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Mechanistic investigation on Ag-Cu_(2)O in electrocatalytic CO_(2) to CH_(4) by in situ/operando spectroscopic and theoretical analysis

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Journal of Energy Chemistry 2024年第1期88卷 521-531,I0012页

作者： Min Sun Luxiao Zhang Fuli Tian Jiaxin Li Yanqiu Lei Heng Zhang Lifeng Han zhihua guo Yonghui Gao Fenrong Liu Yan Wang Luhui Wang Shanghong Zeng School of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot 010021Inner MongoliaChina Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province Hainan Vocational University of Science and TechnologyHaikou 571126HainanChina State Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030Inner MongoliaChina Zhejiang Key Laboratory of Petrochemical Environmental Pollution Control Zhejiang Ocean UniversityZhoushan 316022ZhejiangChina

Silver-copper electrocatalysts have demonstrated effectively catalytic performance in electroreduction CO_(2) toward CH_(4),yet a revealing insight into the reaction pathway and mechanism has remained elusive.Herein,we construct chemically bonded Ag-Cu_(2)O boundaries,in which the complete reduction of Cu_(2)O to Cu has been strongly impeded owing to the presence of surface Ag shell.The interfacial confinement effect helps to maintain Cu^(+)sites at the Ag-Cu_(2)O boundaries.Using in situ/operando spectroscopy and theoretical simulations,it is revealed that CO_(2) is enriched at the Ag-Cu_(2)O boundaries due to the enhanced physisorption and chemisorption to CO_(2),activating CO_(2) to form the stable intermediate^(*)CO.The boundaries between Ag shell and the Cu_(2)O mediate local^(*)CO coverage and promote^(*)CHO intermediate formation,consequently facilitating CO_(2)-to-CH_(4) conversion.This work not only reveals the structure-activity relationships but also offers insights into the reaction mechanism on Ag-Cu catalysts for efficient electrocatalytic CO_(2) reduction.

关键词： Ag shell Interfacial confinement effect Cu~+ Local*CO coverage CO_(2)reduction

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黄芪活性成分治疗心力衰竭作用机制的研究进展

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中国实验方剂学杂志 2024年第3期30卷 208-217页

作者：施敏魏佳明袁惠郭志华湖南中医药大学长沙410208 慢病中医智能诊断与治未病湖南省重点实验室长沙410208 互联网+慢病中医诊治与养生智能化应用研究生联合培养基地长沙410208

心力衰竭是当前主要的心血管系统疾病之一,是一种因心脏结构及功能变化,导致射血功能受损或心室充盈的临床综合征,已成为21世纪最为重要的心血管病症,近年来,心力衰竭的发病率逐年上升,且心力衰竭患者的生存率极低。中医药在防治心力衰... 详细信息

心力衰竭是当前主要的心血管系统疾病之一,是一种因心脏结构及功能变化,导致射血功能受损或心室充盈的临床综合征,已成为21世纪最为重要的心血管病症,近年来,心力衰竭的发病率逐年上升,且心力衰竭患者的生存率极低。中医药在防治心力衰竭方面有着丰富经验,随着中医药现代化发展,中药有效活性成分的研究与开发应用得到越来越多的关注。中医药通过辨证论治多靶点多通路在改善心力衰竭患者的心功能方面有独特优势。中药黄芪作为一种益气活血类药物,有益气活血、扶正祛邪的功效,具有改善心肌能量代谢、改善血流动力学、保护心肌、促进血管生成等作用,临床中以黄芪治疗各类心力衰竭患者,常获良效。近年来研究发现黄芪主要活性成分黄芪甲苷、黄芪多糖、槲皮素、毛蕊异黄酮等可通过抑制炎症反应、抑制心肌细胞凋亡、抑制心肌纤维化等多种途径改善心功能治疗心力衰竭。该文通过梳理相关文献,对黄芪活性成分在治疗心力衰竭的作用及机制进行了综述,以期为其在防治心力衰竭中的深入研究及开发应用提供参考。

关键词：黄芪黄芪甲苷Ⅳ 黄芪多糖槲皮素毛蕊异黄酮心力衰竭

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Nonintubated thoracoscopic lobectomy plus lymph node dissection following segmentectomy for central type pulmonary masses

