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Acta Pharmaceutica Sinica B 2024年第7期14卷 2901-2926页

作者： Xiaoman mao Shuang Wu Dandan Huang Chong Li College of Pharmaceutical Sciences Southwest UniversityChongqing 400715China Medical Research Institute Southwest UniversityChongqing 400715China School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou 510515China

Despite the considerable advancements in chemotherapy as a cornerstone modality in cancer treatment,the prevalence of complications and pre-existing diseases is on the rise among cancer patients along with prolonged survival and aging *** relationships between these disorders and cancer are intricate,bearing significant influence on the survival and quality of life of individuals with cancer and presenting challenges for the prognosis and outcomes of ***,we review the prevailing complications and comorbidities that often accompany chemotherapy and summarize the lessons to learn from inadequate research and management of this scenario,with an emphasis on possible strategies for reducing potential complications and alleviating comorbidities,as well as an overview of current preclinical cancer models and practical advice for establishing bio-faithful preclinical models in such complex context.

关键词： Complications Comorbidities Chemotherapy Preclinical cancer models Drug design Drug delivery

Simulation of Underground Reservoir Stability of Pumped Storage Power Station Based on Fluid-Structure Coupling

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1381-1399页

作者： Peng Qiao Shuangshuang Lan Hongbiao Gu Zhengtan mao Faculty of Architecture Civil and Transportation EngineeringBeijing University of TechnologyBeijing100020China College of Transportation Engineering Nanjing Tech UniversityNanjing210000China

Based on global initiatives such as the clean energy transition and the development of renewable energy,the pumped storage power station has become a new and significant way of energy storage and regulation,and its construction environment is more complex than that of a traditional *** particular,the stability of the rock strata in the underground reservoirs is affected by the seepage pressure and rock stress,which presents some challenges in achieving engineering safety and *** the advantages of the numerical simulation method in dealing deal with nonlinear problems in engineering stability,in this study,the stability of the underground reservoir of the Shidangshan(SDS)pumped storage power station was numerically calculated and quantitatively analyzed based on fluid-structure coupling theory,providing an important reference for the safe operation and management of the underground ***,using the COMSOL software,a suitablemechanicalmodel was created in accordance with the geological structure and project characteristics of the underground ***,the characteristics of the stress field,displacement field,and seepage field after excavation of the underground reservoir were simulated in light of the seepage effect of groundwater on the nearby rock of the underground ***,based on the construction specifications and Molar-Coulomb criterion,a thorough evaluation of the stability of the underground reservoir was performed through simulation of the filling and discharge conditions and anti-seepage strengthening *** findings demonstrate that the numerical simulation results have a certain level of reliability and are in accordance with the stress measured in the project *** underground reservoir excavation resulted in a maximum displacement value of the rock mass around the caverns of 3.56 mm in a typical section,and the safety coefficient of the parts,as determined using the Molar-Coulomb criterion,was highe

关键词： Underground reservoir fluid-structure coupling numerical simulation pumped storage power station filling and discharge

Temporal changes in mixing effects on litter decay and nitrogen release in a boreal riparian forest in northeastern China

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Journal of Forestry Research 2024年第2期35卷 33-41页

作者： Simin Wang Bo Liu Rui Li Xiaoxin Sun Rong mao Key Laboratory of National Forestry and Grassland Administration on Forest Ecosystem Protection and Restoration of Poyang Lake Watershed College of ForestryJiangxi Agricultural UniversityNanchang 330045People’s Republic of China Key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102People’s Republic of China Key Laboratory of Sustainable Forest Ecosystem Management of Ministry of Education School of ForestryNortheast Forestry UniversityHarbin 150040People’s Republic of China Heilongjiang Sanjiang Plain Wetland Ecosystem Research Station Fuyuan 156500People’s Republic of China

In riparian forests,litter decay provides essential energy and nutrients for both terrestrial and fluvial *** mixing effects(LMEs)are crucial in regulating litter decay and nutrient dynamics,yet how LMEs change over time is unclear in riparian *** this study,leaf litter of three common species(Alnus sibirica *** Turcz,Betula platyphylla Sukaczev,and Betula fruticosa Pall.)were mixed in an equal mass ratio and LMEs were measured for mass and nitrogen(N)remaining in whole litter mixtures over a 3-year period in a boreal riparian forest,northeastern *** were also assessed for component litter mass and N remaining by separating litter mixtures by *** the decay of litter mixtures,antagonistic effects on mass and N remaining were dominant after one and two years of decay,whereas only additive effects were observed after three *** correlated negatively with functional diversity after the first and two years of decay but disappeared after three *** sorting litter mixtures by species,non-additive LMEs on mass and N remaining decreased over incubation ***,non-additive LMEs were more frequent for litter of both *** and *** with lower N concentration than for *** litter with higher N *** results indicate that incubation time is a key determinant of litter mixing effects during decay and highlight that late-stage litter mixture decay may be predicted from single litter decay dynamics in boreal riparian forests.

