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Calcification-associated molecular traits and therapeutic strategies in hormone receptor-positive HER2-negative breast cancer

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Cancer Biology & Medicine 2024年第5期21卷 400-415页

作者： Yuwei Li Yuzheng Xu Caijin Lin Xi Jin Ding Ma zhiming shao Department of Breast Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China

Objective:Mammographic calcifications are a common feature of breast cancer,but their molecular characteristics and treatment implications in hormone receptor-positive(HR+)/human epidermal growth factor receptor 2-negative(HER2−)breast cancer remain ***:We retrospectively collected mammography records of an HR+/HER2−breast cancer cohort(n=316)with matched clinicopathological,genomic,transcriptomic,and metabolomic *** the basis of mammographic images,we grouped tumors by calcification status into calcification-negative tumors,tumors with probably benign calcifications,tumors with calcification of lowmoderate suspicion for maligancy and tumors with calcification of high suspicion for *** then explored the molecular characteristics associated with each calcification status across multiple ***:Among the different statuses,tumors with probably benign calcifications exhibited elevated hormone receptor immunohistochemical staining scores,estrogen receptor(ER)pathway activation,lipid metabolism,and sensitivity to endocrine *** with calcifications of high suspicion for malignancy had relatively larger tumor sizes,elevated lymph node metastasis incidence,Ki-67 staining scores,genomic instability,cell cycle pathway activation,and may benefit from cyclin-dependent kinase 4 and 6(CDK4/6)***:Our research established links between tumor calcifications and molecular features,thus proposing potential precision treatment strategies for HR+/HER2−breast cancer.

关键词： HR+/HER2−breast cancer mammographic calcifications molecular features precision treatment

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IMAGGS: a radiogenomic framework for identifying multi-way associations in breast cancer subtypes

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Journal of Genetics and Genomics 2024年第4期51卷 443-453页

作者： Shuyu Liang Sicheng Xu Shichong Zhou Cai Chang zhiming shao Yuanyuan Wang Sheng Chen Yunxia Huang Yi Guo Department of Electronic Engineering School of Information Science and TechnologyFudan UniversityShanghai 200433China The Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention(MICCAI)of Shanghai Shanghai 200032China Shanghai Key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200433China Department of Ultrasound Fudan University Shanghai Cancer CenterDepartment of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China Department of Breast Surgery Fudan University Shanghai Cancer CenterDepartment of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China

Investigating correlations between radiomic and genomic profiling in breast cancer(BC)molecular subtypes is crucial for understanding disease mechanisms and providing personalized *** present a well-designed radiogenomic framework image–gene–gene set(IMAGGS),which detects multi-way associations in BC subtypes by integrating radiomic and genomic *** dataset consists of 721 patients,each of whom has 12 ultrasound(US)images captured from different angles and gene mutation *** better characterize tumor traits,12 multi-angle US images are fused using two distinct ***,we analyze complex many-to-many associations between phenotypic and genotypic features using a machine learning algorithm,deviating from the prevalent one-to-one relationship pattern observed in previous *** radiomic and genomic features are screened using these *** addition,gene set enrichment analysis is performed to investigate the joint effects of gene sets and delve deeper into the biological functions of BC *** further validate the feasibility of IMAGGS in a glioblastoma multiforme dataset to demonstrate the scalability of IMAGGS across different modalities and *** together,IMAGGS provides a comprehensive characterization for diseases by associating imaging,genes,and gene sets,paving the way for biological interpretation of radiomics and development of targeted therapy.

关键词： IMAGGS Radiogenomic framework "lmage-gene-geneset"associations Molecular subtypes Breast cancer

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职业教育特色专业群与区域产业集群协同发展研究——以上海旅游高等专科学校海派餐饮非遗传创专业群建设为例

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职业技术教育 2024年第2期45卷 40-44页

作者：邵志明上海旅游高等专科学校上海师范大学旅游学院酒店与烹饪学院上海201418

特色专业群建设作为职业院校内涵发展的重要方面,承载着服务区域产业发展的重要功能。针对“海派非遗美食+预制菜”区域产业发展需求,坚持高质量发展目标引领、专业群特色化聚焦、校企双集群联动的思路,上海旅游高等专科学校构建了海派... 详细信息

