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Peptide therapeutics and assemblies for cancer immunotherapy

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Science China Materials 2019年第11期62卷 1759-1781页

作者： Mingming Li Xinran Zhao Jianfang Dai zhilin yu Key Laboratory of Functional Polymer Materials Ministry of Education State Key Laboratory of Medicinal Chemical Biology Institute of Polymer Chemistry College of Chemistry Nankai University

Immunotherapy has been considered as one of the most promising strategies for protection against cancer cells due to the tremendous advantages arising from host immune ***,establishing versatile strategies with high biosafety and the capability for efficient modulation of immune responses remains *** structural features resembling native proteins of peptides bestow their great potential to address these challenges via either directly eliciting immune responses or improving the efficacy of *** review summarizes the progress of cancer immunotherapy achieved based on the strategies utilizing short peptides as therapeutic agents or peptide assemblies as delivery scaffolds,beyond long sequences like proteins and *** from a brief introduction of cancer immunotherapy,we outline the peptide sequences in terms of their specific functions including immune checkpoint blockades,vaccine antigens and *** particularly highlight peptide-based nanomaterials as scaffolds for targeting delivery or co-delivery of multiple therapeutics to enhance *** extraordinary therapeutic efficacy of the limited examples covered here demonstrates the great potency of the peptide-based strategies in modulating immune responses,thus potentially facilitating the clinical translation of cancer immunotherapy in the future.

关键词： cancer immunotherapy peptides self-assembly checkpoint blockades combinatorial immunotherapy

Photoinduced directional domain sliding motion in peptide hydrogels promotes ectodermal differentiation of embryonic stem cells

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Science China Materials 2020年第3期63卷 467-478页

作者： Zhifei Cheng Shanshan Nai Shuxin Song Lingyi Chen zhilin yu Key Laboratory of Functional Polymer Materials Ministry of EducationState Key Laboratory of Medicinal Chemical BiologyInstitute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin 300071China State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Protein SciencesNational Demonstration Center for Experimental Biology Education and College of Life SciencesNankai UniversityTianjin 300071China

Mechanical cues present in the stem cell niche resulting from intracellular processes or external force sources significantly affect the basic functions of stem cells such as self-renewal and *** of artificial cellular matrices exhibiting intrinsic mechanical cues generated by mechanical movements remains ***,we reported on mechanically dynamic hydrogel matrices undergoing photo-induced directional domain sliding movement and their role in regulating embryonic stem cell(ESC)*** mechanically dynamic hydrogels were prepared via the self-assembly of an alternating hydrophilic and hydrophobic peptide with a photocaged cysteine *** light irradiation,the assemblies of the caged peptide were converted to non-equilibrated non-caged peptide bilayers that underwent the directional domain sliding motion induced by the thermodynamically favorable hydrophobic collapse *** murine ESCs on the mechanically dynamic hydrogels resulted in biased differentiation toward the ectodermal *** further showed that the mechanically dynamic hydrogels stimulated the translocation of a mechanotransduction protein Yes-associated protein(YAP)into the nucleus,implicating a potential mechanotransduction mechanism for the biased differentiation of *** finding of the biased ectodermal differentiation of ESCs induced by the mechanically dynamic hydrogels implies the great potency of the mechanically dynamic hydrogels as biomaterials for disease therapy and tissue regeneration in the future.

关键词： hydrogels peptide self-assembly mechanical movement stem cell differentiation photo-response

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王赡家族与北宋中后期西北沿边的寒族蕃将

中国边疆史地研究 2024年第2期34卷 175-185,F0003页

作者：于志霖浙江大学哲学学院 310058

与唐代蕃将相仿,北宋蕃将亦可依据其与部落的关系分为部酋蕃将和寒族蕃将。通过对王赡家族的个案考察,可以了解北宋寒族蕃将的特征。其家族原为秦州宁远寨控制下的弓箭手,在熙河开边中崛起。因其与部酋蕃将不同的社会基础,寒族蕃将表现... 详细信息

