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Mixed 2D-Dion–Jacobson/3D Sn-Pb alloyed perovskites for efficient photovoltaic solar devices

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Nano Research 2023年第2期16卷 3142-3148页

作者： zhili lu Chaohui Li Hongwei Lai Xinming Zhou Chunfeng Wang Xianhu Liu Fei Guo Caofeng Pan National Engineering Research Center for Advanced Polymer Processing Technology Key Laboratory of Advanced Material Processing&Mold(Ministry of Education)Zhengzhou UniversityZhengzhou 450002China Institute of New Energy Technology College of Information Science and TechnologyJinan UniversityGuangzhou 510632China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesNational Center for Nanoscience and Technology(NCNST)Beijing 100083China Institute of Materials for Electronics and Energy Technology(i-MEET) Friedrich-Alexander University Erlangen-NürnbergMartensstrasse 7Erlangen 91058Germany

Tin-lead(Sn-Pb)alloyed perovskites with tunable bandgaps hold great potential for constructing highly efficient single-junction and tandem photovoltaic ***,the efficiency and stability of Sn-Pb perovskite solar cells(PSCs)are greatly hampered by severe nonradiative recombination due to the easy oxidation of Sn(II).In this work,we report the construction of mixed dimensional two-dimensional(2D)Dion–Jacobson(DJ)and three-dimensional(3D)perovskites to improve the efficiency and stability of Sn-Pb alloyed *** a small amount of 1,4-butanediammonium diiodide as spacer cations of DJ perovskites into precursor,the prepared mixed dimensional Sn-Pb alloyed perovskites exhibit reduced trap-state density due to the passivation of 2D DJ *** a result,nonradiative charge recombination is greatly *** prepared Sn-Pb alloyed PSCs based on 2D-DJ/3D heterojunction deliver a power conversion efficiency of 19.02%with an impressive fill factor of 80%.As well,improved device stability is realized due to the presence of DJ perovskites which serves as a protection barrier against oxidation and water invasion.

关键词： Sn-Pb perovskite narrow bandgap Dion–Jacobson perovskite solar cells two-dimensional(2D)/three-dimensional(3D)

Optimal Design of 850nm 2 × 2 Multimode Interference Polymer Waveguide Coupler by Imprint Technique

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Photonic Sensors 2016年第3期6卷 234-242页

作者： Yuchen SHAO Xiuyou HAN Xiaonan HAN zhili lu Zhenlin WU Jie TENG Jinyan WANG Geert MORTHIER Mingshan ZHAO School of Physics and Optoelectronic Engineering Dalian University of Technology Dalian 116024 China School of Chemical Engineering Dalian University of Technology Dalian 116024 China No. 38 Research Institute China Electronics Technology Group Corporation Hefei 230088 China Photonics Research Group Department of Information Technology Ghent University-IMEC 9000 Ghent Belgium

A 2 × 2 optical waveguide coupler at 850 nm based on the multimode interference （MMI） structure with the polysilsesquioxanes liquid series （PSQ-Ls） polymer material and the imprint technique is presented. The influence of the structural parameters, such as the single mode condition, the waveguide spacing of input/output ports, and the width and length of the multimode waveguide, on the optical splitting performance including the excess loss and the uniformity is simulated by the beam propagation method. By inserting a taper section of isosceles trapezoid between the single mode and multimode waveguides, the optimized structural parameters for low excess loss and high uniformity are obtained with the excess loss of -0.040 dB and the uniformity of-0.007 dB. The effect of the structure deviations induced during the imprint process on the optical splitting performance at different residual layer thicknesses is also investigated. The analysis results provide useful instructions for the waveguide device fabrication.

