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Copper-catalyzed C(sp)-H aryl amination enables modular synthesis of quinolines and 2-quinolinones

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science china Chemistry 2024年第2期67卷 595-603页

作者： Yang gao Haixia li Simin Yang Yanping Huo Qian Chen Xianwei li Zhe Wang Xiao-Qiang Hu School of Chemical Engineering and light Industry Guangdong University of TechnologyGuangzhou510006China Jieyang Branch of Chemistry and Chemical Engineering Guangdong laboratory Jieyang515200China key laboratory of Catalysis and Energy Materials Chemistry of ministry of education&Hubei key laboratory of Catalysis and Materials science School of Chemistry and Materials ScienceSouth-Central University for NationalitiesWuhan430074China

Herein,we disclose a novel copper-catalyzed C(sp)-H aryl amination of terminal alkynes with anthranils,enabling the rapid generation of highly reactive secondary N-aryl ynamines for the modular synthesis of structurally diverse C2-substituted quinolines and *** in-situ formed carbonyl-ynamines are prone to tautomerize to carbonyl-ketenimines,which can efficiently react with a series of nucleophiles,including amines,alcohols,phenols,thiols,thiophenols,active-methylene compounds,and even water to produce various quinoline derivatives with the generation of H_(2)O as a sole and green *** method also unlocks a practical route to create various quinoline-fused heterocycles and can be successfully applied to the late-stage modification of complex molecules and the concise synthesis of bioactive *** studies reveal a coppercatalyzed inner-sphere nitrene transfer process by using anthranils as novel aryl nitrene precursors.

关键词： copper catalysis anthranils C(sp)-H aryl amination carbonyl-ketenimines quinolines

Dynamic shielding of bacterial outer membrane vesicles for safe and efficient chemo-immunotherapy against tumors

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Nano Research 2024年第2期17卷 836-847页

作者： Shuping li Xin li Jiaqi Meng Weier Bao Shuang Wang Peng Ye Xiao-Dong gao Wei Wei key laboratory of Carbohydrate Chemistry and Biotechnology ministry of education School of BiotechnologyJiangnan UniversityWuxi 214122China State key laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Bacterial outer membrane vesicles(OMVs)are potent immunostimulants of regulating the tumor microenvironment(TME)for immunotherapy,and can be used to deliver ***,the severe systemic inflammatory response triggered by OMVs upon intravenous(i.v.)injection has limited their ***,we developed a safe and effective strategy by conjugating doxorubicin-loaded serum albumin(SA-DOX,AD)onto the surface of OMVs using a matrix metalloproteinase(MMP)-cleavable peptide linker(cL).This approach enabled the dynamic shielding of OMVs to reduce the systemic side effects while simultaneously enhancing the anti-tumor effects through ***,the resulting OMV-cL-AD formulation exhibited significantly enhanced accumulation at the tumor site after ***,facilitated by the SA decoration on the OMVs ***,the shield on the OMV-cL-AD was cleaved by the over-expressed MMP in the TME,leading to the release of both OMVs and *** process provided OMV-induced immunotherapy and DOX-induced chemotherapy,resulting in synergistic tumor *** conclusion,our work demonstrated the potential of OMV-cL-AD as an effective immunochemotherapy strategy that can prolong the survival time of mice without inducing side effects.

关键词： outer membrane vesicles doxorubicin tumor microenvironment immunotherapy chemotherapy

Mechanical reliable,NIR light-induced rapid self-healing hydrogel electrolyte towards flexible zinc-ion hybrid supercapacitors with low-temperature adaptability and long service life

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Journal of Energy Chemistry 2024年第5期92卷 63-73页

作者： Tengjia gao Na li Yang Yang Jing li Peng Ji Yunlong Zhou Jianxiong Xu School of Materials and Advanced Manufacturing Hunan Key Laboratory of Electrochemical Green Metallurgy TechnologyHunan University of TechnologyZhuzhou 412007HunanChina School of life sciences and Chemistry Hunan Key Laboratory of Biomedical Nanomaterials and DevicesHunan University of TechnologyZhuzhou 412007HunanChina