与唐代蕃将相仿,北宋蕃将亦可依据其与部落的关系分为部酋蕃将和寒族蕃将。通过对王赡家族的个案考察,可以了解北宋寒族蕃将的特征。其家族原为秦州宁远寨控制下的弓箭手,在熙河开边中崛起。因其与部酋蕃将不同的社会基础,寒族蕃将表现出更高的汉化水平,甚至刻意隐讳蕃族出身,族属较难识别,因此宋军内部的蕃族因素可能遭到低估。此外,寒族蕃将高度依附国家体制,在面对政治风波时较为脆弱。

关键词：北宋寒族蕃将王赡家族《王博施墓志》

宋金之際慶陽官員的動向與心態——以《鄭祖吉墓誌》爲例

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文史 2024年第2期 132-149页

作者：于志霖浙江大學哲學學院

《鄭祖吉墓誌》的誌主出身江南名族,北宋末年通判慶陽,在宋金之際的變亂中輾轉仕宦宋、齊、金諸政權並終老於此。參與《墓誌》製作的誌主親舊亦均有類似經歷,這反映出慶陽地區的北宋官員在宋金之際普遍選擇留居當地、歷仕諸朝的動向。... 详细信息

《鄭祖吉墓誌》的誌主出身江南名族,北宋末年通判慶陽,在宋金之際的變亂中輾轉仕宦宋、齊、金諸政權並終老於此。參與《墓誌》製作的誌主親舊亦均有類似經歷,這反映出慶陽地區的北宋官員在宋金之際普遍選擇留居當地、歷仕諸朝的動向。僞齊、金朝對慶陽控制意願和力度有限,仍較依賴北宋舊官實現統治,後者亦在亂局中抱圑自保,得以維持門第不墜。墓誌在行文中刻意回避朝代更迭並隱諱誌主歷仕諸朝的經歷,這種叙事策略顯示該群體在入金以後對金朝仍保持一定心理距離,他們的政治認同與政治選擇並非同步。從金代陝西地區墓誌文獻中宋金易代史事的書寫方式來看,這種對金朝既服從又疏離的心態在陝西地區的官宦家族中長期存在。

关键词：鄭祖吉墓誌宋金之際慶陽官員陝西

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重審金熙宗官階制度改革--以南北制度的整合過程爲中心

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中华文史论丛 2024年第2期 331-359,418,419页

作者：于志霖浙江大學哲學學院

學界認爲金朝官階制度從本官階體系轉向散官體系的節點是金熙宗天眷元年官制改革,但天眷年間金朝官員結銜的實態與此多有不合。歸納金前期石刻史料中官員結銜的時間、地域、文武差異,可發現金熙宗官階制度改革存在次第實施的過程。新的... 详细信息

學界認爲金朝官階制度從本官階體系轉向散官體系的節點是金熙宗天眷元年官制改革,但天眷年間金朝官員結銜的實態與此多有不合。歸納金前期石刻史料中官員結銜的時間、地域、文武差異,可發現金熙宗官階制度改革存在次第實施的過程。新的官階制度並非同時頒行,在金朝原直屬區,武階制度於天眷元年出臺,文階制度頒行於天眷三年。在僞齊故地,兩種制度均於天眷三年前後逐步行用。金熙宗官階制度改革是金代前期南北制度整合過程的縮影。

关键词：金熙宗官階制度天眷改制黄河南北

资源型城市低碳技术进步驱动碳减排的多重异质性

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中国人口·资源与环境 2022年第11期32卷 156-170页

作者：王家明余志林山东石油化工学院经济管理与文法学院山东东营257061 中共山东省委党校山东济南250103

随着“双碳”目标的深入推进,不同情境下低碳技术进步驱动碳减排的异质性表现是精准减碳的重要依据。资源型城市作为同时肩负国家能源资源安全与碳减排的重要特殊主体,能否同步实现碳达峰是“双碳”目标的关键一环。文章梳理了资源型城... 详细信息

