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Nano Research 2024年第7期17卷 6430-6442页

作者： peng Wang Qianjin Wang Dengxian Wu Yunyang Zhang Shixiong Kang Xucai Wang Jiayu Gu Hao Wu zhihong Xu Qing Jiang School of Biomedical Engineering and Informatics Nanjing Medical UniversityNanjing 211166China State Key Laboratory of Pharmaceutical Biotechnology Department of Sports Medicine and Adult Reconstructive SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Center of Modem Analysis Nanjing UniversityNanjing 210008China State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and DevicesSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210009China Co-Innovation Center for Efficient Processing and Utilization of Forest Resources College of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China Jiangsu Institute of Metrology Nanjing 210023China

Bone tissue engineering provides a promising strategy for the treatment of bone ***,the clinical utilization of biomaterial-based scaffolds is constrained by their inadequate mechanical strength and absence of osteo-inductive ***,we proposed to endow nano-scaffold(NS)constructed by coaxial electrospinning technique with enhanced osteogenic bioactivities and mechanical properties by incorporating biocompatible magnetic iron oxide nanoparticles(IONPs)and icaritin(ICA).Four types of nano-scaffolds(NS,ICA@NS,NS-IONPs and ICA@NS-IONPs)were *** incorporation of ICA and IONPs minimally impact their surface morphological and chemical *** enhanced the mechanical properties of NS scaffolds,including hardness,tensile strength,and elastic *** vitro assessments demonstrated that ICA@NS-IONPs exhibited enhanced osteogenic bioactivities towards mouse calvarial pre-osteoblast cell line MC3T3-E1 as evidenced by detecting the alkaline phosphatase(ALP)activity level,expressions of osteogenesis-related genes and proteins as well as mineralized nodule *** investigations revealed that MEK/ERK(MAP kinase-ERK kinase(MEK)/extracellularsignal-regulated kinase(ERK))signaling pathway could offer a plausible explanation for the osteogenic differentiation of MC3T3-E1 cells induced by ICA@***,the implantation of nano-scaffolds in rat skull defects exhibited a substantial improvement in in vivo bone ***,IONPs and ICA incorporated coaxial electrospinning nano-scaffolds present a novel strategy for the optimization of scaffolds for bone tissue engineering.

关键词： iron oxide nanoparticles icaritin coaxial electrospinning nano-scaffolds MEK/ERK signaling pathway bone regeneration

Chemical composition and pharmacological activity of seco-prezizaane-type sesquiterpenes

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Chinese Herbal Medicines 2024年第1期16卷 70-81页

作者： Ye Jin Yanqing Xie peng Zhang Afsar Khan zhihong Zhou Lu Liu Yunnan Yunzhong Institute of Nutrition and Health Yunnan University of Chinese MedicineKunming 650500China Department of Chemistry COMSATS University IslamabadAbbottabad CampusAbbottabad 22060Pakistan

The seco-prezizaane-type sesquiterpenes(SPS),as a special class of sesquiterpenes with a highly oxidative five-ring cage structure and seven consecutive chiral centers,are isolated from the genus Illicium,which have a variety of biological activities,including neurotoxicity and neurotrophic effects,*** review summarizes the chemical constituents and pharmacological effects of SPS,and discusses the potential trend and scope of future research.

关键词： anisatin chemical composition Illicium genus majucin pharmacological activity seco-prezizaane-type sesquiterpenes

Nutrition strategies to control post-weaning diarrhea of piglets: From the perspective of feeds

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Animal Nutrition 2024年第2期17卷 297-311页

作者： Qingsong Tang Tianyi Lan Chengyu Zhou Jingchun Gao Liuting Wu Haiyang Wei Wenxue Li Zhiru Tang Wenjie Tang Hui Diao Yetong Xu Xie peng Jiaman Pang Xuan Zhao zhihong Sun Laboratory for Bio-Feed and Molecular Nutrition College of Animal Science and Technology Southwest University Animal Breeding and Genetics Key Laboratory of Sichuan Province Sichuan Animal Science Academy Yibin Academy of Southwest University

