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Noncoding RNAs:the shot callers in tumor immune escape

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1557-1580页

作者： Lei Liu Qin Wang zhilin qiu Yujuan Kang Jiena Liu Shipeng Ning Yanling Yin Da Pang Shouping Xu Department of Breast Surgery Harbin Medical University Cancer HospitalHarbin 150081China Heilongjiang Academy of Medical Sciences Harbin 150086China

Immunotherapy,designed to exploit the functions of the host immune system against tumors,has shown considerable potential against several ***,the utility of immunotherapy is heavily limited due to the low response rate and various side effects in the clinical *** escape of tumor cells may be a critical reason for such low response *** RNAs(ncRNAs)have been identified as key regulatory factors in tumors and the immune ***,ncRNAs show promise as targets to improve the efficacy of immunotherapy in ***,the relationship between ncRNAs and tumor immune escape(TIE)has not yet been comprehensively *** this review,we provide a detailed account of the current knowledge on ncRNAs associated with TIE and their potential roles in tumor growth and survival *** review bridges the gap between ncRNAs and TIE and broadens our understanding of their relationship,providing new insights and strategies to improve immunotherapy response rates by specifically targeting the ncRNAs involved in TIE.

关键词： immunotherapy clinical escape

Passively stable 0.7-octave microcombs in thin-film lithium niobate microresonators

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Chinese Optics Letters 2024年第5期22卷 53-56页

作者：赵泽兴王晨宇邱静远叶志霖尹志军王振林贾琨鹏田晓慧谢臻达祝世宁 National Laboratory of Solid State Microstructures School of Electronic Science and EngineeringSchool of PhysicsCollege of Engineering and Applied Sciencesand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China Nanzhi Institute of Advanced Optoelectronic Integration Technology Co. Ltd.Nanjing 210093China

The optical frequency comb based on microresonators(microcombs)is an integrated coherent light source and has the potential to promise a high-precision frequency standard;self-reference and a long-term stable microcomb are the keys to this ***,we demonstrated a 0.7-octave spectrum Kerr comb via dispersion engineering in a thin-film lithium niobate microresonator,and the single-soliton state can be accessed passively with long-term stability over 3 *** such a robust broadband coherent comb source using thin-film lithium niobate,a fully stabilized microcomb can be expected for massive practical applications.

关键词： thin-film lithium niobate soliton microcomb photorefractive effect

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广东省热带气旋潜在风险指数时空分布特征

广东水利水电 2024年第2期 1-6页

作者：张之琳邱静洪昌红刘达广东省水利水电科学研究院广州510635 河口水利技术国家地方联合工程实验室广州510635

热带气旋在广东省内造成的影响具有显著的时空不均匀性,采用统计方法对1949—2022年间热带气旋登陆广东省情况进行分析,并根据PRITC V1.0数据集提供的数据对1949—2018年间热带气旋潜在风险指数的时空分布特征开展分析。结果表明:热带... 详细信息

热带气旋在广东省内造成的影响具有显著的时空不均匀性,采用统计方法对1949—2022年间热带气旋登陆广东省情况进行分析,并根据PRITC V1.0数据集提供的数据对1949—2018年间热带气旋潜在风险指数的时空分布特征开展分析。结果表明:热带气旋主要在6—10月登陆广东,数量占登陆总数的94.2%;主要在粤西三市登陆,占比47.8%;珠江口以西登陆的热带气旋强度较珠江口以东更大。1970年以来,逐年平均指数10 a滑动平均呈上升趋势。热带气旋给广东省带来的降水影响超过大风影响。累计潜在风险指数最高的城市为湛江、汕尾、阳江、江门;且湛江、茂名、汕头的风雨综合指数10 a滑动平均基本呈增加趋势;结果可为各地区水公共安全防御工作提供参考。

关键词：热带气旋潜在风险指数台风登陆时空分布广东省

益气养阴解毒方联合化疗治疗非小细胞肺癌临床研究

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中医学报 2014年第10期29卷 1397-1399页