随着“双碳”目标的深入推进,不同情境下低碳技术进步驱动碳减排的异质性表现是精准减碳的重要依据。资源型城市作为同时肩负国家能源资源安全与碳减排的重要特殊主体,能否同步实现碳达峰是“双碳”目标的关键一环。文章梳理了资源型城市低碳技术进步与碳排放的相关理论文献,分析了低碳技术进步与碳排放的驱动机理,以中国116个地级资源型城市2005—2019年的面板数据为研究样本,综合考虑具有资源型城市特色的六种非期望产出来定义资源型城市的低碳技术进步,运用DEA‑Malmquist指数模型、STIRPAT模型与阈值模型,厘清资源型城市低碳技术进步与碳排放现状,深入剖析低碳技术进步与碳减排之间的驱动关系与门槛效应,并对其多重异质性进行对比分析。研究发现:样本期内,116个地级资源型城市低碳技术进步大致呈阶段性上升趋势,碳排放存在明显的区域异质性与类型异质性。资源型城市低碳技术进步对碳排放具有一定的抑制作用,且呈现类型异质性、地区异质性和双重门槛效应。在不同的门槛区间内,低碳技术对碳减排效应与碳减排回弹效应的驱动效应存在差异,国内生产总值、命令型环境规制、市场型环境规制、自愿型环境规制、产业结构、能源消费结构、外商直接投资七个控制变量对碳排放的驱动也表现各异。根据研究结论,从不同区域、不同类型资源型城市及资源型城市低碳技术进步的不同水平角度,有针对性地提出相关政策建议,旨在推动资源型城市低碳技术进步与碳减排目标的同步实现。

关键词：资源型城市低碳技术进步碳排放 STIRPAT模型阈值模型

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沿黄地区中心城市及城市群高质量发展的测度及影响因素

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中国人口·资源与环境 2021年第10期31卷 47-58页

作者：王家明余志林中国石油大学胜利学院文法与经济管理学院山东东营257061 中共山东省委党校山东济南250103

黄河流域是我国重要的生态屏障和经济地带,是启动内循环、促进乡村振兴高质量发展的重要区域,研究中心城市及城市群高质量发展对促进黄河流域经济社会全面发展具有重要的指导作用。文章运用模糊综合评价法对沿黄地区中心城市进行界定,... 详细信息

黄河流域是我国重要的生态屏障和经济地带,是启动内循环、促进乡村振兴高质量发展的重要区域,研究中心城市及城市群高质量发展对促进黄河流域经济社会全面发展具有重要的指导作用。文章运用模糊综合评价法对沿黄地区中心城市进行界定,运用综合指数模型确定沿黄城市群,构建DEA⁃Malmquist指数模型对2003—2018年沿黄地区中心城市及城市群高质量发展水平进行测度,在此基础上运用系统GMM模型对影响其高质量发展的因素进行分析,旨在明晰沿黄地区中心城市及城市群高质量发展水平及影响因素,为其高质量发展政策制定提供参考,共同推动黄河流域高质量发展。研究表明:①样本期内,兰州市、西安市、济南市在沿黄地区中心城市空间维度上高质量发展水平位居前列,关中平原城市群、兰西白城市群高质量发展水平位居前列。②沿黄地区中心城市高质量发展水平在2012—2013年前后有明显的提升,不同约束下沿黄地区中心城市及城市群的高质量发展水平在梯度分布上呈“正态分布”。③财政因素、技术因素、人均实际生产总值、人均可支配收入对沿黄地区中心城市及城市群高质量发展水平有正向推动作用,环境规制倒逼技术创新效应显现,但环境规制对高质量发展的影响呈现异质性特征。这意味着,在沿黄地区中心城市及城市群高质量发展现状基础上,需根据不同因素的异质性影响具有针对性的提出对策建议。最后,文章从政府引导、突出优势,点面结合、协同规划,综合治理、分类施策,系统提升、构建现代化经济体系四方面提出促进沿黄地区中心城市及城市群高质量发展的政策建议。

关键词：沿黄地区中心城市沿黄城市群高质量发展 DEA⁃Malmquist指数模型系统GMM模型

Stabilization Control and Simulation of an Unmanned Surface Vessel

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Stabilization Control and Simulation of an Unmanned Surface ...