关键词： Polymer waveguide coupler multimode interference

Ultra-short-course and intermittent TB47-containing oral regimens produce stable cure against Buruli ulcer in a murine model and prevent the emergence of resistance for Mycobacterium ulcerans

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Acta Pharmaceutica Sinica B 2021年第3期11卷 738-749页

作者： Yamin Gao HMAdnan Hameed Yang Liu Lingmin Guo Cuiting Fang Xirong Tian Zhiyong Liu Shuai Wang zhili lu Md Mahmudul Islam Tianyu Zhang State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China University of Chinese Academy of Sciences Beijing 100049China Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China Institute of Physical Science and Information Technology Anhui UniversityHefei 230601China

Buruli ulcer(BU),caused by Mycobacterium ulcerans,is currently treated with rifampin estreptomycin or rifampineclarithromycin daily for 8 weeks recommended by World Health Organization(WHO).These options are lengthy with severe side effects.A new anti-tuberculosis drug,TB47,targeting QcrB in cytochrome bc1:aa3 complex is being developed in ***47-containing regimens were evaluated in a well-established murine model using an autoluminescent *** *** TB47-resistant spontaneous *** mutants were selected and their qcrB genes were *** in vivo activities of TB47 against both low-level and high-level TB47-resistant mutants were tested in BU murine ***,we show that TB47-containing oral 3-drug regimens can completely cure BU in 2 weeks for daily use or in 3 weeks given twice per week(6 doses in total).All high-level TB47-resistant mutants could only be selected using the low-level mutants which were still sensitive to TB47 in *** is the first report of double mutations in QcrB in *** summary,TB47-containing regimens have promise to cure BU highly effectively and prevent the emergence of drug *** QcrB mutations found here may guide the potential clinical molecular diagnosis of resistance and the discovery of new drugs against the high-level resistant mutants.

关键词： Mycobacterium ulcerans Buruli ulcer Electron transport chain QcrB Chemotherapy TB47 Drug resistance Clofazimine

Reversal of tamoxifen resistance by artemisinin in ER+breast cancer:bioinformatics analysis and experimental validation

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Oncology Research 2024年第6期32卷 1093-1107页

作者： zhili ZHUO DONGNI ZHANG WENPING lu XIAOQING WU YONGJIA CUI WEIXUAN ZHANG MENGFAN ZHANG Department of Oncology China Academy of Chinese Medical Sciences Guang’anmen HospitalBeijingChina

Breast cancer is the leading cause of cancer-related deaths in women worldwide,with Hormone Receptor(HR)+being the predominant ***(TAM)serves as the primary treatment for HR+breast ***,drug resistance often leads to recurrence,underscoring the need to develop new therapies to enhance patient quality of life and reduce recurrence ***(ART)has demonstrated efficacy in inhibiting the growth of drug-resistant cells,positioning art as a viable option for counteracting endocrine *** study explored the interaction between artemisinin and tamoxifen through a combined approach of bioinformatics analysis and experimental *** characterized genes(ar,cdkn1a,erbb2,esr1,hsp90aa1)and seven drug-disease crossover genes(cyp2e1,rorc,mapk10,glp1r,egfr,pgr,mgll)were identified using WGCNA crossover *** functional enrichment analyses were *** findings confirm a significant correlation between key cluster gene expression and immune cell infiltration in tamoxifen-resistant and-sensitized ***-seq analysis revealed high expression of key cluster genes in epithelial cells,suggesting artemisinin’s specific impact on tumor cells in estrogen receptor(ER)-positive BC *** target docking and in vitro experiments with artemisinin on LCC9 cells demonstrated a reversal effect in reducing migratory and drug resistance of drug-resistant cells by modulating relevant drug resistance *** results indicate that artemisinin could potentially reverse tamoxifen resistance in ER-positive breast cancer.