特色专业群建设作为职业院校内涵发展的重要方面,承载着服务区域产业发展的重要功能。针对“海派非遗美食+预制菜”区域产业发展需求,坚持高质量发展目标引领、专业群特色化聚焦、校企双集群联动的思路,上海旅游高等专科学校构建了海派餐饮非遗传创专业群与“海派非遗美食+预制菜”区域产业集群协同发展路径:专业群与产业链衔接,建立匹配式集群优化动态调整机制;文化育人与企业品牌传导的衔接,推进非遗文化传承演进的价值融合;课程体系与职业标准衔接,设计模块化进阶型的共建结构;教学过程与生产过程衔接,构建互助式工学结合的实践模式;学校师资与企业师资衔接,协同组建互补型双师团队;双创教育与工艺革新衔接,孵化培育互动科创中心;社会化培训与行业需求培训衔接,共育非遗传创格局新向导;就业需求与岗位设置衔接,系统规划订单化人才培养与评估。

关键词：职业教育产教融合专业群产业集群协同发展

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The advance of adjuvant treatment for triple-negative breast cancer

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Cancer Biology & Medicine 2022年第2期19卷 187-201页

作者： Jingyu Ge Wenjia Zuo Yiyu Chen zhiming shao Keda Yu Department of Breast Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Shanghai Medical College Fudan UniversityShanghai 200032China

Triple-negative breast cancer(TNBC)is a subtype of breast cancer characterized by its highly aggressive behavior,early recurrence,and poor outcomes,when compared with other *** to the absence of the estrogen receptor,progesterone receptor,and human epidermal growth factor receptor 2 expression,TNBC lacks meaningful biomarkers and an effective therapeutic *** remains the main adjuvant treatment for patients with ***/taxane-based regimens are the standard of care in adjuvant *** addition of capecitabine or platinum may offer extra benefits to patients with TNBC,but at the cost of increased toxicity or adverse ***-dense chemotherapy may enhance treatment efficacy in patients who are able to tolerate the treatment regimen,especially in high-risk *** a heterogenous disease,TNBC can be classified into several molecular subtypes according to genomic or transcriptional features,which may indicate potential targets for more precise and individualized treatment *** our increased understanding of signal pathways associated with TNBC,as well as the discovery of novel biomarkers indicative of TNBC prognosis,several new therapeutic options are under investigation,and some have already reported good *** this review,we summarized the current conventional therapeutic strategies and emerging clinical trials regarding adjuvant treatment for ***,we evaluated the prognostic value of several potential targets and the progress of targeted therapy in TNBC,both in neoadjuvant and adjuvant settings.

关键词： Triple-negative breast cancer adjuvant chemotherapy targeted therapy prognostic factors

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Inertinite in coal and its geoenvironmental significance:Insights from AI and big data analysis

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Science China Earth Sciences 2024年第6期67卷 1779-1801页

作者： Longyi shao Jiamin ZHOU Timothy PJONES Fanghui HUA Xiaotao XU zhiming YAN Haihai HOU Dongdong WANG Jing LU State Key Laboratory for Fine Exploration and Intelligent Development of Coal Resources and College of Geoscience and Surveying Engineering China University of Miningand Technology(Beijing)Beijing 100083China School of Earth and Environmental Sciences Cardiff UniversityCardiff CF103YEWalesEngland General Prospecting Institute of China National Administration of Coal Geology Beijing 100039China Institute of Architectural Engineering Weifang UniversityWeifang 261061China College of Mining Liaoning Technical UniversityFuxin 123000China College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China

Inertinite,as an important and abundant maceral group in coal,is critical for the study of palaeowildfires and their roles in the Earth’s ***,there has been a significant amount of research on the relationship between palaeowildfire,palaeoclimate change and palaeovegetation evolution based on inertinite *** reflectance of fusinite and semifusinite has been used to estimate the combustion temperature and type of palaeowildfires,and then to evaluate the combustion characteristics of different types of *** relative abundance of inertinite can be used to estimate the atmospheric oxygen *** rapid development of artificial intelligence(AI)and online tools to search scientific databases has presented an opportunity for us to find,collect,arrange,and analyse data from the earliest to latest publications on *** data extraction tool Deep Shovel is used to collect and analyse global inertinite data from the Silurian to the *** software programs such as Gplates,ArcGIS pro and Tableau are then applied to model the relative abundance of inertinite over geological time,which can be correlated with other parameters such as atmospheric oxygen contents,plant evolution and palaeoclimate *** distribution of inertinite in coals varied over different geological periods,being typified by the“high inertinite content-high atmospheric oxygen level”period in the Permian and the“low inertinite content-low atmospheric oxygen level”period in the *** study has proposed a possible model of the positive and negative feedbacks between inertinite characteristics and palaeoenvironmental factors,and has revealed the exceptional role of inertinite in palaeoenvironmental *** research on inertinite will be focused on the integrated study of organic petrology and organic geochemistry of inertinite,the big data-driven research on the temporal and spatial distribution of the global inertinite,the exploration of the