Post-weaning diarrhea(PWD) is a globally significant threat to the swine industry. Historically, antibiotics as well as high doses of zinc oxide and copper sulfate have been commonly used to control ***, the development of bacterial resistance and environmental pollution have created an interest in alternative strategies. In recent years, the research surrounding these alternative strategies and the mechanisms of piglet diarrhea has been continually updated. Mechanically, diarrhea in piglets is a result of an imbalance in intestinal fluid and electrolyte absorption and secretion. In general, enterotoxigenic Escherichia coli(ETEC) and diarrheal viruses are known to cause an imbalance in the absorption and secretion of intestinal fluids and electrolytes in piglets, resulting in diarrhea when Cl secretion-driven fluid secretion surpasses absorptive capacity. From a perspective of feedstuffs, factors that contribute to imbalances in fluid absorption and secretion in the intestines of weaned piglets include high levels of crude protein(CP), stimulation by certain antigenic proteins, high acid-binding capacity(ABC), and contamination with deoxynivalenol(DON) in the diet. In response, efforts to reduce CP levels in diets,select feedstuffs with lower ABC values, and process feedstuffs using physical, chemical, and biological approaches are important strategies for alleviating PWD in piglets. Additionally, the diet supplementation with additives such as vitamins and natural products can also play a role in reducing the diarrhea incidence in weaned piglets. Here, we examine the mechanisms of absorption and secretion of intestinal fluids and electrolytes in piglets, summarize nutritional strategies to control PWD in piglets from the perspective of feeds, and provide new insights towards future research directions.

关键词： Post-weaning diarrhea Fluid secretion Feed Nutritional regulation strategies Piglet

Phage-displayed heptapeptide sequence conjugation significantly improves the specific targeting ability of antimicrobial peptides against Staphylococcus aureus

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mLife 2024年第2期3卷 251-268页

作者： Tao Wang peng Tan Qi Tang Chenlong Zhou Yakun Ding Shenrui Xu Mengda Song Huiyang Fu Yucheng Zhang Xiaohui Zhang Yueyu Bai zhihong Sun Xi Ma State Key Laboratory of Animal Nutrition and Feeding College of Animal Science and TechnologyChina Agricultural UniversityBeijingChina Luoyang Key Laboratory of Animal Genetic and Breeding College of Animal ScienceHenan University of Science and TechnologyLuoyangChina Key Laboratory of Innovative Utilization of Indigenous Cattle and Sheep Germplasm Resources(Co‐construction by Ministry and Province) Ministry of Agriculture and Rural AffairsZhengzhou UniversityZhengzhouChina Animal Health Supervision in Henan Province ZhengzhouChina Laboratory for Bio‐Feed and Molecular Nutrition Department of Animal Science and TechnologySouthwest UniversityChongqingChina

Broad-spectrum antibacterial drugs often lack specificity,leading to indiscriminate bactericidal activity,which can disrupt the normal microbial balance of the host flora and cause unnecessary cytotoxicity during systemic *** this study,we constructed a specifically targeted antimicrobial peptide against Staphylococcus aureus by introducing a phage-displayed peptide onto a broad-spectrum antimicrobial peptide and explored its structure–function relationship through one-factor ***2 obtained by screening based on the selectivity index and the targeting index showed specific killing ability against ***,SFK2 showed excellent biocompatibility in mice and piglet,and demonstrated significant therapeutic efficacy against *** *** conclusion,our screening of phage-derived heptapeptides effectively enhances the specific bactericidal ability of the antimicrobial peptides against ***,providing a theoretical basis for developing targeted antimicrobial peptides.

