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Betulinic acid protects against ovarian impairment by decreasing F-2 toxin-induced oxidative stress and inflammation associated with the downregulation of p38 expression in mice

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Food Science and Human Wellness 2024年第3期13卷 1292-1302页

作者： Li Kong Xinyu Gao Lijuan Zhu Xing Lin You Huang Chunlin Huang Wenjiang Yang Yazhi Chen Haoqiang Zhao Jing Wu zhihang yuan Jin’e Yi Hunan Engineering Research Center of Livestock and Poultry Health Care College of Veterinary MedicineHunan Agricultural UniversityChangsha 410128China

F-2 toxin is an estrogenic mycotoxin that causes reproductive disorders in *** acid(BA)is a natural pentacyclic lupane-structure triterpenoid that has diverse pharmacological *** this study,the antioxidative and anti-inflammatory effects of BA and its underlying mechanism are explored in F-2 toxin-triggered mouse ovarian *** found that BA alleviated the F-2 toxin-induced ovarian impairment by stimulating follicle growth,reducing inflammatory cell infiltration,repairing damaged mitochondria and endoplasmic ***,BA not only reversed F-2 toxin-induced reduction of follicle stimulating hormone(FSH)and luteinizing hormone(LH)levels in the serum,but also restrained the protein expression of the estrogen receptors a(ERa)and ERβ.Moreover,BA restored the balance of F-2 toxin-induced ovarian redox system ***,we found that 0.25 mg/kg BA played an anti-inflammatory role in the F-2 toxin-induced ovarian impairment by decreasing interleukin-1β(IL-1β).IL-6,and tumor necrosis factor-α(TNF-α)mRNA expression,as well as inhibiting p38 protein *** data demonstrated that BA exerts its protective effect on F-2 toxin-induced ovarian oxidative impairment and inflammation by inhibiting p38 expression,which implies a natural product-based medicine to ameliorate F-2 toxin-caused female reproductive toxicity and provides a detoxifying method for food contaminated by mycotoxin.

关键词： Betulinic acid F-2 toxin Ovarian damage p38 MAPK signaling pathway

市政污泥衍生功能化炭材料合成及热解过程污染控制研究进展

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硅酸盐通报 2021年第5期40卷 1520-1528页

作者：袁志航楼紫阳上海交通大学环境科学与工程学院上海市固体废物处理与资源化工程研究中心上海200240 上海污染控制与生态安全研究院上海200240

市政污泥产量巨大、出路困难,如何进行有效处理并应用是个巨大挑战。本文聚焦于污泥富碳组分,利用热化学方法将其转化为功能化炭材料作为其出路的重要途径。通过对污泥衍生功能化炭材料的合成及修饰方法和热解过程污染产物原位控制研究... 详细信息

市政污泥产量巨大、出路困难,如何进行有效处理并应用是个巨大挑战。本文聚焦于污泥富碳组分,利用热化学方法将其转化为功能化炭材料作为其出路的重要途径。通过对污泥衍生功能化炭材料的合成及修饰方法和热解过程污染产物原位控制研究进行梳理发现,相较于其他方法,化学后活化法具有较强的造孔能力,其中钾系化合物效果最佳。通过污泥炭表面氧化、氨化或磺化改性可强化材料物化吸附和特异性催化特性,拓展了材料应用范围。污泥炭-纳米结构表面复合则可赋予材料多重性能,提升纳米材料稳定性和分散性。基于对污泥典型元素热化学转化分析,理清了硫氧化物和氮氧化物等的产生路径,发现金属氧化物共混热解和热源优化可显著抑制污染产物的排放。

关键词：市政污泥热解造孔方法表面修饰热解产物污染控制

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电厂燃煤与废白土混烧特性研究

环境污染与防治 2021年第10期43卷 1280-1285,1320页

作者：沈耀亚隋爱民袁志航中国石化上海高桥石油化工有限公司上海200137 上海交通大学环境科学与工程学院上海200240

以废白土作为电厂燃煤的补充燃料,进行共混燃烧,考察废白土对烟气及尾渣的影响,探讨掺烧的可行性。结果表明:(1)由管式电加热炉/傅立叶红外光谱分析可知,煤与废白土质量比为5∶1时,燃烧尾气中SO 2浓度较煤燃烧降低了32.2%,NO_(x)变化不... 详细信息

