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Underground Space 2024年第6期19卷 279-300页

作者： Weiping luo Dajun Yuan Yannick Choy Hing ng Dalong Jin Ping Lu Teng Wang Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China Key Laboratory of the Ministry of Education for Urban Underground Engineering Beijing Jiaotong UniversityBeijing 100044China Department of Civil and Environmental Engineering National University of SingaporeSingapore 119077Singapore

Many empirical and analytical methods have been proposed to predict fracturing pressure in cohesive *** of them take into account three to four specific influencing factors and rely on the assumption of a failure *** this study,a novel data-mining approach based on the XGBoost algorithm is investigated for predicting fracture initiation in cohesive *** has the advantage of handling multiple influencing factors simultaneously,without pre-determining a failure mode.A dataset of 416 samples consisting of 14 distinct features was herein collected from past studies,and used for developing a regressor and a classifier model for fracturing pressure prediction and failure mode classification *** results show that the intrinsic characteristics of the soil govern the failure mode while the fracturing pressure is more sensitive to the stress *** XGBoost-based model was also tested against conventional approaches,as well as a similar machine learning algorithm namely random forest ***,several large-scale triaxial fracturing tests and an in-situ case study were carried out to further verify the generalization ability and applicability of the proposed data mining approach,and the results indicate a superior performance of the XGBoost model.

关键词： Fracturing pressure Failure mode Cohesive soil Data-mining Large-scale tests

Role of inflammatory lipid and fatty acid metabolic abnormalities induced by plastic additives exposure in childhood asthma

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Journal of Environmental Sciences 2024年第3期137卷 172-180页

作者： Zhiyu Chen Fang Li Lei Fu Yu Xia Ying luo Ang Guo Xiaona Zhu Huifang Zhong Qian luo Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Rheumatology&Immunology Department of Shenzhen Children’s Hospital Shenzhen 518038China Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances Institute of Environment and HealthJianghan UniversityWuhan 430056China

Lipid metabolism play an essential role in occurrence and development of asthma,and it can be disturbed by phthalate esters(PAEs)and organophosphate fame retardants(OPFRs).As a chronic infammatory respiratory disease,the occurrence risk of childhood asthma is increased by PAEs and OPFRs exposure,but it remains not entirely clear how PAEs and OPFRs contribute the onset and progress of the *** have profiled the serum levels of PAEs and OPFRs congeners by liquid chromatography coupled with mass spectrometry,and its relationships with the dysregulation of lipid metabolism in asthmatic,bronchitic(acute infammation)and healthy(non-infammation)*** PAEs and nine OPFRs congeners were found in the serum of children(1–5 years old)from Shenzhen,and their total median levels were 615.16 ng/m L and 17.06 ng/m L,***,the serum levels of mono-methyl phthalate(MMP),tri-propyl phosphate(TPP)and tri-n-butyl phosphate(TNBP)were significant higher in asthmatic children than in healthy and bronchitic children as ***-one characteristic lipids and fatty acids of asthma were screened by machine-learning random forest model based on serum lipidome data,and the alterations of infammatory characteristic lipids and fatty acids including palmitic acids,12,13-Di HODE,14,21-Di HDHA,prostaglandin D2 and Lyso PA(18:2)showed significant correlated with high serum levels of MMP,TPP and *** results imply PAEs and OPFRs promote the occurrence of childhood asthma via disrupting infammatory lipid and fatty acid metabolism,and provide a novel sight for better understanding the effects of plastic additives on childhood asthma.

