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Sources appointment and health risks of PM_(2.5)-bound trace elements in a coastal city of southeastern China

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Journal of Environmental Sciences 2024年第4期138卷 561-571页

作者： Ziyi Lin Xiaolong Fan Gaojie chen Youwei Hong Mengren Li Lingling Xu Baoye Hu chen Yang Yanting chen zhiqian Shao Jinsheng chen Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Key Lab of Urban Environment and Health Institute of Urban EnvironmentChinese Academy ofSciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China Minnan Normal University Zhangzhou 363000China

To gain a comprehensive understanding of sources and health risks of trace elements in an area of China with high population densities and low PM_(2.5)concentrations,15 trace elements(Al,K,Ca,Ti,V,Cr,Mn,Fe,Ni,Cu,Zn,As,Sn,Ba,Pb)in PM_(2.5)were monitored from December 2020 to November 2021 in a representative city,*** concentrations of trace elements in Xiamen displayed an obvious seasonal variation and were dominated by K,Fe,Al,Ca and *** on Positive Matrix Factorization analysis,source appointment revealed that the major sources of trace elements in Xiamen were traffic,dust,biomass and firework combustion,industrial manufacture and shipping *** to health risk assessment combined with the source appointment results,it indicated that the average noncarcinogenic risk was below the threshold and cancer risk of four hazardous metals(Cr,Ni,As,Pb)exceeded the threshold(10^(-6)).Traffic-related source had almost half amount of contribution to the health risk induced by PM_(2.5)-bound trace *** the dust transport period or Spring Festival period,the health risks exceeded an acceptable threshold even an order of magnitude higher,suggesting that the serious health risks still existed in low PM_(2.5)environment at certain *** risk assessment reminded that the health risk reduction in PM_(2.5)at southeastern China should prioritize traffic-related hazardous trace elements and highlighted the importance of controlling vehicles emissions in the future.

关键词： PM_(2.5)-bound trace elements Seasonal variations Source appointment Health risks Traffic-related source

320排CT血管造影联合经胸壁超声检查诊断复杂型先天性心脏病的价值

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西北国防医学杂志 2017年第2期38卷 80-83页

作者：闵智乾陈小龙张国安张小玲雷晓燕汤敏陕西省人民医院CT&MR室陕西西安710068

目的:探讨320排CT血管造影(CTA)联合经胸壁超声(TTE)诊断复杂型先天性心脏病(CCHD)的价值。方法:收集43例经手术证实CCHD的CTA及TTE检查结果,按照心内畸形与心外畸形分组,分析单一CTA及CTA联合TTE检查后的漏、误诊情况。结果:与手术结... 详细信息

目的:探讨320排CT血管造影(CTA)联合经胸壁超声(TTE)诊断复杂型先天性心脏病(CCHD)的价值。方法:收集43例经手术证实CCHD的CTA及TTE检查结果,按照心内畸形与心外畸形分组,分析单一CTA及CTA联合TTE检查后的漏、误诊情况。结果:与手术结果对照,单一CTA与联合应用TTE诊断心内畸形漏、误诊率分别为13.8%、2.3%,心外畸形漏、误诊率分别为8.2%、4.5%,对所有畸形漏、误诊率分别为10.7%、3.6%,两者在心外畸形的诊断上未见统计学差异,而在心内畸形及总体心脏畸形的判断上具有统计学差异,联合应用优于单一CTA检查。结论:CTA联合TTE检查较单一CTA检查可以降低CCHD诊断的漏、误诊率,尤其是在CTA诊断困难或病变不典型时,应联合TTE检查进行综合判断。

关键词： CT 经胸壁超声联合应用复杂型先天性心脏病

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姜黄素对血管平滑肌细胞增殖及迁移的影响

中华老年心脑血管病杂志 2025年第1期27卷 89-93页

作者：苏朝江刘俪婷熊智倩张帅陈彦刘宗旸姜燕贵州医科大学附属肿瘤医院肾内科贵阳550003 贵州医科大学附属肿瘤医院实验室贵阳550003 贵州医科大学临床医学院

目的探讨姜黄素对血管平滑肌细胞(vascular smooth muscle cells,VSMC)异常增殖和迁移的影响及其作用机制。方法将VSMC分为对照1组,血管紧张素Ⅱ(AngiotensinⅡ,AngⅡ)1组,姜黄素1组,姜黄素2组和姜黄素3组(n=11),除对照1组外,其他4组使... 详细信息

