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Vitamin D-binding protein in plasma microglia-derived extracellular vesicles as a potential biomarker for major depressive disorder

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Genes & Diseases 2024年第2期11卷 1009-1021页

作者： Gaojia Zhang Ling Li Yan Kong Dandan Xu yu Bao Zhiting Zhang Zhixiang Liao Jiao Jiao Dandan Fan Xiaojing Long Ji Dai Chunming Xie Zhiqiang Meng zhijun Zhang Department of Neurology Affiliated Zhongda HospitalResearch Institution of NeuropsychiatrySchool of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Biochemistry and Molecular Biology School of MedicineSoutheast UniversityNanjingJiangsu 210009China Shenzhen Key Laboratory of Drug Addiction Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of Sciences (CAS)ShenzhenGuangdong 518000China CAS Key Laboratory of Brain Connectome and Manipulation The Brain Cognition and Brain Disease Institute (BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China Lauterbur Research Center for Biomedical Imaging Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China Shenzhen-Hong Kong Institute of Brain Sciences-Shenzhen Fundamental Research Institutions ShenzhenGuangdong 518000China Brain Cognition and Brain Disease Institute Department of Mental Health and Public HealthFaculty of Life and Health SciencesShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China

No well-established biomarkers are available for the clinical diagnosis of major depressive disorder(MDD).Vitamin D-binding protein(VDBP)is altered in plasma and postmortem dorsolateral prefrontal cortex(DLPFC)tissues of MDD patients.Thereby,the role of VDBP as a potential biomarker of MDD diagnosis was further assessed.Total extracellular vesicles(EVs)and brain cell-derived EVs(BCDEVs)were isolated from the plasma of first-episode drug-naïve or drug-free MDD patients and well-matched healthy controls(HCs)in discovery(20 MDD patients and 20 HCs)and validation cohorts(88 MDD patients and 38 HCs).VDBP level in the cerebrospinal fluid(CSF)from chronic glucocorticoid-induced depressed rhesus macaques or prelimbic cortex from lipopolysaccharide(LPS)-induced depressed mice and wild control groups was measured to evaluate its relationship with VDBP in plasma microglia-derived extracellular vesicles(MDEVs).VDBP was significantly decreased in MDD plasma MDEVs compared to HCs,and negatively correlated with HAMD-24 score with the highest diagnostic accuracy among BCDEVs.VDBP in plasma MDEVs was decreased both in depressed rhesus macaques and mice.A positive correlation of VDBP in MDEVs with that in CSF was detected in depressed rhesus macaques.VDBP levels in prelimbic cortex microglia were negatively correlated with those in plasma MDEVs in depressed mice.The main results suggested that VDBP in plasma MDEVs might serve as a prospective candidate biomarker for MDD diagnosis.

关键词： Biomarker Cerebrospinal fluid Major depressive disorder Microglia derived extracellular vesicles Vitamin-D binding protein

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Efficient and stable organic solar cells enabled by a poly(carbazole phosphonic acid)hole transporter

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Science China Chemistry 2024年第6期67卷 1941-1945页

作者： zhijun Ren Siwei Luo Xiaoyu Shi yunjie Dou Tianxiao Liu Lingyuan Wang Kwok Kiu Tsang Feifei Wang yu Zhao Yangyang Liu Xiaodong Hu Xiaoxiao Peng Wei Liu He Yan Shangshang Chen State Key Laboratory of Coordination Chemistry MOE Key Laboratory of High Performance Polymer Materials&TechnologySchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing210023China Department of Chemistry Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional MaterialsEnergy Institute and Hong Kong Branch of Chinese NationalEngineering Research Center for Tissue Restoration and ReconstructionHong Kong University of Science and TechnologyHong Kong999077China

Conventional self-assembled monolayer(SAM)hole transporters in organic solar cells(OSCs)generally suffer from poor uniformity and limited thickness tolerance,hindering their large-scale production.To overcome these limitations,we introduce a novel polymeric hole transporter synthesized by polymerizing carbazole phosphonic acid(PACz).The resultant Poly-2PACz material exhibits exceptional conductivity,high tolerance for variations in layer thickness,and improved film uniformity compared with conventional SAMs.Consequently,the OSCs utilizing Poly-2PACz achieve a remarkable power conversion efficiency of 19.1%and a high fill factor of 81.2%,surpassing the devices based on 2PACz.Moreover,Poly-2PACz-based OSCs demonstrate excellent operational stability,retaining over 80%of their initial efficiency after 1,400 h of continuous light exposure in ambient conditions.This work presents a novel strategy for designing hole transporters,paving the way for more efficient and stable OSCs.

