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Journal of Systems Science & Complexity 2018年第1期31卷 130-146页

作者： LIU Bin HILL David John ZHANG Changfan sun zhijie Department of Information and Computing Science Hunan University of Technology Zhuzhou 412008 China Department of Electrical and Electronic Engineering The University of Hong Kong Hong Kong China School of Electrical and Information Engineering Hunan University of Technology Zhuzhou 412008 China Mork Family Department of Chemical Engineering and Materials Science Viterbi School of Engineering University of Southern California Los Angeles CA 90089 USA

This paper investigates the issue of stabilization for discrete-time dynamical systems（DDS）by event-triggered impulsive control（ETIC）. Based on some relatively simple threshold constants, three levels of event conditions are set and thus the ETIC scheme is designed. Three cases for ETIC with and without time-delays and data dropouts are studied respectively, and the criteria on exponential stability are derived for the controlled DDS. The stabilization in the form of exponential stability is achieved for DDS under the designed ETIC with or without time-delays. And in the case of the ETIC data dropouts, the conditions of exponential stabilization are derived for DDS and the maximal allowable dropout rates for ETIC are estimated. Finally, one example with numerical simulations is worked out for illustration.

关键词： Data dropout discrete-time dynamical systems event-triggered control exponential stability impulsive control stabilization time-delay

The clinical antiprotozoal drug nitazoxanide and its metabolite tizoxanide extend Caenorhabditis elegans lifespan and healthspan

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3266-3280页

作者： Wenfeng Li Shuming Chen Jing Lang Jing Luo Jiahui Chen Liping Zhang zhijie sun Deli Dong Department of Pharmacology China Pharmaceutical UniversityNanjing 210009China

The drugs extending healthspan in clinic have always been *** is an FDA-approved clinical antiprotozoal *** is rapidly metabolized to tizoxanide after absorption in *** previous studies find that nitazoxanide and its metabolite tizoxanide induce mild mitochondrial uncoupling and activate cellular AMPK,oral nitazoxanide protects against experimental hyperlipidemia,hepatic steatosis,and ***,we demonstrate that both nitazoxanide and tizoxanide extend the lifespan and healthspan of Caenorhabditis elegans through Akt/AMPK/sir 2.1/daf16 ***,both nitazoxanide and tizoxanide improve high glucose-induced shortening of *** *** has been a clinical drug with a good safety profile,we suggest that it is a novel anti-aging drug.

关键词： Nitazoxanide Tizoxanide C.elegans Healthspan Lifespan AMPK Akt Mitochondrial uncoupling

Quasi-Carbon Fibers and the Composites

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Journal of Materials Science & Technology 2000年第5期16卷 486-490页

作者： Lulu SONG, Weihong ZHONG+, Zuoguang ZHANG and zhijie sun (Department of Materials Science & Engineering, Beijing University of Aeronautics and Astronautics, Beijing 100083, China) Department of Materials Science and Engineering Beijing University of Aeronautics and Astronautics Beijing 100083 China

The aim of this report is to study the properties of quasi-carbon fibers (QCF) prepared from the PAN fiber precursor by pyrolysis at a temperature between 400℃ and 1200℃. The resistivity of QCF with different heat-treated temperature (HTT) was investigated by a Hall-35 testing system, and the flexural properties of the result composites (QCFC) are also discussed. In addition, the scanning electronic microscope (SEM) was utilized to observe the surface morphology of QCF and the fracture section of QCFC obtained from flexural testing.

关键词： QCF Quasi-Carbon Fibers and the Composites HTT

Anthelmintics nitazoxanide protects against experimental hyperlipidemia and hepatic steatosis in hamsters and mice

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Acta Pharmaceutica Sinica B 2022年第3期12卷 1322-1338页

作者： Fengfeng Li Man Jiang Minghui Ma Xuyang Chen Yidan Zhang Yixin Zhang Yuanyuan Yu Yunfeng Cui Jiahui Chen Hui Zhao zhijie sun Deli Dong Department of Pharmacology(the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China Key Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin 150086China Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbin Medical UniversityHarbin 150086China Department of Pharmacology China Pharmaceutical UniversityNanjing 211198China

Lipid metabolism disorders contribute to hyperlipidemia and hepatic *** is ideal to develop drugs simultaneous improving both hyperlipidemia and hepatic *** is an FDA-approved oral antiprotozoal drug with excellent pharmacokinetic and safety *** found that nitazoxanide and its metabolite tizoxanide induced mild mitochondrial uncoupling and subsequently activated AMPK in Hep G2 *** administration of nitazoxanide inhibited high-fat diet(HFD)-induced increases of liver weight,blood and liver lipids,and ameliorated HFD-induced renal lipid accumulation in *** significantly improved HFD-induced histopathologic changes of hamster *** the hamsters with pre-existing hyperlipidemia and hepatic steatosis,nitazoxanide also showed therapeutic *** administration of nitazoxanide improved HFD-induced hepatic steatosis in C57BL/6J mice and western diet(WD)-induced hepatic steatosis in Apoe-/-*** present study suggests that repurposing nitazoxanide as a drug for hyperlipidemia and hepatic steatosis treatment is promising.

