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Exploring the stage-specific roles of Tcf-1 in T cell development and malignancy at single-cell resolution

Cellular & Molecular Immunology 2021年第3期18卷 644-659页

作者： Fang Wang zhihong qi Yingpengao Guotao Yu Tao Feng Tianyan Zhao Hai-Hui Xue Yaofeng Zhao Peng Jiang Li Bao Shuyang Yu State Key Laboratory of Agrobiotechnology College of Biological SciencesChina Agricultural UniversityYuanmingyuan West Road 2100193 BeijingChina Department of Microbiology and Immunology Carver College of MedicineUniversity of IowaIowa CityIA 52242USA Regenerative Biology Laboratory Morgridge Institute for ResearchMadisonWI 53707USA Department Hematology Beijing Jishuitan Hospital100096 BeijingChina

Tcf-1(encoded by Tcf7)not only plays critical roles in promoting T cell development and differentiation but also has been identified as a tumor suppressor involved in preventing T cell ***,the comprehensive mechanisms of Tcf-1 involved in T cell transformation remain poorly *** this study,Tcf7^(fl/fl)mice were crossed with Vav-cre,Lck-cre,or Cd4-cre mice to delete Tcf-1 conditionally at the beginning of the HSC,DN2-DN3,or DP stage,*** defective T cell development phenotypes became gradually less severe as the deletion stage became more advanced in distinct mouse ***,consistent with Tcf7^(-/-)mice,Tcf^(fl/fl)Vav-cre mice developed aggressive T cell lymphoma within 45 weeks,but no tumors were generated in Tcf7^(fl/fl)Lck-cre or Tcf^(fl/fl)CdA-cre ***-cell RNA-seq(ScRNA-seq)indicated that ablation of Tcf-1 at distinct phases can subdivide DN1 cells into three clusters(C1,C2,and C3)and DN2-DN3 cells into three clusters(C4,C5,and C6).Moreover,Tcf-1 deficiency redirects bifurcation among divergent cell fates,and clusters C1 and C4 exhibit high potential for leukemic ***,we found that Tcf-1 directly binds and mediates chromatin accessibility for both typical T cell regulators and proto-oncogenes#including Myb,Mycn,Runxl,and Lyl1 in the DN1 phase and Lefb ld2,Dtxb Fyn,Bclllb,and Zfp36l2 in the DN2-DN3 *** aberrant expression of these genes due to Tcf-1 deficiency in very early T cells contributes to subsequent ***,we demonstrated that Tcf-1 plays stage-specific roles in regulating early thymocyte development and transformation,providing new insights and evidence for clinical trials on T-ALL leukemia.

关键词： ScRNA-seq Tcf-1 T cell Lymphoma development Malignancy Leukemic transformation

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译传合一:中国话语对外翻译传播研究的理路

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上海交通大学学报（哲学社会科学版） 2024年第1期32卷 55-67,80页

作者：祁芝红天津师范大学外国语学院天津师范大学政治与行政学院天津300387

国际传播与对外翻译同根相系,密不可分。然而,中国话语的国际传播研究与对外翻译研究长期在传播学和翻译学两个学科框架内各自行进,相互区隔,前者蕴含的民族—国家本位思维与后者蕴含的人类—全球本位思维之间更是存有内生性矛盾。这种... 详细信息

国际传播与对外翻译同根相系,密不可分。然而,中国话语的国际传播研究与对外翻译研究长期在传播学和翻译学两个学科框架内各自行进,相互区隔,前者蕴含的民族—国家本位思维与后者蕴含的人类—全球本位思维之间更是存有内生性矛盾。这种情势严重削弱了相关学术成果的实践效能。将中国话语的国际传播与对外翻译视为两种各自独立的行为,并分别展开研究,是造成这一情势的根本原因。将国际传播与对外翻译视为一个整体,并以国际传播为立足点,展开译传合一的中国话语对外翻译传播研究,将有益于拓展国际传播研究的理论视野,提升中国话语国际传播研究的实践效能,最终为提升中国话语的国际影响力做出更大贡献。

关键词：中国话语国际传播翻译传播

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SRSF1 plays a critical role in invariant natural killer T cell development and function