关键词： antimicrobial peptides membrane disruption mechanism microbial infection phage display technology Staphylococcus aureus

一种道路裂缝检测的变尺度VS-UNet模型

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湖南大学学报（自然科学版） 2024年第6期51卷 63-72页

作者：赵志宏何朋郝子晔石家庄铁道大学省部共建交通工程结构力学行为与系统安全国家重点实验室河北石家庄050043 石家庄铁道大学信息科学与技术学院河北石家庄050043

为解决目前现有的图像分割算法存在检测精度低、对裂缝检测缺乏针对性等问题,采用多尺度特征融合方法,提出一种扩展LG Block模块Extend-LG Block,其由多个并行不同膨胀率的空洞卷积组成.通过参数可调节分支数量和空洞卷积膨胀率,从而改... 详细信息

为解决目前现有的图像分割算法存在检测精度低、对裂缝检测缺乏针对性等问题,采用多尺度特征融合方法,提出一种扩展LG Block模块Extend-LG Block,其由多个并行不同膨胀率的空洞卷积组成.通过参数可调节分支数量和空洞卷积膨胀率,从而改变其感受野大小,进而提取和融合不同尺度的裂缝特征.对比在深层使用多尺度特征融合模块的网络以及使用固定尺度结构进行多尺度特征融合的网络的优劣,提出一种变尺度结构的UNet模型VS-UNet,使用多个不同参数的Extend-LG Block替换UNet网络中的基本卷积块.该结构在网络浅层进行多尺度特征融合,多尺度特征融合模块提取的尺度随网络层加深逐渐减少.此结构在加强图像的细节特征提取能力的同时保持原有的抽象特征提取能力,还可避免网络参数的增加.在DeepCrack数据集以及CFD数据集上进行实验验证,结果表明,相较于其他两种结构和方法,提出的变尺度结构的网络在有更高检测精度的同时,在可视化实验对比上对各种大小的裂缝有更好的分割效果.最后与其他图像分割算法进行对比,各项指标与UNet相比均有一定程度提升,证明了网络改进的有效性.研究结果可为进一步提升道路裂缝检测效果提供参考.

关键词： U-Net 多尺度裂缝检测空洞卷积深度学习

基于深度学习域适应的飞机结冰图像气泡提取方法

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南京航空航天大学学报 2024年第2期56卷 291-299页

作者：赵红梅彭博周志宏易贤西南石油大学计算机科学学院成都610050 四川大学建筑与环境学院成都610041 中国空气动力研究与发展中心结冰与防除冰重点实验室绵阳621050

针对采用深度学习方法提取结冰显微图像中的气泡需要大量标注数据,但人工标注气泡任务较为困难的问题,提出了一种基于风格迁移网络CycleGAN和图像分割网络Attention U-Net的域适应提取方法。该方法通过程序模拟气泡形态生成的图像为源域... 详细信息

针对采用深度学习方法提取结冰显微图像中的气泡需要大量标注数据,但人工标注气泡任务较为困难的问题,提出了一种基于风格迁移网络CycleGAN和图像分割网络Attention U-Net的域适应提取方法。该方法通过程序模拟气泡形态生成的图像为源域,结冰显微图像为目标域,通过CycleGAN将源域图像转为目标域风格,采用风格转换后的源域数据集训练Attention U-Net网络。通过对比实验对无标注结冰图像和少量标注图像两种情况进行验证。实验结果表明,在无标注图像的情况下,可实现无监督的结冰显微图像的气泡提取;在只有少量标注图像的情况下,该方法可实现更精确的气泡提取。

关键词：动态结冰气泡提取图像分割域适应 Attention U-Net

面向探索式搜索的领域知识图谱构建及实验探索

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图书情报工作 2024年第3期68卷 105-116页

作者：王娟曹树金王志红彭碧涛广东外语外贸大学信息科学与技术学院广州510420 山东理工大学信息管理研究院淄博255000 中关村实验室北京100094

[目的/意义]特定领域中的信息检索系统,往往因为用户自身领域知识不足存在检索效率低下的问题。现有的面向特定领域的知识组织工具,如领域知识图谱,可以有效缓解这一问题,但是如何将其更好地嵌入到现有信息检索系统中是目前尚未解决的... 详细信息

