China Department of Bio-bank Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China

Objective: Anti-vascular endothelial growth factor(VEGF) monoclonal antibodies are an effective means of treating non-small cell lung cancer(NSCLC). Here, we aim to update the equivalent efficacy assessment between QL1101 and bevacizumab based on two-year follow-up ***: In total, 535 eligible NSCLC patients were enrolled in this randomized controlled trial. Patients were randomly assigned 1:1 to the QL1101 group and the bevacizumab group. The full end time of this study was defined as 24 months after the last enrolled patient was randomized. The primary endpoint was the objective response rate(ORR);equivalence was confirmed if the two-sided 90% confidence interval(90% CI) of the relative risk was within the range of 0.75-1.33. The secondary endpoints were progression-free survival(PFS) and overall survival(OS).Results: The two-year updated data showed similar ORR(QL1101 vs. bevacizumab: 53.1% vs. 54.3%;relative risk=0.977;90% CI: 0.838-1.144), PFS(235 d vs. 254 d, log-rank P=0.311), and OS(577 d vs. 641 d, log-rank P=0.099) results between the QL1101 group and the bevacizumab group. The mean shrinkage ratio of targeted lesions was also similar between the QL1101 group and the bevacizumab group(22.5% vs. 23.5%). For patients who received QL1101 maintenance therapy, similar results were shown between the QL1101 group(n=157) and the bevacizumab group(n=148)(PFS: 253 d vs. 272 d, log-rank P=0.387;OS: 673 d vs. 790 d, log-rank P=0.101;mean tumor shrinkage rate: 26.6% vs. 27.5%).Conclusions: This study reported that QL1101 had similar efficacy in treating nonsquamous NSCLC in terms of ORR, PFS and OS based on two-year updated data, providing a basis for the clinical application of QL1101.

关键词： QL1101 biosimilar non-small cell lung cancer bevacizumab VEGF

On the characteristics of ADRC: a PID interpretation

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2020年第10期63卷 258-260页

作者： Huiyu JIN Jingchao SONG Weiyao LAN zhiqiang gao School of Aerospace Engineering Xiamen University Center for Advanced Control Technologies Cleveland State University

Dear editor,This study reports the discovery of active disturbance rejection control (ADRC).Second-order linear ADRC (LADRC),the basic and most popular ADRC,can be interpreted as a modified proportional-integral-derivative (PID) *** filters the PID feedback compensator with a second-order low-pass filter;it also adds a ***,each given PID con-

关键词： Active disturbance rejection control PID Feedback compensator Bode plot Low-pass filter

Mechanical behavior and response mechanism of porous metal structures manufactured by laser powder bed fusion under compressive loading

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 737-749页

作者： Xuanming Cai Yang Hou Wei Zhang zhiqiang Fan Yubo gao Junyuan Wang Heyang Sun Zhujun Zhang Wenshu Yang School of Aerospace Engineering North University of ChinaTaiyuan 030051China School of Materials Science and Engineering North University of ChinaTaiyuan 030051China School of Astronautics Harbin Institute of TechnologyHarbin 150080China School of Mechanical Engineering North University of ChinaTaiyuan 030051China Shijiazhuang Campus Army Engineering University of PLAShijiazhuang 050003China 65589 Unit 91 Detachment Daqing 163411China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150080China

Al Si10Mg porous protective structure often produces different damage forms under compressive loading,and these damage modes affect its protective *** order to well meet the service requirements,there is an urgent need to comprehensively understand the mechanical behavior and response mechanism of AlSi10Mg porous structures under compressive *** this paper,Al Si10Mg porous structures with three kinds of volume fractions are designed and optimized to meet the requirements of high-impact,strong-energy absorption,and lightweight *** mechanical behaviors of AlSi10Mg porous structures,including the stress-strain relationship,structural bearing state,deformation and damage modes,and energy absorption characteristics,were obtained through experimental studies at different loading *** damage pattern of the damage section indicates that AlSi10Mg porous structures have both ductile and brittle mechanical *** simulation studies show that the AlSi10Mg porous structure undergoes shear damage due to relative misalignment along the diagonal cross-section,and the damage location is almost at 45°to the load direction,which is the most direct cause of its structural damage,revealing the damage mechanism of AlSi10Mg porous structures under the compressive *** normalized energy absorption model constructed in the paper well interprets the energy absorption state of Al Si10Mg porous structures and gives the sensitive location of the structures,and the results of this paper provide important references for peers in structural design and optimization.