关键词： Nitazoxanide Tizoxanide Hyperlipidemia Hepatic steatosis AMPK Autophagy SQSTM1/P62 Mitochondrial uncoupling

Improved PSO-RBF Neural Network Based Prediction of Slope Stability Factors

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Improved PSO-RBF Neural Network Based Prediction of Slope St...

Design and synthesis of active peptides based on BRCA1(782-786) and interaction of they with target peptide RAD51(181-200)

第31届中国过程控制会议（CPCC2020）

作者： Yutao Liu Xiaobo Chi Jianbing Liu zhijie sun School of Mathematical Sciences Shanxi University

This paper proposes an improved PSO-RBF neural network learning method for slope stability prediction. By using the improved learning factor and the particles with normal attenuation inertia weight, the PSO algorithm is optimized. An RBF expansion speed control factor is added to reduce the training time of the proposed RBF neural network. This paper considers the conditioning factors of volumetric weight, internal friction angle, cohesion, slope inclination angle, pore water pressure ratio, and slope height to achieve a reliable prediction of the safety factor. After training the proposed PSO-RBF neural network, the future safety factor can be predicted to evaluate slope stability. Compared with the traditional methods, the prediction results demonstrate that the proposed PSO-RBF neural network method has higher accuracy in slope stability prediction.

关键词： Slope stability Particle Swarm Optimization(PSO) algorithm Radial Basis Function(RBF) neural network Learning factors Expansion speed control factors

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Design and synthesis of active peptides based on BRCA1(782-7...

随机OD需求下的多目标离散交通网络设计模型与算法

河南省化学会2018年学术年会

作者： Mengwei Wang Mingxiu Lv Kui Lu Guangbin Liu zhijie sun College of Chemistry and Molecular Engineering Zhengzhou University School of Material and Chemical Engineering Henan University of Engineering School of Chemical Engineering and Food Science Zhengzhou Institute of Technology

BRCA1 is known as a crucial tumor suppressor gene, play an important role in cell reproduction, growth, DNA damage repair and the maintenance of genome integrity[1]. RAD51 can affect the repair of double stranded DNA by homologous recombination, play a key role in genome stability[2]. The interaction between RAD51 and BRCA1 peptide were studied, aimed at providing valuable information about function model, and providing a new design concept and theoretical basis for the development of peptide drugs and the treatment of cancer. BRCA1(782-786)(SISLL) is one of conservative sequence in BRCA1, of which 784 S is a mutation point. In this work, RAD51(181-200) as the target peptide, a serious of analog-BRCA1 peptides were synthesized by Solid phase synthesis, purified by RP-HPLC, and characterized by ESI-MS. The interaction of RAD51 with BRCA1 or analog-BRCA1 peptides were investigated by fluorescence spectroscopy and circular dichroism(CD). The results obtained showed that the quenchcd intensity of fluorescence caused by the increaing of BRCA1 or analog-BRCA1 peptides. Through circular dichroism spectrum, found the secondary structure of RAD51(181-200) has changed with adding BRCA1 or analog-BRCA1 peptides. Comprehensive comparison, SICLL was bigger than the other peptides with the interaction of RAD51.

关键词： BRCA1 RAD51 Solid phase synthesis Interaction

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西南交通大学学报 2014年第1期49卷 119-125页

作者：杨明苏标孙志杰许怡长沙理工大学交通运输工程学院湖南长沙410004

为解决实际OD对之间交通需求不确定性及优化目标多样性问题,采用机会约束模型及多目标优化理想点模型构建上层规划模型,采用固定需求下的用户平衡配流模型构建下层规划模型,建立了同时优化交通管理目标、环境保护目标、投资费用目标和... 详细信息

为解决实际OD对之间交通需求不确定性及优化目标多样性问题,采用机会约束模型及多目标优化理想点模型构建上层规划模型,采用固定需求下的用户平衡配流模型构建下层规划模型,建立了同时优化交通管理目标、环境保护目标、投资费用目标和用户出行目标的随机多目标离散交通网络设计双层规划模型.为保证所构建模型的求解精度,设计了基于Frank-Wolfe算法、Monte Carlo模拟和自适应小生境淘汰技术的遗传算法求解模型,并在Matlab平台上开发了相应的算法程序.采用Nguyen-Dupuis网络测试了模型和算法的有效性,结果表明:模型可以反映实际路网规划目标和约束,算法具有良好的全局收敛性,可为路网规划提供指导.

