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子痫前期患者血清miR-20b、miR-4443水平及与不良妊娠结局的关系

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中国妇幼健康研究 2024年第10期35卷 43-49页

作者：刘志明李苏杭戚桂杰蒋天从唐山市妇幼保健院唐山市出生缺陷筛查与诊断重点实验室河北唐山063000 河北医科大学第二医院河北石家庄050000

目的检测子痫前期(PE)患者血清微小RNA-20b(miR-20b)、微小RNA-4443(miR-4443)的水平,并探讨二者对PE患者妊娠结局的预测价值。方法选取2021年2月至2023年1月在本院接受治疗的212名PE患者为研究组,根据病情严重程度分为重度PE组(n=106)... 详细信息

目的检测子痫前期(PE)患者血清微小RNA-20b(miR-20b)、微小RNA-4443(miR-4443)的水平,并探讨二者对PE患者妊娠结局的预测价值。方法选取2021年2月至2023年1月在本院接受治疗的212名PE患者为研究组,根据病情严重程度分为重度PE组(n=106)和轻度PE组(n=106);另选取同期106例孕检健康的孕妇作为对照组。根据重度PE组患者的妊娠结局分为妊娠结局良好组和妊娠结局不良组。采用实时荧光定量PCR法(qRT-PCR)检测所有受试者血清中miR-20b和miR-4443的表达水平;使用多因素Logistic回归分析患者妊娠结局的影响因素;采用受试者工作特征(ROC)曲线评估miR-20b、miR-4443对重度PE孕妇妊娠不良结局的预测价值。结果对照组、轻度PE组、重度PE组血清miR-20b、miR-4443水平逐渐升高(F值分别为486.199和354.434,P<0.001),胎儿宫内窘迫和早产的发生率在各组之间差异显著(χ^(2)值为10.498和15.163,P<0.001)。重度PE组不良妊娠结局总发生率为48.11%,显著高于轻度PE组及对照组(χ^(2)=50.956,P<0.001)。妊娠结局不良组miR-20b水平及miR-4443水平均显著高于妊娠结局良好组(t=5.750,5.853,P<0.001)。多因素Logistic回归分析表明,miR-20b(OR=3.564,95%CI:1.546~8.214)、miR-4443(OR=2.365,95%CI:1.472~3.800)、收缩压(OR=2.869,95%CI:1.373~5.995)、尿蛋白(OR=3.837,95%CI:1.910~7.709)、甘油三酯(TG)(OR=4.236,95%CI:2.027~8.851)是患者发生不良妊娠结局的危险因素(P<0.05)。ROC曲线分析结果显示,miR-20b、miR-4443联合预测重度PE妊娠结局的曲线下面积(AUC)为0.945(95%CI:0.901~0.989),显著高于miR-20b及miR-4443单独预测(Z值分别为2.412和2.055,P<0.05)。结论重度PE患者血清miR-20b、miR-4443呈高表达,与不良妊娠结局的发生风险有关,二者联合使用可作为重度PE患者不良妊娠结局的预测指标。

关键词：子痫前期微小RNA-20b 微小RNA-4443 妊娠结局预测

抑制miRNA-376c-3p对肾透明细胞癌生长的影响

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河北医药 2024年第8期46卷 1132-1137页

作者：镡云辉赵蓉刘志明卓奥刘唐兴哈尔滨医科大学附属第二医院泌尿外三科哈尔滨市150086 哈尔滨医科大学附属第二医院心血管介入治疗中心哈尔滨市150086

目的探究miRNA-376c-3对肾透明细胞癌(ccRCC)中肿瘤细胞生长的影响。方法以实时荧光定量PCR(RT-PCR)检测人ccRCC细胞系786-O、Caki-1、SN12-PM6、ACHN及正常人近段肾小管上皮细胞系HKC中miRNA-376c-3p的表达。体外培养786-O细胞,随机分... 详细信息

目的探究miRNA-376c-3对肾透明细胞癌(ccRCC)中肿瘤细胞生长的影响。方法以实时荧光定量PCR(RT-PCR)检测人ccRCC细胞系786-O、Caki-1、SN12-PM6、ACHN及正常人近段肾小管上皮细胞系HKC中miRNA-376c-3p的表达。体外培养786-O细胞,随机分为对照组、miR-376c-3p inhibitor组(转染miR-376c-3p inhibitor)、miR-376c-3p mimics组(转染miR-376c-3p mimics)、阴性对照组(转染miR-376c-3p阴性对照),分组转染后以RT-PCR检测4组细胞miRNA-376c-3p表达;以Ki67免疫荧光染色、集落生成实验检测4组786-O细胞增殖;以TUNEL染色检测4组786-O细胞凋亡;以免疫荧光染色检测4组786-O细胞凋亡相关蛋白Bax、Bcl-2表达并比较其Bax/Bcl-2。于右腋窝皮下接种上述4组786-O细胞建立其裸鼠移植瘤模型,3周后测定其肿瘤体积与质量;以Ki67免疫荧光染色、TUNEL染色分别检测4组裸鼠肿瘤细胞增殖与凋亡。结果与HKC细胞比较,ccRCC细胞系786-O、Caki-1、SN12-PM6、ACHN中miR-376c-3p表达降低(P0.05)。结论抑制miRNA-376c-3p可削弱ccRCC细胞增殖及集落生成活性,促进其凋亡,并在裸鼠体内抑制其移植瘤生长。

