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Xuebijing injection alleviates liver injury by inhibiting secretory function of Kupffer cells in heat stroke rats

Journal of Traditional Chinese Medicine 2013年第2期33卷 243-249页

作者： Yi Chen Huasheng tong Xingqin Zhang Liqun Tang zhiguo Pan Zhifeng Liu Pengkai Duan Lei Su Guangzhou University of Chinese Medicine Department of ICU General Hospital of Guangzhou Military CommandKey Laboratory of Tropical Zone Trauma Care andTissue Repair of PLA

OBJECTIVE： To evaluate the effects of Xuebijing （XBJ） injection in heat stroke （HS） rats and to inves- tigate the mechanisms underlying these effects. METHODS： Sixty anesthetized rats were random- ized into three groups and intravenously injected twice daily for 3 days with 4 mL XBJ （XBJ group） or phosphate buffered saline （HS and Sham groups） per kg body weight. HS was initiated in the HS and XBJ groups by placing rats in a simulated climate chamber （ambient temperature 40℃：, humidity 60% ）. Rectal temperature, aterial pressure, and heart rate were monitored and recorded. Time to HS onset and survival were determined, and serum concentrations of tumor necrosis factor （TNF）-α, in-terleukin （IL）-1β, IL-6, alanine-aminotransferase （ALT）, and aspartate-aminotransferase （AST） were measured. Hepatic tissue was harvested for patho- logical examination and electron microscopic ex- amination. