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Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing,China

Science China(Life Sciences) 2020年第5期63卷 706-711页

作者： zhiliang hu Ci Song Chuanjun Xu Guangfu Jin Yaling Chen Xin Xu Hongxia Ma Wei Chen Yuan Lin Yishan Zheng Jianming Wang Zhibin hu Yongxiang Yi Hongbing Shen Nanjing Infectious Disease Center the Second Hospital of NanjingNanjing University of Chinese MedicineNanjing 210003China Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166China State Key Laboratory of Reproductive Medicine Nanjing Medical UniversityNanjing 211166China Department of Radiology the Second Hospital of NanjingNanjing University of Chinese MedicineNanjing 210003China Department of Clinical Research Center the Second Hospital of NanjingNanjing University of Chinese MedicineNanjing 210003China Department of Maternal Child and Adolescent HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166China Department of Critical Medicine the Second Hospital of NanjingNanjing University of Chinese MedicineNanjing 210003China

Previous studies have showed clinical characteristics of patients with the 2019 novel coronavirus disease(COVID-19)and the evidence of person-to-person *** data are available for asymptomatic *** study aims to present the clinical characteristics of 24 cases with asymptomatic infection screened from close contacts and to show the transmission potential of asymptomatic COVID-19 virus *** investigations were conducted among all close contacts of COVID-19 patients(or suspected patients)in Nanjing,Jiangsu Province,China,from Jan 28 to Feb 9,2020,both in clinic and in *** carriers were laboratory-confirmed positive for the COVID-19 virus by testing the nucleic acid of the pharyngeal swab *** clinical records,laboratory assessments,and chest CT scans were *** a result,none of the 24 asymptomatic cases presented any obvious symptoms while nucleic acid *** cases(20.8%)developed symptoms(fever,cough,fatigue,etc.)during ***(50.0%)cases showed typical CT images of ground-glass chest and 5(20.8%)presented stripe shadowing in the *** remaining 7(29.2%)cases showed normal CT image and had no symptoms during *** 7 cases were younger(median age:14.0 years;P=0.012)than the *** of the 24 cases developed severe COVID-19 pneumonia or *** median communicable period,defined as the interval from the first day of positive nucleic acid tests to the first day of continuous negative tests,was 9.5 days(up to 21 days among the 24 asymptomatic cases).Through epidemiological investigation,we observed a typical asymptomatic transmission to the cohabiting family members,which even caused severe COVID-19 ***,the asymptomatic carriers identified from close contacts were prone to be mildly ill during ***,the communicable period could be up to three weeks and the communicated patients could develop severe ***

关键词： COVID-19 asymptomatic infections close contact China

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An unusual COVID-19 case with over four months of viral shedding in the presence of low neutralizing antibodies: a case report

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The Journal of Biomedical Research 2020年第6期34卷 470-474页

作者： Wei Chen zhiliang hu Changhua Yi Yun Chi Qingfang Xiong Chee Wah Tan Yongxiang Yi Lin-Fa Wang Clinical Research Center the Second Hospital of NanjingNanjing University of Chinese MedicineNanjingJiangsu 210003China Nanjing infectious Disease Center the Second Hospital of NanjingNanjing University of Chinese MedicineNanjingJiangsu 210003China Center for Global Health School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Programme in Emerging Infectious Diseases Duke-NUS Medical SchoolSingapore 169857Singapore

The ongoing coronavirus disease 2019(COVID-19)pandemic is a global public health crisis,causing social and economic disasters in many *** China,two-consecutive negative results of nucleic acid tests for SARS-CoV-2 from the respiratory samples are required to end the quarantine of COVID-19 ***,clinicians face a dilemma in case of patients with long-term viral *** report described an unusual COVID-19 case who had persistent viral RNA positivity for more than 4 months after initial illness in the presence of low neutralizing antibodies,but without prolonged clinical *** anti-viral drug treatments had no impact and there was no evidence of *** the patient was self-quarantined at home,no infection occurred to the three family members living with her for 15 to 19 *** viral culture in BSL-3 laboratory on the 102nd day after symptom onset was *** the 129th day on,8 continuous nucleic acid tests of sputum samples showed negative *** patient was discharged on 137th days since symptom *** conclusion,viral RNA shedding in the sputum of the COVID-19 patient may last over 4 *** no evidence shows the existence of infectious virus,two-consecutive negative nucleic acid tests may not be the prerequisite for ending quarantine of COVID-19 patients with prolonged viral shedding.

