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Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retrospective analyses of the POPLAR/OAK and CHOICE-01 trial

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Science China Life Sciences 2025年第1期68卷 249-262页

作者： Jinliang Wang Wenyong Zhou Yu Xu Jianchun Duan Qiaoxia Zhou Guoqiang Wang Leo Li Chunwei Xu Wenxian Wang Shangli Cai zhijie Wang Jie Wang Department of Oncology The Fifth Medical Center of Chinese PLA General Hospital Department of Thoracic Surgery Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong University Burning Rock Biotech CAMS Key Laboratory of Translational Research on Lung Cancer State Key Laboratory of Molecular OncologyDepartment of Medical OncologyNational Cancer Center/National Clinical Research Center for ancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences Department of Clinical Trial The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)

In non-small cell lung cancers,the non-squamous and squamous subtypes（nsqNSCLC and sqNSCLC） exhibit disparities in pathophysiology,tumor immunology,and potential genomic correlates affecting responses to immune checkpoint inhibitor（ICI）-based *** our inhouse training cohort（n=85）,the presence of the LRP1B deleterious mutation（LRP1B-del） was associated with longer and shorter progression-free survival（PFS） on ICIs alone in nsqNSCLCs and sqNSCLCs,respectively(Pinteraction=0.008).These results were validated using a larger public ICI cohort(n=208,Pinteraction<0.001).Multiplex immunofluorescence staining revealed an association between LRP1B-del and increased and decreased numbers of tumor-infiltrating CD8+T cells in nsqNSCLCs（P=0.040） and sqNSCLCs（P=0.014）,*** the POPLAR/OAK cohort,nsqNSCLCs with LRP1B-del demonstrated improved PFS benefits from atezolizumab over docetaxel(hazard ratio（HR）=0.70,P=0.046),whereas this benefit was negligible in those without LRP1B-del（HR=1.05,P=0.64）.Conversely,sqNSCLCs without LRP1B-del benefited more from atezolizumab（HR=0.60,P=0.002） than those with LRP1B-del（HR=1.30,P=0.31）.Consistent results were observed in the in-house CHOICE-01 cohort,in which nsqNSCLCs with LRP1B-del and sqNSCLCs without LRP1B-del benefited more from toripalimab plus chemotherapy than from chemotherapy alone(Pinteraction=0.008).This multi-cohort study delineates the antithetical impacts of LRP1B-del in nsqNSCLCs and sqNSCLCs on predicting the benefits from ICI alone or with chemotherapy over chemotherapy *** findings highlight the distinct clinical utility of LRP1B-del in guiding treatment choices for nsqNSCLCs and sqNSCLCs,emphasizing the necessity for a detailed analysis based on pathological subtypes when investigating biomarkers for cancer therapeutics.

关键词： non-squamous NSCLC squamous NSCLC LRP1B deleterious mutations predictive biomarker immune checkpoint inhibitor

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Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun Jiang Zhenjie Lu Yanwen Ding Shujun Liu zhijie Qi Tian Tang Yunfan Zhang Zhiyuan Ma Jingwen Sun Liang Xue Wenyao Zhang Pan Xiong Xin Wang Junwu Zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Ductility

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Adaptive Control of a Flexible Manipulator With Unknown Hysteresis and Intermittent Actuator Faults

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 148-158页

作者： Shouyan Chen Weitian He Zhijia Zhao Yun Feng zhijie Liu Keum-Shik Hong School of Mechanical and Electrical Engineering Guangzhou University the School of Control Science and Engineering Shandong University IEEE the College of Electrical and Information Engineering Hunan University the National Engineering Research Center for Robot Visual Perception and Control Technology Hunan University the School of Intelligence Science and Technology University of Science and Technology Beijing (USTB) the Institute for Future the School of AutomationQingdao University the School of Mechanical Engineering Pusan National University

In this study, we consider a single-link flexible manipulator in the presence of an unknown Bouc-Wen type of hysteresis and intermittent actuator faults. First, an inverse hysteresis dynamics model is introduced, and then the control input is divided into an expected input and an error compensator. Second,a novel adaptive neural network-based control scheme is proposed to cancel the unknown input hysteresis. Subsequently,by modifying the adaptive laws and local control laws, a fault-tolerant control strategy is applied to address uncertain intermittent actuator faults in a flexible manipulator system. Through the direct Lyapunov theory, the proposed scheme allows the state errors to asymptotically converge to a specified interval. Finally,the effectiveness of the proposed scheme is verified through numerical simulations and experiments.