作者：邱芝琳葛信国南京中医药大学第一临床医学院江苏南京210046 常州市中医医院江苏常州213000

目的:探讨益气养阴解毒方联合化疗治疗晚期非小细胞肺癌的临床疗效。方法:随机将40例晚期非小细胞肺癌患者分为治疗组(益气养阴解毒方+化疗)和对照组(单纯化疗),每组各20例,治疗2个周期,每周期为21 d。2个周期后对各组治疗前后及两组治... 详细信息

目的:探讨益气养阴解毒方联合化疗治疗晚期非小细胞肺癌的临床疗效。方法:随机将40例晚期非小细胞肺癌患者分为治疗组(益气养阴解毒方+化疗)和对照组(单纯化疗),每组各20例,治疗2个周期,每周期为21 d。2个周期后对各组治疗前后及两组治疗后的临床疗效、中医症状、体力状况、不良反应等指标进行比较,评价疗效。结果:临床疗效方面,两组比较无显著差异(P>0.05)。中医症状比较,治疗组治疗后有效率为70%,对照组治疗后有效率20%,治疗组明显优于对照组(P0.05),治疗后治疗组疗效明显优于对照组(P0.05)。结论:益气养阴解毒方联合化疗较单纯化疗治疗晚期非小细胞肺癌在改善患者体力状况,减轻中医症状方面具有明显优势,能一定程度上降低血液系统毒性,减轻消化道反应,提高晚期非小细胞肺癌患者化疗耐受性。

关键词：非小细胞肺癌益气养阴解毒方化疗

In-situ observation and mechanism of calcium–magnesium–alumina–silicate(CMAS)melts-induced degradation of RE_(2)SiO_(5)(RE=Tb,Dy,Ho,Y,Er,Tm,and Yb)ceramics at 1500℃

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Journal of Advanced Ceramics 2023年第12期12卷 2315-2330页

作者： zhilin Tian Keyu Ming Liya Zheng zhilin Chen Fan Zhou Peng Liu Zihao qiu Donghui Wei Bin Li Jingyang Wang School of Materials Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China School of Metallurgy Northeastern UniversityShenyang 110819China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

Rare earth(RE)silicate is one of the most promising environmental barrier coatings for silicon-based ceramics in gas turbine ***,calcium-magnesium-alumina-silicate(CMAS)corrosion becomes much more serious and is the critical challenge for RE silicate with the increasing operating ***,it is quite urgent to clarify the mechanism of high-temperature CMAS-induced degradation of RE silicate at relatively high ***,the interaction between RE_(2)SiO_(5) and CMAS up to 1500℃was investigated by a novel high temperature in-situ observation *** temperature promotes the growth of the main reaction product(Ca_(2)RE_(8)(SiO_(4))6O_(2))fast along the[001]direction,and the precipitation of short and horizontally distributed Ca_(2)RE_(8)(SiO_(4))6O_(2) grains was accelerated during the cooling *** increased temperature increases the solubility of RE elements,decreases the viscosity of CMAS,and thus elevates the corrosion reaction rate,making RE_(2)SiO_(5) fast interaction with CMAS and less affected by RE element species.

关键词： calcium-magnesium-alumina-silicate(CMAS)corrosion environmental barrier coating rare earth(RE)silicate high temperature

基于网络药理学和分子对接的白藜芦醇治疗口腔鳞状细胞癌的机制研究

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口腔疾病防治 2024年第3期32卷 178-187页

作者：陈虹君雷奇王治林钟晓武邱亚李丽华川北医学院附属医院口腔科四川南充637000 川北医学院口腔医学系四川南充637000 川北医学院附属医院检验科四川南充637000 川北医学院附属医院医学研究中心四川南充637000