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Cellular & Molecular Immunology 2021年第11期18卷 2502-2515页

作者： Jingjing Liu Menghao You Yingpeng Yao Ce Ji Zhao Wang Fang Wang Di Wang zhihong qi Guotao Yu Zhen Sun Wenhui Guo Juanjuan Liu Shumin Li Yipeng Jin Tianyan Zhao Hai-Hui Xue Yuanchao Xue Shuyang Yu State Key Laboratory of Agrobiotechnology College of Biological SciencesChina Agricultural UniversityBeijingChina Key Laboratory of RNA Biology Institute of BiophysicsChinese Academy of SciencesBeijingChina Clinical Department College of Veterinary MedicineChina Agricultural UniversityBeijingChina Center for Discovery and Innovation Hackensack Meridian HealthNutleyNJUSA

Invariant natural killer T(iNKT)cells are highly conserved innate-like T lymphocytes that originate from CD4^(+)CD8^(+)double-positive(DP)***,we report that serine/arginine splicing factor 1(SRSF1)intrinsically regulates iNKT cell development by directly targeting Myb and balancing the abundance of short and long *** ablation of SRSF1 in DP cells led to a substantially diminished iNKT cell pool due to defects in proliferation,survival,and TCRα*** transition from stage 0 to stage 1 of iNKT cells was substantially blocked,and the iNKT2 subset was notably diminished in SRSF1-deficient ***1 deficiency resulted in aberrant expression of a series of regulators that are tightly correlated with iNKT cell development and iNKT2 differentiation,including Myb,PLZF,Gata3,ICOS,and *** particular,we found that SRSF1 directly binds and regulates pre-mRNA alternative splicing of Myb and that the expression of the short isoform of Myb is substantially reduced in SRSF1-deficient DP and iNKT ***,ectopic expression of the Myb short isoform partially rectified the defects caused by ablation of ***,we confirmed that the SRSF1-deficient mice exhibited resistance to acute liver injury uponα-GalCer and Con A *** findings thus uncovered a previously unknown role of SRSF1 as an essential post-transcriptional regulator in iNKT cell development and functional differentiation,providing new clinical insights into iNKT-correlated disease.

关键词： Invariant natural killer T cell SRSF1 Development Function Alternative splicing

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重视急性肾损伤实验指标检测的影响因素及结果判读

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中华检验医学杂志 2016年第12期39卷 879-884页

作者：齐志宏崔巍中国医学科学院北京协和医学院北京协和医院检验科北京100730 中国医学科学院肿瘤医院检验科

血肌酐、胱抑素C、尿微量白蛋白、N－乙酰－β－D－葡萄糖苷酶（ NAG ）、肾损伤分子－1（KIM－1）、中性粒细胞明胶酶相关脂质运载蛋白（NGAL）、白介素18（IL－18）、L型脂肪酸结合蛋白（L－FABP）等越来越多的实验室指标用于诊断和... 详细信息

血肌酐、胱抑素C、尿微量白蛋白、N－乙酰－β－D－葡萄糖苷酶（ NAG ）、肾损伤分子－1（KIM－1）、中性粒细胞明胶酶相关脂质运载蛋白（NGAL）、白介素18（IL－18）、L型脂肪酸结合蛋白（L－FABP）等越来越多的实验室指标用于诊断和监测急性肾损伤（AKI），而这些指标的临床适用性和局限性、检测影响因素及生物学变异等对AKI的诊断和监测均很重要，尤其是如何结合检测影响因素及生物学变异判读检测结果值得实验室人员的重视。

关键词：急性肾损伤肌酐酸半胱氨酸蛋白酶抑制物C

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Effect of chemical component on shape memory effect of Fe-Mn-Si-Ni-C-RE shape memory alloy

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Rare Metals 2004年第1期23卷 87-87页

作者： SI Naichao, JIA zhihong, and qi Longbiao

Effect of chemical component on shape memory effect (SME) of Fe-Mn-Si-Ni-C-RE shape memory alloys was studied by bent measurement, thermal cycle training, SEM etc. Results of study indicate that the alloys with high Mn content (25%) appeare better SME, especially in lower strain. SME improves evidently when Si is higher content, especially it’s range from 3% up to 4%. But brittleness of Fe-Mn-Si-Ni-C-RE alloy increases by increasing the Si content. SME of the alloy is weakening gradually as carbon content increases under small strain (3%). But in the condition of large strain (above 6%), SME of the alloy whose carbon content ranges from 0.1 % to 0.12% shows small decreasing range, especially of alloy with the addition of compound RE.