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Finite-Time Convergence Disturbance Rejection Control for a Flexible Timoshenko Manipulator

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IEEE/CAA Journal of Automatica Sinica 2021年第1期8卷 157-168页

作者： Zhijia Zhao zhijie Liu the School of Mechanical and Electrical Engineering Guangzhou UniversityGuangzhou 510006China the School of Automation and Electrical Engineering University of Science and Technology Beijing(USTB)Beijing 100083 Shunde Graduate School of USTB Foshan 528300China

This paper focuses on a new finite-time convergence disturbance rejection control scheme design for a flexible Timoshenko manipulator subject to extraneous *** suppress the shear deformation and elastic oscillation,position the manipulator in a desired angle,and ensure the finitetime convergence of disturbances,we develop three disturbance observers(DOs)and boundary *** the derived DOs-based control schemes,the controlled system is guaranteed to be uniformly bounded stable and disturbance estimation errors converge to zero in a finite *** the end,numerical simulations are established by finite difference methods to demonstrate the effectiveness of the devised scheme by selecting appropriate parameters.

关键词： Disturbance observer disturbance rejection control finite-time convergence Timoshenko manipulator vibration control

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Non-equilibrium thermodynamic analysis of coupled heat and moisture transfer across a membrane

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Chinese Journal of Chemical Engineering 2022年第4期35卷 497-506页

作者： zhijie Shen Jingchun Min Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Engineering MechanicsTsinghua UniversityBeijing 100084China

Non-equilibrium thermodynamics theory is used to analyze the transmembrane heat and moisture transfer process,which can be observed in a membrane-type total heat exchanger(THX).A theoretical model is developed to simulate the coupled heat and mass transfer across a membrane,total coupling equations and the expressions for the four characteristic parameters including the heat transfer coefficient,molardriven heat transfer coefficient,thermal-driven mass transfer coefficient,and mass transfer coefficient are derived and provided,with the Onsager’s reciprocal relation being confirmed to verify the rationality of the *** are conducted to investigate the effects of the membrane property and air state on the coupling transport *** results show that the four characteristic parameters directly affect the transmembrane heat and mass fluxes:the heat and mass transfer coefficients are both positive,meaning that the temperature difference has a positive contribution to the heat transfer and the humidity ratio difference has a positive contribution to the mass *** molar-driven heat transfer and thermal-driven mass transfer coefficients are both negative,implying that the humidity ratio difference acts to reduce the heat transfer and the temperature difference works to diminish the mass *** mass transfer affects the heat transfer by 1%–2%while the heat transfer influences the mass transfer by7%–14%.The entropy generation caused by the temperature difference-induced heat transfer is much larger than that by the humidity difference-induced mass transfer.

关键词： Membrane Non-equilibrium thermodynamics Heat transfer Mass transfer Coupling effect

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MULTIPLE PARAMETERS IDENTIFICATION PROBLEMS IN RESISTIVITY WELL-LOGGING

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Chinese Annals of Mathematics,Series B 1998年第3期19卷 265-272页

作者： CAI zhijie Department of Mathematics Fudan University Shanghai 200433 China

In petroleum exploitation, the main aim of resistivity well-logging is to determine the resistivity of the layers by measuring the potential on the electrodes. This mathematical problem can be described as an inverse problem for the elliptic equivalued surface boundary value problem. In this paper, the author gets the expression of the derivative functions of the potential on the electrodes with respect to the resistivity of the layers. This allows us to solve the identification problem of the resistivity of the layers.

