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A new method for preparing a rat intracerebral hemorrhage model by combining focused ultrasound and microbubbles

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Animal Models and Experimental Medicine 2023年第2期6卷 103-110页

作者： Yao He Jie Yang Fengying Hu Min Liao Yuru Nie Xiaoxia Zhu Tao Zhang Keer Song Qinxi Li Xiaojie Li Chenghan Mei Zhe Wu Qiang Lu zhihui zhong Laboratory of Nonhuman Primate Disease Modeling Research State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduChina Department of Medical Ultrasound West China HospitalSichuan UniversityChengduChina School of Life Science and Technology University of Electronic Science and Technology of ChinaChengduChina School of Bioscience and Technology Chengdu Medical CollegeChengduChina Franklin College of Arts and Science University of GeorgiaAthensGeorgiaUSA

Background:We aimed to prepare a non-invasive,reproducible,and controllable rat model of intracerebral hemorrhage with focused ultrasound(FUS).Methods:A rat intracerebral hemorrhage(ICH)model was established by combining FUS and microbubbles(μBs),and edaravone was used to verify whether the free radical scavenger had a protective effect on the model.The brain tissue of each group was sectioned to observe the gross histology,blood-brain barrier(BBB)permeability,cerebral infarction volume,and histopathological changes.Results:Compared with the FUS group,the BBB permeability was significantly increased in the FUS+μBs(F&B)group(p=0.0021).The second coronal slice in the F&B group had an obvious hemorrhage lesion,and the FUS+μBs+edaravone(F&B&E)group had smaller hemorrhage areas;however,ICH did not occur in the FUS group.The cerebral infarction volume in the F&B group was significantly larger than that in the FUS group(p=0.0030)and F&B&E group(p=0.0208).HE staining results showed that nerve fibrinolysis,neuronal necrosis,microglia production,and erythrocytes were found in both the F&B group and the F&B&E group,but the areas of the nerve fibrinolysis and neuronal necrosis in the F&B group were larger than the F&B&E group.Conclusions:A rat ICH model was successfully prepared using theμBs assisted FUS treatment,and edaravone had a therapeutic effect on this model.This model can be used to study the pathophysiological mechanism of ICH-related diseases and in preclinical research on related new drugs.

关键词： focused ultrasound(FUS) ICH model microbubbles(μBs) rat

Optimal design of anchor cables for slope reinforcement based on stress and displacement fields

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Journal of Rock Mechanics and Geotechnical Engineering 2015年第4期7卷 411-420页

作者： Guanghua Yang zhihui zhong Yucheng Zhang Xudong Fu School of Civil and Architectural Engineering Wuhan University Guangdong Research Institute of Water Resources and Hydropower Geotechnical Engineering Technology Center of Guangdong Province Emergency Technology Research Center of Guangdong Province for Public Events

How to determine reasonable position and length of anchor cable is a frequently encountered but not well addressed problem in slope reinforcement projects. In this paper, the variable-modulus elastoplastic strength reduction method （SRM） is used to obtain the stress field, displacement field, and factor of safety of slope. Slope reinforcement using anchor cables is modeled by surface loading, i.e. different distributions of surface loading represent various reinforcement schemes. Optimal reinforcement scheme of anchor cables can be determined based on slope stress and displacement fields. By comparing the factor of safety and stress field before and after slope reinforcement, it is found that better rein-forcement results can be achieved if strong reinforcement is applied upon the regions with high stress and large displacement. This method can well optimize the arrangement of anchor cables. In addition, several cases are employed to verify the proposed method.

关键词： Slope Stress levelDisplacement fieldOptimal arrangementVariable-modulus elastoplastic model

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城市碧道建设理念下的河涌分段岸线整治实践

云南水力发电 2024年第3期40卷 135-138页

作者：钟志慧吴川市长岐水利工程管理所广东吴川524500

碧道建设旨在改善河道周边环境,提升河道生态功能,湛江市旧县河流域碧道工程,沿着河道岸线布设了碧道道路和碧道绿色景观,在河道沿线6个节点处因地制宜布置与流域现状和当地特色相符合的人行栈桥、亲水平台、景观廊架、景观亭、滨水公... 详细信息

碧道建设旨在改善河道周边环境,提升河道生态功能,湛江市旧县河流域碧道工程,沿着河道岸线布设了碧道道路和碧道绿色景观,在河道沿线6个节点处因地制宜布置与流域现状和当地特色相符合的人行栈桥、亲水平台、景观廊架、景观亭、滨水公园、园林绿化等景观,并对河流进行清淤疏浚和护岸整治,打造了属于旧县河人文与自然相结合的独特碧道生态名片。

