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Regulation of tumor cell migration by protein tyrosine phosphatase (PTP)-proline-, glutamate-, serine-,and threonine-rich sequence(PEST)

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Chinese Journal of Cancer 2013年第2期32卷 75-83页

作者： Yanhua Zheng zhimin lu Brain Tumor Center and Department of Neuro-Oncology The University of Texas MD Anderson Cancer Center Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer Center The University of Texas Graduate School of Biomedical Sciences at Houston

Protein tyrosine phosphatase (PTP)-proline-,glutamate-,serine-,and threonine-rich sequence (PEST) is ubiquitously expressed and is a critical regulator of cell adhesion and ***-PEST activity can be regulated transcriptionally via gene deletion or mutation in several types of human cancers or via post-translational modifications,including phosphorylation,oxidation,and caspase-dependent ***-PEST interacts with and dephosphorylates cytoskeletal and focal adhesion-associated ***-phorylation of PTP-PEST substrates regulates their enzymatic activities and/or their interaction with other proteins and plays an essential role in the tumor cell migration process.

关键词：蛋白酪氨酸磷酸酶细胞迁移 PEST 肿瘤细胞脯氨酸 PTP 谷氨酸丝氨酸

A direct atomic layer deposition method for growth of ultra-thin lubricant tungsten disulfide films

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Science China(Technological Sciences) 2017年第1期60卷 51-57页

作者： SUN YongFeng CHAI zhimin lu XinChun HE DanNong National Engineering Research Center for Nanoteehnology Shanghai 200241 China

We describe a direct atomic layer deposition method to grow lubricant tungsten disulfide （WS2） films. The WS2 films were deposited on a Si （100） substrate and a zinc sulfide （ZnS） film coated the Si （100） substrate using tungsten hexacarbonyl and hydrogen sulfide as precursors. The ZnS film served as an intermediate layer to facilitate the nucleation and growth of the WS2 films. The thickness of the WS2 films was measured via scanning electron microscope, the microstructure was probed with an X-ray diffractometer and a transmission electron microscope. The friction coefficient was measured with a ball-on-disk tester under dry nitrogen. The results reveal that the WS2 films deposited on both substrates are N175 nm and have （002） and （101） crystal orientations. The WS2 film deposited on the ZnS coated Si substrate exhibits a stronger （002） orientation and a denser crystal structure than that deposited on the Si substrate. The WS2 films on both substrates have low friction coefficients. How- ever, due to the stronger （002） orientation and denser crystal structure, the friction coefficient of the WS2 film deposited on ZnS coated Si substrate is smaller with longer wear life.

关键词： atomic layer deposition tungsten disulfide crystal orientation friction

Metabolic features of cancer cells

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Cancer Communications 2018年第1期38卷 695-700页

作者： Yugang Wang Yan Xia zhimin lu Brain Tumor Center and Department of Neuro-Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Molecular and Cellular Oncology The University of Texas MD Anderson Can-cer CenterHoustonTX 77030USA Cancer Biology Program The University of Texas MD Anderson Cancer Center UT Health Graduate School of Biomedical SciencesHoustonTX 77030USA

Cancer cells uniquely reprogram their cellular activities to support their rapid proliferation and migration and to coun-teract metabolic and genotoxic stress during cancer *** this reprograming,cancer cells’metabolism and other cellular activities are integrated and mutually regulated,and cancer cells modulate metabolic enzymes spatially and temporally so that these enzymes not only have altered metabolic activities but also have modulated subcellular localization and gain non-canonical *** review and several others in this issue of Cancer Communications discuss these enzymes’newly acquired functions and the non-canonical functions of some metabolites as features of cancer cell metabolism,which play critical roles in various cellular activities,including gene expression,anabolism,catabolism,redox homeostasis,and DNA repair.