关键词： organic solar cells hole transporters poly(carbazole phosphonic acid) stability

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Protein regulation mechanism of cold tolerance in Haemaphysalis longicornis

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Insect Science 2023年第3期30卷 725-740页

作者： Ningmei Wang Aimeng Ji Abolfazl Masoudi Shuang Li yuhong Hu Yefei Zhang Zhijun Yu Han Wang Hui Wang Jingze Liu Ministry of Education Key Laboratory of Molecular and Cellular Biology Hebei Key Laboratory of Animal PhysiologyBiochemistry and Molecular BiologyCollege of Life SciencesHebei Normal UniversityShijiazhuangChina Instrumental Analysis Center Hebei Normal UniversityShjiazhuangChina Hebei Xiaowutai Mountain National Nature Reserve Management Center ZhangjiakouHebei ProvinceChina

Ticks are external parasitic arthropods that can transmit a variety of pathogens by sucking blood.Low-temperature tolerance is essential for ticks to survive during the cold winter.Exploring the protein regulation mechanism of low-temperature tolerance of Haemaphysalis longicornis could help to explain how ticks survive in winter.In this study,the quantitative proteomics of several tissues of H.longicornis exposed to low temperature were studied by data independent acquisition technology.Totals of 3699,3422,and 1958 proteins were identified in the salivary gland,midgut,and ovary,respectively.The proteins involved in energy metabolism,cell signal transduction,protein synthesis and repair,and cytoskeleton synthesis changed under low-temperature stress.The comprehensive analysis of the protein regulation of multiple tissues of female ticks exposed to low temperature showed that maintaining cell homeostasis,maintaining cell viability,and enhancing cell tolerance were the most important means for ticks to maintain vital signs under low temperature.The expression of proteins involved in and regulating the above cell activities was the key to the survival of ticks under low temperatures.Through the analysis of a large amount of data,we found that the expression levels of arylamine N-acetyltransferase,inositol polyphosphate multikinase,and dual-specificity phosphatase were up-regulated under low temperature.We speculated that they might have important significance in low-temperature tolerance.Then,we performed RNA interference on the mRNA of these 3 proteins,and the results showed that the ability of female ticks to tolerate low temperatures decreased significantly.

关键词： low-temperature tolerance protein regulation tick survival strategy

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CircRNA DICAR as a novel endogenous regulator for diabetic cardiomyopathy and diabetic pyroptosis of cardiomyocytes

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1889-1900页

作者： Qiong yuan yunwei Sun Fan Yang Dan Yan Meihua Shen Zhigang Jin Lin Zhan Guangqi Liu Ling Yang Qianyi Zhou Zhijun Yu Xiangyu Zhou Yang yu Yong Xu Qingming Wu Jianfang Luo Xiamin Hu Chunxiang Zhang Department of Cardiology the Affiliated Hospital of Southwest Medical University and Key Laboratory of Medical ElectrophysiologyMinistry of EducationInstitute of Cardiovascular Research and Institute of Metabolic DiseasesSouthwest Medical UniversityLuzhou 646000China College of Medicine Wuhan University of Science and TechnologyWuhan 430065China Department of Emergency and Critical Care Medicine Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China China Resource&WISCO General Hospital Wuhan University of Science and TechnologyWuhan 430065China Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial Key Laboratory of Coronary Heart Disease PreventionGuangdong General HospitalGuangzhouChina College of Pharmacy Shanghai University of Medicine and Health SciencesShanghai 210000China

In this study,we identified that a conserved circular RNA(circRNA)DICAR,which was downregulated in diabetic mouse hearts.DICAR had an inhibitory effect on diabetic cardiomyopathy(DCM),as the spontaneous cardiac dysfunction,cardiac cell hypertrophy,and cardiac fibrosis occurred in DICAR deficiency(DICAR+/−)mice,whereas the DCM was alleviated in DICARoverexpressed DICARTg mice.At the cellular level,we found that overexpression of DICAR inhibited,but knockdown of DICAR enhanced the diabetic cardiomyocyte pyroptosis.At the molecular level,we identified that DICAR-VCP-Med12 degradation could be the underlying molecular mechanism in DICAR-mediated effects.The synthesized DICAR junction part(DICAR-JP)exhibited a similar effect to the entire DICAR.In addition,the expression of DICAR in circulating blood cells and plasma from diabetic patients was lower than that from health controls,which was consistent with the decreased DICAR expression in diabetic hearts.DICAR and the synthesized DICAR-JP may be drug candidates for DCM.

