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Survival and proliferation of the lysogenic bacteriophage CTXΦ in Vibrio cholerae

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Virologica Sinica 2015年第1期30卷 19-25页

作者： Fenxia Fan Biao kan State Key Laboratory for Infectious Disease Prevention and Control National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention

The lysogenic phage CTXΦ of Vibrio cholerae can transfer the cholera toxin gene both horizontally(inter-strain) and vertically(cell proliferation). Due to its diversity in form and species, the complexity of regulatory mechanisms, and the important role of the infection mechanism in the production of new virulent strains of ***, the study of the lysogenic phage CTXΦ has attracted much attention. Based on the progress of current research, the genomic features and their arrangement, the host-dependent regulatory mechanisms of CTXΦ phage survival, proliferation and propagation were reviewed to further understand the phage's role in the evolutionary and epidemiological mechanisms of V. cholerae.

关键词： Vibrio cholerae lysogenic bacteriophage CTXΦ regulation evolution

Damage Imaging in Mesoscale Concrete Modeling Based on the Ultrasonic Time-Reversal Technique

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Acta Mechanica Solida Sinica 2020年第1期33卷 61-70页

作者： kan Feng Qian Zhao Yaping Qiu Faculty of Civil Engineering and Mechanics Jiangsu UniversityZhenjiang 212013China Hengshen Co. Ltd.Zhenjiang 212314China

A novel method combining the time-reversal method(TRM)with wavelet analysis was proposed for damage imaging in mesoscale concrete *** damage was imaged by the convergence of time-reversed wave signals after wavelet *** numerical study,three concrete models of different damage sizes were built with randomly distributed aggregate *** time-reversal process was simulated using the reverse damage-scattered ultrasonic wave signals as excitations recorded by the ***,the wavelet analysis was employed to extract certain frequency component,which can enhance detection precision and the signalto-noise *** damage imaging showed clearly the location of the *** results from experimental testing also demonstrated that this detection technique is an efficient and effective method for damage imaging in mesoscale concrete.

关键词： Damage imaging Mesoscale concrete Time-reversal method Wavelet analysis

Analysis of particle dispersion and cavity formation during bulk particle water entry using fully coupled CFD-DEM-VOF approach

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Particuology 2024年第7期90卷 558-580页

作者： Utkan Çalışkan Sanja Mišković Norman B.Keevil Institute of Mining Engineering University of British Columbia2329 West MallVancouverBC V6T 1Z4Canada

This paper presents the development and validation of a fully coupled computational fluid dynamics—discrete element method—volume of fluid(CFD-DEM-VOF)model to simulate the complex behavior of particle-laden flows with free *** coupling between the fluid and particle phases is established through the implemented continuity,momentum,and alpha transport *** coupled particle forces such as drag,pressure gradient,dense virtual mass,viscous,and interface forces are also integrated,with drag and dense virtual mass forces being dependent on local *** integrated conservative alpha transport equation ensures phase volume conservation during interactions between particles and ***,we have implemented a trilinear interpolation method designed to operate on unstructured hexahedral *** method has been tested for its ability to properly resolve the coupling effects in the numerical simulations,particularly in cases with a relatively low cell-size *** model is validated through three distinct test cases:single particle water entry,dam break with particles,and water entry of a group of particles *** experimental setup is built to study the dynamics of the water entry of a group of particles,where three key flow features are analyzed:the evolution of average particle velocity,cavity shape,and particle dispersion cloud profiles in *** tests involve four different scenarios,including two different water levels(16.1 and 20.1 cm)and two different particle densities(2650 and 4000 kg/m3).High-speed videometry and particle tracking velocimetry(using ImageJ/TrackMate)methods are employed for experimental data *** is demonstrated that numerical results are in excellent agreement with theoretical predictions and experimental *** study highlights the significance of vortices in cavity shaping and particle *** validated CFD-DEM-VOF model constitutes a robust tool for simulating particle-laden flows,cont

关键词： CFD-DEM-VOF Trilinear interpolation Particle-laden flow Free-surface Particle water entry Volume conservation

Epidemiological Characteristics of Influenza A and B in Macao,2010–2018

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Virologica Sinica 2021年第5期36卷 1144-1153页