关键词： COVID-19 SARS-CoV-2 viral shedding neutralizing antibodies quarantine

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Impact of inactivated COVID-19 vaccines on viral shedding in B.1.617.2(Delta)variant-infected patients

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Science China(Life Sciences) 2022年第12期65卷 2556-2559页

作者： zhiliang hu Yi Yin Kai Wang Miaomiao Xu Chengyuan Ding Yan Song Changhua Yi Junwei Li Yongxiang Yi Zhihang Peng Nanjing Infectious Disease Center the Second Hospital of NanjingNanjing University of Chinese MedicineNanjing 210003 China Center for Global Health School of Public HealthNanjing Medical UniversityNanjing 211166 China School of Public Health Nanjing Medical UniversityNanjing 211166China The First Affiliated Hospital of Nanjing Medical University Nanjing 210029China

Dear Editor,The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2)has waged a global pandemic. As of April 15, 2022, more than 500 million cases of COVID-19 had been reported, with more than 6 million deaths. The ultimate arsenal to fight against this pandemic is highly effective vaccines (Bok et al.,2021;Sadarangani et al., 2021).

关键词： vaccines acute

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Effectiveness of switching to bictegravir/emtricitabine/tenofovir alafenamide in virologically suppressed people with HIV with historical drug resistance mutations

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中华医学杂志(英文版) 2024年第22期137卷 2758-2760页

作者： Chang Ziwei Zhu Hongyan Zhang Yiting Chen Yaling Li Jiahui Qin Jiamin Zhu Yueping Wei Hongxia Yang Yongfeng Zou Meiyin Qian Feng hu zhiliang Department of Infectious Disease The Second Hospital of Nanjing Nanjing University of Chinese Medicine Nanjing Jiangsu China Clinical Research Center The Second Hospital of Nanjing Nanjing University of Chinese Medicine Nanjing Jiangsu China Department of Infectious Diseases The Affiliated Infectious Diseases Hospital Suzhou Medical College of Soochow University Suzhou Jiangsu China Department of Infectious Diseases Nantong Third People’s Hospital Affiliated Nantong Hospital of Nantong University Nantong Jiangsu China

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近代中国地理学科高等教育的萌芽与发展

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自然辩证法通讯 2016年第4期38卷 83-88页

作者：胡志良哈尔滨师范大学马克思主义学院黑龙江哈尔滨150025

近代中国地理学科高等教育的起源可追溯到1876年京师同文馆开设的地理课程,在其后经历了京师大学堂的历史地理类、高等师范学校时期的历史地理部、东南大学地学系等不同阶段,到20世纪20年代后期,基本形成了相对固定的科系名称和课程设置... 详细信息

近代中国地理学科高等教育的起源可追溯到1876年京师同文馆开设的地理课程,在其后经历了京师大学堂的历史地理类、高等师范学校时期的历史地理部、东南大学地学系等不同阶段,到20世纪20年代后期,基本形成了相对固定的科系名称和课程设置,至1949年近代中国地理学科高等教育体系基本上完成了近代化的进程。文章将近代中国地理学科高等教育的发展分为三个阶段1876-1911、1912-1927、1928-1949,并从相关的地理学科高等教育法规、地理学科系名称和课程设置、师资队伍的变化等角度对中国地理学科高等教育发展的各阶段主要特点进行了概括和分析。

关键词：地理学科高等教育萌芽发展

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新中国建立初期的科学改造活动研究:以地理学为例

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自然辩证法通讯 2015年第2期37卷 75-81页

作者：胡志良哈尔滨师范大学马克思主义学院黑龙江哈尔滨150025

新中国建立初期,科学领域发生的一系列大规模科学改造运动对中国科学的发展产生了深远的影响。本文通过对地理学改造的发生背景、理论基础和改造方式的分析,阐明这场地理学改造对地理学发展的影响。

关键词：科学改造科学批判地理学

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4H-SiC NMOS电子、质子辐照数值模拟

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强激光与粒子束 2011年第5期23卷 1387-1390页

作者：胡志良贺朝会西安交通大学能源与动力工程学院西安710049

分析了高能电子、质子对4H-SiC的损伤机理,建立了4H-SiC NMOS器件物理模型。电子、质子辐照效应模型。应用ISE-TCAD软件进行数值模拟计算,得出在能量为2.5 MeV、注量为5×1013cm-2的电子辐照及能量为6.5 MeV、注量为2×1014cm-2的质子... 详细信息