以废白土作为电厂燃煤的补充燃料,进行共混燃烧,考察废白土对烟气及尾渣的影响,探讨掺烧的可行性。结果表明:(1)由管式电加热炉/傅立叶红外光谱分析可知,煤与废白土质量比为5∶1时,燃烧尾气中SO 2浓度较煤燃烧降低了32.2%,NO_(x)变化不大。(2)由热重/质谱分析可知,由于废白土中的活性金属氧化物的催化脱氢和脱羧作用及层状多孔结构可提供氧接触位点,它的引入可使煤的分解温度由475~931℃降至475~815℃,提升燃烧效率。(3)废白土的掺烧不会增加尾渣中的重金属污染风险。(4)化学吸附作用及硫氧化物和NO_(x)间的氧化还原反应可能是主要的污染物固定机理。

关键词：废白土共混燃烧固硫作用协同作用

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日本与东盟的经贸往来与科技合作

东北亚经济研究 2018年第4期2卷 102-111页

作者：袁志航黄栋华中科技大学公共管理学院湖北武汉430074

二战以后日本非常关注与东盟国家的合作,近年来双方在经济和科技两个层面的合作日益密切,且一直保持稳定合作的态势。由于东盟国家内部存在异质性,他们与日本合作时也表现出较强的非均衡性。中国和日本同属东盟"10+3"多边机制国家,密切... 详细信息

二战以后日本非常关注与东盟国家的合作,近年来双方在经济和科技两个层面的合作日益密切,且一直保持稳定合作的态势。由于东盟国家内部存在异质性,他们与日本合作时也表现出较强的非均衡性。中国和日本同属东盟"10+3"多边机制国家,密切关注这些周边国家或地区的合作态势,对在"一带一路"倡议下中国如何进一步加强同相关国家的经贸往来和科技合作具有很好的借鉴意义。

关键词：日本-东盟经贸合作科技合作文献计量分析

桦木酸对T-2毒素诱导小鼠肝损伤的保护作用

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食品科学 2021年第9期42卷 107-114页

作者：杨成林黄超刘娟黄卫梅袁志航易金娥梁曾恩妮邬静湖南农业大学动物医学院湖南长沙410128 畜禽保健湖南省工程研究中心湖南长沙410128 湖南省农产品加工研究所湖南长沙410125

目的:探讨桦木酸(betulinic acid,BA)对T-2毒素致小鼠肝脏损伤的保护作用及其分子机制。方法:选取60只成年雄性昆明小鼠随机分为6组,分别为空白对照组、4 mg/kg mb T-2毒素组、0.25 mg/kg m_(b)BA+T-2组、0.5 mg/kg m_(b)BA+T-2组、1 mg... 详细信息

目的:探讨桦木酸(betulinic acid,BA)对T-2毒素致小鼠肝脏损伤的保护作用及其分子机制。方法:选取60只成年雄性昆明小鼠随机分为6组,分别为空白对照组、4 mg/kg mb T-2毒素组、0.25 mg/kg m_(b)BA+T-2组、0.5 mg/kg m_(b)BA+T-2组、1 mg/kg m_(b)BA+T-2组和100 mg/kg m_(b)VE+T-2组。连续灌服BA 14 d后,除空白对照组外,其余各组腹腔注射T-2毒素,建立肝损伤模型。检测小鼠血清谷丙转氨酶(alanine aminotransferase,ALT)、谷草转氨酶(aspartate aminotransferase,AST)、碱性磷酸酶(alkaline phosphatase,ALP)活力以及总蛋白(total protein,TP)质量浓度;苏木精-伊红染色观察肝脏组织病理变化;检测肝组织中总抗氧化能力(totalantioxidant capacity,T-AOC)、过氧化氢酶(catalase,CAT)、超氧化物歧化酶(superoxide dismutase,SOD)活力以及谷胱甘肽(glutathione,GSH)和丙二醛(malondialdehyde,MDA)含量;TUNEL染色检测肝细胞的凋亡;Western blot法检测肝组织中Bax、Bcl-2、Caspase-3、Janus激酶2(Janus kinase 2,JAK2)、信号传导与转录激活因子3(signal transducer and activator of transcription 3,STAT3)蛋白的表达量变化。结果:BA预处理能够缓解T-2毒素引起的小鼠血清ALT、AST、ALP活力升高和TP质量浓度的降低;能够升高肝组织中T-AOC,CAT、SOD活力和GSH含量,并降低MDA含量;减少凋亡细胞的数量,使Bcl-2表达量升高,Bax、Caspase-3、JAK2、STAT3表达量降低。结论:BA具有抗氧化能力,可通过JAK2/STAT3通路抑制肝细胞凋亡,进而缓解T-2诱导的小鼠肝脏损伤。

