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Synthesis, Antitumor Activity and Preliminary Structure-activity Relationship of 2-Aminothiazole Derivatives

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Chemical Research in Chinese Universities 2016年第6期32卷 929-937页

作者： LI Hongshuang WANG Xinran DUAN Guiyun XIA Chengcai XIAO Yuliang LI Furong GE Yanqing you Guirong HAN Junfen FU Xiaopan School of Pharmaceutical Sciences Taishau Medical University Taian 2 71016 P. R. China

In this paper, we described the synthesis of 2-aminoflfiazole sublibrary containing methyl, bromo, phenylor butylidene at 4- or/and 5-position of its core. All target compounds were evaluated tbr their antitumor activitiesagainst human lung cancer cell line H1299 and human glioma cell line SHG-44. Among the compotmds screened,4,5,6,7-tetrahydrobenzo[d]thiazole（26b） exhibited the most potent antittunor activities with IC50 values of 4.89 and4.03 μmol/L against the two tested cell lines, respectively. Preliminary structure-activity relationship（SAR） studies ofthese compound were subsequently investigated.

关键词： 2-Aminotlfiazole Antitumor activity Structure-activity relationship

Neuroprotective Effects of Electroacupuncture Preventive Treatment in Senescence-Accelerated Mouse Prone 8 Mice

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Chinese Journal of Integrative Medicine 2018年第2期24卷 133-139页

作者： HE Xiao-li ZHAO Shi-hui you Wei CAI Yu-ying WANG Yan-yun YE Yong-ming JIA Bao-hui Research Center for Pharmacology and Toxicology Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100193China Guang'anmen Hospital China Academy of Chinese Medical Sciences Beijing 100053 China Beijing Hospital of Traditional Chinese Medicine Capital Medical University Beijing100010 China

Objective： To investigate the preventive treatment effects of electroacupuncture（EA） on cognitive changes and brain damage in senescence-accelerated mouse prone 8（SAMP8） mice. Methods： The 5-month-old male SAMP8 and age-matched homologous normal aging mice（SAMR1） were adopted in this study. EA stimulation at Baihui（GV 20） and Yintang（EX-HN 3） was performed every other day for 12 weeks, 4 weeks as a course. Morris water maze test and Nissl-stained with cresyl violet were used for cognitive impairments evaluation and brain morphometric analysis. Amyloid-β（Aβ） expression in hippocampus and parietal cortex was detected by immunohistochemistry, and apoptosis was observed by TUNEL staining. Results： After 3 courses of EA preventive treatment, the escape latencies of 8-month-old SAMP8 mice in EA group were significantly shortened than those of un-pretreated SAMP8 mice. Compared with SAMR1 mice, extensive neuronal changes were visualized in the CA1 area of hippocampus in SAMP8 mice, while these pathological changes and attenuate cell loss in hippocampal CA1 area of SAMP8 mice markedly reduced after EA preventive treatment. Furthermore, Aβ expression in hippocampus and parietal cortex of SAMP8 mice decreased significantly after EA treatment, and neuronal apoptosis decreased as well. Conclusion： EA preventive treatment at GV 20 and EX-HN 3 might improve cognitive deficits and neuropathological changes in SAMP8 mice, which might be, at least in part, due to the effects of reducing brain neuronal damage, decreasing neuronal apoptosis and inhibiting Aβ-containing aggregates.

关键词： electroacupuncture senescence-accelerated mouse prone 8 mice prevention learning and memory cognitive impairment brain damage

Effects of Extract of Medium Residue from Cultivation of Pleurotus citrinopileatus on Mycelial Growth of 3 Edible Fungi

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Agricultural Biotechnology 2016年第6期5卷 44-45,49页

作者： Ming JIANG Jie LIU Fengxia LV Xianchun ZONG zhimin JIN Mudanjiang Normal University College of Life Science and Technology

Effects of extract of medium residue of Pleurotus citrinopileatus on mycelial growth of P. citrinopileatus, G. lucidum and L. edodes were investigated by plate cultivation method. The results showed that extract of medium residue of P. citrinopileatus promoted mycelial growth of L. edodes, and showed the best effects at the addition amount of 75%, while the myedial growth of G. lucidum and P. citrinopileatus was inhibited by the extract.

关键词： Edible fungus Medium residue Mycelium Growth

Comparison of Oxygen Consumption between Clethrionomys rufocanus and Apodemus agrarius

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Animal Husbandry and Feed Science 2015年第5期7卷 292-293页

作者： Jin zhimin Yang Changyu Xin Di Fu Dahang Zhu Xianbing College of Life Science and Technology Mudanjiang Normal University

[ Objective] The paper was to find out the difference in oxygen consumption between Clethrionomys rufocanus and Apodemus agrarius. [ Method] The oxygen consumption value of C. rufocanus and A. agrarius was measured using improved closed pressure breathing apparatus, and the oxygen consumption rate was calculated. [ Result] The oxygen consumption of C. rufocanus and A. agrarius increased with the increasing body weight, while the increase amplitude ofA. agrarius was relatively smaller. The oxygen consumption rate decreased with the increasing body weight. [ Conclusion] The result provides a biological basis for breeding and research of experimental rats.