关键词：离散型交通网络设计双层规划模型遗传算法随机规划多目标优化

硬岩水文地质参数井同径止水与分层抽水试验研究

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水文地质工程地质 2022年第4期49卷 55-61页

作者：董崇泽孙智杰山西能源学院山西晋中030600 山西省第三地质工程勘察院山西晋中030620

针对传统施工程序无法解决坚硬岩石止水环隙很小(仅3 mm)钻孔的同径止水及分层抽水试验问题,以山西某水文地质参数井为研究对象,采用现场和室内综合试验的方法,对同径止水方案、材料、技术、分层抽水等工艺进行研究。结果表明:(1)同径... 详细信息

针对传统施工程序无法解决坚硬岩石止水环隙很小(仅3 mm)钻孔的同径止水及分层抽水试验问题,以山西某水文地质参数井为研究对象,采用现场和室内综合试验的方法,对同径止水方案、材料、技术、分层抽水等工艺进行研究。结果表明:(1)同径止水装置经过特殊的“外掏内缩”设计与制作,使止水外环间隙由3 mm增大到8.5 mm,解决了“极小止水环隙”下的同径止水问题;经抽水检验,止水效果良好。(2)在孔外一系列试验的基础上,定制的止水材料和选择的止水组合与本孔的适应性强,下管风险小,实施过程相当顺利。(3)专门设计的分层导水管路,其上串接的隔离封水胶球与止水套管柱内设置的锥形隔水接头相互契合,封水可靠,形成了两套独立的导水管路,满足了上、下含水层分层抽水试验的工况。研究结果可为类似水文地质参数井开展同径止水或分层抽水试验研究提供参考。

关键词：硬岩深孔同径止水外掏内缩接头止水材料与组合隔离封水胶球锥形隔水接头分层抽水

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纤维/树脂浸润测试仪的研制与应用

北京航空航天大学学报 2005年第3期31卷 359-362页

作者：张佐光陈亮李敏孙志杰北京航空航天大学材料科学与工程学院北京100083

针对复合材料成型工艺的特点 ,依据毛细原理 ,研制了浸润性能测试仪 .该测试仪包括浸润质量测试系统与温度控制系统 ,能够定量测试在较宽的温度范围内发生浸润的速率和浸润程度 .对该测试仪的准确性与稳定性进行了校准与标定 ,并运用该... 详细信息

针对复合材料成型工艺的特点 ,依据毛细原理 ,研制了浸润性能测试仪 .该测试仪包括浸润质量测试系统与温度控制系统 ,能够定量测试在较宽的温度范围内发生浸润的速率和浸润程度 .对该测试仪的准确性与稳定性进行了校准与标定 ,并运用该仪器研究了纤维种类、树脂粘度和纤维体积含量对树脂 /纤维浸润性能的影响规律 .研究结果表明该设备为研究各类复合材料中增强材料与基体间的浸润性能提供了方便的测试手段。

关键词：复合材料浸润纤维测试装置树脂基体

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砂土环剪力学特性与数值模拟

地下空间与工程学报 2017年第S1期13卷 70-74页

作者：赵紫阳孙志杰山西省交通科学研究院太原030006 黄土地区公路建设与养护技术山西省重点实验室太原030006

鉴于常规直剪仪与三轴仪等受其应变范围所限,本文首先利用环剪仪开展干砂环剪试验,通过控制剪切速度与固结压力,获得了不同条件下的干砂剪切强度,试验结果证明剪切速度与固结压力对干砂残余强度影响较大,几乎呈线性关系。根据砂土剪切强... 详细信息

鉴于常规直剪仪与三轴仪等受其应变范围所限,本文首先利用环剪仪开展干砂环剪试验,通过控制剪切速度与固结压力,获得了不同条件下的干砂剪切强度,试验结果证明剪切速度与固结压力对干砂残余强度影响较大,几乎呈线性关系。根据砂土剪切强度,进一步获得不同围压和剪切速率条件下的表观黏度系数。然后从微观角度入手,通过运用一种新型力学方法——分子动力学方法(简称MD)分析了低围压下砂土的流动特性,进而验证了分子动力学数值模拟方法在砂土流动问题中的适用性,有利于进一步提高防治土体大变形流动灾害的研究水平,具有重要的现实意义。

关键词：环剪试验残余强度表观粘度分子动力学