关键词：桦木酸 T-2毒素肝损伤氧化应激细胞凋亡

The dopaminergic system and Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuhan Zhang yuan Liang Yixue Gu International Medical College Chongqing Medical UniversityChongqingChina College of Pharmacy Chongqing Medical UniversityChongqingChina Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzheimer's disease is a common neurodegenerative disorder in older *** its prevalence,its pathogenesis remains unclea *** addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this *** is a crucial catecholaminergic neurotransmitter in the human ***-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical *** r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive *** review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related *** aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

关键词： adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional Chinese medicine treatment

Toward Analytical Homogenized Relaxation Modulus for Fibrous Composite Material with Reduced Order Homogenization Method

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Computers, Materials & Continua 2025年第1期82卷 193-222页

作者： Huilin Jia Shanqiao Huang Zifeng yuan HEDPS Center for Applied Physics and Technology(CAPT)Department of Mechanics and Engineering SciencePeking UniversityBeijing100871China State Key Laboratory for Turbulence and Complex Systems Peking UniversityBeijing100871China

In this manuscript,we propose an analytical equivalent linear viscoelastic constitutive model for fiber-reinforced composites,bypassing general computational *** method is based on the reduced-order homogenization(ROH)*** ROH method typically involves solving multiple finite element problems under periodic conditions to evaluate elastic strain and eigenstrain influence functions in an‘off-line’stage,which offers substantial cost savings compared to direct computational homogenization *** to the unique structure of the fibrous unit cell,“off-line”stage calculation can be eliminated by influence functions obtained *** the standard solid model to the ROH method enables the creation of a comprehensive analytical homogeneous viscoelastic constitutive *** method treats fibrous composite materials as homogeneous,anisotropic viscoelastic materials,significantly reducing computational time due to its analytical *** approach also enables precise determination of a homogenized anisotropic relaxation modulus and accurate capture of various viscoelastic responses under different loading *** sets of numerical examples,including unit cell tests,three-point beam bending tests,and torsion tests,are given to demonstrate the predictive performance of the homogenized viscoelastic ***,the model is validated against experimental measurements,confirming its accuracy and reliability.

关键词： Homogenized relaxation modulus viscoelastic standard solid model reduced order homogenization fibrous composite material

Optimal Scheduling of an Independent Electro-Hydrogen System with Hybrid Energy Storage Using a Multi-Objective Standardization Fusion Method

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Energy Engineering 2025年第1期122卷 63-84页

作者： SuliangMa ZeqingMeng Mingxuan Chen yuan Jiang School of Electrical and Control Engineering North China University of TechnologyBeijing100144China ChinaThree Gorges Technology Co. Ltd.Beijing100032China School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing100083China

In the independent electro-hydrogen system(IEHS)with hybrid energy storage(HESS),achieving optimal scheduling is ***,it presents a challenge due to the significant deviations in values ofmultiple optimization objective functions caused by their physical *** deviations seriously affect the scheduling process.A novel standardization fusion method has been established to address this issue by analyzing the variation process of each objective function’s *** optimal scheduling results of IEHS with HESS indicate that the economy and overall energy loss can be improved 2–3 times under different optimization *** proposed method better balances all optimization objective functions and reduces the impact of their *** the cost of BESS decreases by approximately 30%,its participation deepens by about 1 ***,if the price of the electrolyzer is less than 15￥/kWh or if the cost of the fuel cell drops below 4￥/kWh,their participation will increase *** study aims to provide a more reasonable approach to solving multi-objective optimization problems.

关键词： Electro-hydrogen system multi-objective optimization standardization method hybrid energy storage system

Sex differences in aging and injured brain

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Neural Regeneration Research 2025年第10期20卷 2901-2902页

作者： Jordan N.Williamson yuan Yang University of Illinois Urbana-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA Northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain disorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic