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Enhanced Precision Therapy of Multiple Myeloma Through Engineered biomimetic Nanoparticles with Dual Targeting

Engineering 2024年第5期36卷 178-192页

作者： Ruogu Qi Shanshan Wang Jiayi Yu Tianming Lu zhiqiang bi Weibo Liu Yuanyuan Guo Yong bian Jianliang Shen Xuesong Zhang Wenhao Hu School of Medicine Nanjing University of Chinese MedicineNanjing 210023China Laboratory Animal Center Nanjing University of Chinese MedicineNanjing 210023China Key Laboratory of Carcinogenesis and Translational Research Ministry of Education/BeijingDepartment of Radiation OncologyBeijing Cancer HospitalBeijing 100142China Department of Orthopedics The Fourth Medical CenterThe Chinese People’s Liberation Army General HospitalBeijing 100853China State Key Laboratory of Ophthalmology Optometry and Vision ScienceSchool of Biomedical EngineeringWenzhou Medical UniversityWenzhou 325027China

Multiple myeloma(MM)is the second most prevalent hematological *** MM treatment strategies are hampered by systemic toxicity and suboptimal therapeutic *** study addressed these limitations through the development of a potent MM-targeting chemotherapy strategy,which capitalized on the high binding affinity of alendronate for hydroxyapatite in the bone matrix and the homologous targeting of myeloma cell membranes,termed T-PB@*** results from our investigations highlight the considerable bone affinity of T-PB@M,both in vitro and in ***,this material demonstrated a capability for drug release triggered by low pH ***,T-PB@M induced the generation of reactive oxygen species and triggered cell apoptosis through the poly(ADP-ribose)polymerase 1(PARP1)-Caspase-3-B-cell lymphoma-2(Bcl-2)pathway in MM ***,T-PB@M preferentially targeted bone-involved sites,thereby circumventing systemic toxic side effects and leading to prolonged survival of MM orthotopic ***,this designed target-MM nanocarrier presents a promising and potentially effective platform for the precise treatment of MM.

关键词： Multiple myeloma Bortezomib Drug delivery Dual targeting Controlled release

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Morphogenesis of Chinese Water Chestnut Pistil and Pollen Tube during Germination

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Asian Agricultural Research 2016年第5期8卷 74-76,79页

作者： Kunpeng OU Fanglian HE Yan WANG Wen JIANG Meiping GAO zhiqiang bi Lijuan CHEN Weiqing DONG Jie GUI biotechnology Research Institute Guangxi Academy of Agricultural Sciences

With the forms of pistil stigma of " Guiti 2" Chinese water chestnut cultivar during the pollination as the object of observation,we reveal the pollination process of Chinese water chestnut from the microscopic point of view,to provide reference for Chinese water chestnut crossbreeding. The results show that the Chinese water chestnut pistil has 2- 4 stigmas which present white filament and vascular bundle forms,and the vessels on epidermis are thick with long translucent branched hairs; after pollination,pollen grains are tightly bound on branched hairs,and after identification,the pollen tube can penetrate branched hairs,continue to grow,and transfer the genetic material in pollen to vascular bundle.

关键词： Chinese water chestnut Stigma Branched hairs Pollination

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非外伤性脑凸面蛛网膜下腔出血

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国际脑血管病杂志 2017年第6期25卷 560-566页

作者：崔志强毕国荣中国医科大学附属盛京医院神经内科沈阳110004

非外伤性脑凸面蛛网膜下腔出血（convexal subarachnoid haemorrhage, cSAH）为非动脉瘤性蛛网膜下腔出血的少见类型，病因和临床表现多样。文章从病因学、临床表现、影像学、诊断、治疗和预后等方面对cSAH进行了综述。

关键词：蛛网膜下腔出血大脑皮质脑淀粉样血管病血管炎,中枢神经系统后部白质脑病综合征诊断显像

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Robust interface and excellent as-built mechanical properties of Ti–6Al–4V fabricated through laser-aided additive manufacturing with powder and wire

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 154-168页

作者： Fei Weng Guijun bi Youxiang Chew Shang Sui Chaolin Tan Zhenglin Du Jinlong Su Fern Lan Ng Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong Engineering&Technology Research Center for Superhard MaterialSchool of Materials Science and EngineeringShandong UniversityJinan 250061China Institute of Intelligent Manufacturing Guangdong Academy of SciencesGuangzhou 510095China Singapore Institute of Manufacturing Technology 5 Cleantech Loop636732Singapore