关键词： Multiple parameters identification problem Resistivity well-logging Inverse problem Equivalued surface boundary value problem

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CGNet:cross-guidance network for semantic segmentation

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Science China(Information Sciences) 2020年第2期63卷 49-64页

作者： zhijie ZHANG Yanwei PANG School of Electrical and Information Engineering Tianjin University

Semantic segmentation is a fundamental task in image analysis. The issue of semantic segmentation is to extract discriminative features for distinguishing different objects and recognizing hard ***, most existing methods have limitations on resolving this problem. To tackle this problem, we identify the contributions of the edge and saliency information for segmentation and present a novel end-to-end network, termed cross-guidance network(CGNet) to leverage them to benefit the semantic segmentation. The edge and saliency detection network are unified into the CGNet, and model the intrinsic information among them, guiding the process of extracting discriminative features. Specifically, the CGNet attempts to extract segmentation, edge, and salient features, simultaneously. Then it transfers them into the cross-guidance module(CGM) to generate the pre-knowledge features based on the modeled information, optimizing the context feature extraction process. The proposed approach is extensively evaluated on PASCAL VOC 2012,PASCAL-Person-Part, and Cityscapes, and achieves state-of-the-art performance, demonstrating the superiority of the proposed approach.

关键词： semantic segmentation fully convolutional networks pyramid network edge detection saliency detection cross-guidance

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A study of indentation scaling relationships of elastic-perfectly plastic solids with an inclusion near the conical indenter tip

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Science China(Technological Sciences) 2019年第5期62卷 721-728页

作者： YU zhijie WEI YueGuang Department of Mechanics and Engineering Science College of Engineering Peking University

Indentation hardness is found to be related to indentation depth when indentation test is applied on homogeneous materials under small indentation depth, which shows strong size effect in the indentation. While in contrast, indentation hardness has a very limited relationship with indentation depth when it is large, showing distinct scaling relationships between hardness and material properties. Previous studies on scaling relationships under deep indentation condition of elastic-perfectly plastic homogeneous materials have been carried out systematically by finite element analysis. In this paper, a heterogeneous material, particlereinforced matrix composite is detailed studied to investigate its scaling relationships under deep indentation with different particle positions and material properties by finite element analysis.

关键词： conical indentation elastic-perfect plastic grain composite scaling relationships

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Application of biomaterials for the repair and treatment of osteonecrosis of the femoral head

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Regenerative Biomaterials 2020年第1期7卷 1-8页

作者： Dewei Zhao zhijie Ma Department of Orthopedics Affiliated Zhongshan Hospital of Dalian UniversityLiaoningDalian 116001China

Osteonecrosis of the femoral head(ONFH)is one of the most common causes of hip disability in young ***,its cause and pathogenesis remain unclear,and might be caused by a variety of *** mainly occurs in young *** not treated,70–80%of patients would progress into femoral head collapse in 3 years,and eventually require hip *** these patients are younger and more physically active,multiple revision hip arthroplasty might be needed in their *** revision hip arthroplasty is difficult and risky,and has many complications,which inevitably affects the physical and mental health of *** delay the time of total hip arthroplasty for young adult patients with ONFH,biomaterials are used for its repair,which has a high clinical and social value for the retention of the patient’s own hip *** present,there are many types of biomaterials used in repairing the femoral head,there is no uniform standard of use and the clinical effects are *** this review,the main biomaterials used in the repair of ONFH are summarized and analyzed,and the prospects are also described.

关键词： osteonecrosis femoral head repair biomaterials

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Variational method based robust adaptive control for a guided spinning rocket

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Chinese Journal of Aeronautics 2021年第3期34卷 164-175页

作者： Zhongjiao Shi Liangyu Zhao zhijie Liu School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing 100083China

In this paper,a robust adaptive controller is designed for a guided spinning rocket,whose dynamics presents the characteristics of pitch-yaw cross coupling,fast time-varying aerodynamics parameters and wide flight ***,a coupled nonlinear six-degree-of-freedom equation of motion for a guided spinning rocket is developed,and the lateral acceleration motion is modeled as a control plant with time-varying matched uncertainties and unmodeled ***,a robust adaptive control method is proposed by combining Bregman divergence and variational method to achieve fast adaption and maintain bounded *** stability of the resulting closed-loop system is proved,and the ultimate bound and convergence rate are also ***,numerical simulations are performed for a single operating point and the whole flight trajectory to show the robustness and adaptability of the proposed method with respect to timevarying uncertainties and unmodeled dynamics.

关键词： Autopilot design Guided spinning rockets Robust adaptive control Second-order adaptive law Variational method

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