关键词： Biodiversity Litter quality Litter mixtures Synergistic effects Functional diversity

Advances in mesenchymal stem cells therapy for tendinopathies

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Chinese Journal of Traumatology 2024年第1期27卷 11-17页

作者： Xu-Feng mao Xi-Qian Zhang Zhe-Yu Yao Hai-Jiao mao Department of Orthopaedic Surgery The First Affiliated Hospital of Ningbo UniversityNingbo315010Zhejiang provinceChina

Tendinopathies are chronic diseases of an unknown etiology and associated with *** stem cells(MSCs)have emerged as a viable therapeutic option to combat the pathological progression of tendinopathies,not only because of their potential for multidirectional differentiation and self-renewal,but also their excellent immunomodulatory *** immunomodulatory effects of MSCs are increasingly being recognized as playing a crucial role in the treatment of tendinopathies,with MSCs being pivotal in regulating the inflammatory microenvironment by modulating the immune response,ultimately contributing to improved tissue *** review will discuss the current knowledge regarding the application of MSCs in tendinopathy treatments through the modulation of the immune response.

关键词： Mesenchymal stem cells Tendinopathy Immunomodulation Treatment Review

The combination of gut microbiota-depleted treatment and fecal microbiota transplantation is an important strategy to verify the efficacy of Traditional Chinese Medicine though modulation of gut dysbiosis

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Journal of Traditional Chinese Medicine 2024年第1期44卷 222-223页

作者： XING Yunqi LI Junxiang YUAN Yali mao Tangyou Gastroenterology Department Dongfang HospitalBeijing University of Chinese MedicineBeijing 100078China Department of Hepatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 201203China

To the Editors:We read with great interest the study recently published by Sun et al 1 entitled“Electroacupuncture at Tianshu(ST25)and Zusanli(ST36)alleviates stress-induced irritable bowel syndrome in mice by modulating gut microbiota and corticotropin-releasing factor”in which the microbial details of electroacupuncture(EA)-induced protection in irritable bowel syndrome(IBS)were investigated.

关键词： releasing treatment details

Topological non-reciprocal robust waveguide transport

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 39-45页

作者： Ruizhi Dong Yihuan Zhu Dongxing mao Xu Wang Yong Li Institute of Acoustics Tongji UniversityShanghai 200092China

Devices that surpass the restriction of reciprocity of classical physical waves have brought intriguing possibilities for wave ***-reciprocal acoustic devices that rely on the viscosity of the medium or nonlinear effect have low efficiency and distortion problems respectively,and poor immunity to *** appearance of acoustic topological insulators achieves nonreciprocal transport with high ***,the local nature of topological states means that their appearance depends on a system with a larger *** is,most of the area of a topological device is occupied by useless lattices that do not directly contribute to non-reciprocal *** extra cost of topology protection severely limits the application scenarios of topology states,decreases the cost-effectiveness of topology devices,and is not conducive to device miniaturization and *** this work,we construct an acoustic three-layer heterojunction by introducing two types of domain walls into a conventional quantum Hall effect acoustic topological insulator,and successfully construct a non-reciprocal scattering network that forms topological modes spanning the interlayer *** extended states are still protected by bulk-band topology,making their non-reciprocity robust against *** structure flawlessly realizes the path broadening in a two-dimensional topological system and can accomplish functions such as non-reciprocal acoustic splitting and multichannel *** work opens up opportunities for developing topological-insulator-based non-reciprocal devices in acoustics.

关键词： reciprocal topological topology

Preparation and Characterization of Sepiolite Microfibers with High Aspect Ratio

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Journal of Donghua University(English Edition) 2022年第6期39卷 542-548页

作者：续通胡叶蕾钱迪朱元昭钟毅张琳萍徐红毛志平 Key Laboratory of Science&Technology of Eco-Textile Ministry of EducationDonghua UniversityShanghai 201620China National Dyeing and Finishing Engineering Technology Research Center Donghua UniversityShanghai 201620China National Manufacturing Innovation Center of Advanced Dyeing and Finishing Technology Taian 271000China Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology Ministry of EducationDepartment of ChemistryTsinghua UniversityBeijing 100084China Sino-German Engineering College Shanghai Technical Institute of Electronics&InformationShanghai 201411China

It is difficult to access exfoliated sepiolite(Sep)fibers with high aspect ratio from Sep *** traditional method used to purify Sep ore also reduces its aspect *** this study,impurities in the Sep ore were removed by acid activation followed by a cetyltrimethylammonium chloride(C16)treatment to organically modify the purified Sep by cation ***,the organically-modified Sep(O-Sep)was stripped and processed by an ultrasonic cell crusher to obtain Sep microfibers at a specific frequency for a given *** Sep samples had relatively high aspect ratio,compared with the Sep fibers gotten by traditional *** electron microscopy(SEM)and transmission electron microscopy(TEM)demonstrate the micro-morphology of exfoliated Sep samples in an intuitive ***,pure inorganic membrane prepared only with the exfoliated Sep fibers exhibited excellent flexibility,further demonstrating the excellent properties of Sep fibers with high aspect ratio.

