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Microstructure and Mechanical Behavior of FeNiCoCr and FeNiCoCrMn High-Entropy Alloys Fabricated by Powder Metallurgy

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Acta Metallurgica Sinica(English Letters) 2021年第4期34卷 445-454页

作者： Chenliang Chu Weiping Chen Zhen Chen Zhenfei Jiang Hao Wang Zhiqiang Fu Guangdong Key Laboratory for Advanced Metallic Materials Processing South China University of TechnologyGuangzhou 510640China Shantou Technician College Shantou 515041China

The present work reports a systematic investigation on phase evolution,microstructure and microstructure-property relationship of two typical face-centered cubic(FCC)structured high-entropy alloys(HEAs),FeNiCoCr and FeNiCoCrMn,prepared via mechanical alloying(MA)followed by spark plasma sintering(SPS).Following 50 h of MA,the two HEAs consisted of a mixture of FCC and body-centered cubic phases.Following SPS,the bulk FeNiCoCr alloy showed a primary FCC phase with a small amount of Cr_(23)C_(6) and Cr_(2)O_(3) contaminants,while the bulk FeNiCoCrMn alloy was composed of a primary FCC phase with some(Cr,Mn)23C6 and MnCr_(2)O_(4) contaminants.The average grain size of the primary FCC phase in the bulk FeNiCoCr alloy was~416 nm,while that of the primary FCC phase in the bulk FeNiCoCrMn alloy was~547 nm.The yield strength,compressive strength and strain-to-failure of the bulk FeNiCoCr alloy are 1525 MPa,1987 MPa and 24.4%,respectively,whereas those of the bulk FeNiCoCrMn alloy are 1329 MPa,1761 MPa and 21.9%,respectively.It suggests that the bulk FeNiCoCrMn exhibited lower strength and plasticity in comparison with the bulk FeNiCoCr alloy.Clearly,the smaller grain size of the primary FCC phase in the FeNiCoCr alloy is mainly responsible for the better mechanical performance.

关键词： High-entropy alloy Mechanical alloying Microstructure Strengthening Contaminants

Cryo-EM Studies of Virus-Antibody Immune Complexes

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Virologica Sinica 2020年第1期35卷 1-13页

作者： Na Li zhiqiang Li Yan fu Sheng Cao CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyWuhan 430071China Center for Biosafety Mega-Science Chinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China

Antibodies play critical roles in neutralizing viral infections and are increasingly used as therapeutic drugs and diagnostic tools. Structural studies on virus-antibody immune complexes are important for better understanding the molecular mechanisms of antibody-mediated neutralization and also provide valuable information for structure-based vaccine design.Cryo-electron microscopy(cryo-EM) has recently matured as a powerful structural technique for studying bio-macromolecular complexes. When combined with X-ray crystallography, cryo-EM provides a routine approach for structurally characterizing the immune complexes formed between icosahedral viruses and their antibodies. In this review, recent advances in the structural understanding of virus-antibody interactions are outlined for whole virions with icosahedral T = pseudo 3(picornaviruses) and T = 3(flaviviruses) architectures, focusing on the dynamic nature of viral shells in different functional states. Glycoprotein complexes from pleomorphic enveloped viruses are also discussed as immune complex antigens. Improving our understanding of viral epitope structures using virus-based platforms would provide a fundamental road map for future vaccine development.

关键词： Cryo-electron microscopy(Cryo-EM) Icosahedral Antigen Virion Immune complex

The Critical Role of Fillers in Composite Polymer Electrolytes for Lithium Battery

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Nano-Micro Letters 2023年第5期15卷 339-375页

作者： Xueying Yang Jiaxiang Liu Nanbiao Pei zhiqiang Chen Ruiyang Li Lijun fu Peng Zhang Jinbao Zhao College of Energy Xiamen UniversityXiamen 361102People’s Republic of China State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Centre of Chemistry for Energy MaterialsState-Province Joint Engineering Laboratory of Power Source Technology for New Energy VehicleEngineering Research Center of Electrochemical TechnologyMinistry of EducationCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005People’s Republic of China College of Energy Nanjing Technical UniversityNanjing 211816People’s Republic of China