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Chinese Journal of Cancer Research 2013年第1期25卷 124-127页

作者： Wenlong Shao Wei Wang Weiqiang Yin zhihua guo Guilin Peng Ying Chen Jianxing He Department of Thoracic Surgery the First Affiliated Hospital of Guangzhou Medical College Guangzhou Research Institute of Respiratory Disease China State Key Laboratory of Respiratory Disease

Lung cancer is the most common cancer worldwide. In the United States, it causes more cancer-related deaths than the next four causes （breast cancer, prostate cancer, colon cancer, and pancreatic cancer） of cancer-related mortality combined （1）. About 30% of people have already progressed to stage III lung cancer and 40% to stage IV at the time they are diagnosed （2）. Although chest X-ray and sputum cytology, when applied in health check-ups, can identify some relatively small tumors, they are not able to lower the overall mortality （3）. More recently,

关键词： node VATS Nonintubated thoracoscopic lobectomy plus lymph node dissection following segmentectomy for central type pulmonary masses lung

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C*-Algebra BH(I) Consisting of Bessel Sequences in a Hilbert Space

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Journal of Mathematical Research with Applications 2015年第2期35卷 191-199页

作者： zhihua guo Maoren YIN Huaixin CAO College of Mathematics and Information Science Shaanxi Normal University Department of Mathematics Junior College of Xinzhou Teachers University

Let H be a separable Hilbert space, B H(I), B(H) and K(H) the sets of all Bessel sequences {f i}i∈I in H, bounded linear operators on H and compact operators on H, respectively. Two kinds of multiplications and involutions are introduced in light of two isometric linear isomorphisms αH : B H(I) → B(?2), β : B H(I) → B(H), respectively, so that B H(I) becomes a unital C*-algebra under each kind of multiplication and involution. It is proved that the two C*-algebras(B H(I), ?, ?) and(B H(I), ·, *) are *-isomorphic. It is also proved that the set F H(I) of all frames for H is a unital multiplicative semi-group and the set R H(I) of all Riesz bases for H is a self-adjoint multiplicative group, as well as the set K H(I) := β-1(K(H)) is the unique proper closed self-adjoint ideal of the C*-algebra B H(I).

关键词： C *-algebra Bessel sequence Hilbert space frame Riesz basis

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Characterizing Bell nonlocality and EPR steering

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Science China(Physics,Mechanics & Astronomy) 2019年第3期62卷 22-35页

作者： HuaiXin Cao zhihua guo School of Mathematics and Information Science Shaanxi Normal University

Bell nonlocality and Einstein-Podolsky-Rosen(EPR) steering are very important quantum correlations in composite quantum systems. Bell nonlocality of a bipartite state is observed in some local quantum measurements, while EPR steering was first observed by Schr o¨dinger in the context of famous EPR paradox. In this paper, we discuss the Bell nonlocality and EPR steering of bipartite states, including mathematical definitions and characterizations of these two quantum correlations, the convexity as well as the closedness of the sets of all Bell local states and all EPR unsteerable states, respectively. We also derive sufficient conditions for a state to be steerable; these conditions imply that Alice can steer Bob's state whenever Alice has two POV measurements such that the sets of Bob's normalized conditional states become two disjoint sets of pure states, or whenever she has one POV measurement such that Bob's normalized conditional states become a linearly independent set of pure states.

关键词： quantum state Bell nonlocality EPR steering composite quantum system quantum measurement

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Reduction-sensitive nanomicelles:Delivery celastrol for retinoblastoma cells effective apoptosis

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Chinese Chemical Letters 2021年第3期32卷 1046-1050页

作者： zhihua guo Liuqi Shi Huayang Feng Fan Yang Zhanrong Li Junjie Zhang Lin Jin Jingguo Li Henan Eye Hospital Henan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhou 450003China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China