关键词： miRNA-376c-3p 肾透明细胞癌肾细胞肿瘤细胞生长

The effect of preparation conditions of Pt/Al2O3 on its catalytic performance for the H2-SCR in the presence of oxygen

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Frontiers of Environmental Science & Engineering 2013年第3期7卷 457-463页

作者： Lei YUAN Xiang ZHENG Kaijiao DUAN Hao HU Jinggang WANG Seong Ihl WOO zhiming liu State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 China School of Environment & Natural Resources Renmin University of China Beijing 100872 China Department of Chemical and Biomolecular Engineering Graduate School of EEWS(WCU) Korea Advanced Institute of Science and Technology Daejeon 305-701 Korea

Selective catalytic reduction of NOχ by H2 in the presence of oxygen has been investigated over Pt/ A12O3 catalysts pre-treated under different conditions. Catalyst preparation conditions exert significant influence on the catalytic performance, and the catalyst pre-treated by HE or H2 then followed by O2 is much more active than that pre-treated by air. The higher surface area and the presence of metallic Pt over Pt/A12O3 pre-treated by HE or pretreated by H2 then followed by O2 can contribute to the formation of NO2, which then promotes the reaction to proceed at low temperatures.

关键词： NOx reduction Pt/A12O3 preparation condi-tion H2-SCR

A survey on federated learning:a perspective from multi-party computation

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Frontiers of Computer Science 2024年第1期18卷 93-103页

作者： Fengxia liu zhiming ZHENG Yexuan SHI Yongxin TONG Yi ZHANG Institute of Artificial Intelligence and Key Laboratory of Mathematics Informatics Behavioral Semantics Beihang UniversityBeijing 100191China State Key Laboratory of Software Development Environment and Advanced Innovation Center for Future Blockchain and Privacy Computing Beihang UniversityBeijing 100191China Pengcheng Laboratory Shenzhen 518055China Zhongguancun Laboratory Beijing 100190China Institute for Mathematical Sciences and Engineering Research Center of Financial Computing and Digital Engineering Renmin University of ChinaBeijing 100872China

Federated learning is a promising learning paradigm that allows collaborative training of models across multiple data owners without sharing their raw *** enhance privacy in federated learning,multi-party computation can be leveraged for secure communication and computation during model *** survey provides a comprehensive review on how to integrate mainstream multi-party computation techniques into diverse federated learning setups for guaranteed privacy,as well as the corresponding optimization techniques to improve model accuracy and training *** also pinpoint future directions to deploy federated learning to a wider range of applications.

关键词： sfederated learning multi-party ycomputation privacy-preserving data mining distributed learning

基于光纤受激布里渊效应的精密光谱分析方法(特邀)

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光电技术应用 2024年第3期39卷 1-10页

作者：刘加庆黄琳周帅杜特张志辉刘志明中电科思仪科技股份有限公司山东青岛山东省电子测量仪器技术创新中心山东青岛电子测试技术重点实验室山东青岛山东大学信息科学与工程学院山东青岛

精密光谱分析仪在高速光通信、光纤传感、光电器件及激光雷达等领域拥有广泛的应用前景。回顾了近年来精密光谱分析技术的研究进展,着重分析了基于光纤受激布里渊效应的精密光谱分析技术的原理及特点,然后介绍了研制的布里渊光谱仪及波... 详细信息

精密光谱分析仪在高速光通信、光纤传感、光电器件及激光雷达等领域拥有广泛的应用前景。回顾了近年来精密光谱分析技术的研究进展,着重分析了基于光纤受激布里渊效应的精密光谱分析技术的原理及特点,然后介绍了研制的布里渊光谱仪及波长和功率校准方法,最后预测了精密光谱分析技术的发展趋势。

关键词：受激布里渊效应精密光谱分析皮米(pm)光谱分辨率高波长精度

Rapid label-free SERS detection of foodborne pathogenic bacteria based on hafnium ditelluride-Au nanocomposites

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Journal of Innovative Optical Health Sciences 2020年第5期3卷 105-115页