With excellent energy densities and highly safe performance,solidstate lithium batteries(SSLBs)have been hailed as promising energy storage devices.Solid-state electrolyte is the core component of SSLBs and plays an essential role in the safety and electrochemical performance of the cells.Composite polymer electrolytes(CPEs)are considered as one of the most promising candidates among all solid-state electrolytes due to their excellent comprehensive performance.In this review,we briefly introduce the components of CPEs,such as the polymer matrix and the species of fillers,as well as the integration of fillers in the polymers.In particular,we focus on the two major obstacles that affect the development of CPEs:the low ionic conductivity of the electrolyte and high interfacial impedance.We provide insight into the factors influencing ionic conductivity,in terms of macroscopic and microscopic aspects,including the aggregated structure of the polymer,ion migration rate and carrier concentration.In addition,we also discuss the electrode-electrolyte interface and summarize methods for improving this interface.It is expected that this review will provide feasible solutions for modifying CPEs through further understanding of the ion conduction mechanism in CPEs and for improving the compatibility of the electrode-electrolyte interface.

关键词： Composite polymer electrolytes Fillers Ionic conductivity Electrode-electrolyte interface

Rationally designed hollow carbon nanospheres decorated with S,P co-doped NiSe_(2) nanoparticles for high-performance potassium-ion and lithium-ion batteries

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Journal of Energy Chemistry 2023年第3期78卷 401-411,I0011页

作者： Jiajia Ye Zizhong Chen zhiqiang Zheng Zhanghua fu Guanghao Gong Guang Xia Cheng Hu Shenzhen Research Institute of Shandong University Shenzhen 518057GuangdongChina Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061ShandongChina Key Laboratory of Colloid and Interface Chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringState Key Laboratory of Crystal MaterialShandong UniversityJinan 250100ShandongChina i-Lab Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of SciencesSuzhou 215123JiangsuChina

Hollow nanostructures with external shells and inner voids have been proved to greatly shorten the transport distance of ions/electrons and buffer volume change,especially for the large-sized potassium-ions in secondary batteries.In this work,hollow carbon(HC) nanospheres embedded with S,P co-doped NiSe_(2)nanoparticles are fabricated by "drop and dry" and "dissolving and precipitation" processes to form Ni(OH)2nanocrystals followed by annealing with S and P dopants to form nanoparticles.The resultant S,P-NiSe_(2)/HC composite exhibits excellent cyclic performance with 131.6 mA h g^(-1)at1000 mA g^(-1)after 3000 cycles for K^(+)storage and a capacity of 417.1 mA h g^(-1)at 1000 mA g^(-1)after1000 cycles for Li^(+)storage.K-ion full cells are assembled and deliver superior cycling stability with a ca pacity of 72.5 mA h g^(-1)at 200 mA g^(-1)after 500 cycles.The hollow carbon shell with excellent electrical conductivity effectively promotes the transporta tion and tolerates large volume variation for both K^(+)and Li^(+).Density functional theory calculations confirm that the S and P co-doping NiSe_(2) enables stronger adsorption of K^(+)ions and higher electrical conductivity that contributes to the improved electrochemical performance.

关键词： S,P co-doping NiSe_(2)nanoparticles Hollow carbon nanospheres Potassium-ion batteries Lithium-ion batteries

Elastohydrodynamic Lubrication Interface Stiffness and Damping Considering Asperity Lateral Contact

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Acta Mechanica Solida Sinica 2024年第1期37卷 109-123页

作者： zhiqiang Gao Yu Zhang Xian Wei Yanfang Zhu Lixia Peng Weiping fu Wen Wang School of Mechanical and Precision Instrument Engineering Xi'an University of TechnologyXi'an 710048China School of Intelligent Manufacturing Panzhihua UniversityPanzhihua 617000China Material Corrosion and Protection Key Laboratory of Sichuan Province Sichuan University of Light Chemical TechnologyYibin 644002China School of Mechanical Engineering Anyang Institute of TechnologyAnyang 455099China

