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A novel multimodal prediction model based on DNA methylation biomarkers and low-dose computed tomography images for identifying early-stage lung cancer

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Chinese Journal of Cancer Research 2023年第5期35卷 511-525页

作者： Jing Zhang Haohua Yao Chunliu Lai Xue Sun Xiujuan Yang Shurong Li Yubiao Guo Junhang Luo zhihua wen Kejing Tang Division of Pulmonary and Critical Care Medicine the First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Urology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Respiratory and Critical Care Medicine the Fourth People’s Hospital of ShenyangShenyang 110031China Department of Pharmacy Zhujiang HospitalSouthern Medical UniversityGuangzhou 510280China Department of Radiology the First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Urology the First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Pharmacy the First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China

Objective:DNA methylation alterations are early events in carcinogenesis and immune signalling in lung *** study aimed to develop a model based on short stature homeobox 2 gene (SHOX2)/prostaglandin E receptor 4gene (PTGER4) DNA methylation in plasma,appearance subtype of pulmonary nodules (PNs) and low-dose computed tomography (LDCT) images to distinguish early-stage lung ***:We developed a multimodal prediction model with a training set of 257 *** performance of the multimodal prediction model was further validated in an independent validation set of 42 *** addition,we explored the association between SHOX2/PTGER4 DNA methylation and driver gene mutations in lung cancer based on data from The Cancer Genome Atlas (TCGA) ***:There were significant differences between the early-stage lung cancers and benign groups in the methylation *** area under a receiver operator characteristic curve (AUC) of SHOX2 in patients with solid nodules,mixed ground-glass opacity nodules and pure ground-glass opacity nodules were 0.693,0.497 and 0.864,respectively,while the AUCs of PTGER4 were 0.559,0.739 and 0.619,*** the highest AUC of0.894,the novel multimodal prediction model outperformed the Mayo Clinic model (0.519) and LDCT-based deep learning model (0.842) in the independent validation *** analysis demonstrated that patients with SHOX2/PTGER4 DNA hypermethylation were enriched in TP53 ***:The present multimodal prediction model could more efficiently distinguish early-stage lung cancer from benign PNs.A prognostic index based on DNA methylation and lung cancer driver gene alterations may separate the patients into groups with good or poor prognosis.

关键词： Pulmonary nodules susceptible loci serum tumor biomarkers polygenic risk score diagnosis

Heterogeneous graph construction and node representation learning method of Treatise on Febrile Diseases based on graph convolutional network

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Digital Chinese Medicine 2022年第4期5卷 419-428页

作者： YAN Junfeng wen zhihua ZOU Beiji School of Informatics Hunan University of Chinese MedicineChangshaHunan 410208China School of Computer Science and Engineering Hunan University of TechnologyZhuzhouHunan 412008China School of Computer Science and Engineering Central South UniversityChangshaHunan 410083China

Objective To construct symptom-formula-herb heterogeneous graphs structured Treatise on Febrile Diseases(Shang Han Lun,《伤寒论》)dataset and explore an optimal learning method represented with node attributes based on graph convolutional network(GCN).Methods Clauses that contain symptoms,formulas,and herbs were abstracted from Treatise on Febrile Diseases to construct symptom-formula-herb heterogeneous graphs,which were used to propose a node representation learning method based on GCN−the Traditional Chinese Medicine Graph Convolution Network(TCM-GCN).The symptom-formula,symptom-herb,and formula-herb heterogeneous graphs were processed with the TCM-GCN to realize high-order propagating message passing and neighbor aggregation to obtain new node representation attributes,and thus acquiring the nodes’sum-aggregations of symptoms,formulas,and herbs to lay a foundation for the downstream tasks of the prediction *** Comparisons among the node representations with multi-hot encoding,non-fusion encoding,and fusion encoding showed that the Precision@10,Recall@10,and F1-score@10 of the fusion encoding were 9.77%,6.65%,and 8.30%,respectively,higher than those of the non-fusion encoding in the prediction studies of the *** Node representations by fusion encoding achieved comparatively ideal results,indicating the TCM-GCN is effective in realizing node-level representations of heterogeneous graph structured Treatise on Febrile Diseases dataset and is able to elevate the performance of the downstream tasks of the diagnosis model.