作者： Yang Li Yanxian Guo Binggang Ye Zhengfei Zhuang Peilin Lan Yue Zhang Huiqing Zhong Hao liu Zhouyi Guo zhiming liu SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology&Guangdong Provincial Key Laboratory of Laser Life Science College of Biophotonics South China Normal University GuangzhouGuangdong 510631P.R.China Healthy Medical Engineering Technology Research Center Guangdong Food and Drug Vocational College Guangzhou 510520 P.R.China

Two-dimensional(2D)nanomaterials have captured an increasing attention in biophotonics owing to their excellent optical ***,2D hafnium ditelluride(HfTe_(2)),a new member of transition metal tellurides,is exploited to support gold nanoparticles fabricating HfTe_(2)-Au *** nanohybrids can serve as novel 2D surface-enhanced Raman scattering(SERS)substrate for the label-free detection of analyte with high sensitivity and *** mechanism originated from HfTe_(2) nanosheets and the electromagnetic enhancement induced by the hot spots on the nano-hybrids may largely contribute to the superior SERS effect of HfTe_(2)-Au ***,HfTe_(2)-Au nanocomposites are utilized for the label-free SERS analysis of foodborne pathogenic bac-teria,which realize the rapid and ultrasensitive Raman test of Escherichia coli,Listeria mono-cytogenes,Staphylococcus aureus and Salmonella with the limit of detection of 10 CFU/mL and the maximum Raman enhancement factor up to 1.7×10^(8).Combined with principal component analysis,HfTe_(2)-Au-based SERS analysis also completes the bacterial classification without extra treatment.

关键词： Two-dimensional nanomaterials hafnium ditelluride surface-enhanced Raman scattering foodborne pathogenic bacteria

Interlayer and intralayer co-modified flexible V_(2)CT_(X) MXene@SWCNT films for high-power Li-ion capacitors

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Journal of Energy Chemistry 2023年第4期79卷 101-109页

作者： Wanli Wang Min Feng Enze Hu Zhaowei Hu Cheng Fan Huifang Li Peng Wang Xiaojun Wang zhiming liu College of Electromechanical Engineering Shandong Engineering Laboratory for Preparation and Application of High-performance Carbon-MaterialsQingdao University of Science&TechnologyQingdao 266061ShandongChina Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266101ShandongChina Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai UniversityTianjin 300071China

As an emerging member of the two-dimensional(2D)material family,V_(2)CT_(X)MXene shows great potential in the application of lithium-ion capacitors(LICs)due to its unique structure and excellent electrical ***,severe nanosheets stacking and intra-layer transport barriers have limited the further development of V_(2)CT_(X)MXene-based ***,we prepared Kions and–O functional group co-modified V_(2)CT_(X)MXene(VCT-K)and further incorporated it with single-walled carbon nanotube(SWCNT),obtaining freestanding V_(2)CT_(X)composite films(VCT-K@C)with the 3D conductive ***,K+ions were introduced into V_(2)CT_(X)MXene to stabilize the interlayer structure and prevent the aggregation of nanosheets,the terminal group of–O was controllably modified on the surface of MXene to improve the Li+ions storage reversible capacities and the SWCNT acted as the bridge between MXene nanosheets to opens up the channels for ion/electron transportation in the longitudinal *** from the synergistic effect of VCT-K and SWCNT,the VCT-K@C exhibits superior reversible specific capacities of 671.8 mA h g^(-1)at 0.1 A g^(-1)and 318 mA h g^(-1)at 1.0 A g^(-1).Furthermore,the assembled LICs with VCT-K@C anode coupling activated carbon(AC)cathode deliver an outstanding power density of 19.0 kW kg^(-1)at 67.4 Wh kg^(-1),a high energy density of 140.5 Wh kg^(-1)at 94.8 W kg^(-1)and a stable capacitance retention of 86%after 6000 cycles at 10 A g^(-1).Such unique structures and excellent electrochemical properties are expected to pave the way for the large-scale application in LICs of MXene-based materials.