关键词：生态文明碧道建设水生态治理景观规划

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三钢6号高炉大修开炉达产实践

福建冶金 2024年第3期53卷 20-23页

作者：钟指辉福建三钢闽光股份有限公司福建三明365000

对福建三钢6号高炉大修后开炉达产操作进行了总结。通过设备可靠性运行调试,严格的烘炉操作,充分的试漏试压,精准的开炉料全炉焦比、碱度及装料位置、合理送风参数的选择,对送风后冶炼进程的有效控制,合理的首炉铁时间选择,料制的动态... 详细信息

对福建三钢6号高炉大修后开炉达产操作进行了总结。通过设备可靠性运行调试,严格的烘炉操作,充分的试漏试压,精准的开炉料全炉焦比、碱度及装料位置、合理送风参数的选择,对送风后冶炼进程的有效控制,合理的首炉铁时间选择,料制的动态优化等实现了高炉顺利开炉、快速强化达产。

关键词：高炉大修开炉达产

Pyrene-tiaraed pillar[5]arene:Strong intramolecular excimer emission applicable for photo-writing

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Chinese Chemical Letters 2021年第1期32卷 345-348页

作者： Chao Peng Wenting Liang Jiecheng Ji Chunying Fan Kuppusamy Kanagaraj Wanhua Wu Guo Cheng Dan Su zhihui zhong Cheng Yang Key Laboratory of Green Chemistry&Technology College of Chemistry and Healthy Food Evaluation Research CenterSichuan UniversityChengdu 610064China Institute of Environmental Science Department of ChemistryShanxi UniversityTaiyuan 030006China Huaxi MR Research Center(HMRRC) Department of RadiologyWest China HospitalSichuan UniversityChengdu 610041China

A pyrene-tiaraed pillar[5]a re ne derivative was synthesized,which showed a concentration-independent intensive excimer emission.Photolysis of the pyrene-tiaraed pillar[5]arene led to a switch from excimer to monomer ... 详细信息

关键词： Pillar[n]arenes Pyrene Excimer Photo-writing

Switched enantioselectivity by solvent components and temperature in photocyclodimerization of 2-anthracenecarboxylate with 6~A,6~X-diguanidio-γ-cyclodextrins

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Chinese Chemical Letters 2018年第1期29卷 87-90页

作者： Jigao Yi Wenting Liang Xueqin Wei Jiabin Yao Zhiqiang Yan Dan Su zhihui zhong Guowei Gao Wanhua Wu Cheng Yang Key Laboratory of Green Chemistry & Technology College of Chemistry and state Key Laboratory of Biotherapy West China Medical Center Sichuan University Institute of Environmental Sciences Department of Chemistry Shanxi University

A series of 6A,6X-diguanidio-y-cyclodextrins （CDs） were used as chiral hosts for mediating the enantiodifferentiating [4 ＋4] photocyclodimerization of 2-anthracenecarboxylic acid （AC）. These γ-CD derivatives form stable 1：2 ternary complexes with AC in aqueous ammonia solutions and the head-to- head photodimers 3 and 4 were greatly enhanced in the presence of these diguanidio-γ-CDs. The enantioselectivity ofchiral photodimers 2 and 3 is a critical function of the temperature and the ammonia contents, showinz inverted oroduct chiralitv by chanzinz these external factors.

关键词： CyclodextrinsPhotocyclodimerizationAnthracenecarboxylic acidSupramolecular complexationSolvent effect

Patient-derived non-small cell lung cancer xenograft mirrors complex tumor heterogeneity

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Cancer Biology & Medicine 2021年第1期18卷 184-198页

作者： Xuanming Chen Cheng Shen Zhe Wei Rui Zhang Yongsheng Wang Lili Jiang Ke Chen Shuang Qiu Yuanli Zhang Ting Zhang Bin Chen Yanjun Xu Qiyi Feng Jinxing Huang zhihui zhong Hongxia Li Guowei Che Kai Xiao National Chengdu Center for Safety Evaluation of Drugs and National Clinical Research Center for Geriatrics West China HospitalSichuan UniversityChengdu 610000China Sichuan Kangcheng Biotechnology Co. Ltd.Chengdu 610000China Department of Thoracic Surgery West China HospitalSichuan UniversityChengdu 610000China GCP Center West China HospitalSichuan UniversityChengdu 610000China Department of Pathology West China HospitalSichuan UniversityChengdu 610000China Laboratory of Nonhuman Primate Disease Modeling Research State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610000China Center for Infectious Diseases West China HospitalSichuan UniversityChengdu 610000China