关键词： Graph convolutional network(GCN) Heterogeneous graph Treatise on Febrile Diseases(Shang Han Lun,《伤寒论》) Node representations on heterogeneous graph Node representation learning

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大疱性系统性红斑狼疮临床资料分析

中国麻风皮肤病杂志 2020年第5期36卷 259-261,266页

作者：温志华姚煦中国医学科学院皮肤病医院南京210042

分析国内近20年发表的大疱性系统性红斑狼疮38篇文献,共57例,其中女47例,男10例,平均(26.6±11.8)岁;典型皮损为暗红色斑疹或正常皮肤上出现水疱大疱;常累及血液系统(64.9%)、肾脏(61.4%)及关节(57.9%);ANA阳性率为100%、dsDNA阳性率为6... 详细信息

分析国内近20年发表的大疱性系统性红斑狼疮38篇文献,共57例,其中女47例,男10例,平均(26.6±11.8)岁;典型皮损为暗红色斑疹或正常皮肤上出现水疱大疱;常累及血液系统(64.9%)、肾脏(61.4%)及关节(57.9%);ANA阳性率为100%、dsDNA阳性率为66.7%、Sm抗体阳性率为59.6%;89.1%患者症状得到控制,其中23.6%患者单用糖皮质激素有效,76.4%患者联用DDS或其他免疫抑制剂。

关键词：大疱性系统性红斑狼疮

“意象”与“比兴”碰撞融合的意义——以《文心雕龙》为例

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上海师范大学学报（哲学社会科学版） 2015年第5期44卷 125-131页

作者：曹旭文志华上海师范大学人文与传播学院上海200234 广西教育学院中文系广西南宁530023

考察了《文心雕龙》中"意象"、"比兴"两个概念,认为两者之间已经开始出现融合的趋势,这种融合为后来的"兴象"理论提供了理论依据。同时指出,这种现象是因为"比兴"理论自身的缺陷造成的,"意象"理论在一定程度上填补了"比兴"理论的缺陷,... 详细信息

考察了《文心雕龙》中"意象"、"比兴"两个概念,认为两者之间已经开始出现融合的趋势,这种融合为后来的"兴象"理论提供了理论依据。同时指出,这种现象是因为"比兴"理论自身的缺陷造成的,"意象"理论在一定程度上填补了"比兴"理论的缺陷,并且为诗歌的意义别开生面,为诗歌的发展提供了新的生长点。

关键词：意象比兴兴象碰撞与融合

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辞赋遗传与宫体诗新变

上海师范大学学报（哲学社会科学版） 2011年第3期40卷 59-67页

作者：曹旭文志华上海师范大学人文与传播学院上海200234

在中国文学形式中,赋是诗的一个旁支,在历史的演变中此消彼长,互相依存、互为补充。辞赋在两汉四百年的流行过程中一度打压了诗,成了一个时代文学的主体样式,对后世的诗歌产生了或多或少的影响。作者通过对战国以来辞赋和宫体诗的文本解... 详细信息

在中国文学形式中,赋是诗的一个旁支,在历史的演变中此消彼长,互相依存、互为补充。辞赋在两汉四百年的流行过程中一度打压了诗,成了一个时代文学的主体样式,对后世的诗歌产生了或多或少的影响。作者通过对战国以来辞赋和宫体诗的文本解读,探索宫体诗在新变的过程中,如何汲取赋的因素和资源。用写赋的方法写诗,重视"铺排",力求"形似",忽略比兴。在内容、结构、语汇、风格上,使宫体诗成为最具辞赋意味和写作方法的诗歌,而新变后的字法、句法、对偶等形式美学,便成了唐人五言绝句和五言律诗的先驱。

关键词：宫体诗辞赋继承关系

Expressions of FAK and Pyk2 in human astrocytic tumors and their relationship with angiogenesis

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The Chinese-German Journal of Clinical Oncology 2008年第11期7卷 658-660页

作者： Zhiqiang Li Xianhou Yuan Zhimin Wu Zhiwang Guo Pucha Jiang zhihua wen Department of Neurosurgery Zhongnan Hospital of Wuhan University Wuhan 430071 China

Objective： To study the expressions of FAK and Pyk2 in human astrocytic tumors and their relationship with angiogenesis. Methods： The S-P immunohistochemical method was used to measure the expressions of FAK, Pyk2 and VEGF proteins in 58 human brain astrocytic tumors, and microvessel density （MVD） was detected by CD31 staining. Results： In astrocytic tumors with Ⅰ, Ⅱ, Ⅲ and Ⅳ grades, the positive rates of FAK were 20.00%, 26.67%, 44.44% and 50.00%, respectively, those of Pyk2 were 40.00%, 60.00%, 77.78% and 85.00%, respectively. FAK and Pyk2 expressions, especially Pyk2, correlated positively with VEGF expression and MVD. Conclusion： FAK and Pyk2 plays the important role in astrocytic tumor angiogenesis through regulation to VEGF.