关键词： AlSi10Mg additive manufacture energy absorption characteristics damage by deformation mechanical behavior

在线全文

学校读者我要写书评

暂无评论

胸部伴睾丸核蛋白基因重排癌2例病例报告

中华转移性肿瘤杂志 2024年第1期7卷 84-87页

作者：马美丽高志强张雪艳聂蔚王姝元钟华韩宝惠上海市胸科医院/上海交通大学医学院附属胸科医院呼吸与危重症科上海200030

伴睾丸核蛋白基因重排癌(NUT癌)是以染色体15q14上睾丸核蛋白重排为特征的一种罕见实体恶性肿瘤。这类肿瘤可以发生在人体各个部位, 但主要好发于胸部(肺、纵隔)、头颈部等中线部位;可发生于任何年龄, 以中青年多见。NUT癌病理诊断不易,... 详细信息

伴睾丸核蛋白基因重排癌(NUT癌)是以染色体15q14上睾丸核蛋白重排为特征的一种罕见实体恶性肿瘤。这类肿瘤可以发生在人体各个部位, 但主要好发于胸部(肺、纵隔)、头颈部等中线部位;可发生于任何年龄, 以中青年多见。NUT癌病理诊断不易, 需结合免疫组织化学、荧光原位杂交、二代测序等进行明确。NUT癌预后差, 对常规治疗效果欠佳。上海交通大学医学院附属胸科医院呼吸与危重症科收治了2例病理提示低分化癌, 经免疫组织化学、荧光原位杂交和二代测序证实为BRD4-NUT融合重排的胸部NUT癌。1例为15岁男孩, 伴全身多发骨、皮下转移, 予化疗加抗血管生成治疗, 疗效为疾病稳定。1例为34岁女性, 化疗加免疫治疗1个周期, 后参加临床试验应用溴结构域和超末端家族蛋白抑制剂靶向治疗, 疗效为部分缓解。本文结合文献回顾性报告了NUT癌的临床病理特征及治疗策略。

关键词：伴睾丸核蛋白基因重排癌化疗免疫治疗靶向治疗

Investigation on Normal Dynamic Contact Characteristics of Mechanical Interface of Machine Tools

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Solida Sinica 2021年第1期34卷 104-123页

作者： zhiqiang gao Weiping Fu Wen Wang Shuangqi Wang Dongya Zhang Zhifei Xue School of Mechanical and Precision Instrument Engineering Xian University of TechnologyXi’an710048China State Key Laboratory of Power System of Tractor China YITUO Group Co.LtdLuoyang471039China

The dynamic contact characteristics of mechanical interface significantly impact the performance of machine *** static contact behaviors of mechanical interface have been ***,most mechanical interfaces are exposed to dynamic *** is necessary to study the dynamic contact characteristics of mechanical interface.A normal dynamic microcosmic contact model is built using the statistical method,and the interactional effects of adjacent asperities are *** influences of the normal preload,vibrational frequency and displacement amplitude on normal contact stiffness and damping of mechanical interface are *** predicted contact stiffness and damping of mechanical interface are verified by a series of simulations and experiments.

关键词： Dynamic Stiffness Damping Asperity interaction Experiment

On transitioning from PID to ADRC in thermal power plants

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Control Theory and Technology 2021年第1期19卷 3-18页

作者： Zhenlong Wu zhiqiang gao Donghai Li YangQuan Chen Yanhong Liu School of Electrical Engineering Zhengzhou UniversityZhengzhou 450001HenanChina Department of Electrical and Computer Engineering Cleveland State UniversityClevelandOH 44115USA State Key Lab of Power Systems Department of Energy and Power EngineeringTsinghua UniversityBeijing 100084China Mechatronics Embedded Systems and Automation(MESA)LabDepartment of Mechanical EngineeringSchool of EngineeringUniversity of CaliforniaMercedCA 95343USA