关键词： sepiolite microfiber high aspect ratio inorganic membrane flexibility

Fault Analysis on AES:A Property-Based Verification Perspective

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Tsinghua Science and Technology 2024年第2期29卷 576-588页

作者： Xiaojie Dai Xingxin Wang Xue Qu Baolei mao Wei Hu School of Cybersecurity Northwestern Polytechnical UniversityXi’an 710072China School of Cyber Science and Engineering Zhengzhou UniversityZhengzhou 450001China

Fault analysis is a frequently used side-channel attack for ***,existing fault attack methods usually involve complex fault fusion analysis or computation-intensive statistical analysis of massive fault *** this work,we take a property-based formal verification approach to fault *** derive fine-grained formal models for automatic fault propagation and fusion,which establish a mathematical foundation for precise measurement and formal reasoning of fault *** extract the correlations in fault effects in order to create properties for fault *** further propose a method for key recovery,by formally checking when the extracted properties can be satisfied with partial keys as the search *** results using both unprotected and masked advanced encryption standard(AES)implementations show that our method has a key search complexity of 216,which only requires two correct and faulty ciphertext pairs to determine the secret key,and does not assume knowledge about fault location or pattern.

关键词： side-channel attack fault analysis fault propagation model property extraction fault verification

Single image defogging via multi-exposure image fusion and detail enhancement

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Journal of Safety Science and Resilience 2024年第1期5卷 37-46页

作者： Wenjing mao Dezhi Zheng Minze Chen Juqiang Chen School of Information and Electronics Advanced Research Institute of Multidisciplinary ScienceBeijing Institute of TechnologyBeijing100081China Chinese Aeronautical Establishment Beijing100012China

Outdoor cameras play an important role in monitoring security and social *** a common weather phenomenon,haze can easily affect the quality of camera shooting,resulting in loss and distortion of image *** paper proposes an improved multi-exposure image fusion defogging technique based on the artificial multi-exposure image fusion(AMEF)***,the foggy image is adaptively exposed,and the fused image is subsequently obtained via multiple *** fusion weight is determined by the saturation,contrast,and ***,the image fused by a multi-scale Laplacian algorithm is enhanced with simple adaptive details to obtain a clearer defogging *** is subjectively and objectively verified that this algorithm can obtain more image details and distinct picture colors without a priori information,effectively improving the defogging ability.

关键词： Image defogging Multi-scale fusion Laplacian pyramid Adaptive detail enhancement

Design strategy and relevant flow mechanisms of highly loaded 3D compressor tandem cascades

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Chinese Journal of Aeronautics 2024年第7期37卷 220-235页

作者： Xiaochen mao Yunyu WANG Zhihua DING Hao CHENG Bo LIU School of Power and Energy Northwestern Polytechnical UniversityXi’an 710129China The National Key Laboratory of Science and Technology on Aerodynamic Design and Research Xi’an 710129China Xi’an Thermal Power Research Institute Co.Ltd Xi’an 710072China

To investigate the design strategy of highly loaded tandem cascades at both the midspan and endwall,the overall performance and flow mechanisms of four typical tandem cascades based on the optimization were analyzed from multiple perspectives *** results show that the interference effects on the Front Blade(FB)and Rear Blade(RB)should not be overlooked during the design phase,and the design strategies at the midspan and endwall are completely *** the midspan,the optimization aims to increase the interference effects and the strength of the gap jet while maintaining the same load on the FB and ***,the endwall optimal airfoil exhibits weakening interference effects,advancement of the gap jet location,and load transfer from the FB to *** further analysis of flow characteristics,the midspan optimal airfoil is beneficial for inhibiting the low-energy fluid from interacting with the suction surface of RB under the design condition,but results in earlier occurrence of corner *** endwall optimal airfoil helps suppress the development of the secondary flow and delay the onset of corner ***,by combining the benefits of these two design approaches,additional forward sweep effects are achieved,further enhancing the performance of the tandem cascade.

关键词： Tandem cascade Interference effect Vortex structure Load split Compressor