目的探讨姜黄素对血管平滑肌细胞(vascular smooth muscle cells,VSMC)异常增殖和迁移的影响及其作用机制。方法将VSMC分为对照1组,血管紧张素Ⅱ(AngiotensinⅡ,AngⅡ)1组,姜黄素1组,姜黄素2组和姜黄素3组(n=11),除对照1组外,其他4组使用AngⅡ建立细胞增殖模型,姜黄素1、2、3组分别给予姜黄素1.5、3.0、4.5μmol/L干预,另取VSMC分为对照2组,AngⅡ2组,姜黄素组和姜黄素+AngⅡ组(n=3)。采用Western blot法检测VSMC分化表型蛋白α平滑肌肌动蛋白(α-smooth muscle actin,α-SMA)、去分化表型蛋白骨桥蛋白(Osteopontin,OPN),自噬相关蛋白(P62、Beclin-1)以及腺苷酸活化蛋白激酶(adenosine monophosphate-activated protein kinase,AMPK)/哺乳动物雷帕霉素靶蛋白(mammaliantargetofrapamycin,mTOR)途径相关蛋白AMPK、磷酸化AMPK(p-AMPK)、mTOR、磷酸化mTOR(p-mTOR)、p70S6K、磷酸化p70S6K(p-p70S6K)表达水平。结果AngⅡ1组VSMC增殖率、迁移率明显高于对照1组(155%vs 100%,66%vs 48%,P<0.05)。与AngⅡ1组比较,姜黄素2、3组VSMC增殖率以及姜黄素1、2、3组VSMC迁移率明显降低(P<0.05)。与AngⅡ1组比较,姜黄素2、3组α-SMA表达明显升高,姜黄素1、2、3组OPN表达明显降低(P<0.05)。与对照2组比较,AngⅡ2组和姜黄素组Beclin-1、p-AMPK/AMPK表达明显升高,P62、p-mTOR/mTOR、p-p70S6K/p70S6K表达明显降低(P<0.05)。与AngⅡ2组比较,姜黄素组和姜黄素+AngⅡ组Beclin-1、p-AMPK/AMPK表达明显升高,P62、p-mTOR/mTOR、p-p70S6K/p70S6K表达明显降低(P<0.05)。结论姜黄素能抑制AngⅡ诱导的VSMC增殖及迁移,其作用机制可能与姜黄素激活AMPK/mTOR信号通路增强VSMC的自噬有关。

关键词：姜黄素肌细胞,平滑肌细胞增殖细胞迁移

两种品牌中支卷烟主流烟气化学成分差异性研究

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西南师范大学学报（自然科学版） 2023年第8期48卷 103-112页

作者：许春平陈治岍郑凯薛云李天笑梁永伟吴攀芦昶彤郑州轻工业大学食品与生物工程学院郑州450000 河南中烟工业有限责任公司许昌卷烟厂河南许昌461000 河南中烟工业有限责任公司技术中心郑州450016

为了解不同品牌中支卷烟产品之间的烟气特征差异,选取了广西中烟真龙品牌中支系列的H和Y品种以及河南中烟黄金叶品牌的S,L,N品种共5款市售卷烟进行研究,用GC/MS,GC以及吸烟机对两种品牌中支卷烟主流烟气中的香气成分和烟气常规成分(烟碱... 详细信息

为了解不同品牌中支卷烟产品之间的烟气特征差异,选取了广西中烟真龙品牌中支系列的H和Y品种以及河南中烟黄金叶品牌的S,L,N品种共5款市售卷烟进行研究,用GC/MS,GC以及吸烟机对两种品牌中支卷烟主流烟气中的香气成分和烟气常规成分(烟碱、CO和焦油含量)进行检测,同时利用主成分分析和相关性分析方法寻求不同品牌中支卷烟风格差异,明晰不同品牌中支卷烟烟气特征差异.实验结果表明:①通过主成分分析可知,两种品牌卷烟在烟气香味成分上具有明显差异.真龙品牌的2款卷烟香气以赋予烟气果香的针叶烯以及赋予烟气花香、木香特征的金合欢醇为主要香气特征;而品种S以赋予烟气烟草本香及甜香的巨豆三烯酮、2,3-二氢-3,5-二羟基-6-甲基-4H-吡喃-4-酮为主要香气特征;品种L,N以赋予烟气强烈花香的3-羟基-β-二氢大马酮、丁香酚、5-羟甲基糠醛为主要香气特征.②两种品牌卷烟均符合低焦油卷烟标准,但黄金叶3款卷烟烟气常规成分含量基本高于真龙的2款卷烟.③相关性分析表明每一款卷烟的烟气常规成分组间检测相似度均在99%以上,说明5款卷烟烟气常规成分具有极强的稳定性;品种H与其他卷烟烟气常规成分的相似度极低,最低至27.5%,但品种Y与其他卷烟的烟气常规成分相似度极高,尤其是与L的相似度达到99.0%以上,说明烟气常规成分不能单独作为区分不同品牌卷烟的指标.