This paper focuscs on the recent progress in the adoption of active disturbance rejection control(ADRC)in thermal pro-cesses as a viable alternative to proportional-_integral-derivative(PID),especially in coa-fired power *** profound interpretation of this paradigm shift,with backward compatibility,is discussed in detail.A few fundamental issues associated with ADRC's applications in thermal processes are discussed,such as implementation,tuning,and the structural *** and case studies are presented,encompassing coal-fired power plants,gas turbines and nuclear power plants,as well as highlighting results of field *** discussed are future research opportunities brought by ADRC's entry as the baseline control technology in thermal processes.

关键词： Active disturbance rejection control(ADRC) Proportional-integral-derivative(PID) Thermal processes Coal-fired power plant Field applications

Advances in diagnosis and non-surgical treatment of Bell's palsy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Otology 2015年第1期10卷 7-12页

作者： Yang Zhao Guodong Feng zhiqiang gao Department of Otolaryngology Peking Union Medical College Hospital China Medical Science Academy

Bell’s palsy is a commonly seen cranial nerve disease and can result in compromised facial appearance and functions. Its etiology, prognosis and treatment are still being debated. This paper is a review of recent dev... 详细信息

关键词： Facial paralysis Non-surgical treatment Steroids

在线全文

学校读者我要写书评

暂无评论

输日实验动物检疫监管政策的解析与思考

中国比较医学杂志 2024年第6期34卷 93-99页

作者：丁宁梁佳琪富宏坤王莹王春霞任娇鱼海琼林志雄麻丽丹朱道中高志强吴晓薇陶雨风广州海关技术中心广州510623 中国合格评定国家认可中心北京100062 丹东海关综合技术服务中心辽宁丹东118300 中国海关科学技术研究中心北京100026

日本是我国进出口实验动物的主要贸易伙伴之一,对于实验动物的进出口检疫监管政策十分细致而严格。本文以实验犬、猫和猴为例,对出口日本的主要实验动物检疫监管政策进行了深入解析,同时对我国目前实验动物相关的法律法规、进出境管理... 详细信息

日本是我国进出口实验动物的主要贸易伙伴之一,对于实验动物的进出口检疫监管政策十分细致而严格。本文以实验犬、猫和猴为例,对出口日本的主要实验动物检疫监管政策进行了深入解析,同时对我国目前实验动物相关的法律法规、进出境管理办法、标准、生物安全、养殖和管理现状以及进出口业务现状展开思考,在完善实验动物法律法规和进出境管理办法、保障国门生物安全、提高实验动物养殖管理水平以及促进实验动物进出口贸易等方面给出了建议,以期为全面提升我国实验动物生产、使用、养殖管理水平,加强中日实验动物贸易往来提供参考。

关键词：实验动物进出境检疫监管政策解读行业发展

同方期刊数据库

芳华七秩正青春——庆祝《中华耳鼻咽喉头颈外科杂志》70年华诞

在线全文

学校读者我要写书评

暂无评论

中华耳鼻咽喉头颈外科杂志 2023年第1期58卷 1-2页

作者：高志强中国医学科学院北京协和医学院北京协和医院耳鼻咽喉科北京100730

70年, 可以将一个人从呱呱落地的婴儿变成"古稀"的老者。然而, 一本真正将学术注入生命, 具有创新精神的杂志, 是不会老去的, 她会伴随着一代代作者、读者的成长而不断迭代, "苟日新, 日日新, 又日新", 永葆青春。在即将到来的2023年, ... 详细信息

70年, 可以将一个人从呱呱落地的婴儿变成"古稀"的老者。然而, 一本真正将学术注入生命, 具有创新精神的杂志, 是不会老去的, 她会伴随着一代代作者、读者的成长而不断迭代, "苟日新, 日日新, 又日新", 永葆青春。在即将到来的2023年, 我们心爱的《中华耳鼻咽喉头颈外科杂志》将迎来她的70华诞。

关键词：耳鼻咽喉头颈外科呱呱落地日日新创新精神华诞杂志中华