Celastrol,a Chinese herbal medicine,has exhibited anticancer activity in many types of cancer cells.However,the further clinical application of celastrol is restricted by its poor water solubility and serious side effects.Furthermore,the apoptosis mechanism of tumor cells induced by celastrol has not been exhausted yet.In this study,we developed a reduction sensitive polymeric vector for tumor-targeted celastrol delivery.And our researches indicated that the celastrol could be delivered by reductionsensitive nanomedicine(RSNMs)with a controlled release strategy.Meanwhile,the cell uptake results indicated that excellent reduction-sensitive behavior of RSNMs could effectively accelerate celastrol into the human retinoblastoma(RB)cell.The cell cytotoxicity assay demonstrated that celastrol inhibited proliferation of human RB Y79 cells growth in a dose-dependent manner.Furthermore,the results of flow cytometry and terminal dUTP nick-end labeling(TUNEL)staining showed that celastrol induced apoptosis of the RB Y79 cells,and revealed a time-dependent increase in apoptosis induction of RB Y79 cells.The results of western blotting showed that celastrol induced the apoptosis of human RB Y79 cells involving the activation of caspase-3 and caspase-9.In conclusion,our results revealed that RSNMs may be utilized as a novel therapy for retinoblastoma.

关键词： Reduction-sensitive Nanomicelles Retinoblastoma Celastrol Cell apoptosis

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心痛泰颗粒对动脉粥样硬化ApoE^(−/−)小鼠ox-LDL、ICAM-1和VCAM-1表达的影响

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中国病理生理杂志 2024年第6期40卷 989-996页

作者：曾清华尹紫薇黄爱思陈景怡郭志华魏佳明湖南中医药大学中医学院慢病中医智能诊断与治未病湖南省普通高等学校重点实验室互联网+慢病中医诊治与养生智能化应用研究生联合培养基地湖南长沙410208

目的:探讨心痛泰颗粒对动脉粥样硬化ApoE^(−/−)小鼠氧化型低密度脂蛋白(ox-LDL)、细胞间黏附分子1(ICAM-1)和血管细胞黏附分子1(VCAM-1)表达的影响及其机制。方法:6~8周龄SPF级健康雄性ApoE^(−/−)小鼠72只,采用高脂饮食喂养12周进行造模... 详细信息

目的:探讨心痛泰颗粒对动脉粥样硬化ApoE^(−/−)小鼠氧化型低密度脂蛋白(ox-LDL)、细胞间黏附分子1(ICAM-1)和血管细胞黏附分子1(VCAM-1)表达的影响及其机制。方法:6~8周龄SPF级健康雄性ApoE^(−/−)小鼠72只,采用高脂饮食喂养12周进行造模,另设SPF级健康雄性C57BL/6J野生小鼠12只为对照组,予以普通饲料喂养。各组相应药物给药8周后,观察各组小鼠体质量及一般情况,采用生化试剂盒检测小鼠血清中总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)含量,HE染色和油红O染色观察主动脉病理结构,ELISA法检测血清ox-LDL及主动脉组织中ICAM-1和VCAM-1水平,Western blot法检测主动脉NADPH氧化酶4(NOX4)、NOX亚单位p22phox、核因子抑制蛋白激酶α(IKK-α)、IKK-β和核因子κB(NF-κB)蛋白表达情况。结果:与对照组比较,模型组小鼠体质量增加(P<0.05),且毛发晦暗无光泽、局部脱落,抓起反应迟钝;血清TC、TG和LDL-C上升,HDL-C下降(P<0.05),血清ox-LDL水平上升(P<0.05),主动脉ICAM-1和VCAM-1水平升高(P<0.05),主动脉NOX4、p22phox、IKK-α、IKK-β和NF-κB蛋白表达增加(P<0.05)。与模型组比较,各用药组小鼠体质量下降(P<0.05),且毛发脱落及反应灵活程度亦有所改善;血清TC、TG和LDL-C降低,HDL-C升高(P<0.05),血清ox-LDL水平下降(P<0.05),主动脉ICAM-1和VCAM-1水平降低(P<0.05),主动脉NOX4、p22phox、IKK-α、IKK-β和NF-κB蛋白表达减少(P<0.05)。HE及油红O染色显示,模型组小鼠血管内可见典型动脉粥样硬化斑块,且红染区域分布广泛;各用药组与模型组比较,以上情况均有不同程度减轻。结论:心痛泰颗粒可减少高脂饮食诱导的ApoE^(−/−)小鼠动脉粥样硬化斑块面积,下调血清TC、TG和LDL-C水平,升高HDL-C水平,减少血清ox-LDL水平,下调主动脉ICAM-1和VCAM-1水平,抑制主动脉NOX4、p22phox、IKK-α、IKK-β和NF-κB蛋白的表达,改善动脉粥样硬化。