作者： HoiMan ng Teng Zhang Guoliang Wang SiMeng kan Guoyi Ma Zhe Li Chang Chen Dandan Wang MengIn Wong ChioHang Wong Jinliang Ni Xiaohua Douglas Zhang Clinical Laboratory Kiang Wu HospitalMacao 999078Macao Faculty of Health Sciences University of MacaoMacao 999078Macao

Influenza is one of the major respiratory diseases in *** is a tourist city with high density of population and special population *** study on the epidemiological characteristics of influenza in Macao should bring great value for preventing influenza in tourist cities like Macao in the *** this study,we collected a total of 104,874 samples with influenza-like illness(ILI)in Macao from 2010 to ***-square test and binary multivariable logistic regression were used to investigate the epidemiological characteristics of influenza A and B in *** these ILI samples,the overall positive rate is 17.17%for influenza A and 6.97%for influenza *** epidemics of influenza in three years(i.e.,2012,2017 and 2018)differ from the remaining years(i.e.,normal years).In a normal year,influenza A occurs year-round whereas influenza B is *** research shows significant differences in influenza infections between different age groups in normal ***,our analysis shows no significant difference between locals and tourists in influenza A and B infection in a normal year,whereas the odds of influenza A in tourists were significantly higher than those in locals in July 2017 and the odds of influenza B in tourists were significantly higher than those in locals in January–February 2012 and January–February *** is possibly attributed by the policy of free vaccination to everyone in *** findings should be valuable for preventing influenza in not only Macao but also the world.

关键词： Influenza Epidemiology Chi-square test Logistic regression Macao

慢性肌筋膜触发点模型大鼠的尿液代谢组学分析

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中国组织工程研究 2025年第8期29卷 1585-1592页

作者：刘琳刘世轩陆馨悦王侃南京体育学院运动健康学院江苏省南京市210014

背景:慢性肌筋膜触发点通过非靶向代谢组学技术可识别差异性代谢物变化,有助于从内源性小分子代谢物层面理解并进一步探究慢性肌筋膜触发点的病理生理过程和发病机制。目的:以慢性肌筋膜触发点模型大鼠为研究对象,基于尿液代谢组学寻找... 详细信息

背景:慢性肌筋膜触发点通过非靶向代谢组学技术可识别差异性代谢物变化,有助于从内源性小分子代谢物层面理解并进一步探究慢性肌筋膜触发点的病理生理过程和发病机制。目的:以慢性肌筋膜触发点模型大鼠为研究对象,基于尿液代谢组学寻找潜在生物标志物及相关代谢通路。方法:将16只SD大鼠随机分为造模组和正常组,造模组大鼠采用钝性打击结合离心运动(跑台坡度为-16°,跑速为16 m/min,训练时间为90 min/次)方式建立慢性肌筋膜触发点动物模型,每周1次,连续干预8周,休息4周;正常组大鼠不做干预。12周造模结束后,采用代谢笼法收集大鼠造模后24 h尿液,利用液相色谱-质谱联用非靶向代谢组学技术对尿样进行代谢图谱检测,筛选出共同差异代谢物,并进行生物信息学分析。结果与结论:①与正常组相比,造模组有32个差异代谢标志物,其中上调21个、下调11个;依据变量权重值>3,共14个差异代谢物被认定为潜在生物标志物;②京都基因与基因组百科全书富集分析表明,慢性肌筋膜触发点的形成与初级胆汁酸生物合成、花生四烯酸代谢通路密切相关。

关键词：肌筋膜触发点大鼠尿液代谢组学生物信息学生物标志物差异代谢物代谢笼法运动损伤

Mendelian Randomization Analysis to Analyze the Effect of Emergency Caesarean Section on Different Allergic Diseases and Related Blood Markers

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Biomedical and Environmental Sciences 2023年第11期36卷 1084-1089页

作者： LI Yu Jian kan Xuan Department of Pediatrics General Hospital of Tianjin Medical UniversityTianjin 300052China

Caesarean section is a well-established surgical procedure that allows for maximum fetal rescue under special circumstances,such as intrauterine distress and intrauterine hypoxia,and minimizes injuries to pregnant women who cannot tolerate vaginal *** caesarean section is a special type of caesarean section that plays an important role in protecting the lives of pregnant mothers and fetuses[1].