Hydrogel electrolytes hold great potential in flexible zinc ion supercapacitors(ZICs)due to their high conductivity,good safety,and ***,freezing of electrolytes at low temperature(subzero)leads to drastic reduction in ionic conductivity and mechanical properties that deteriorates the performance of flexible ***,the mechanical fracture during arbitrary deformations significantly prunes out the lifespan of the flexible ***,a Zn^(2+)and li^(+)co-doped,polypyrrole-dopamine decorated Sb_(2)S_(3)incorporated,and polyvinyl alcohol/poly(N-(2-hydroxyethyl)acrylamide)double-network hydrogel electrolyte is constructed with favorable mechanical reliability,anti-freezing,and self-healing *** addition,it delivers ultra-high ionic conductivity of 8.6 and 3.7 S m^(-1)at 20 and−30°C,respectively,and displays excellent mechanical properties to withstand tensile stress of 1.85 MPa with tensile elongation of 760%,together with fracture energy of 5.14 MJ m^(-3).Notably,the fractured hydrogel electrolyte can recover itself after only 90 s of infrared illumination,while regaining 83%of its tensile strain and almost 100%of its ionic conductivity during−30–60°***,ZICs coupled with this hydrogel electrolyte not only show a wide voltage window(up to 2 V),but also provide high energy density of 230 Wh kg^(-1)at power density of 500 W kg^(-1)with a capacity retention of 86.7%after 20,000 cycles under 20°***,the ZICs are able to retain excellent capacity even under various mechanical deformation at−30°*** contribution will open up new insights into design of advanced wearable flexible electronics with environmental adaptability and long-life span.

关键词： Flexible zinc ion supercapacitor Hydrogel electrolyte Self-healing Anti-freezing

Landslide Displacement Prediction Based on Time Series and PSO-BP Model in Three Georges Reservoir, china

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Journal of Earth science 2024年第3期35卷 1079-1082页

作者： Dexiang gao Kou li Yuncheng Cai Tao Wen School of Geosciences Yangtze UniversityWuhan 430100China School of science Yunnan Agricultural UniversityKunming 650201China

0 INTRODUCTION Landslides are one of the most frequent geological disasters in the world(Wen et al.,2020;Froude and Petley,2018),which have occurred frequently and widely distributed in china for a long *** landslides are essentially a complex multidimensional nonlinear dynamic system affected by its own geological conditions and external factors(Ma et al.,2021;Wang et al.,2019),including geotechnical characteristics,hydrogeology,geomorphologic conditions,climate,and weathering(Ma et al.,2020).The interaction of these factors makes the change of landslide displacement random,fuzzy and variable(Park and Michalowski,2017),and also brings great difficulties to the landslide displacement prediction(Ma et al.,2018).

关键词： landslide Landslide weathering

Constraints of palaeoenvironment on organic matter of Benxi Formation shale and discussion on enrichment mechanism under different facies

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Frontiers of Earth science 2024年第1期18卷 148-171页

作者： Qianyang HE Delu li Qiang SUN Jianwen gao Haibin li Xinhu li Xiaochen ZHAO Shaofei WANG gaozhe JI College of Geology and Environment Xi’an University of Science and TechnologyXi’an 710054China Shaanxi Provincial key laboratory of Geological Support for Coal Green Exploitation Xi’an University of Science and TechnologyXi’an 710054China Geological Research Institute for Coal Green Mining Xi’an University of Science and TechnologyXi’an 710054China Research Institute of Exploration and Development PetroChina Changqing Oilfield CompanyXi’an 710018China School of Civil Engineering and Architecture Shaanxi University of TechnologyHanzhong 723001China