关键词： Inertinite Palaeowildfires Atmospheric oxygen Palaeoclimates Palaeoecosystems

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Bioinformatics study indicates possible microRNA-regulated pathways in the differentiation of breast cancer

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Chinese Science Bulletin 2010年第10期55卷 927-936页

作者： PEI YunFei WANG ZhiMin FEI Fei shao zhiming HUANG Wei ZHANG XueGong MOE Key Laboratory of Bioinformatics and Bioinformatics Division TNLIST/Department of Automation Tsinghua University Beijing 100084 China Chinese National Human Genome Center at Shanghai Shanghai 201203 China Breast Cancer Institute Cancer Hospital Department of Oncology Shanghai Medical College Institutes of Biomedical Sciences Fudan University Shanghai 200032 China Department of Breast Surgery Cancer Hospital/Cancer Institute Breast Cancer Institute Fudan University Shanghai 200032 China

microRNAs (miRNAs) have been reported to be associated with the pathogenesis and progression of breast ***,little is known about the pathways through which miRNAs regulate these processes,e.g.,the interaction between miRNAs and their target genes with regard to different pathological status of breast cancer,such as histological *** study investigated the possible roles of miRNAs in the differentiation of histological grades of breast cancer with a computational *** on a microarray dataset,15 candidate miRNAs were identified,whose predicted target genes are enriched as differentially expressed between grade I and grade III breast *** them,9 key miRNAs focalize their target genes on 6 central signaling *** SMAD7 protein,the main inhibitory protein in the TGF-β pathway,is predicted as a target of several miRNAs and is also regulated by several other pathways that are possibly targeted by *** was hypothesized that miRNAs participate in the differentiation of breast cancer and the TGF-β pathway acts as a major implementary pathway on which several miRNAs take effect through multiple *** prediction power of the predicted miRNA target genes was validated on three independent *** differential expression of three miRNAs was validated by real-time PCR on breast carcinoma samples of 10 patients.

关键词：信号通路乳腺癌小分子RNA 生物信息学分化 miRNAs 转化生长因子-β 病理状态

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Cancer cell employs a microenvironmental neural signal transactivating nucleus-mitochondria coordination to acquire stemness

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3818-3836页

作者： Bin He Rui Gao Shasha Lv Ailin Chen Junxiu Huang Luoxuan Wang Yunxiu Feng Jiesi Feng Bing Liu Jie Lei Bing Deng Bin He Bai Cui Fei Peng Min Yan Zifeng Wang Eric W-F Lam Bilian Jin zhiming shao Yulong Li Jianwei Jiao Xi Wang Quentin Liu State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer CenterGuangzhou 510060PR China Department of Medical Oncology The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 510275PR China Institute of Cancer Stem Cell Cancer CenterDalian Medical UniversityDalian 116023PR China Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510080PR China State Key Laboratory of Membrane Biology Peking University School of Life SciencesBeijing 100871PR China Department of Surgery and Cancer Imperial College LondonLondon W120NNUK Department of Breast Surgery Precision Cancer Medicine CenterFudan University Shanghai Cancer CenterShanghai 200032PR China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101PR China

Cancer cell receives extracellular signal inputs to obtain a stem-like status,yet how tumor microenvironmental(TME)neural signals steer cancer stemness to establish the hierarchical tumor architectures remains ***,a pan-cancer transcriptomic screening for 10852 samples of 33 TCGA cancer types reveals that cAMP-responsive element(CRE)transcription factors are convergent activators for cancer *** of transcriptomic profiles,specification of neural markers and illustration of norepinephrine dynamics uncover a bond between TME neural signals and cancer-cell CRE ***,neural signal norepinephrine potentiates the stemness of proximal cancer cells by activating cAMP-CRE axis,where ATF1 serves as a conserved *** activation by norepinephrine,ATF1 potentiates cancer stemness by coordinated trans-activation of both nuclear pluripotency factors MYC/NANOG and mitochondrial biogenesis regulators NRF1/TFAM,thereby orchestrating nuclear reprograming and mitochondrial ***,single-cell transcriptomes confirm the coordinated activation of nuclear pluripotency with mitochondrial biogenesis in cancer stem-like *** findings elucidate that cancer cell acquires stemness via a norepinephrine-ATF1 driven nucleus-mitochondria collaborated program,suggesting a spatialized stemness acquisition by hijacking microenvironmental neural signals.