关键词：中支卷烟烟气化学主成分分析相关性分析品牌

Micropaleontology and palaeoclimate during the early Cretaceous in the Lishu depression,Songliao basin,Northeast China

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Geoscience Frontiers 2017年第1期8卷 93-106页

作者： Wei Yan Tailiang Fan Hongyu Wang chen Zhu zhiqian Gao Xiangjie Meng Yangzi Sun Fan Yang School of Energy Resources China University of GeosciencesBeijing 100083China Key Laboratory of Marine Reservoir Evolution and Hydrocarbon Accumulation Mechanism Ministry of EducationChina University of GeoscieneesBeijing 100083China Department of Geosciences Indiana University BloomingtonBloomington47405USA Exploration and Development Research Institute of Huabei Oilfield PetroChinaRenqiu062550China The Research Institute of CNOOC Shenzhen Branch ZhuangzhouGuangdong510000China The First Oil Production of SINOPEC North Chino Company QingyangCansu745000China

Diverse and abundant microfossils, such as palynomorphs, algae and Ostracoda, were collected from lower Cretaceous strata of Lishu depression, located in southeastern Songliao basin, and were identified and classified in order to provide relevant, detailed records for paleoclimate research. The early Creta- ceous vegetation and climate of southeastern Songliao basin have been inferred from the analysis of palynomorph genera, algae and Ostracoda of the LSI and SW110 wells. The lower Cretaceous strata include, in ascending stratigraphic order, the Shahezi, Yingcheng and Denglouku formations. Palyno- logical assemblages for each formation, based on biostratigraphic and statistical analyses, provide an assessment of their longitudinal variations. During deposition of the Shahezi Formation, the climate was mid-subtropical. Vegetation consisted of coniferous forest and herbage. During deposition of the Ying- cheng Formation, the climate was south Asian tropical. Vegetation consisted mainly of coniferous forest and herbal shrub. In addition, fresh and saline non-marine water dominated the lacustrine setting during deposition of these formations. Deposition of the Denglouku Formation, however, occurred under a hot and dry tropical climate. The vegetation was mostly coniferous forest and lake waters became saline. Palaeoclimate variation is correlated by the lake level change and the development of sedimentary facies. Palaeoclimate contribute to the formation of hydrocarbon source rocks and reservoir.

关键词： Palynomorph Palaeoclimate Early Cretaceous Lishu depression Songliao Basin

Molecular exchange and passivation at interface afford high-performing perovskite solar cells with efficiency over 24%

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Journal of Energy Chemistry 2023年第7期82卷 219-227,I0005页

作者： Jianjun Sun Wangchao chen Yingke Ren Yunjuan Niu zhiqian Yang Li'e Mo Yang Huang Zhaoqian Li Hong Zhang Linhua Hu Key Laboratory of Photovoltaic and Energy Conservation Materials Institute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031AnhuiChina School of Chemistry and Chemical Engineering Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of TechnologyHefei 230009AnhuiChina College of Science Hebei University of Science and TechnologyShijiazhuang 050018HebeiChina Hebei Computational Optical Imaging and Photoelectric Detection Technology Innovation Center Hebei International Joint Research Center for Computational Optical Imaging and Intelligent SensingSchool of Mathematics and Physics Science and EngineeringHebei University of EngineeringHandan 056038HebeiChina University of Science and Technology of Chin1 Anhui 230026HefeiChina

The interface is crucial for perovskite solar cells(PSCs).However,voids at interfaces induced by the trapped hygroscopic dimethyl sulfoxide(DMSO)can reduce charge extraction and accelerate the film degradation,seriously damaging the efficiency and *** this work,4,4’-dinonyl-2,2’-dipyridine(DN-DP),a Lewis base with long alkyl chains is introduced to solve this *** calculated and experimental results confirm that the dipyridyl group on DN-DP can more strongly coordinate with Pb^(2+)than that of the S=O group on *** strong coordination effect plays a crucial role in removing the DMSO-based adduct and reducing the formation of *** to the electron-donating properties of pyridine,the existence of DN-DP in the perovskite film can passivate the defects and optimize the energy level alignment of the perovskite *** open-circuit voltage(VOC)of the DN-DP-based PSC is improved from 1.107 V(control device)to 1.153 V,giving rise to a power conversion efficiency(PCE)of24.02%.Furthermore,benefiting from the moisture resistance stemming from the hydrophobic nonyl group,the PCE retains 90.4%of the initial performance after 1000 h of storage in the ambient condition.