关键词： Phthalate esters Organophosphate fame retardants Childhood asthma Lipid and fatty acid metabolism Machine-learning random forest model Chronic airway infammation

Self-assembled monolayers(SAMs)in inverted perovskite solar cells and their tandem photovoltaics application

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Interdisciplinary Materials 2024年第2期3卷 203-244页

作者： Zijun Yi Xin Li Yuchen Xiong Guibin Shen Wenguang Zhang Yihuai Huang Qinghui Jiang Xin Ren ng Yubo luo Jianghui Zheng Wei Lin Leong Fan Fu Tongle Bu Junyou Yang State Key Laboratory of Material Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhanChina China‐Eu Institute for Clean and Renewable Energy Huazhong University of Science and TechnologyWuhanChina School of Electrical and Electronic Engineering Nanyang Technological UniversitySingaporeSingapore Department of Chemistry National University of SingaporeSingaporeSingapore School of Physics The University of SydneySydneyNew South WalesAustralia Laboratory for Thin Films and Photovoltaics Empa‐Swiss Federal Laboratories for Materials Science and TechnologyDübendorfSwitzerland State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhanChina

Self-assembled monolayers(SAMs)employed in inverted perovskite solar cells(PSCs)have achieved groundbreaking progress in device efficiency and stability for both single-junction and tandem configurations,owing to their distinctive and versatile ability to manipulate chemical and physical interface *** this regard,we present a comprehensive review of recent research advancements concerning SAMs in inverted perovskite singlejunction and tandem solar cells,where the prevailing challenges and future development prospects in the applications of SAMs are *** thoroughly examine the mechanistic roles of diverse SAMs in energy-level regulation,interface modification,defect passivation,and charge *** is achieved by understanding how interfacial molecular interactions can be finely tuned to mitigate charge recombination losses in inverted *** this comprehensive review,we aim to provide valuable insights and references for further investigation and utilization of SAMs in inverted perovskite single‐junction and tandem solar cells.

关键词： inverted perovskite solar cells power conversion efficiency self-assembled monolayers tandem

High-frequency repetitive transcranial magnetic stimulation promotes neural stem cell proliferation after ischemic stroke

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Neural Regeneration Research 2024年第8期19卷 1772-1780页

作者： Jing luo Yuan Feng Zhongqiu Hong Mingyu Yin Haiqing Zheng Liying Zhang Xiquan Hu Department of Rehabilitation Medicine The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Hepatobiliary Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Prolife ration of neural stem cells is crucial for promoting neuronal regeneration and repairing cerebral infarction *** magnetic stimulation(TMS)has recently emerged as a tool for inducing endogenous neural stem cell regeneration,but its underlying mechanisms remain unclea r In this study,we found that repetitive TMS effectively promotes the proliferation of oxygen-glucose deprived neural stem ***,repetitive TMS reduced the volume of cerebral infa rction in a rat model of ischemic stro ke caused by middle cerebral artery occlusion,im p roved rat cognitive function,and promoted the proliferation of neural stem cells in the ischemic ***-sequencing found that repetitive TMS activated the Wnt signaling pathway in the ischemic penumbra of rats with cerebral ***,PCR analysis revealed that repetitive TMS promoted AKT phosphorylation,leading to an increase in mRNA levels of cell cycle-related proteins such as Cdk2 and *** effect was also associated with activation of the glycogen synthase kinase 3β/β-catenin signaling pathway,which ultimately promotes the prolife ration of neural stem ***,we validated the effect of repetitive TMS on AKT *** found that repetitive TMS promoted Ca2+influx into neural stem cells by activating the P2 calcium channel/calmodulin pathway,thereby promoting AKT phosphorylation and activating the glycogen synthase kinase 3β/β-catenin *** findings indicate that repetitive TMS can promote the proliferation of endogenous neural stem cells through a Ca2+influx-dependent phosphorylated AKT/glycogen synthase kinase 3β/β-catenin signaling *** study has produced pioneering res ults on the intrinsic mechanism of repetitive TMS to promote neural function recove ry after ischemic stro *** results provide a stro ng scientific foundation for the clinical application of repetitive ***,repetitive TMS treatment may not only be an efficient an

关键词： AKT/β-catenin signaling brain stimulation Ca2+influx cell proliferation ischemic stroke middle cerebral artery occlusion neural stem cells neurological rehabilitation repetitive transcranial magnetic stimulation

Impact of inorganic and organic pollutants from a Belgian wastewater treatment plant on adjacent surface and groundwaters