As a hydrocarbon-rich sedimentary basin in china,the Ordos Basin has enormous potential for shale gas *** shale of the Upper Carboniferous Benxi Formation is rich in organic matter,however,its palaeoenvironment and organic matter enrichment mode are yet to be *** this study,the geochemical characteristics of the shale of the Benxi Formation in the east-central part of the Ordos Basin were analyzed to investigate its *** the same time,the organic matter enrichment modes in different sedimentary facies were compared and *** results indicate that:1)the shale of the Benxi Formation was mainly deposited on the continental margin and strong terrestrial clastic input;2)the deposition period of the Benxi Formation shale had a hot and humid climate with high palaeoproductivity and local volcanic hydrothermal fluid,and a high sedimentation rate with the strong stagnant *** bottom water was in dysoxic conditions and a semi-saline deposition environment;3)multiple factors,such as palaeoproductivity,volcanic hydrothermal,redox conditions,and palaeosalinity interact to influence the enrichment of shale organic matter in Benxi Formation;4)the organic matter enrichment modes of continental,marine-continental transitional,and marine shales can be classified into three types:“production mode”,“hybrid mode of preservation and production”,and“preservation mode”,*** study provides a reference for the organic matter enrichment mode,shale gas formation conditions,and core area evaluation in these marine-continental transitional shales,and also offers new guidance for exploration ideas for shale gas in different sedimentary facies.

关键词： Benxi Formation shale palaeoenvironment organic matter enrichment facies

Influence of Mass Ratio of Resin and Stabilizer on Mechanical Properties of Mo Fiber-reinforced Granite Polymer Composite

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Journal of Wuhan University of Technology(Materials science) 2024年第4期39卷 912-920页

作者：张超任秀华 BA Dongzhe ZHANG Jianhua li Jianyong GUO Mengnan gao Yinghao WANG Guixin li Jiayang School of Mechanical and Electronic Engineering Shandong Jianzhu UniversityJinan 250101China key laboratory of High Efficiency and Clean Mechanical Manufacture Ministry of Education of ChinaSchool of Mechanical EngineeringShandong UniversityJinan 250061China

Because inferior mechanical strength of granite polymer composite(GPC)has become the main drawback limiting its application and popularization,Mo fibers were added into(GPC)to improve its mechanical *** properties of matrix materials with different mass ratio of resin and stabilizer(MRRS)were investigated *** influences of MRRS on interface bonding strength of Mo fiber-matrix,wettability and mechanical strength of GPC were discussed,respectively,and the theoretical calculation result of MRRS k was obtained,with the optimal value of k=*** k=4,tensile strength,tensile strain and fracture stress of the cured resin achieve the maximum *** for k=7,the corresponding values reach the *** the increase of MRRS k,surface free energy of the cured resin first increases and then decreases,while contact angles between Mo sample and matrix have displayed the opposite *** of resin to Mo fiber is the best at k=*** load of Mo fiber and interface bonding strength appear the maximum at k=4,followed by k=5,k=3 the third,and k=7 the *** k=4,mechanical properties of Mo fiber-reinforced GPC are optimal,which is consistent with the result of theoretical *** study is of great significance to get better component formulas of Mo fiber reinforced GPC and to improve its application in machine tools.

关键词： polymer composite fiber mechanical strength interface bonding

Yuzaoea gen. nov., a new biraphid diatom(Bacillariophyceae)genus and its phylogenetic significance

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Acta Oceanologica Sinica 2024年第2期43卷 130-136页

作者： Honghan liu Chenhong li Lang li Xuesong li lin Sun Junrong liang Jun Zhang Yahui gao Changping Chen key laboratory of ministry of education for Coastal and Wetland Ecosystems and School of life sciences Xiamen UniversityXiamen 361102China State key laboratory of Marine Environmental science Xiamen UniversityXiamen 361102China Guangxi key laboratory of Marine Environmental science Guangxi Academy of Marine SciencesGuangxi Academy of SciencesNanning 530007China Beibu Gulf Marine Industry Research Institute Fangchenggang 538000China