关键词： diabetic endogenous cardiomyopathy

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激光尾波场电子加速及新型辐射源(特邀)

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中国激光 2024年第1期51卷 44-68页

作者：余昌海秦志勇张志钧刘建胜上海师范大学物理系上海200234 中国科学院上海光学精密机械研究所强场激光物理国家重点实验室上海201800

受益于超短超强激光技术的持续迅猛发展,飞秒强激光为人类提供了全新的实验手段与极端的物理条件,使激光物质相互作用进入到一个极端非线性的强场超快新范畴,催生了大量新原理、新现象,推动了技术变革。飞秒强激光驱动的等离子体尾波场... 详细信息

受益于超短超强激光技术的持续迅猛发展,飞秒强激光为人类提供了全新的实验手段与极端的物理条件,使激光物质相互作用进入到一个极端非线性的强场超快新范畴,催生了大量新原理、新现象,推动了技术变革。飞秒强激光驱动的等离子体尾波场加速原理是一种具有超高加速梯度的粒子加速新原理,该技术的加速梯度可达100 GV/m,相比于传统射频加速器提高了3个数量级以上,可在厘米量级的加速长度内获得GeV量级的高品质高能电子束,极大地降低了加速器的成本,为发展新一代粒子加速技术和新型超快辐射源提供了新机遇和新途径。从飞秒强激光驱动等离子体尾波场中的电子注入、能量啁啾控制和高品质电子束产生以及基于高品质电子束的betatron X射线辐射、高能伽马射线和小型化自由电子激光这几个方面介绍了激光等离子体尾波场电子加速的若干主要研究进展,并对未来进行了展望。

关键词：激光光学激光尾波场电子加速能量啁啾 betatron辐射逆康普顿散射自由电子激光

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稀燃条件下甲烷-空气预混射流的着火特性

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同济大学学报（自然科学版） 2024年第5期52卷 815-821页

作者：于洋瞿宗举谢巍邓俊吴志军同济大学汽车学院上海201804

基于可控热氛围燃烧试验系统,探究射流当量比、射流速率和协流速率对甲烷-空气预混射流着火特性的影响。根据试验规律对天然气发动机稀薄燃烧的控制策略提出优化建议,以减少失火现象的发生。结果表明:随着协流温度的升高,甲烷-空气预混... 详细信息

基于可控热氛围燃烧试验系统,探究射流当量比、射流速率和协流速率对甲烷-空气预混射流着火特性的影响。根据试验规律对天然气发动机稀薄燃烧的控制策略提出优化建议,以减少失火现象的发生。结果表明:随着协流温度的升高,甲烷-空气预混射流的稀燃极限降低而富燃极限升高,符合大多数碳氢燃料预混合气的着火界限分布规律。不同的射流速率和协流速率下均存在临界当量比,当低于临界当量比时,着火温度随射流当量比的升高而显著降低,当高于临界当量比时,着火温度趋于稳定。在较低的射流当量比工况(0.20~0.62)下,提高射流速率可以降低着火温度从而优化着火性能。

关键词：动力机械工程天然气发动机稀薄燃烧着火温度失火

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Effects of meteorological factors on the defoliation dynamics of the larch caterpillar(Dendrolimus superans Butler)in the Great Xing’an boreal forests

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Journal of Forestry Research 2021年第6期32卷 2683-2697页

作者： Lei Fang yue yu Guofei Fang Xu Zhang Zhijun Yu Xudong Zhang Ellen Crocker Jian Yang CAS Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110016LiaoningPeople’s Republic of China Key Laboratory of State Forestry and Grassland Administration On Forest Pest Monitoring and Warning General Station of Forest and Grassland Pest ManagementNational Forestry and Grassland AdministrationShenyang 110034LiaoningPeople’s Republic of China Department of Forestry and Natural Resources University of KentuckyLexingtonKY 40546USA

Larch caterpillars are widely distributed in the Great Xing’an boreal forests;however,the relationship between caterpillar defoliation dynamics and climatic factors is poorly understood.The aims of this study are to investigate the primary weather conditions that might influence forest defoliation and to identify the most important life stage of the larch caterpillar at which forest defoliation might be mitigated by incorporating more inhibitory influences from climatic factors.The life cycle of the larch caterpillar was partitioned into four stages and multiple linear regression and mixed effect models were combined with a relative weight analysis approach to evaluate the importance and influence of meteorological variables on defoliation dynamics.The results show that warmer temperatures in growing seasons and overwintering periods can increase the defoliation area,while rainy and humid growing seasons decrease the defoliation area.Total precipitation during the early instar larval period had the greatest power to explain the variance in defoliation dynamics and had a very strong inhibitory effect,followed by the accumulative temperatures of the late instar larval period which had a positive impact,and precipitation during the middle instar larval period which had a negative impact.Weather conditions during the early instar larval period had the greatest influence on the area defoliated and accounted for 40%of the explained variance.This study demonstrates that climatic warming and drying will increase the risk of larch caterpillar outbreaks in the Great Xing’an Mountains.