关键词： Metabolic enzymes Metabolites Non-canonical functions Protein kinase Lipid metabolism Gene expression Anabolism Catabolism Redox homeostasis DNA repair

Analyzing of mixing performance determination factors for the structure of radial multiple jets-in-crossflow

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Chinese Journal of Chemical Engineering 2019年第11期27卷 2626-2634页

作者： Meifang Zhou Hao Jiang Yanjie Hu zhimin lu Haibo Jiang Chunzhong Li Key Laboratory for Ultrafine Materials of the Ministry of Education School of Materials Science and EngineeringEast China University of Science&TechnologyShanghai 200237China School of Materials Science and Engineering Yancheng Institute of TechnologyYancheng 224051China

The radial multiple jets-in-crossflow mixing structure(RMJCMS) is extensively used in industrial manufacture. In this research, the effects of thickness of injection ring on mixing performance and factors influencing the mixing performance of RMJCMS were discussed based on the results of computational fluid dynamics. The simulation results showed that the dimensionless mixing distance, with the increase of the thickness of injection ring, drops from 1.1 to 0.18 first and then increases to 0.27 while the uniformity of flux monotonously improves, manifesting that the consistency of flux is not the single element determining the mixing performance. Analyzing the simulation results, a conclusion was drawn that the consistency of flux, penetration mode and interaction among injection flows which can be altered by adjusting the thickness of injection ring, determine the mixing performance of RMJCMS jointly. That is to say, in RMJCMS an injection ring with a suitable thickness can realize the function of injection and rectification simultaneously, which not only improves the mixing performance but also reduces the complexity of RMJCMS as well.

关键词： Thickness of injection ring Multiple jets mixing structure Computational fluid dynamics Penetration mode Jet interaction

Determiners of cell fates: the tricarboxylic acid cycle versusthe citrate-malate shuttle

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Protein & Cell 2023年第3期14卷 162-164页

作者： Dong Guo Haiyan He Ying Meng Shudi luo zhimin lu Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affliated Hospitaland Institute of Translational MedicineZhejiang University School of MedicineZhejiang UniversityHangzhou 310029China Cancer Center Zhejiang UniversityHangzhou 310029China

The tricarboxylic acid(TCA)cycle identified in 1937 by Hans Adolf Krebs and William Arthur Johnson(also known as the Krebs cycle or citric acid cycle)is a central route for oxidative metabolism to generate cellular energy and intermediates for the biosynthesis of amino acids,lipids,and nucleic acids(Krebs and Johnson 1937).The TCA cycle connects carbohydrate,fat,and protein metabolism and converts these nutrient catabolism-derived acetyl-CoA into carbon dioxide and water,with the production of reduced NAD+(NADH),reduced flavin adenine dinucleotide(FADH2),and guanosine triphosphate(GTP).The generated NADH and FADH2 are,in turn,used by the oxidative phosphorylation pathway to generate energy-rich adenosine triphosphate(ATP)(Chakrabarty and Chandel 2021).

关键词： cycle oxidative carboxylic

A newly discovered role ofmetabolic enzyme PCK1 as a protein kinase to promote cancer lipogenesis

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Cancer Communications 2020年第9期40卷 389-394页

作者： Hongfei Jiang Lei Zhu Daqian Xu zhimin lu The Affiliated Hospital of Qingdao University and Qingdao Cancer Institute QingdaoShandong 266071P.R.China Department of Hepatobiliary and Pancreatic Surgery Zhejiang Provincial Key Laboratory of Pancreatic DiseaseInstitute of Translational Medicinethe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310029P.R.China