The feasibility of manufacturing Ti-6Al-4V samples through a combination of laser-aided additive manufacturing with powder(LAAM_(p))and wire(LAAM_(w))was explored.A process study was first conducted to successfully circumvent defects in Ti-6Al-4V deposits for LAAM_(p) and LAAM_(w),*** the optimized process parameters,robust interfaces were achieved between powder/wire deposits and the forged substrate,as well as between powder and wire *** characterization results revealed the epitaxial prior β grains in the deposited Ti-6Al-4V,wherein the powder deposit was dominated by a finerα′microstructure and the wire deposit was characterized by lamellar α *** mechanisms of microstructure formation and correlation with mechanical behavior were analyzed and *** mechanical properties of the interfacial samples can meet the requirements of the relevant Aerospace Material Specifications(AMS 6932)even without post heat *** fracture occurred within the interfacial area,further suggesting the robust *** findings of this study highlighted the feasibility of combining LAAM_(p) and LAAM_(w) in the direct manufacturing of Ti-6Al-4V parts in accordance with the required dimensional resolution and deposition rate,together with sound strength and ductility balance in the as-built condition.

关键词： laser-aided additive manufacturing powder deposition wire deposition interfacial characteristic mechanical behavior

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物流工程与国际物流运作

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中国市场 2008年第32期 78-79页

作者：郑显春李志强毕全超朱守芹河北建筑工程学院

我国大型企业要进入世界企业100强或500强的行列,必须极大地提高我国国际物流的支持能力。我国已经加入世界贸易组织,国际贸易和跨国经营都面临着巨大商机和严峻挑战。为了使我国在世界贸易格局中占据有利的地位,提高中国跨国公司的竞... 详细信息

我国大型企业要进入世界企业100强或500强的行列,必须极大地提高我国国际物流的支持能力。我国已经加入世界贸易组织,国际贸易和跨国经营都面临着巨大商机和严峻挑战。为了使我国在世界贸易格局中占据有利的地位,提高中国跨国公司的竞争能力和成本优势,开展和加强物流的研究具有重要意义。

关键词：物流工程物流系统网络国际物流物流国际化

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Photosynthetic reaction pathways of natural and artificial systems

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Science China Chemistry 2025年

作者： Shixing Lei Liting bi Lingxuan Chen Zhanting Li Jia Tian State Key Laboratory of Organometallic Chemistry and Shanghai Hong Kong Joint Laboratory in Chemical Synthesis Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences

Photosynthesis converts solar energy into chemical energy through highly coordinated photosynthetic *** by natural systems,artificial photosynthesis aims to develop an efficient,sustainable,and cost-effective pathway for solar-tochemical *** review examines natural photosynthetic pathways,including retinal/rhodopsin-,bacteriochlorophyll-,and chlorophyll-based systems,highlighting their key components and ***,we outline reaction pathways in artificial photosynthetic systems constructed via heterogeneous,homogeneous,self-assembly,and semi-artificial strategies,focusing on water splitting,carbon fixation,and nitrogen ***,we offer insights into future directions for artificial photosynthesis,emphasizing the importance of using self-assembly strategies and the potential of using primitive phototrophic microorganisms as models.

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Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats

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Neural Regeneration Research 2025年第4期20卷 1164-1177页

作者： Pengfei Wang Yuewei bi Min Li Jiazhi Chen Zhuyong Wang Huantao Wen Ming Zhou Minjie Luo Wangming Zhang Neurosurgery Center Department of Pediatric NeurosurgeryGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Long-term levodopa administration can lead to the development of levodopa-induced *** oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced ***,studies have reported increased oscillation power in cases of levodopa-induced ***,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced ***,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is *** found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s ***,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma *** of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum ***,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum *** findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.