关键词： Larch caterpillar Defoliation area Climatic warming Life cycle Great xing’an mountains Relative importance

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不同推进比下螺旋桩在砂土中安装力的离散元研究

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岩土工程学报 2024年第6期46卷 1166-1176页

作者：王乐李钰徐志军刘波张春会田英辉天津大学水利工程仿真与安全国家重点实验室天津300350 河南工业大学土木工程学院河南郑州450001 香港理工大学土木与环境工程学系中国香港999077 河北科技大学建筑工程学院河北石家庄050018 河北省岩土与结构体系防灾减灾技术创新中心河北石家庄050018 墨尔本大学基础设施工程系维多利亚3010

螺旋桩作为一种颇具潜力的海上风电基础形式,其安装问题是螺旋桩能否成功应用在海上风电工程中的关键。基于离散元方法,采用PFC^(3D)模拟分析了螺旋桩在不同推进比下安装时的桩身受力情况以及对周围土体的影响。宏观上,研究了螺旋桩在... 详细信息

螺旋桩作为一种颇具潜力的海上风电基础形式,其安装问题是螺旋桩能否成功应用在海上风电工程中的关键。基于离散元方法,采用PFC^(3D)模拟分析了螺旋桩在不同推进比下安装时的桩身受力情况以及对周围土体的影响。宏观上,研究了螺旋桩在不同推进比下安装时螺旋桩连杆侧壁、连杆端部、螺旋叶片上下表面的受力变化规律;微观上,分析了螺旋桩安装过程中桩周土体孔隙率、配位数及应力变化规律。研究表明:随着推进比的减小,螺旋桩安装时受到的竖向力与扭矩也随之降低,对桩周土体的扰动也更小;螺旋桩在推进比为1时安装与在推进比小于1时安装存在两种不同的安装机制。研究结果对进一步确定螺旋桩在不同推进比下的安装条件具有一定意义。

关键词：螺旋桩推进比砂土离散元法

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2023年度工程地质领域自然科学基金项目受理与资助分析

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工程地质学报 2024年第1期32卷 337-348页

作者：刘羽任建国吴志军吕大炜国家自然科学基金委员会地球科学部北京100085

对2023年度工程地质领域(涵盖地质学学科下属的工程地质和环境地球科学学科下属的工程地质环境与灾害)的基金申请情况、资助情况、研究队伍等进行详细分析。工程地质领域的基金项目申请数量稳步上升,并以青年基金申请量涨幅最大。近10... 详细信息

对2023年度工程地质领域(涵盖地质学学科下属的工程地质和环境地球科学学科下属的工程地质环境与灾害)的基金申请情况、资助情况、研究队伍等进行详细分析。工程地质领域的基金项目申请数量稳步上升,并以青年基金申请量涨幅最大。近10年的统计数据表明,同行评议专家对申请书的评议尺度稳定。面上项目申请者的年龄结构趋于年轻化,青年科学基金申请者的年龄结构比较合理。工程地质领域在多个不同的项目类型中都获得了资助,表现出较强的竞争力。

关键词：工程地质工程地质环境与灾害自然科学基金人才培养

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新型政商关系能够缓解企业的融资约束吗

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安徽商贸职业技术学院学报 2024年第1期23卷 37-42页

作者：张雨张之君安徽商贸职业技术学院会计学院安徽芜湖241002

新型政商关系是推动国家治理体系和治理能力现代化的基础性、关键性环节。我国正在构建以“亲清”为特征的新型政商关系。以2011—2020年沪深A股上市公司为研究样本,考察新型政商关系的构建对企业融资约束的影响。研究发现:新型政商关... 详细信息

新型政商关系是推动国家治理体系和治理能力现代化的基础性、关键性环节。我国正在构建以“亲清”为特征的新型政商关系。以2011—2020年沪深A股上市公司为研究样本,考察新型政商关系的构建对企业融资约束的影响。研究发现:新型政商关系的构建程度越高越能够缓解企业的融资约束;在非国有企业中,这种缓解作用更为显著。该研究为我国推进营商环境改革,构建新型政商关系提供了企业微观视角的经验。

关键词：新型政商关系融资约束企业特质

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