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 75-90页

作者： Mingyue luo Yiqi Su Delphine Jenny Vandeputte Yuwei Jia Guanlei Li Willy Baeyens Marijke Huysmans Marc Elskens Yue Gao Analytical Environmental and Geo-Chemistry Department(AMGC)Vrije Universiteit Brussel(VUB)Pleinlaan 21050 BrusselsBelgium Hydrology and Hydraulic Engineering(HYDR) Vrije Universiteit Brussel(VUB)Pleinlaan 21050 BrusselsBelgium

Under the pressure of global droughts and water shortage,it is essential to evolve toward a sustainable and robust water *** possible avenue is the maximum reuse of treated wastewater,but the quality of which determines its ***,inorganic(Cd,Pb,Cr,Ni,Cu,and As)and organic(xenoestrogens and polycyclic aromatic contaminants,PACs)contaminants were monthly monitored in an effluent of the wastewater treatment plant(WWTP),the surrounding surface waters and the local groundwater in *** and particulate concentrations of inorganic contaminants in these water bodies were *** addition,Diffusive Gradients in Thin-films(DGT)was used in situ to obtain bioavailable metal *** the WWTP effluent and surface waters,only Ni exceeds the Annual Average-Environmental Quality Standard(AA-EQS),while in the groundwater,dissolved As was the predominant ***,in the surface and effluent waters the highest lability degrees were observed for Cd and *** concentrations of these metal species in the effluent water were lower than in the other water ***-organic pollutants,xenoestrogens and PACs were analyzed by dual Estrogen and Aryl hydrocarbon Receptor-Chemical Activated LUciferase gene eXpression(ER&AhR-CALUX)*** the annual averaged(AA)bioequivalent concentration of E2(0.18 ng/L)is below the AA-EQS standard(0.4 ng/L),and the bioequivalent concentration of benzo[a]pyrene never exceeded the maximum admissible concentration(MAC),the reclamation and reuse of treated wastewater for groundwater replenishment and agricultural irrigation should pose no environmental problems,at least in a short-term.

关键词： Metal contaminants DGT Labile metal fractions ERE/AhR-CALUX BEQ Xenoestrogens and polycyclic aromatic contaminants

马来西亚东北部Setiu潟湖1970年以来沉积环境演化及其对ENSO的响应

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海洋学报 2024年第4期46卷 79-89页

作者：赵周平李超骆正骅 Nicholasng Chia Wei 戴璐同济大学海洋地质国家重点实验室上海200092

马来半岛位于低纬热带地区,厄尔尼诺-南方涛动(El Nino-Southern Oscillation,ENSO)如何影响该区域的气候,尤其是降水仍然存在争议。本文以马来半岛东北部登嘉楼州Setiu潟湖钻孔NTT-3为研究对象,通过分析粒度、总有机碳及总氮含量、C/N... 详细信息

马来半岛位于低纬热带地区,厄尔尼诺-南方涛动(El Nino-Southern Oscillation,ENSO)如何影响该区域的气候,尤其是降水仍然存在争议。本文以马来半岛东北部登嘉楼州Setiu潟湖钻孔NTT-3为研究对象,通过分析粒度、总有机碳及总氮含量、C/N比值和XRF岩心扫描等,探讨该钻孔的沉积环境变化及其对ENSO的响应。研究结果显示,钻孔记录中自1970年前后(84 cm处)出现两种不同的变化趋势。1970年之前钻孔下部沉积物粒度、有机和无机地球化学特征趋势波动明显,沉积速率较低。而1970年以来,潟湖沉积环境总体稳定,沉积物中的有机组分主要来自红树林,同时伴有河流输入的淡水浮游植物的贡献。频谱分析结果显示1970年以来钻孔上部存在明显的ENSO周期变化。强厄尔尼诺现象基本对应低Zr/Rb比值和低Zr/Ti比值,而强拉尼娜(La Nina)现象基本对应高Zr/Rb比值和高Zr/Ti比值。该结论不仅支持了现代观测对马来半岛东部沿海地区气候变化的认识,同时也在地质记录中发现了ENSO变化的直接证据,对全面认识和理解ENSO对亚洲气候变化的影响、区域陆海相互作用过程和环境响应等方面具有重要现实意义。