关键词：动脉粥样硬化心痛泰颗粒氧化型低密度脂蛋白细胞间黏附分子1 血管细胞黏附分子1

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Ca^(2+)-supplying black phosphorus-based scaffolds fabricated with microfluidic technology for osteogenesis

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Bioactive Materials 2021年第11期6卷 4053-4064页

作者： Zhanrong Li Xingcai Zhang Jiang Ouyang Dandan Chu Fengqi Han Liuqi Shi Ruixing Liu zhihua guo Grace X.Gu Wei Tao Lin Jin Jingguo Li Henan Provincial People’s Hospital Zhengzhou University People’s HospitalZhengzhou450003People’s Republic of China International Joint Research Laboratory for Biomedical Nanomaterials of Henan Zhoukou Normal UniversityZhoukou466001People’s Republic of China Center for Nanomedicine Brigham and Women’s HospitalHarvard Medical SchoolBostonMA02115United States School of Engineering and Applied Sciences Harvard UniversityCambridgeMA02138United States School of Engineering Massachusetts Institute of TechnologyCambridgeMA02139United States Department of Mechanical Engineering University of CaliforniaBerkeleyCA94720-1740United States

Effective osteogenesis remains a challenge in the treatment of bone defects.The emergence of artificial bone scaffolds provides an attractive solution.In this work,a new biomineralization strategy is proposed to facilitate osteogenesis through sustaining supply of nutrients including phosphorus(P),calcium(Ca),and silicon(Si).We developed black phosphorus(BP)-based,three-dimensional nanocomposite fibrous scaffolds via microfluidic technology to provide a wealth of essential ions for bone defect treatment.The fibrous scaffolds were fabricated from 3D poly(L-lactic acid)(PLLA)nanofibers(3D NFs),BP nanosheets,and hydroxyapatite(HA)-porous SiO2 nanoparticles.The 3D BP@HA NFs possess three advantages:i)stably connected pores allow the easy entrance of bone marrow-derived mesenchymal stem cells(BMSCs)into the interior of the 3D fibrous scaffolds for bone repair and osteogenesis;ii)plentiful nutrients in the NFs strongly improve osteogenic differentiation in the bone repair area;iii)the photothermal effect of fibrous scaffolds promotes the release of elements necessary for bone formation,thus achieving accelerated osteogenesis.Both in vitro and in vivo results demonstrated that the 3D BP@HA NFs,with the assistance of NIR laser,exhibited good performance in promoting bone regeneration.Furthermore,microfluidic technology makes it possible to obtain high-quality 3D BP@HA NFs with low costs,rapid processing,high throughput and mass production,greatly improving the prospects for clinical application.This is also the first BP-based bone scaffold platform that can self-supply Ca^(2+),which may be the blessedness for older patients with bone defects or patients with damaged bones as a result of calcium loss.

关键词： Black phosphorus Bone defect Osteogenesis Artificial bone scaffold Biomineralization

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Underpotential Deposition Preparation of Pt-loading AuNPs/Reduced Graphene Oxide and Its Catalytic Detection of Catechol

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Chinese Journal of Chemistry 2016年第11期34卷 1151-1157页

作者： Cong Wang zhihua guo Li Zhang Na Zhang Keying Zhang Bailu Fei Hongyan Wang Jigui Xu Hongwei Shi Miao Qin Lei Ren Xingxing Wu A nhui Key Laboratory of Spin Electron and Nanomaterials School of Chemistry and Chemical Engineering Suzhou University Suzhou Anhui 234000 China School of Biology and Food Engineering Suzhou University Suzhou Anhui 234000 China College of Chemistry and Materials Science Anhui Normal University Wuhu Anhui 241000 China

Ultralow Pt-loading Au nanoparticles have been fabricated on the surface of reduced graphene oxide （RGO） by using underpotential deposition （UPD） monolayer redox replacement process. The Pt/Au/RGO modified electrode exhibits an excellent electrocatalytic activity toward catechol and hydroquinone. Under the optimized condition, the separation of peak-to-peak between hydroquinone and catechol is 197 mV, which is wide enough to distinguish the isomers of benzenediol. Catechol is detected by the Pt/Au/RGO/GCE with a low detection limit in the presence of hydroquinone.