Carbon dioxide exchange and the mechanism of environmental control in a farmland ecosystem in North China Plain

第三十届中国控制会议

作者： LIU zhilin,yu Ruiting,ZHU Qidan College of Automation,Harbin Engineering University,Harbin,Heilongjiang,P.R.China

＜正＞This paper addresses the asymptotic stabilization problem of an unmanned surface *** unmanned vessel under consideration is propelled by a water-jet and not actuated in the sway direction.A backstepping control law is proposed to make the origin of the unmanned vessel asymptotically *** construction of the controller is facilitated by the introduction of several nonlinear coordinate changes.A virtual simulation system is designed by using Vega *** effectiveness of the proposed control law is verified by simulation.

关键词： Unmanned surface vessel Underactuated system Asymptotic stable Backstepping Virtual simulation

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Science China Earth Sciences 2006年第S2期49卷 226-240页

作者： LI Jun, yu Qiang, SUN Xiaomin, TONG Xiaojuan, REN Chuanyou, WANG Jing, LIU Enmin, ZHU zhilin & yu Guirui Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China Graduate University of the Chinese Academy of Sciences, Beijing 100049, China College of Resources and Environmental studies, Beijing Forestry University, Beijing 100083, China 1. Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China2. Graduate University of the Chinese Academy of Sciences Beijing 100049 China3. College of Resources and Environmental studies Beijing Forestry University Beijing 100083 China

CO2 flux was measured continuously in a wheat and maize rotation system of North China Plain using the eddy covariance technique to study the characteristic of CO2 exchange and its response to key environmental factors. The results show that nighttime net ecosystem exchange (NEE) varied exponentially with soil temperature. The temperature sensitivities of the ecosystem (Q10) were 2.94 and 2.49 in years 2002-2003 and 2003-2004, respectively. The response of gross primary productivity (GPP) to photosynthetically active radiation (PAR) in the crop field can be expressed by a rectangular hyperbolic function. Average Amax andαfor maize were more than those for wheat. The values ofαincreased positively with leaf area index (LAI) of wheat. Diurnal variations of NEE were significant from March to May and from July to September, but not remarkable in other months. NEE, GPP and ecosystem respiration (Rec) showed significantly seasonal variations in the crop field. The highest mean daily CO2 uptake rate was -10.20 and -12.50 gC·m-2·d-1 in 2003 and 2004, for the maize field, respectively, and -8.19 and -9.50 gC·m-2·d-1 in 2003 and 2004 for the wheat field, respectively. The maximal CO2 uptake appeared in April or May for wheat and mid-August for maize. During the main growing seasons of winter wheat and summer maize, NEE was controlled by GPP which was chiefly influenced by PAR and LAI. Rec reached its annual maximum in July when Rec and GPP contributed to NEE equally. NEE was dominated by Rec in other months and temperature became a key factor controlling NEE. Total NEE for the wheat field was -77.6 and -152.2 gC·m-2·a-1 in years 2002-2003 and 2003-2004, respectively, and -120.1 and -165.6 gC·m-2·a-1 in 2003 and 2004 for the maize field, respectively. The cropland of North China Plain was a carbon sink, with annual -197.6 and -317.9 gC·m-2·a-1 in years 2002-2003 and 2003-2004, respectively. After considering the carbon in grains, the cropland became a carbon source, which was

关键词： net ecosystem exchange gross primary productivity ecosystem respiration carbon budget eddy covariance winter wheat summer maize.