关键词： Setiu潟湖沉积记录频谱分析 ENSO

Dapagliflozin and sacubitril on myocardial microperfusion in patients with post-acute myocardial infarction heart failure and type 2 diabetes

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World Journal of Clinical Cases 2024年第22期12卷 5008-5015页

作者： Yuan Lv Wei-Jun luo Department of Cardiology Lishui People's HospitalLishui 323000Zhejiang ProvinceChina

BACKGROUND Coronary heart disease and type 2 diabetes mellitus(T2DM)frequently coexist,creating a complex and challenging clinical scenario,particularly when complicated with acute myocardial infarction(AMI).AIM To examine the effects of dapagliflozin combined with sakubactrovalsartan sodium tablets on myocardial *** In total,98 patients were categorized into control(n=47)and observation(n=51)*** control group received noxital,while the observation group was treated with dapagliflozin combined with noxital for 6 *** in myocardial microperfusion,blood glucose level,cardiac function,N-terminal prohormone of brain natriuretic peptide(NT-proBNP)level,growth differentiation factor-15(GDF-15)level,and other related factors were compared between the two ***,the incidence of major adverse cardiovascular events(MACE)and adverse reactions were *** After treatment,in the observation and control groups,the corrected thrombolysis in myocardial infarction frame counts were 37.12±5.02 and 48.23±4.66,*** NT-proBNP levels were 1502.65±255.87 and 2015.23±286.31 pg/mL,the N-terminal pro-atrial natriuretic peptide(NT-proANP)levels were 1415.69±213.05 and 1875.52±241.02 ng/mL,the GDF-15 levels were 0.87±0.43 and 1.21±0.56 g/L,and the high-sensitivity C-reactive protein(hs-CRP)levels were 6.54±1.56 and 8.77±1.94 mg/L,respectively,with statistically significant differences(P0.05).CONCLUSION Dapagliflozin combined with nocinto can improve myocardial microperfusion and left ventricular remodeling and reduce MACE incidence in patients with post-AMI heart failure and *** underlying mechanism may be related to the reduction i

关键词： Dagelin Nocinto Acute myocardial infarction Type 2 diabetes Heart failure Myocardial microperfusion

“将进酒”的汉唐音义与“音韵学+诗学”的诗味今读

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江汉论坛 2024年第10期 64-73页

作者：罗漫中南民族大学文学与新闻传播学院湖北武汉430074

“将qiāng进酒”音义之争引发的“蝴蝶效应”,是部分音韵学人强制推行“全部以今音读古诗”,致使部分“古诗不古”以及“美诗”退化为“非诗”:无韵、无律、无诗味。如何在“音韵学+诗学”的协同规约下,进行杜甫式“不薄今人爱古人”... 详细信息

“将qiāng进酒”音义之争引发的“蝴蝶效应”,是部分音韵学人强制推行“全部以今音读古诗”,致使部分“古诗不古”以及“美诗”退化为“非诗”:无韵、无律、无诗味。如何在“音韵学+诗学”的协同规约下,进行杜甫式“不薄今人爱古人”的协同研辩,坚守“汉唐古体诗有韵、唐宋格律诗有律”的“诗味今读”,成为汉唐以降古诗今读全部问题的根本所在。现有辞书并非全部韵读标准,一些真正的韵读标准尚有遗漏,亟待利用大数据+智能检索不断地发现、确认与增补。只有在文学史语境里通观汉唐“将进酒”一以贯之的音与义,才可能更深入理解汉唐《将qiāng进酒》的系列诗篇,尤其是李白“宰酒”的巅峰之作《将进酒》。

关键词： “将qiāng进酒” “诗味今读” 音韵诗律两美并存

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非离子聚丙烯酰胺絮凝剂对减水剂分散性能的影响

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铁道建筑技术 2024年第8期 1-4页

作者：檀军锋杨雷 Serina ng 李想东宋欣罗鑫陈福现中铁京诚工程检测有限公司北京104442 石家庄市长安育才建材有限公司河北石家庄051430 四川砼道科技有限公司四川成都610200 中铁二十二局集团有限公司北京100043