关键词： Cancer neural architectures

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聚焦核心素养的高等职业教育餐饮类专业课程体系创新

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职业技术教育 2020年第14期41卷 39-43页

作者：邵志明上海旅游高等专科学校烹饪与餐饮专业部上海201418

核心素养作为时代教育的方向性指引,影响教育目标定位素养化转型。聚焦核心素养下高等职业教育餐饮类专业,以普适性框架为参照,以国家课程标准为依据,结合行业学者共识性价值凝练餐饮类专业素养指标内容,按照课程体系构建逻辑和素养融... 详细信息

核心素养作为时代教育的方向性指引,影响教育目标定位素养化转型。聚焦核心素养下高等职业教育餐饮类专业,以普适性框架为参照,以国家课程标准为依据,结合行业学者共识性价值凝练餐饮类专业素养指标内容,按照课程体系构建逻辑和素养融合路径,系统化创新设计"5+X的模块联动、融合贯通"课程体系。同时,为保障基于核心素养培育的课程体系实施,采取生态化环境支持、智慧型教学推进、区块链评价追溯等保障措施。

关键词：高职院校核心素养餐饮类专业课程体系智慧型教学区块链评价

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基于代际差异视角的健康饮食研究

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社会科学论坛 2022年第4期 143-154页

作者：李晓云邵志明高海薇上海旅游高等专科学校酒店与烹饪学院上海200000

该研究选取70、80年代出生的人群及其子代为研究对象,从两代人对健康饮食的知识认知、价值认知、信息媒介信任度、道德或伦理考量等四个方面进行比较和分析。研究发现父代对健康饮食的关注度、知识认知、价值认知均高于子代;父代更愿意... 详细信息

该研究选取70、80年代出生的人群及其子代为研究对象,从两代人对健康饮食的知识认知、价值认知、信息媒介信任度、道德或伦理考量等四个方面进行比较和分析。研究发现父代对健康饮食的关注度、知识认知、价值认知均高于子代;父代更愿意承担健康饮食带来的经济成本,子代则与之相反。相比父代,短视频对子代的健康饮食态度有更明显的积极影响;两代人对健康饮食的便利性与环境影响的认知无显著差异。该研究旨在为促进民众的健康饮食行为实践提供参考,同时也为促进健康饮食的“食育”政策制定及实施提供参考。

关键词：健康饮食子代父代代际差异

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乳腺癌细胞凋亡及相关基因表达的预后研究

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上海医学 1999年第1期22卷 27-31页

作者：吴炅沈镇宙邵志敏上海医科大学肿瘤医院胸外科

目的对细胞凋亡及其相关基因在乳腺癌预后中的作用，以及它们的表达水平与乳腺癌生物学行为的关系进行研究。方法运用ＴＵＮＥＬ法、免疫组化检测乳腺癌组织细胞凋亡水平以及凋亡相关基因ｂｃ１２、ｂａｘ、ｐ２７ｋｉｐｌ表达。结果... 详细信息

目的对细胞凋亡及其相关基因在乳腺癌预后中的作用，以及它们的表达水平与乳腺癌生物学行为的关系进行研究。方法运用ＴＵＮＥＬ法、免疫组化检测乳腺癌组织细胞凋亡水平以及凋亡相关基因ｂｃ１２、ｂａｘ、ｐ２７ｋｉｐｌ表达。结果９１例乳腺癌病例中，５６／９１（６１．５％）的病例凋亡指数较高，３５／９１（３８．５％）凋亡指数较低；ｂｃ１２高表达占２９．７％（２７／９１），ｂａｘ高表达占３０．８％（２８／９１）。１８１例乳腺癌中，ｐ２７ｋｉｐｌ高表达占３３．１％（６０／８１）。相关性分析发现，ｂｃ１２高表达，ＡＩ低的病例，组织学分级高，易出现腋淋巴结转移和术后复发；ｂａｘ、ｐ２７ｋｉｐｌ高表达者，组织学分级低，腋淋巴结转移及术后复发少。单因素生存分析显示，ＡＩ高，ｂａｘ、ｐ２７ｋｉｐｌ高表达，ｂｃ１２低表达的病例，术后无复发生存率、总生存率优于ＡＩ低，ｂａｘ、ｐ２７ｋｉｐｌ低表达，ｂｃ１２高表达者。ＣＯＸ模型多因素分析发现，ｂｃ１２、ｐ２７ｋｉｐｌ蛋白具有独立的预后价值；８４例淋巴结阴性乳腺癌中，ｐ２７ｋｉｐｌ表达有独立预后作用。结论凋亡相关基因ｂｃ１２、ｂａｘ、ｐ２７ｋｉｐｌ表达状态失控，使细胞凋亡过程失调，?

关键词：乳腺癌预后细胞凋亡癌基因

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