关键词： Artemisinin Tamoxifen resistance Breast cancer

Advances in the development of molecular genetic tools for Mycobacterium tuberculosis

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Journal of Genetics and Genomics 2018年第6期45卷 281-297页

作者： Chiranjibi Chhotaray Yaoju Tan Julius Mugweru Md Mahmudul Islam H.M.Adnan Hameed Shuai Wang zhili lu Changwei Wang Xinjie Li Shouyong Tan Jianxiong Liu Tianyu Zhang State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Respiratary Disease Department of Clinical LaboratoryCuangzhou Chest HospitalGuangzhou 510095China Department of Biological Sciences University of EmbuP.O Box 6-60100EmbuKenya

Mycobacterium tuberculosis, a Gram-positive bacterium of great clinical relevance, is a lethal pathogen owing to its complex physiological characteristics and development of drug resistance. Several molecular genetic tools have been developed in the past few decades to study this microorganism. These tools have been instrumental in understanding how M. tuberculosis became a successful pathogen. Advanced molecular genetic tools have played a significant role in exploring the complex pathways involved in M. tuberculosis pathogenesis. Here, we review various molecular genetic tools used in the study of M. tuberculosis. Further, we discuss the applications of clustered regularly interspaced short palindromic repeat interference（CRISPRi）, a novel technology recently applied in M. tuberculosis research to study target gene functions. Finally, prospective outcomes of the applications of molecular techniques in the field of M. tuberculosis genetic research are also discussed.

关键词： Mycobacterium tuberculosis Molecular genetic tools Gram-positive Recombineering Drug resistance

The First Global Map of Atmospheric Ammonia(NH_(3)) as Observed by the HIRAS/FY-3D Satellite

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Advances in Atmospheric Sciences 2024年第3期41卷 379-390页

作者： Minqiang ZHOU zhili DENG Charles ROBERT Xingying ZHANG lu ZHANG Yapeng WANG Chengli QI Pucai WANG Martine De MAZIÈRE Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China Royal Belgian Institute for Space Aeronomy(BIRA-IASB) Brussels 1180Belgium National Satellite Meteorology Center China Meteorological AdministrationBeijing 100081China Department of Science&Technology and Climate Change China Meteorological AdministrationBeijing 100081China University of Chinese Academy of Sciences Beijing 100049China

Atmospheric ammonia(NH_(3)) is a chemically active trace gas that plays an important role in the atmospheric environment and climate change. Satellite remote sensing is a powerful technique to monitor NH_(3) concentration based on the absorption lines of NH_(3) in the thermal infrared region. In this study, we establish a retrieval algorithm to derive the NH_(3)column from the Hyperspectral Infrared Atmospheric Sounder(HIRAS) onboard the Chinese Feng Yun(FY)-3D satellite and present the first atmospheric NH_(3) column global map observed by the HIRAS instrument. The HIRAS observations can well capture NH_(3) hotspots around the world, e.g., India, West Africa, and East China, where large NH_(3) emissions exist. The HIRAS NH_(3) columns are also compared to the space-based Infrared Atmospheric Sounding Interferometer(IASI)measurements, and we find that the two instruments observe a consistent NH_(3) global distribution, with correlation coefficient(R) values of 0.28–0.73. Finally, some remaining issues about the HIRAS NH_(3) retrieval are discussed.

关键词： ammonia HIRAS/FY-3D satellite thermal-infrared observation remote sensing optimal estimation method

Graphene binding on black phosphorus enables high on/off ratios and mobility

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National Science Review 2024年第2期11卷 188-195页

作者： Fanrong Lin Zhonghan Cao Feiping Xiao Jiawei Liu Jiabin Qiao Minmin Xue zhili Hu Ying Liu Huan lu Zhuhua Zhang Jens Martin Qingjun Tong Wanlin Guo Yanpeng Liu Key Laboratory for Intelligent Nano Materials and Devices of Ministry of Education State Key Laboratory of Mechanics and Control of Mechanical Structures and Institute for Frontier Science Nanjing University of Aeronautics and Astronautics Centre for Advanced 2D Materials National University of Singapore School of Physics and Electronics Hunan University Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and MeasurementSchool of PhysicsBeijing Institute of Technology Leibniz Institute für Kristallzüchtung