The flexed frustules in pennate diatoms are usually associated with monoraphid diatoms. Interestingly, we found a biraphid diatom species with flexed frustules in an offshore intertidal beach environment on Weizhou Island,Beihai City, Guangxi Zhuang Autonomous Region, china. Therefore, based on morphological characteristics, we described a new genus of diatoms Yuzaoea sinensis gen. et sp. nov. CH li, HH liu, YH gao & CP Chen. The frustule of this genus is characterized by heterogeneous frustule with one concave valve and one convex valve,complete raphe on both valves, straight and moderately eccentric raphe, uniseriate striae and girdle bands with a single row of areolae. The most identifying feature of this genus was the flexed frustule, which is rare in biraphid diatoms and common in monoraphid diatoms. We compared the morphometric characteristics of genus Yuzaoea with genus Rhoikoneis and several genera within the family Rhoicospheniaceae, including Rhoicosphenia,Campylopyxis, and Cuneolus. Phylogenetic analyses based on SSU rRNA and rbc L showed that the genus Yuzaoea was the sister group to the clade of Rhoicosphenia with a high support value(bootstrap values = 100%), and the clade “Yuzaoea+Rhoicosphenia” was sister to the clade of monoraphid diatoms, in which the genera Achnanthidium, Planothidium and some Cocconeis with high support values(bootstrap = 100%).Morphologically, the genus Yuzaoea shares many morphological features with monoraphid diatoms like genera Achnanthidium and Planothidium and the members within the Rhoicospheniaceae. Therefore, based on a combined morphological studies and phylogenetic results we suggested that this branch may represented the evolution of one kind monoraphid diatoms, from biraphid diatoms(e.g. genus Yuzaoea), to incompleted biraphid diatoms(e.g. genera Rhoicosphenia, Campylopyxis), to monoraphid diatoms(e.g. genera Achnanthidium and Planothidium).

关键词： biraphid diatom marine new genus Rhoicospheniaceae taxonomy Yuzaoea

Spatial-Temporal Analysis of Drinking Water Type of Endemic Fluorosis—china,2009–2022

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china CDC weekly 2024年第2期6卷 25-29页

作者： lijun Zhao Zhe li Mang li Hongna Sun Wei Wei lin gao Qiaoshi Zhao Yang liu Xiaohong Ji Cheng li Jian Wang Yanhui gao Junrui Pei Center for Endemic Disease Control Chinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina key Lab of Etiology and Epidemiology Education Bureau of Heilongjiang Province(23618504)Ministry of Health of PRHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina

What is already known about this topic?Endemic fluorosis,caused by high fluoride levels in drinking water,has been a significant health issue in rural areas of china for many *** is added by this report?There has been a notable decline in the detection rate of dental fluorosis in children aged 8–12 years in drinking water fluorosis areas across the country from 2009 to *** 14 provincial-level administrative divisions are classified as low-probability clusters,Tianjin remains classified as a high-probability *** are the implications for public health practice?The current policy for preventing and controlling endemic fluorosis in china needs *** than focusing solely on regions with high incidence,there should be a shift towards monitoring and early warning of fluoride ***,local containment measures should be intensified.

关键词： intensified Spatial fluoride

10 Gb/s classical secure key distribution based on temporal steganography and private chaotic phase scrambling

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Photonics Research 2024年第2期12卷 321-330页

作者： ZHENSEN gao ZHITAO DENG liHONG ZHANG XUliN gao YUEHUA AN ANBANG WANG SONGNIAN FU ZHAOHUI li YUNCAI WANG YUWEN QIN School of Information Engineering Guangdong University of TechnologyGuangzhou 510006China Pengcheng laboratory Shenzhen 518062China key laboratory of Photonic Technology for Integrated Communication and Sensing Ministry of EducationGuangzhou 510006China School of Optoelectronic Engineering Guangdong Polytechnic Normal UniversityGuangzhou 510665China School of Electrical and Information Technology Sun Yat-sen UniversityGuangzhou 510006China

Secure distribution of high-speed digital encryption/decryption keys over a classical fiber channel is strongly pursued for realizing perfect secrecy communication ***,it is still challenging to achieve a secret key rate in the order of tens of gigabits per second to be comparable with the bit rate of commercial fiber-optic *** this paper,we propose and experimentally demonstrate a novel solution for high-speed secure key distribution based on temporal steganography and private chaotic phase scrambling in the classical physical *** encryption key is temporally concealed into the background noise in the time domain and randomly phase scrambled bit-by-bit by a private chaotic signal,which provides two layers of enhanced security to guarantee the privacy of key distribution while providing a high secret key *** experimentally achieved a record classical secret key rate of 10 Gb/s with a bit error rate lower than the hard-decision forward error correction(HD-FEC)over a 40 km standard single mode *** proposed solution holds great promise for achieving high-speed key distribution in the classical fiber channel by combining steganographic transmission and chaotic scrambling.

关键词： chaotic distribution phase