关键词： aperiodic components dopamine D3 receptor dorsolateral striatum functional connectivity gamma oscillations levodopa-induced-dyskinesia local field potentials neuromodulation Parkinson’s disease primary motor cortex

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乙烯利对香蕉抗寒性的影响

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热带作物学报 2009年第12期30卷 1789-1792页

作者：韦弟李杨瑞邸南南闭志强卜朝阳广西大学广西亚热带生物资源保护利用重点实验室广西南宁530005 广西农业科学院生物技术研究所广西南宁530007 广西农业科学院广西作物遗传改良生物技术重点开放实验室广西南宁530007

用乙烯利喷洒香蕉幼苗叶片1d后,于6℃低温胁迫1d,研究乙烯利对香蕉幼苗抗寒性的影响。结果显示:乙烯利预处理可以保护低温胁迫后香蕉叶片细胞结构的完整性,降低低温胁迫后叶片的萎蔫程度和相对电导率,提高低温胁迫后叶片的光合速率。表... 详细信息

用乙烯利喷洒香蕉幼苗叶片1d后,于6℃低温胁迫1d,研究乙烯利对香蕉幼苗抗寒性的影响。结果显示:乙烯利预处理可以保护低温胁迫后香蕉叶片细胞结构的完整性,降低低温胁迫后叶片的萎蔫程度和相对电导率,提高低温胁迫后叶片的光合速率。表明乙烯利可以提高香蕉幼苗抗寒性,其中浓度为200mg/L时效果最佳。

关键词：香蕉乙烯利抗寒性

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早强剂对充填膏体宏观力学性能和微观结构的影响

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矿业研究与开发 2020年第3期40卷 135-139页

作者：施现院于光耀毕智强杜兆文尹大伟冯帆山东康格能源科技有限公司山东济宁市272175 山东省充填开采工程技术研究中心山东济宁市272175 山东科技大学矿业与安全工程学院山东青岛市266510

为了尽快提高充填膏体的早期强度,从而加速采-充循环频率和控制顶板下沉,对内掺不同含量硫酸钠早强剂的充填膏体试件进行了单轴抗压强度试验,并分析其微观结构变化和反应机理。试验结果表明:掺有硫酸钠早强剂的充填膏体试件在不同龄期... 详细信息

为了尽快提高充填膏体的早期强度,从而加速采-充循环频率和控制顶板下沉,对内掺不同含量硫酸钠早强剂的充填膏体试件进行了单轴抗压强度试验,并分析其微观结构变化和反应机理。试验结果表明:掺有硫酸钠早强剂的充填膏体试件在不同龄期内的单轴抗压强度均远高于对照试件。当养护3d和7d时,掺量为2%的硫酸钠早强剂对充填膏体强度提升最大,分别提高了131%和116%;当养护28d时,掺量为1%的硫酸钠早强剂对充填膏体强度提升最大,提高了135%。扫描电镜结果显示,掺有1%和2%硫酸钠早强剂的充填膏体试件内部结构致密性更好,针状晶体更粗、絮状凝结物更多。硫酸钠作为一种早强剂掺入充填膏体后能与水泥水化产物氢氧化钙发生反应生成二水硫酸钙,进一步与水化产物铝酸钙(C3A)迅速反应生成水化硫铝酸钙针状晶体(AFt),在充填体内部形成早期骨架从而提高早期强度。

关键词：早强剂充填膏体力学性能微观结构反应机理

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乙烯利提高香蕉幼苗抗寒性的生理效应

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热带作物学报 2009年第10期30卷 1447-1451页

作者：韦弟李杨瑞邸南南卜朝阳闭志强广西大学广西亚热带生物资源保护利用重点实验室广西南宁530005 广西农业科学院生物技术研究所广西南宁530007 广西农业科学院广西作物遗传改良生物技术重点开放实验室广西南宁530007

用200mg/L乙烯利喷洒香蕉幼苗叶片1d,再于8℃低温胁迫1d后,研究乙烯利对香蕉幼苗抗寒性的影响。结果表明:乙烯利预处理提高了香蕉叶片的SOD、POD、CAT活性和香蕉叶片的游离脯氨酸和可溶性蛋白含量;降低了丙二醛含量。表明乙烯利可通过... 详细信息

用200mg/L乙烯利喷洒香蕉幼苗叶片1d,再于8℃低温胁迫1d后,研究乙烯利对香蕉幼苗抗寒性的影响。结果表明:乙烯利预处理提高了香蕉叶片的SOD、POD、CAT活性和香蕉叶片的游离脯氨酸和可溶性蛋白含量;降低了丙二醛含量。表明乙烯利可通过提高抗氧化酶活性和减少膜损伤来增强香蕉幼苗抗寒性。

关键词：香蕉乙烯利抗寒性

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