Graphene is one of the most promising candidates for integrated circuits due to its robustness against short-channel effects, inherent high carrier mobility and desired gapless nature for Ohmic contact, but it is difficult to achieve satisfactory on/off ratios even at the expense of its carrier mobility, limiting its device applications. Here, we present a strategy to realize high back-gate switching ratios in a graphene monolayer with well-maintained high mobility by forming a vertical heterostructure with a black phosphorus multi-layer. By local current annealing, strain is introduced within an established area of the graphene, which forms a reflective interface with the rest of the strain-free area and thus generates a robust off-state via local current depletion. Applying a positive back-gate voltage to the heterostructure can keep the black phosphorus insulating, while a negative back-gate voltage changes the black phosphorus to be conductive because of hole accumulation. Then, a parallel channel is activated within the strain-free graphene area by edge-contacted electrodes, thereby largely inheriting the intrinsic carrier mobility of graphene in the on-state. As a result, the device can provide an on/off voltage ratio of >10～3 as well as a mobility of ～8000 cm2V-1s-1at room temperature, meeting the low-power criterion suggested by the International Roadmap for Devices and Systems.

关键词： graphene on/off ratio mobility black phosphorus reflective interface

老年翼状胬肉患者翼状胬肉切除联合结膜移植术后绷带式角膜接触镜的应用及效果评价

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吉林大学学报（医学版） 2016年第5期42卷 1005-1009页

作者：卢嬿秦秀虹马翔鲁智莉大连医科大学附属第一医院眼科辽宁大连116011

目的:探讨老年人翼状胬肉切除联合结膜移植术后应用绷带式角膜接触镜(BCL)的临床疗效,并阐明该疗法的优势。方法:回顾性分析本院70例70眼老年翼状胬肉患者的临床资料,按术后处理方法分为2组,观察组(BCL组)35例35眼,行翼状胬肉切除联合... 详细信息

目的:探讨老年人翼状胬肉切除联合结膜移植术后应用绷带式角膜接触镜(BCL)的临床疗效,并阐明该疗法的优势。方法:回顾性分析本院70例70眼老年翼状胬肉患者的临床资料,按术后处理方法分为2组,观察组(BCL组)35例35眼,行翼状胬肉切除联合结膜移植术,术毕术眼立即配戴BCL;对照组35例35眼,术毕常规纱块敷料包眼。观察患者术后1、3和7和10d视物模糊、畏光、异物感、流泪和眼痛的症状评分、角膜荧光素染色(FSC)评分和角膜上皮缺损面积。结果:术后第1、3和7天,观察组患者视物模糊、畏光、异物感、流泪和眼痛症状评分均低于对照组(P0.05)。随访期间,所有患者均未发生角膜感染和植片脱落等并发症。结论:BCL能明显缓解老年人翼状胬肉切除术后的不适感,促进角膜上皮愈合。

关键词：翼状胬肉绷带式角膜接触镜角膜上皮结膜移植

Wave nature of Rosensweig instability

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Chinese Physics B 2024年第3期33卷 471-479页

作者：李柳李德才戚志强王璐张志力 School of Mechanical Electronicand Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Beijing Key Laboratory of Flow and Heat Transfer of Phase Changing in Micro and Small Scale Beijing 100044China State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China

The explicit analytical solution of Rosensweig instability spikes'shapes obtained by Navier-Stokes(NS)equation in diverse magnetic field H vertical to the flat free surface of ferrofluids are systematically studied experimentally and *** carefully analyzing and solving the NS equation in elliptic form,the force balanced surface equations of spikes in Rosensweig instability are expressed as cosine wave in perturbated magnetic field and hyperbolic tangent in large magnetic field,whose results both reveal the wave-like nature of Rosensweig *** results of hyperbolic tangent form are perfectly fitted to the experimental results in this paper,which indicates that the analytical solution is basically *** the forementioned theoretical results,the total energy of the spike distribution pattern is *** analyzing the energy components under different magnetic field intensities H,the hexagon-square transition of Rosensweig instability is systematically discussed and explained in an explicit way.

关键词： ferrofluids Rosensweig instability hexagon-square transition