关键词： astrocytic tumor FAK Pyk2 angiogenesis

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宫体诗与萧纲的“文学放荡论”

上海师范大学学报（哲学社会科学版） 2010年第4期39卷 53-61,136页

作者：曹旭文志华上海师范大学人文与传播学院上海200234

作为影响深远的诗歌流派和类型,宫体诗从产生至消亡,至少有一百年以上的历史;宫体诗学则延绵数世纪,其内涵伴随中国诗学的发展已成为其中不可缺或的审美要素。它的产生、发展、繁荣,绝对有理论的支撑和思想的指导。但现在的宫体诗理论,... 详细信息

作为影响深远的诗歌流派和类型,宫体诗从产生至消亡,至少有一百年以上的历史;宫体诗学则延绵数世纪,其内涵伴随中国诗学的发展已成为其中不可缺或的审美要素。它的产生、发展、繁荣,绝对有理论的支撑和思想的指导。但现在的宫体诗理论,似乎只是一些任人掇拾的书信和理论的碎片,这其实是一种误解。作者以萧纲的"文学放荡论"为核心,结合萧绎和其他宫体诗人的序跋、书信、言论,从整体上考察萧纲的宫体诗学理论,包括诗歌的发生论、本质论、创作论、功能论和新变论。考察宫体诗创作和"文学放荡论"之间的互动关系。把"立身"与"文章",把身边真实的世界和文学幻想的世界截然分开的"文学放荡论",既是宫体诗审美意识新变的产物,反过来又指导创作,促进审美意识的新变,在中国古代诗学上,具有独一无二的意义。

关键词：萧纲萧绎宫体诗文学放荡论诗学意义

Ezrin蛋白与E钙黏素在脑胶质瘤中的表达及意义

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武汉大学学报（医学版） 2010年第5期31卷 676-679,I0002页

作者：周龙袁先厚文志华武汉大学中南医院神经外科湖北武汉430071

目的:研究埃兹蛋白(Ezrin)和E钙黏素(E-cadherin)在人脑胶质瘤中的表达及其意义。方法:采用SP免疫组化方法检测Ezrin、E-cadherin在40例不同级别胶质瘤及10例正常脑组织中的表达。结果:Ezrin蛋白、E-cadherin蛋白的阳性表达,在正常脑组... 详细信息

目的:研究埃兹蛋白(Ezrin)和E钙黏素(E-cadherin)在人脑胶质瘤中的表达及其意义。方法:采用SP免疫组化方法检测Ezrin、E-cadherin在40例不同级别胶质瘤及10例正常脑组织中的表达。结果:Ezrin蛋白、E-cadherin蛋白的阳性表达,在正常脑组织与胶质瘤组之间存在显著差异(P2年组与生存时间≤2年组之间差异亦有显著性(P<0.01,P<0.05)。Ezrin的阳性表达随着肿瘤级别的升高而增高(P<0.05),E-cadherin的阳性表达随着肿瘤级别的升高而降低(P<0.05);Ezrin与E-cadherin的阳性表达呈明显负相关(rs=-0.685,P<0.01)。结论:Ezrin的过度表达和E-cadherin的表达下调在胶质瘤的侵袭及恶性进展中起着重要作用。Ezrin和E-cadherin的表达可能与胶质瘤患者的预后密切相关,提示可作为反映胶质瘤恶性程度与预后的指标。

关键词：神经胶质瘤埃兹蛋白 E钙黏素免疫组织化学技术

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以绩效指标体系推进教育信息化建设

开放教育研究 2005年第2期11卷 84-86页

作者：焦宝聪温志华首都师范大学北京100037

该文针对我国目前中小学教育信息化效益低下的问题,提出必须对教育信息化的绩效进行评价, 建立科学、可行、导向性强的绩效指标体系,并通过对教育信息化绩效指标体系内涵的探讨,提出了绩效指标体系的独特作用及构建指标体系的一些原则。

关键词：绩效指标体系教育信息化建设中小学教育信息化效益低下独特作用导向性