关键词： reduced graphene oxide catechol underpotential deposition Pt-loading Au nanoparticles

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益心泰对慢性心力衰竭大鼠线粒体分裂蛋白Fis1、Mff的影响

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中国实验方剂学杂志 2024年第4期30卷 143-151页

作者：刘承鑫魏佳明王子焱施敏袁惠唐云李雅郭志华湖南中医药大学第一中医临床学院中医学院药学院慢病中医智能诊断与治未病湖南省普通高等学校重点实验室互联网+慢病中医诊治与养生智能化应用研究生联合培养基地长沙410208

目的:研究益心泰对慢性心力衰竭大鼠线粒体分裂蛋白的干预作用及其机制。方法:60只SD大鼠随机抽取10只作为假手术组,剩余50只采用结扎左冠状动脉前降支法制备心肌梗死后心力衰竭大鼠模型。将造模成功的大鼠随机分为模型组、益心泰低、... 详细信息

目的:研究益心泰对慢性心力衰竭大鼠线粒体分裂蛋白的干预作用及其机制。方法:60只SD大鼠随机抽取10只作为假手术组,剩余50只采用结扎左冠状动脉前降支法制备心肌梗死后心力衰竭大鼠模型。将造模成功的大鼠随机分为模型组、益心泰低、中、高剂量组(1.4、2.8、5.6 g·kg^(-1))、曲美他嗪组(10 mg·kg^(-1)),各给药组予相应剂量药物灌胃,模型组和假手术组给予等体积的生理盐水灌胃,连续给药28 d。采用酶联免疫吸附测定法(ELISA)检测大鼠血清氨基末端B型利钠肽(NT-pro BNP)、B型利钠肽(BNP)、腺嘌呤核苷三磷酸(ATP)含量;彩色多普勒超声成像仪检测心功能指标;苏木素-伊红(HE)染色、马松(Masson)染色法观察心脏病理形态学改变,使用Image J软件计算胶原容积分数(CVF);透射电镜观察心肌细胞超微结构变化;原位末端标记法(TUNEL)染色检测心肌组织细胞凋亡率;蛋白免疫印迹法(Western blot)检测心肌组织线粒体外膜线粒体分裂蛋白1(Fis1)、线粒体分裂因子(Mff)表达。结果:与假手术组比较,模型组血清NT-pro BNP、BNP含量显著升高(P<0.01),ATP含量显著降低(P<0.01),左心室射血分数(LVEF)及左心室短轴缩短率(LVFS)下降(P<0.01),左室舒张末期内径(LVIDd)、左室收缩末期内径(LVIDs)升高(P<0.01),心肌细胞排列紊乱、炎性细胞浸润、胶原纤维增多、CVF上升(P<0.01),心肌及线粒体出现损伤,心肌细胞凋亡指数升高(P<0.01),心肌组织线粒体分裂蛋白Fis1、Mff表达上调(P<0.01);与模型组比较,益心泰低、中、高剂量组及曲美他嗪组血清NT-pro BNP、BNP含量降低(P<0.05),ATP含量升高(P<0.05),益心泰低、中、高剂量组及曲美他嗪组LVEF、LVFS升高(P<0.01),LVIDd、LVIDs均降低(P<0.01),各剂量益心泰治疗组及曲美他嗪组心肌炎症损伤减轻、纤维化得到改善,CVF降低(P<0.01),各剂量益心泰治疗组及曲美他嗪组心肌线粒体结构得到改善,各剂量益心泰治疗组及曲美他嗪组心肌细胞凋亡指数下降(P<0.01);益心泰中、高剂量组及曲美他嗪组心肌组织Fis1、Mff蛋白表达下调(P<0.05)。结论:益心泰可改善线粒体结构、减轻心肌细胞凋亡、提升心功能,其作用机制可能与抑制心肌组织线粒体分裂蛋白Fis1、Mff表达有关。

关键词：益心泰心力衰竭线粒体动力学凋亡线粒体分裂

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