Objective:Patient-derived xenograft(PDX)models have shown great promise in preclinical and translational applications,but their consistency with primary tumors in phenotypic,genetic,and pharmacodynamic heterogeneity has not been well-studied.This study aimed to establish a PDX repository for non-small cell lung cancer(NSCLC)and to further elucidate whether it could preserve the heterogeneity within and between tumors in patients.Methods:A total of 75 surgically resected NSCLC specimens were implanted into immunodeficient NOD/SCID mice.Based on the successful establishment of the NSCLC PDX model,we compared the expressions of vimentin,Ki67,EGFR,and PD-L1 proteins between cancer tissues and PDX models using hematoxylin and eosin staining and immunohistochemical staining.In addition,we detected whole gene expression profiling between primary tumors and PDX generations.We also performed whole exome sequencing(WES)analysis in 17 first generation xenografts to further assess whether PDXs retained the patient heterogeneities.Finally,paclitaxel,cisplatin,doxorubicin,atezolizumab,afatininb,and AZD4547 were used to evaluate the responses of PDX models to the standard-of-care agents.Results:A large collection of serially transplantable PDX models for NSCLC were successfully developed.The histology and pathological immunohistochemistry of PDX xenografts were consistent with the patients’tumor samples.WES and RNA-seq further confirmed that PDX accurately replicated the molecular heterogeneities of primary tumors.Similar to clinical patients,PDX models responded differentially to the standard-of-care treatment,including chemo-,targeted-and immuno-therapeutics.Conclusions:Our established PDX models of NSCLC faithfully reproduced the molecular,histopathological,and therapeutic characteristics,as well as the corresponding tumor heterogeneities,which provides a clinically relevant platform for drug screening,biomarker discovery,and translational research.

关键词： Patient-derived xenograft(PDX) non-small cell lung cancer(NSCLC) tumor heterogeneity

A case report of iodine-125 seed placement during operation for the treatment of advanced gallbladder carcinoma with septic shock

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Oncology and Translational Medicine 2021年第2期7卷 95-98页

作者： Zhuo zhong Fei Gao Zhuo Lv zhihui zhong De Long Department of Oncology Guangzhou Hospital of Integrated Traditional and West MedicineGuangzhou 510800China Department of Minimally Invasive Interventional Radiology Sun Yat-sen University Cancer CenterGuangzhou 510060China

This case report describes a patient with advanced gallbladder cancer who developed septic shock associated with iodine-125(^(125)I)seed implantation.The treatment process is described to provide a clinical reference for similar cases.A 52-year-old woman with recurrence of advanced gallbladder cancer underwent ^(125)I seed implantation and developed postoperative sepsis with septic shock.The blood culture suggested infection with Aeromonas caviae and Enterococcus faecalis.Vancomycin and imipenem were immediately administered according to the drug sensitivity results,along with immunoglobulin therapy and vasoactive drugs.The patient’s condition gradually stabilized after comprehensive treatment.Sepsis with septic shock is a rare but potentially fatal complication of ^(125)I seed implantation.Timely administration of broad-spectrum antibiotics,immunoglobulin therapy,and vasoactive drugs is very important to stabilize the patient’s condition.Our treatment of this patient can serve as a reference for clinicians to manage this complication in similar cases.

关键词： advanced gallbladder cancer ^(125)I seed placement sepsis septic shock

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响应面优化黑青稞饼干配方研究

粮食加工 2024年第1期49卷 32-37,81页

作者：朱镇华邓艺薇胡金祥钟志惠四川旅游学院. 成都610100

为了制作一款口味与营养俱佳的黑青稞饼干,以黑青稞、面粉、鸡蛋、异麦芽糖酮醇、黄油为主要原料,利用单因素和响应面优化确定最佳配方工艺,黑青稞粉添加量57 g、鸡蛋添加量31 g、异麦芽糖醇添加量30 g、黄油添加量35 g。优化的配方工... 详细信息

为了制作一款口味与营养俱佳的黑青稞饼干,以黑青稞、面粉、鸡蛋、异麦芽糖酮醇、黄油为主要原料,利用单因素和响应面优化确定最佳配方工艺,黑青稞粉添加量57 g、鸡蛋添加量31 g、异麦芽糖醇添加量30 g、黄油添加量35 g。优化的配方工艺能够有效提高黑青稞饼干的口感、色泽、香味等。该研究对黑青稞饼干的生产和工艺优化具有一定的指导意义。

关键词：黑青稞异麦芽糖醇营养价值响应面饼干