关键词： Blood injuries Emergency

Triaxial tension and compression tests on saturated lime-treated plastic clay upon consolidated undrained conditions

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第12期15卷 3328-3342页

作者： Kuchvichea kan Bertrand François Department of Civil Engineering Institute of Technology of CambodiaPhnom PenhCambodia BATir Department UniversitéLibre de BruxellesBrusselsBelgium ArGEnCo Departement Universitéde LiègeLiègeBelgium

Lime-treatment of clayey soil significantly increases its shear and tensile ***,the tensile strength of lime-treated soils deserves careful investigation because it may provide an appreciable benefit for the stability of earth *** study investigates the tensile and shear strengths of an untreated and lime-treated(3%of lime)plastic clay at different curing times(7 d,56 d and 300 d),through triaxial tension and compression *** tension tests are performed using“diabolo-shaped”soil samples with reduced central section,such that the central part of the specimen can be under axial tension while both end-sections remain in axial *** undrained(CU)conditions with measurement of pore water pressure allow analyzing the failure conditions through effective stress and total stress *** results of triaxial tension tests reveal that the failure occurs under tensile mode at low confining pressure while extensional shear failure mode is observed under higher confining ***,a classical Mohr-Coulomb shear failure criterion must be combined with a cut-off tensile strength criterion that is not affected by the confining *** comparing shear failure under compression and tension,a slight anisotropy is observed.

关键词： Tensile strength Consolidated undrained(CU)triaxial test Lime-treated soils Failure criterion

Applying the Theory of Numerical Radius of Operators to Obtain Multi-observable Quantum Uncertainty Relations

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Acta Mathematica Sinica,English Series 2022年第7期38卷 1241-1254页

作者： kan HE Jin Chuan HOU College of Mathematics Taiyuan University of TechnologyTaiyuan 030024P.R.China College of Information and Computer Science Taiyuan University of TechnologyTaiyuan 030024P.R.China

Quantum uncertainty relations are mathematical inequalities that describe the lower bound of products of standard deviations of observables(i.e.,bounded or unbounded self-adjoint operators).By revealing a connection between standard deviations of quantum observables and numerical radius of operators,we establish a universal uncertainty relation for k observables,of which the formulation depends on the even or odd quality of *** universal uncertainty relation is tight at least for the cases k=2 and k=*** two observables,the uncertainty relation is a simpler reformulation of Schr?dinger’s uncertainty principle,which is also tighter than Heisenberg’s and Robertson’s uncertainty relations.

关键词： Numerical radius of operators quantum uncertainty principle quantum observables quantum deviations

Electromechanically reconfigurable plasmonic photodetector with a distinct shift in resonant wavelength

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Microsystems & Nanoengineering 2023年第2期9卷 219-226页

作者： Masaaki Oshita Shiro Saito Tetsuo kan Graduate School of Informatics and Engineering The University of Electro-Communications1-5-1ChofugaokaChofu-cityTokyo 182-8585Japan IMRA JAPAN CO. LTD2-36Hachiken-choKariyaAichi 448-8650Japan

Plasmonic photodetectors have received increasing attention because their detection properties can be designed by tailoring their metal structures on surfaces without using any additional *** of the plasmonic resonant state in a photodetector is relevant for various applications,including investigating in situ adaptive detection property changes,depending on the situation,and performing single-pixel spectroscopy in geometrically limited ***,the spectral responsivity change with conventional reconfiguration methods is relatively ***,we propose a plasmonic photodetector that reconfigures its spectral responsivity with electromechanical deformation instead of bias *** photodetector consists of a gold plasmonic grating formed on an n-type silicon cantilever,and the spectral responsivity is reconfigured by electromechanically scanning at an incident angle to the grating on the *** photodetector exhibits peak shifts in spectral responsivity in a wavelength range from 1250 to 1310 nm after electromechanical ***,for potential future applications,we demonstrate near-infrared spectroscopy using the *** photodetector has the potential to be adopted as a near-infrared spectrometer in industrial silicon imaging systems because its structure enables subbandgap photodetection on silicon by a Schottky junction.

关键词： tuning reconfigurable resonant