关键词： Clethrionomys rufocanus Apodemus agrarius Oxygen consumption

Measuring internal residual stress in Al-Cu alloy forgings by crack compliance method with optimized parameters

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Journal of Central South University 2020年第11期27卷 3163-3174页

作者： DONG Fei YI you-ping HUANG Shi-quan Research Institute of Light Alloy Central South UniversityChangsha 410083China State Key Laboratory of High Performance Complex Manufacturing Changsha 410083China School of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China

Measuring the internal stress of Al alloy forgings accurately is critical for controlling the deformation during the subsequent machine *** this work,the crack compliance method was used to calculate the internal residual stress of Al-Cu high strength alloys,and the effect of various model parameters of crack compliance method on the calculated precision was studied by combining the numerical simulation and experimental *** results show that the precision first increased and then decreased with increasing the crack *** decreased precision when using a high crack range was due to the strain fluctuation during the machining process,and the optimized crack range was 71%of the thickness of *** orders of Legendre polynomial can result in residual stress curve more smooth,while high orders led to the occurrence of *** Tikhonov regularization method effectively suppressed the distortion of residual stress caused by the fluctuation of strain data,which significantly improved the *** addition,The crack compliance method with optimized parameters was used to measure the residual stress of Al-Cu alloy with different quenching *** calculated results demonstrated that the distribution of residual stress was obtained accurately.

关键词： residual stress crack compliance method crack range interpolation orders Tikhonov regularization method

The contribution of the first forbidden transitions to the nuclear β^--decay half-life

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Chinese Physics C 2019年第11期43卷 91-99页

作者： Ji-Lin you Xiao-Ping Zhang Qi-Jun Zhi Zhong-Zhou Ren Qing-Dong Wu School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550001China State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao 999078China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550001China School of Physics Science and Engineering Tongji UniversityShanghai 200092China

β-decay half-life is a key quantity for nuclear structure and nucleosynthesis *** exist large uncertainties in the contributions of allowed and forbidden transitions to the totalβ-decay life,which limits the resolution of the predictedβ-decay *** systematically study the contribution of the first forbidden(FF)transitions to theβ--decay half-life,and quantify it with a formula based on simple physics *** also propose a new formula for calculation of theβ--decay half-life that includes the FF *** is shown that the inclusion of the contribution of FF transitions significantly improves the precision of calculations of theβ--decay *** fitting of the RQRPA results for neutron-rich Z=47,57 isotopes and N=80,94 isotones,the formula for the contribution of the FF transitions gives similar results as the RQRPA ***,because of limited experimental data for the branching ratios of unstable nuclei,the fit parameters are not fully ***,the proposed formula for theβ--decay half-life is more suitable for calculations of half-lives than of the FF *** formula could be used to predict theβ?-decay half-life in nuclear structure studies as well as nucleosynthesis calculations in stars.

关键词： β^--decay half-life nucleosynthesis first forbidden transitions branching ratios

Application Potential of Quinoa as Forage

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Asian Agricultural Research 2021年第12期13卷 41-42页

作者： Wei LU Jianhan HE Meiyan PEI zhimin WEI Chuan LU The Semi-arid Agriculture Engineering & Technology Research Center of P. R. China Shijiazhuang 050000 China Institute of Crops Hebei Academy of Agriculture and Forestry Sciences Shijiazhuang 050035 China Hanshan District Agricultural and Rural Bureau of Handan City Handan 056001 China Institute of Millet Crops Hebei Academy of Agriculture and Forestry Sciences Cereal Crops Research Laboratory of Hebei Province National Foxtail Millet Improvement Center Shijiazhuang 050035 China

Quinoa is a crop as both food and *** has a tolerance to cold,drought,and *** is rich in vitamins,polyphenols,flavonoids,phytosterols and other substances,and has rich nutritional value and health care,which provides great potential for being as *** this paper,the application potential and prospects of quinoa as forage are studied.

关键词： Planting environment Nutritional value Application of forage Potential analysis

Large enhancement of transient photovoltage induced by the absorption of the metal Al

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Science China(Physics,Mechanics & Astronomy) 2012年第7期55卷 1240-1244页

作者： WU Bo SUN XiaoYu SUN ZhengYi you YinTao LU Min DING XunMin HOU XiaoYuan State Key Laboratory of Surface Physics Fudan University Shanghai 200433China

The transient photovoltage of ITO/CuPc/AI is studied. The transient photovoltage under the Al side illumination is much greater than that under ITO side illumination. It is not negligible while light is almost completely absorbed by the Al layer. It seems that the light absorption of the Al layer could enhance the generation of the photoinduced carriers in the organic layer, which is further shown by the transient photovoltage study of ITO/Al/NPB/Au. A possible mechanism proposed is that the holes generated in the Al are because of light absorption that is injected from the AI to organic materials. This results in further charge separation by the internal built-in electric field.

关键词： light absorption excitons interfacial effects organic solar cells photovoltaic effects

A Note about Multi-criteria Fuzzy Decision Making Method Based on a Novel Accuracy Function Defined on Two Opposite Aspects

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管理科学与研究（中英文版） 2015年第4期4卷 50-55页

作者： Xinshang you Tong Chen College of Management and Economics Tianjin University Tianjin 300072 China