Elastohydrodynamic lubrication(EHL)point contact occurs between two rough surfaces at the mesoscopic level,while the interaction of rough surfaces involves contact between asperities at the microscale level.In most cases,the contact between asperities within an interface takes the form of lateral contact rather than peak contact.Regions devoid of contact asperities are filled with lubricating oil.However,conventional models often oversimplify lateral contact forms as interactions between asperities and a smooth,rigid plane.These simplifications fail to accurately represent the true contact conditions and can lead to inaccuracies in the analysis of EHL’s contact performance.To address this issue,we have developed a novel EHL interface model comprising two rough surfaces.This model allows us to explore the influence of asperity height,contact angle,and contact azimuth angle on EHL interface performance.

关键词： EHL interface Asperity lateral contact Contact stiffness Damping

An investigation on adaptively machining the leading and tailing edges of an SPF/DB titanium hollow blade using free-form deformation

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Chinese Journal of Aeronautics 2018年第1期31卷 178-186页

作者： Zhengcai ZHAO Jiuhua XU Yucan fu zhiqiang LI College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 China Beijing Aeronautics Manufacturing Technology Research Institute Beijing 100024 China

Titanium hollow blades are characterized with lightweight and high structural strength, which are widely used in advanced aircraft engines nowadays. Superplastic forming/diffusion bonding （SPF/DB） combined with numerical control （NC） milling is a major solution for manufacturing titanium hollow blades. Due to the shape deviation caused by multiple heat and pressure cycles in the SPF/DB process, it is hard to manufacture the leading and tailing edges by the milling process. This paper presents a new adaptive machining approach using free-form deformation to solve this problem. The actual SPF/DB shape of a hollow blade was firstly inspected by an on-machine measurement method. The measured point data were matched to the nominal SPF/DB shape with an improved ICP algorithm afterwards, by which the point-pairs between the measurement points and their corresponding points on the nominal SPF/DB shape were established, and the maximum modification amount of the final nominal shape was constrained. Based on the displacements between the point-pairs, an accurate FFD volume was iteratively calculated. By embedding the final nominal shape in the deformation space, a new final shape of the hollow blade was built. Finally, a series of measurement and machining tests was performed, the results of which validated the feasibility of the proposed adaptive machining approach.

关键词： Adaptive machining Blade geometry Free-form deformation Reconstruction Titanium

Genetic engineering of T cells with chimeric antigen receptors for hematological malignancy immunotherapy

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Science China(Life Sciences) 2018年第11期61卷 1320-1332页

作者： Dongdong Ti Yunfei Niu zhiqiang Wu Xiaobing fu Weidong Han Department of Immunology Institute of Basic Medicine Chinese PLA General Hospital Department of Orthopaedics Changhai Hospital Second Military Medical University

The host immune system plays an instrumental role in the surveillance and elimination of tumors by recognizing and destroying cancer cells. In recent decades, studies have mainly focused on adoptive immunotherapy using engineered T cells for the treatment of malignant diseases. Through gene engraftment of the patient's own T cells with chimeric antigen receptor(CAR),they can recognize tumor specific antigens effectively and eradicate selectively targeted cells in an MHC-independent fashion.To date, CAR-T cell therapy has shown great clinical utility in patients with B-cell leukemias. Owing to different CAR designs and tumor complex microenvironments, genetically redirected T cells may generate diverse biological properties and thereby impact their long-term clinical performance and outcome. Meanwhile some unexpected toxicities that result from CAR-T cell application have been examined and limited the curative effects. Diverse important parameters are closely related with adoptively transferred cell behaviors, including CAR-T cells homing, CAR constitutive signaling, T cell differentiation and exhaustion. Thus, understanding CARs molecular design to improve infused cell efficacy and safety is crucial to clinicians and patients who are considering this novel cancer therapeutics. In this review, the developments in CAR-T cell therapy and the limitations and perspectives in optimizing this technology towards clinical application are discussed.