关键词： chemical component Fe-Mn-Si-Ni-C-RE shape memory alloy shape memory effect strain

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翻译教学思政育人新路向——基于韦斯特利-麦克莱恩传播模式的探索

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外语研究 2024年第6期41卷 1-7页

作者：祁芝红李智天津师范大学外国语学院天津300387 天津师范大学政治与行政学院天津300387 中国传媒大学传播研究院北京100084

人文社会科学语篇翻译具有知识性与政治性双重属性,其翻译教学因而自带思政育人基因,具有极强的思政育人潜能。然而,潜能不会自动转化为效能,翻译教学思政育人实践仍然面临硬性植入难题。理论研究和教学实践表明,紧扣翻译和教学的传播本... 详细信息

人文社会科学语篇翻译具有知识性与政治性双重属性,其翻译教学因而自带思政育人基因,具有极强的思政育人潜能。然而,潜能不会自动转化为效能,翻译教学思政育人实践仍然面临硬性植入难题。理论研究和教学实践表明,紧扣翻译和教学的传播本质,以韦斯特利-麦克莱恩模式为基础框架,以传播为观察视角,以翻译传播为底层逻辑组织翻译教学,能够将翻译教学的思政育人潜能转化为效能,是解决翻译教学思政育人硬性植入难题的有效路径。

关键词：翻译教学课程思政传播韦斯特利-麦克莱恩模式

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中国科协所属全国学会国际化发展探究

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科技导报 2021年第10期39卷 90-98页

作者：高然齐志红崔正中国科协学会服务中心北京100081 北京工商大学商学院北京100048

在实施更加开放包容、互惠共享的国际科技合作战略形势下,中国科技社团的国际化发展拥有巨大的空间和潜力。然而中国科技社团国际化发展起步较晚,相关的理论与实践仍在完善。以中国科协所属全国学会为研究对象,对其国际化发展的历史和... 详细信息

在实施更加开放包容、互惠共享的国际科技合作战略形势下,中国科技社团的国际化发展拥有巨大的空间和潜力。然而中国科技社团国际化发展起步较晚,相关的理论与实践仍在完善。以中国科协所属全国学会为研究对象,对其国际化发展的历史和现状进行分析,并针对其国际化发展中面临的问题提出相应的政策建议,以期为“十四五”期间中国科技社团更好地发挥其在全球科技治理中的作用提供参考。

关键词：科技社团国际化中国科协

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TCF-1 deficiency influences the composition of intestinal microbiota and enhances susceptibility to colonic inflammation

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Protein & Cell 2020年第5期11卷 380-386页

作者： Guotao Yu Fang Wang Menghao You Tiansong Xu Chunlei Shao Yuning Liu Ruiqi Liu Min Deng zhihong qi Zhao Wang Jingjing Liu Yingpeng Yao Jingjing Chen Zhen Sun Shanshan Hao Wenhui Guo Tianyan Zhao Zhengquan Yu qian Zhang Yaofeng Zhao Feng Chen Shuyang Yu State Key Laboratory of Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health College of Biological SciencesChina Agricultural UniversityBeijing 100193China Central Laboratory School of StomatologyPeking UniversityBeijing 100081China

Dear Editor,The diversity and composition of gut microbiota play critical roles for maintaining the homeostasis of host commensal bacteria which are correlated with mammalian health(Ding and Schloss,2014).Disorder of microbial community is implicated in the pathogenesis of several human diseases,such as autoimmune disease,allergy,diabetes,obesity,and inflammatory bowel disease(IBD),which is clearly demonstrated to relate to gut dysbiosis in patients and mouse models(Saleh and Elson,2011).

关键词： inflammation homeostasis diseases

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