目的通过网络药理学及分子对接等生物学信息方法,探讨白藜芦醇治疗口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)的分子机制,为白藜芦醇治疗OSCC的临床应用提供参考。方法利用Swiss Target Prediction(http://***)、SEA数据库(htt... 详细信息

目的通过网络药理学及分子对接等生物学信息方法,探讨白藜芦醇治疗口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)的分子机制,为白藜芦醇治疗OSCC的临床应用提供参考。方法利用Swiss Target Prediction(http://***)、SEA数据库(http://***)、Pharm mapper数据库(http://***)检索获得白藜芦醇的相关靶点,以DISGENET(***)、OMIM(https://***)、GeneCards(https://***)数据库筛选OSCC疾病靶点,取药物与疾病靶点的交集,再采用Cytoscape 3.7.2软件构建“药物-疾病-靶点-通路”网络,String数据库构建靶蛋白相互作用网络,采用DAVID数据库对关键蛋白进行富集分析,最后通过AutoDock及PyMOL对关键蛋白进行分子对接验证,结合富集分析和分子对接结果预测白藜芦醇治疗OSCC可能的分子作用机制;细胞水平采用Western blot检测不同浓度(50、100μmol/L)白藜芦醇对OSCC细胞株HSC-3细胞Src酪氨酸激酶(Src tyro-sine kinase,SRC)、表皮生长因子受体(epidermal growth factor receptor,EGFR)、雌激素受体基因1(estrogen receptor gene 1,ESR1)及磷脂酰肌醇三激酶/蛋白激酶B(phosphatidylinositol 3 kinase/protein kinase B,PI3K/AKT)信号通路蛋白表达的影响。结果数据库得到白藜芦醇药物靶点243个,OSCC疾病靶点6094个,将药物与疾病的靶点进行交集获得116个潜在靶点,潜在靶点主要集中参与体内蛋白质自磷酸化、肽基酪氨酸磷酸化、跨膜受体蛋白酪氨酸激酶信号通路、RNA聚合酶Ⅱ启动子转录的正调控等生物过程,干预PI3K/AKT信号通路发挥抗OSCC的作用。分子对接结果表明白藜芦醇与EGFR、ESR1、SRC等OSCC关键靶点具有较好的结合活性。细胞实验结果表明,白藜芦醇药物干预以剂量依赖的方式抑制了HSC-3细胞中SRC、EGFR、ESR1及p-PI3K和p-AKT的蛋白表达。结论白藜芦醇对OSCC细胞SRC、EGFR、ESR1、p-PI3K、p-AKT靶点具有抑制作用。

关键词：白藜芦醇口腔鳞状细胞癌网络药理学分子对接 Src酪氨酸激酶表皮生长因子受体雌激素受体基因1 磷脂酰肌醇三激酶/蛋白激酶B信号通路

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大型舰艇编队装备维修保障能力评估及仿真研究

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舰船电子工程 2013年第9期33卷 121-123,126页

作者：邱志林戴明强海军工程大学理学院武汉430033

大型舰艇编队装备维修保障力量的实施,关系到我国海军实力扩充和突破的时间点,也是大型舰艇编队建设前期不能绕开的关键步骤。论文立足于保障大型舰艇编队装备遂行战斗任务的目标,选取装备可用性来评估大型舰艇编队的装备维修保障能力... 详细信息

大型舰艇编队装备维修保障力量的实施,关系到我国海军实力扩充和突破的时间点,也是大型舰艇编队建设前期不能绕开的关键步骤。论文立足于保障大型舰艇编队装备遂行战斗任务的目标,选取装备可用性来评估大型舰艇编队的装备维修保障能力。在构建装备可用性指标体系的基础上,分析大型舰艇编队的特点,建立大型舰艇编队装备可用性模型,采用试探性建模与分析评估方法,仿真不同任务下的装备可用性,根据计算结果,总结出可用的优化维修策略,能够在保证大型舰艇编队装备运行任务的同时,提供更多时间和精力用于战备训练,优化装备维修保障性能。