关键词： genetic engineering chimeric antigen receptors cancer immunotherapy

Comparative Study of Gacun and Youre Silver–Lead–Zinc–Copper Deposits in Sichuan, SW China, and their Mineralization Significance

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Acta Geologica Sinica(English Edition) 2018年第1期92卷 162-182页

作者： DANG Yuan CHEN Maohong fu Bin XUE zhiqiang School of Earth Science and Resources China University of Geosciences Beijing 100087 China MLR Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral Resources CAGS Beijing 100037 China Research School of Earth Sciences The Australian National University Canberra ACT 2601 Australia NO.1 Institute of Geological and Mineral Resources Survey of Henan Luoyang 471000 China

The large Gacun silver-lead-zinc-copper deposit in Sichuan Province is one of the largest volcanogenic massive sulfide （VMS） deposits in China. The deposit consists of western and central ore bodies, which form a vein-stockwork mineralization system corresponding to hydrothermal channels, and eastern ore bodies, which form an exhalative chemical sedimentary system derived from a brine pool in a submarine basin. The Youre lead-zinc deposit, which is currently under exploration and lies adjacent to the southern part of the Gacun deposit, is characterized by intense silicification and vein- stockwork structures and consists of massive silicified rhyolitic volcanics, banded rhyolitic tuff, and phyllitic sericite tuff. From a comparison of their ore-bearing horizons, the Gacun and Youre deposits have a continuous and stable hanging wall （calcareous slate and overlying andesite） and foot wall （rhyolite-dacite breccia and agglomerate）, and the Uthologic sequence includes lower intermediate to felsic rocks and upper felsic rocks. Thus, the Youre deposit, which comprises relatively thinly layered low-grade ore, is regarded as forming a southward extension of the Gacun deposit. A further comparison of the structures of the ore-bearing belts between the two deposits suggests that the Youre ore bodies are similar to the western ore bodies of the Gacun deposit. Moreover, the characteristics of fluid inclusions and stable isotopes in the Youre deposit are also similar to those of the western ore bodies of the Gacun deposit. Genetic models of the deposits are proposed for the Gacun-Youre ore district, and massive concealed ore bodies may occcur in the Youre deposit at depths that are similar to those of the eastern ore bodies of the Gacun deposit.

关键词： ore-bearing horizon structure of ore-bearing belt VMS deposit Gacun-Youre ore district

Cryo-EM structure of glycoprotein C from Crimean-Congo hemorrhagic fever virus

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Virologica Sinica 2022年第1期37卷 127-137页

作者： Na Li Guibo Rao zhiqiang Li Jiayi Yin Tingting Chong Kexing Tian Yan fu Sheng Cao CAS Key Laboratory of Special Pathogens Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China

Crimean-Congo hemorrhagic fever virus(CCHFV)is a causative agent of serious hemorrhagic diseases in humans with high mortality rates.CCHFV glycoprotein Gc plays critical roles in mediating virus-host membrane fusion and has been studied extensively as an immunogen.However,the molecular mechanisms involved in membrane fusion and Gc-specific antibody-antigen interactions remain unresolved largely because structural information of this glycoprotein is missing.We designed a trimeric protein including most of the ectodomain region of Gc from the prototype CCHFV strain,Ib Ar10200,which enabled the cryo-electron microscopy structure to be solved at a resolution of 2.8Å.The structure confirms that CCHFV Gc is a class Ⅱ fusion protein.Unexpectedly,structural comparisons with other solved Gc trimers in the postfusion conformation revealed that CCHFV Gc adopted hybrid architectural features of the fusion loops from hantaviruses and domain Ⅲ from phenuiviruses,suggesting a complex evolutionary pathway among these bunyaviruses.Antigenic sites on CCHFV Gc that protective neutralizing antibodies target were mapped onto the CCHFV Gc structure,providing valuable information that improved our understanding of potential neutralization mechanisms of various antibodies.

关键词： Crimean-Congo hemorrhagic Fever virus(CCHFV) Glycoprotein C fusion protein Bunyavirus