Lipid metabolism,in particular fatty acid and cholesterol synthesis,is essential to convert nutrients into metabolic intermediates for membrane biosynthesis,energy storage and the generation of signaling *** cells maintain high level of lipid metabolism for rapid cell proliferation[1-4].Transcription of genes required for fatty acid and cholesterol synthesis and cholesterol uptake is controlled by membrane-bound transcription factor sterol regulatory element-binding proteins(SREBPs),including SREBP-1a,SREBP-1c/ADD1 and SREBP-2 isoforms[5].The function of SREBPs is mainly regulated by an escort protein(the SREBP cleavage-activating protein[SCAP])and endoplasmic reticulum(ER)anchor proteins(insulininduced genes[Insigs]),during the feedback loop of cholesterol synthesis[6-8].Under sterol-depleted conditions,SCAP and SREBPs complex is captured by COPIImediated vesicles and transported from the ER to the Golgi apparatus[7,9],where the SREBPs are proteolytically processed by Site-1 protease(S1P)and Site-2 protease(S2P)to yield active amino-terminal fragments that enter the nucleus for gene transcription[10,11].Under high intracellular sterol conditions,abundant cholesterol in the ER membrane binds to SCAP,induces its conformational change,and enables it to bind to Insigs.

关键词： synthesis maintain apparatus

Coldness impedes tumor growth

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Life Metabolism 2022年第3期1卷 205-206页

作者： Shudi luo Xiaoming Jiang zhimin lu Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospitaland Institute of Translational MedicineZhejiang University School of MedicineHangzhouZhejiang 310029China Cancer Center Zhejiang UniversityHangzhouZhejiang 310029China

The Warburg effect is critical for tumor growth.A new study showed that cold acclimatization activates brown adipose tissue(BAT),reduces blood glucose levels,and subsequently blunts aerobic glycolysis in cancer and tumor *** cells preferentially use glucose as an energy resource even in the presence of ample oxygen,to generate ATP and metabolic intermediates for the production of amino acids,fatty acids and cholesterol,and *** Warburg effect or aerobic glycolysis occurring in various types of solid tumors has been used for cancer diagnosis and monitoring tumor progression and response to therapies by positron emission tomography–computed tomography(PET–CT)imaging analysis,which detects the substantially enhanced uptake of ^(18)F-fluorodeoxyglucose(^(18)FFDG)of tumor cells[1].

关键词： diagnosis cancer cholesterol

Abrogation of nuclear entry of TERT by fructose 1,6-bisphosphatase 1-mediated dephosphorylation

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Cancer Communications 2024年第10期44卷 1102-1105页

作者： Pengbo Yao Gaoxiang Zhao Min Li Wensheng Qiu zhimin lu Department of Oncology The Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao Cancer InstituteQingdaoShandongP.R.China Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospitaland Institute of Translational MedicineZhejiang University School of MedicineHangzhouZhejiangP.R.China Cancer Center Zhejiang UniversityHangzhouZhejiangP.R.China Institute of Fundamental and Transdisciplinary Research Zhejiang UniversityHangzhouZhejiangP.R.China

Telomeres maintain chromosome *** of telomere function,which is attributed to progressively shortened telomeres in each round of DNA replication,induces endto-end fusion of chromosomes,anaphase bridges with subsequent chromosome breakage,and eventually leads to senescence and apoptosis in normal cells[1].In cancer cells,highly activated telomerase synthesizes telomere repeats to promote telomere elongation.

关键词： eventually bridges maintain

Fructose and fructose kinase in cancer and other pathologies

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Journal of Genetics and Genomics 2021年第7期48卷 531-539页

作者： Hongfei Jiang Qian Lin Leina Ma Shudi luo Xiaoming Jiang Jing Fang zhimin lu Cancer Institute of The Affiliated Hospital of Qingdao University and Qingdao Cancer Institute Qingdao 266061China Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated HospitalInstitute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Zhejiang University Cancer Center Hangzhou 310029China

Fructose metabolism and fructose kinase KHKe C/A are key factors in the development of lipid oversynthesis-promoted metabolic disorders and ***,we summarize and discuss the current knowledge about the specific features of fructose metabolism and the distinct roles of KHKe C and KHKe A in metabolic liver diseases and their relevant metabolic disorders and cancer,and we highlight the specific protein kinase activity of KHKe A in tumor *** addition,different approaches that have been used to inhibit KHK and the exploration of KHK inhibitors in clinical treatment are introduced.

关键词： Fructose Glucose KHKe-C KHK-A Cancer NAFLD NASH Metabolic disorders