关键词： Interlayer and intralayer co-modification MXene SWCNT Flexible self-supported anodes Lithium-ion capacitors

Effect of sodium content on the interaction between Ni and support and catalytic performance for syngas methanation over Ni/Zr–Yb–O catalysts

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Chinese Journal of Chemical Engineering 2019年第11期27卷 2705-2711页

作者： Songshou Ye Jiawei Guo Yanbing Wang Jianrong Xie zhiming liu Nuowei Zhang Jinbao Zheng Zhikai Cao Binghui Chen Department of Chemical and Biochemical Engineering National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-EstersCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China

In this paper, Ni/Zr–Yb–O catalysts with different sodium contents are prepared by a co-precipitation method, using aqueous Na2CO3 solution as a precipitant, and the effect of sodium on the catalyst structure and catalytic performance for syngas methanation is extensively investigated using five Ni/Zr–Yb–O catalysts, containing 0, 0.5, 1.5,4.5 and 13.5 wt% Na^+, those are denoted as Cat-1, Cat-2, Cat-3, Cat-4 and Cat-5 respectively. It is found that the interaction between Ni and support determines the catalytic performance of Ni/Zr–Yb–O and the residual sodium content negatively affects the interaction between Ni and support. Cat-1 exhibits an excellent catalytic *** a long run time of 380 h, no deactivation is observed and both CO conversion and CH4 selectivity maintain a level above 90%. However, Cat-3 and Cat-5 suffer rapid deactivation under the same reaction condition. The characterization results indicate the strong interaction between Ni and support enables Cat-1 to possess well dispersed Ni species, resistance to sintering and carbon deposition and thus the excellent catalytic performance. However, the presence of sodium ions over Ni/Zr–Yb–O degrades the interaction between Ni and support and the catalytic performance, especially for the stability. The relative weak interaction between Ni and support results in severe sintering of both ZrO2 and Ni under the reaction condition, carbon deposition and the poor catalytic performance.

关键词： CO methanation Ni/Zr–Yb–O catalyst Sodium content Syngas Stability

川陈皮素调节RhoA/ROCK信号通路对妊娠高血压大鼠内皮功能障碍的影响

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中国优生与遗传杂志 2024年第1期32卷 41-47页

作者：谷孝月刘志明赵会新蒋天从唐山市妇幼保健院产前诊断遗传病诊断中心河北唐山063000 华北理工大学附属医院药学部河北唐山063000

目的探讨川陈皮素调节Ras同源基因家族成员A(RhoA)/Rho相关的卷曲螺旋激酶(ROCK)信号通路对妊娠高血压(PIH)大鼠内皮功能障碍的影响。方法取SD大鼠雌雄合笼制备孕鼠,通过灌胃N-硝基-左旋精氨酸甲酯(L-NAME)构建PIH大鼠模型,随机分为模... 详细信息

目的探讨川陈皮素调节Ras同源基因家族成员A(RhoA)/Rho相关的卷曲螺旋激酶(ROCK)信号通路对妊娠高血压(PIH)大鼠内皮功能障碍的影响。方法取SD大鼠雌雄合笼制备孕鼠,通过灌胃N-硝基-左旋精氨酸甲酯(L-NAME)构建PIH大鼠模型,随机分为模型组、川陈皮素低剂量(3.6 mg/kg)组、川陈皮素高剂量(7.2 mg/kg)组、川陈皮素高剂量(7.2 mg/kg)+溶血磷脂酸(LPA)(RhoA/ROCK信号激活剂,1 mg/kg)组,每组均10只孕鼠,另取10只孕鼠灌胃等剂量生理盐水设为对照组,采用川陈皮素和LPA分组处理后,测量各组大鼠血压;检测各组大鼠24 h尿蛋白含量并以H-E染色检测其肾组织与胎盘组织病理形态;以酶联免疫吸附测定(ELASA)法检测各组大鼠血清内皮功能生物标志因子内皮素1(ET-1)、血栓素B2(TXB2)、一氧化氮(NO)与炎症因子肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-6、IL-17水平;以免疫印迹法检测各组大鼠胎盘组织RhoA/ROCK通路相关蛋白表达。结果与对照组比较,模型组大鼠肾组织与胎盘组织形态发生严重病理损伤,收缩压、舒张压、平均动脉压、24h尿蛋白含量、血清ET-1、TXB2、TNF-α、IL-6与IL-17水平、胎盘组织RhoA、ROCK1与ROCK2蛋白表达升高(P<0.05),血清NO水平降低(P<0.05);与模型组比较,川陈皮素低剂量组、川陈皮素高剂量组大鼠肾组织与胎盘组织形态病理损伤均减轻,收缩压、舒张压、平均动脉压、24 h尿蛋白含量、血清ET-1、TXB2、TNF-α、IL-6与IL-17水平、胎盘组织RhoA、ROCK1与ROCK2蛋白表达均降低(P<0.05),血清NO水平均升高(P<0.05),且高剂量川陈皮素作用更强;LPA可减弱川陈皮素对PIH模型大鼠的作用。结论川陈皮素通过抑制RhoA/ROCK信号激活而抑制PIH大鼠炎症,从而改善大鼠内皮功能障碍,并减轻其肾脏及胎盘组织损伤,最终缓解大鼠高血压症状。

关键词：川陈皮素 RhoA/ROCK 妊娠高血压内皮功能障碍