分析了高能电子、质子对4H-SiC的损伤机理,建立了4H-SiC NMOS器件物理模型。电子、质子辐照效应模型。应用ISE-TCAD软件进行数值模拟计算,得出在能量为2.5 MeV、注量为5×1013cm-2的电子辐照及能量为6.5 MeV、注量为2×1014cm-2的质子辐照下,4H-SiC NMOS转移特性曲线和亚阈值漏电流曲线变化的初步规律。数值模拟结果与相同条件下Si NMOS实验结果吻合较好。

关键词： 4H-SiC 电子辐照质子辐照数值模拟

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The Simulation of Surface Charge Accumulation on PMMA with Different Surface Roughness in Vacuum

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Energy and Power Engineering 2017年第4期9卷 644-658页

作者： Jiyuan Yan Jie Ren Qing Xie Haofan Lin zhiliang hu huijuan Ran Weitao hu Si Li Hebei Provincial Key Laboratory of Power Transmission Equipment Security Defense North China Electric Power University Baoding China Hebei Electric Power Corporation maintenance branch Shijiazhuang China Beijing Electric Power Corporation Beijing China

The surface insulation properties of insulating material under DC voltage are closely related to the characteristics of surface charge accumulation, and the surface roughness of these materials has a direct impact on the surface charge distribution in vacuum. Therefore, it is significant to study their connection. In this paper, based on the secondary electron emission avalanche model, the surface charge accumulation on polymethyl methacrylate (PMMA) with different surface roughness was simulated by using particle in cell and Monte Carlo Collision method. The simulated environment was under the finger shaped electrode and in vacuum. The results showed that under the action of the electric field the electrons emitted from the cathode triple junction moved forward and collided with the insulating material, which may lead to the generation of secondary electrons or the accumulation of surface charge. The surface charge near the cathode was mostly negative since the effect of surface electron injection was greater than that of the collision ionization. Due to the change of electron energy and the influence of electric field distribution, the number of positive charge on the insulator gradually increased, reached the maximum, and then gradually reduced with the approaching of the anode. Moreover, when the surface roughness of the material increases or the secondary electron emission coefficient decreases, the amount of surface charge accumulated on the PMMA will reduce. This paper can provide some guidance for the practical application of insulating materials.

关键词： Surface Charge Secondary Electron Emission Surface Roughness PMMA

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求解互联电网经济调度的层级协调方法

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电工技术学报 2010年第10期25卷 176-182页

作者：谢国辉张粒子舒隽杨湛华北电力大学电气与电子工程学院北京102206

为适应我国目前多级调度管理体制,促进分层分区经济调度实施,提出求解互联电网经济调度的层级协调方法。首先,基于层级调度协调运作的思想,建立区域协调中心和分区调度的层级协调运作机制,进而通过层级之间的信息交互实现解耦优化;然后... 详细信息

为适应我国目前多级调度管理体制,促进分层分区经济调度实施,提出求解互联电网经济调度的层级协调方法。首先,基于层级调度协调运作的思想,建立区域协调中心和分区调度的层级协调运作机制,进而通过层级之间的信息交互实现解耦优化;然后基于序列无约束化方法(SUMT)的二次罚函数法,构建区域协调中心和分区的层级协调优化模型,分别采用拟牛顿算法和原对偶内点算法求解。IEEE30测试系统表明,层级协调是一种新颖而有效的方法,可以用于求解互联电网经济调度,能够方便实现区域协调中心的一对多全局控制目标。

关键词：层级协调方法解耦优化二次罚函数法拟牛顿算法原对偶内点算法

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工艺参数对SOI NMOS总剂量效应的影响

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核技术 2010年第10期33卷 779-782页

作者：胡志良贺朝会西安交通大学西安710049

本文模拟了0.25μm SOI NMOS的总剂量效应,I-V特性曲线随总剂量变化趋势与实测曲线一致。在此基础上探讨了器件在不同掺杂浓度、硅膜厚度、埋氧层厚度以及栅氧层厚度等工艺条件下的总剂量效应,分析了一定剂量条件下各项工艺引起器件性... 详细信息

本文模拟了0.25μm SOI NMOS的总剂量效应,I-V特性曲线随总剂量变化趋势与实测曲线一致。在此基础上探讨了器件在不同掺杂浓度、硅膜厚度、埋氧层厚度以及栅氧层厚度等工艺条件下的总剂量效应,分析了一定剂量条件下各项工艺引起器件性能变化的原因。结果表明,源漏高掺杂、薄硅膜、适当厚度的埋氧层和较薄的栅氧层均有利于提高SOI NMOS的抗总剂量效应的能力。这为器件提高抗总剂量效应设计和加固提供了一定的理论依据。

关键词：总剂量效应 SOI NMOS 数值模拟

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