关键词： Perovskite solar cell Anti-solvent 4 4′-Dinonyl-2 2′-dipyridine Optimized interfaceStability

Dendron-polymer hybrid mediated anticancer drug delivery for suppression of mammary cancer

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Journal of Materials Science & Technology 2021年第4期63卷 115-123页

作者： Dayi Pan Xiuli Zheng Miao chen Qianfeng Zhang zhiqian Li Zhenyu Duan Qiyong Gong Zhongwei Gu Hu Zhang Kui Luo Huaxi MR Research Center(HMRRC) Department of RadiologyFunctional and Molecular Imaging Key Laboratory of Sichuan ProvinceNational Clinical Research Center for GeriatricsState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China Department of Orthodontics West China Hospital of StomatologySichuan UniversityChengdu610041SichuanChina Amegen Bioprocessing Centre Keck Graduate InstituteCA91711USA

Dendron-polymer-based nanoscale and stimuli-responsive drug delivery systems have shown great promise in tumor-targeting accumulation without significant *** we report a dendronized polymer-doxorubicin(DOX)hybrid(DPDH)with an improved in vivo drug delivery efficiency for cancer therapy compared with a linear polymer-DOX conjugate(LPDC).The in vitro drug release profile of DOX indicates that DPDH displays pH-responsive drug release due to cleavage of hydrazone bonds since a greater amount of DOX is released at pH 5.2 at a faster rate than at pH *** efficiently enters 4 T1 cells and releases DOX to induce cytotoxicity and *** to the dendronzied structure,DPDH has a significantly longer blood circulation time than *** substantially enhances the therapeutic efficacy to suppress tumor growth in a 4 T1 mammary cancer model than LPDC as well as free drug,evidenced from tumor growth inhibition,TUNEL assessment and histological *** of DPDH is also confirmed from hemolysis,body weight shifts during treatment and pathological *** study demonstrates the use of dendronized polymer-DOX hybrids for specific drug molecules is a promising approach for drug delivery.

关键词： cancer analysis. release

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石棉矿精选车间家犬自然染尘的研究

四川医学院学报 1983年第4期14卷 345-350页

作者：柯佛心端木彬如王绵珍罗素琼朱蓉杨惠如青玉孝李洪洋吴忠舜陈志潜四川医学院尘肺研究室四川新康石棉矿四川医学院卫生系病理学教研室四川医学院卫生系病理学教研室教授

作者选用雄性家犬,于石棉矿精选车间进行自然染尘。染尘后家犬肺组织有不同程度病变,病变以纤维化为主,并有脂肪和胶原成份增加。通过自然染尘,获得比较接近人体病变的石棉肺模型,也提示了加强对石棉工人劳动保护的迫切性。

关键词：肺组织病理改变石棉纤维矿物纤维石棉肺家犬纤维化肺湿重尘组动物粉尘浓度病变车间

ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis

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Frontiers of Medicine 2023年第5期17卷 972-992页

作者： zhiqian Bi Jia chen Xiaoyao Chang Dangran Li Yingying Yao Fangfang Cai Huangru Xu Jian cheng Zichun Hua Hongqin Zhuang The State Key Laboratory of Pharmaceutical Biotechnology College of Life SciencesNanjing UniversityNanjing210023China Changzhou High-Tech Research Institute of Nanjing University and Jiangsu TargetPharma Laboratories Inc. Changzhou213164China School of Biopharmacy China Pharmaceutical UniversityNanjing211198China Institute of Neuroscience Soochow UniversitySuzhou215123China

Owing to the increasing incidence and prevalence of inflammatory bowel disease(IBD)worldwide,effective and safe treatments for IBD are urgently *** sulfide(H2S)is an endogenous gasotransmitter and plays an important role in *** date,H2S-releasing agents are viewed as potential anti-inflammatory *** slow-releasing H_(2)S donor 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione(ADT-OH),known as a potent therapeutic with chemopreventive and cytoprotective properties,has received attention ***,we reported its anti-inflammatory effects on dextran sodium sulfate(DSS)-induced acute(7 days)and chronic(30 days)*** found that ADT-OH effectively reduced the DSS-colitis clinical score and reversed the inflammation-induced shortening of colon ***,ADT-OH reduced intestinal inflammation by suppressing the nuclear factor kappa-B *** vivo and in vitro results showed that ADT-OH decreased intestinal permeability by increasing the expression of zonula occludens-1 and occludin and blocking increases in myosin II regulatory light chain phosphorylation and epithelial myosin light chain kinase protein expression *** addition,ADT-OH restored intestinal microbiota dysbiosis characterized by the significantly increased abundance of Muribaculaceae and Alistipes and markedly decreased abundance of Helicobacter,Mucispirillum,Parasutterella,and *** ADT-OH-modulated microbiota can alleviate DSS-induced colitis and negatively regulate the expression of local and systemic proinflammatory ***,ADT-OH is safe without any short-term(5 days)or long-term(30 days)toxicological adverse effects and can be used as an alternative therapeutic agent for IBD treatment.

关键词： inflammatory bowel disease ADT-OH intestinal permeability gut microbiota

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