[目的/意义]特定领域中的信息检索系统,往往因为用户自身领域知识不足存在检索效率低下的问题。现有的面向特定领域的知识组织工具,如领域知识图谱,可以有效缓解这一问题,但是如何将其更好地嵌入到现有信息检索系统中是目前尚未解决的问题。因此,提出一套基于领域知识图谱的探索式搜索系统的全流程解决方案,包括从实体及关系的联合抽取、领域知识图谱构建到探索式搜索系统的实现。[方法/过程]以图情领域学术文献为研究对象,对图情领域的实体及其间关系的形式化定义进行深入的探索、提出基于Paddle UIE实现实体及关系的联合抽取任务方法,并构建一个基于可交互图情领域知识图谱的原型检索系统。[结果/结论 ]通过比较不同实体及关系联合抽取方法的效果,包括Paddle UIE、Cas Rel、Sp ERT和CORE,发现基于提示学习的预训练大语言模型Paddle UIE具有更好的抽取效果,特别是在样本量较少的情况下。此外,从进一步设计的两个搜索实验任务结果中可以发现,与通用搜索引擎相比,本文系统可以显著提高用户满意度,有效解决用户领域知识不足(如跨学科场景)下检索性能低下的问题,表明本文提出的全流程解决方案可以为学术文献服务提供方开发用户支持工具提供流程指导和建议。

关键词：领域知识图谱提示学习大模型联合抽取探索式搜索

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苛碱体系低模数硅酸钠溶液的结构

中南大学学报（自然科学版） 2024年第4期55卷 1281-1290页

作者：连选彭志宏申雷霆齐天贵周秋生李小斌刘桂华中南大学冶金与环境学院湖南长沙410083

通过红外光谱测试技术,研究二氧化硅质量浓度、模数以及放置时间对苛碱体系低模数m(m≤1)硅酸钠溶液结构的影响,比较纯硅酸钠溶液和预脱硅溶液在结构上的差异。研究结果表明:苛碱体系预脱硅溶液结构与纯硅酸钠溶液结构相似,模数0.75≤m... 详细信息

通过红外光谱测试技术,研究二氧化硅质量浓度、模数以及放置时间对苛碱体系低模数m(m≤1)硅酸钠溶液结构的影响,比较纯硅酸钠溶液和预脱硅溶液在结构上的差异。研究结果表明:苛碱体系预脱硅溶液结构与纯硅酸钠溶液结构相似,模数0.75≤m≤1.00,ρ(SiO2)≤20 g/L的硅酸钠溶液主要含有硅氧环状和三元环状这2种复杂阴离子;模数m≤0.50、30≤ρ(SiO2)≤50 g/L的硅酸钠溶液以单体和线型这2种简单形态出现;钠硅渣形成过程主要消耗单体硅酸根离子,ρ(SiO2)=50 g/L左右的预脱硅溶液结构稳定,溶液中的铝酸根离子不会影响硅酸根离子结构。

关键词：苛碱体系纯硅酸钠溶液预脱硅溶液结构红外光谱

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Convective heat transfer of water flow in intersected rock fractures for enhanced geothermal extraction

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第1期14卷 108-122页

作者： Yuedu Chen zhihong Zhao Huan peng Department of Civil Engineering Tsinghua UniversityBeijing100084China

Numerous intersected rock fractures constitute the fracture network in enhanced geothermal *** complicated convective heat transfer behavior in intersected fractures is critical to the heat recovery in fractured geothermal reservoirs.A series of three-dimensional intersected fracture models is constructed to perform the flow-through heat transfer *** geometry effects of dead-end fractures(DEFs)on the heat transfer are evaluated in terms of intersected angles,apertures,lengths,and the *** results indicate that annular streamlines appear in the rough DEF and cause an ellipse distribution of the cold *** to plate DEFs,the fluid flow in the rough DEF enhances the heat *** the increment of outlet water temperatureΔToutand the ratio of heat production Qrpresent the largest at the intersected angle of 90°while decline with the decrease of the intersected angle between the main flow fracture(MFF)and the *** extension of the length of intersected DEFs is beneficial to heat production while enhancing its aperture is not *** increasing the number of intersected DEFs induces a little increase of heat extraction,and more significant heat production can be obtained through connecting these DEFs with the MFF forming the flow network.

关键词： Heat transfer Fracture intersection Fluid flow Rough fracture Geothermal extraction