本文选用非离子聚丙烯酰胺絮凝剂和不同侧链长度、酸醚比的聚羧酸减水剂、萘系减水剂,通过试验研究聚丙烯酰胺与减水剂之间的相互作用及对减水剂分散性能的影响。研究结果:随聚丙烯酰胺含量增加,减水剂的初始分散性能和保持性能均随之下... 详细信息

本文选用非离子聚丙烯酰胺絮凝剂和不同侧链长度、酸醚比的聚羧酸减水剂、萘系减水剂,通过试验研究聚丙烯酰胺与减水剂之间的相互作用及对减水剂分散性能的影响。研究结果:随聚丙烯酰胺含量增加,减水剂的初始分散性能和保持性能均随之下降,而萘系减水剂所受影响较小;随聚羧酸侧链长度增加,聚羧酸减水剂的初始分散性能和保持性能下降严重;随聚羧酸酸醚比增加,各种聚羧酸减水剂的初始分散性能和保持性能受聚丙烯酰胺的影响差距不大;聚羧酸减水剂先吸附于水泥颗粒上,侧链再与聚丙烯酰胺通过氢键相互作用、缠结,从而降低了减水剂的空间位阻效应,随水泥水化更易被水化产物覆盖。

关键词：非离子聚丙烯酰胺絮凝剂减水剂侧链长度酸醚比

TL1A Promotes Fibrogenesis in Colonic Fibroblasts via the TGF-β1/Smad3 Signaling Pathway

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Current Medical Science 2024年第3期44卷 519-528页

作者： Jia SOng Dong-lei SUN Chen-yang LI Yu-xin luo Qian LIU Yue YAO Hong ZHAng Ting-ting YAng Mei SOng Xin-li BAI Xiao-lan ZHAng Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesShijiazhuang050000China Department of Pediatrics The Second Hospital of Hebei Medical UniversityShijiazhuang050000China

Objective Intestinal fibrosis is a refractory complication of inflammatory bowel disease(IBD).Tumor necrosis factor ligand-related molecule-1A(TL1A)is important for IBD-related intestinal fibrosis in a dextran sodium sulfate(DSS)-induced experimental colitis *** study aimed to explore the effects of TL1A on human colonic *** A trinitrobenzene sulfonic acid(TNBS)-induced experimental colitis model of LCK-CD2-TL1A-GFP transgenic(Tg)or wild-type(WT)mice was established to determine the effect and mechanism of TL1A on intestinal *** human colonic fibroblast CCD-18Co cell line was treated concurrently with TL1A and human peripheral blood mononuclear cell(PBMC)*** proliferation and activation of CCD-18Co cells were detected by BrdU assays,flow cytometry,immunocytochemistry and Western *** metabolism was tested by Western blotting and real-time quantitative polymerase chain reaction(RT-qPCR).Results The level of collagen metabolism in the TNBS+ethyl alcohol(EtOH)/Tg group was greater than that in the TNBS+EtOH/WT *** growth factor-β1(TGF-β1)and p-Smad3 in the TNBS+EtOH/Tg group were upregulated as compared with those in the TNBS+EtOH/WT *** proliferation of CCD-18Co cells was promoted by the addition of human PBMC supernatant supplemented with 20 ng/mL TL1A,and the addition of human PBMC supernatant and TL1A increased CCD-18Co proliferation by 24.4%at 24 ***1A promoted cell activation and increased the levels of COL1A2,COL3A1,and TIMP-1 in CCD-18Co *** of CCD-18Co cells with TL1A increased the expression of TGF-β1 and *** TL1A promotes TGF-β1-mediated intestinal fibroblast activation,proliferation,and collagen deposition and is likely related to an increase in the TGF-β1/Smad3 signaling pathway.

关键词： tumor necrosis factor ligand-related molecule-1A fibrosis inflammatory bowel disease myofibroblasts transforming growth factor-β1