关键词：大型舰艇编队保障维修评估

气候变化以两种不同方式驱动了丝绸之路路线的变迁

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Science Bulletin 2024年第8期69卷 1153-1160页

作者：王海鹏陈建徽仇梦晗史志林张盛达董广辉马帅艾涛任冠陈发虎 State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China MOE Key Laboratory of Western China’s Environmental Systems Lanzhou UniversityLanzhou 730000China Institute of Dunhuang Studies School of History&CultureLanzhou UniversityLanzhou 730000China School of Geography and Remote Sensing Guangzhou UniversityGuangzhou 510000China Xinjiang Institute of Cultural Relics and Archaeology Ürümqi 830011China Archaeology of Northern Ethnicity Institute Renmin University of ChinaBeijing 100872China ALPHA State Key Laboratory of Tibetan Plateau Earth SystemEnvironment and ResourcesInstitute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China

Although climate change has convincingly been linked to the evolution of human civilization on different temporal scales,its role in influencing the spatial patterns of ancient civilizations has rarely been investigated,The northward shift of the ancient Silk Road(SR)route from the Tarim Basin(TB)to the Junggar Basin during~420-850 CE provides the opportunity to investigate the relationship between climate change and the spatial evolution of human ***,we use a new high-resolution chironomidbased temperature reconstruction from arid China,combined with hydroclimatic and historical datasets,to assess the possible effects of climate fluctuations on the shift of the ancient SR route,We found that a cooling/drying climate in the TB triggered the SR route shift during~420-600 CE,However,a warming/wetting climate during~600-850 CE did not inhibit this shift,but instead promoted it,because of the favorable climate-induced geopolitical conflicts between the Tubo Kingdom and the Tang Dynasty in the *** findings reveal two distinct ways in which climate change drove the spatial evolution of human civilization,and they demonstrate the flexibility of societal responses to climate change.

关键词： Chironomids Temperature reconstruction Water resources Geopolitical conflicts

Multilayer dielectric grating pillar-removal damage induced by a picosecond laser

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High Power Laser Science and Engineering 2022年第6期10卷 66-74页

作者： Kun Shuai Xiaofeng Liu Yuanan Zhao Keqiang qiu Dawei Li He Gong Jian Sun Li Zhou Youen Jiang Yaping Dai Jianda Shao zhilin Xia School of Materials Science and Engineering Wuhan University of TechnologyWuhanChina Laboratory of Thin Film Optics Shanghai Institute of Optics and Fine MechanicsShanghaiChina National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefeiChina School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghaiChina National Laboratory on High Power Laser and Physics Shanghai Institute of Optics and Fine MechanicsCASShanghaiChina Research Center of Laser Fusion China Academy of Engineering PhysicsMianyangChina Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhouChina

Multilayer dielectric gratings typically remove multiple-grating pillars after picosecond laser irradiation;however,the dynamic formation process of the removal is still *** this study,the damage morphologies of multilayer dielectric gratings induced by an 8.6-ps laser pulse were closely *** damage included the removal of a single grating pillar and consecutive adjacent grating pillars and did not involve the destruction of the internal high-reflection mirror *** analysis of the two damage morphological characteristics indicated the removal of adjacent pillars was related to an impact process caused by the eruption of localized materials from the left-hand pillar,exerting impact pressure on its adjacent pillars and eventually resulting in multiple pillar removal.A finite-element strain model was used to calculate the stress distribution of the grating after *** to the electric field distribution,the eruptive pressure of the dielectric materials after ionization was also *** results suggest that the eruptive pressure resulted in a stress concentration at the root of the adjacent pillar that was sufficient to cause damage,corresponding to the experimental removal of the adjacent pillar from the *** study provides further understanding of the laser-induced damage behavior of grating pillars and some insights into reducing the undesirable damage process for practical applications.

关键词： grating pillar removal laser-induced damage multilayer dielectric gratings picosecond laser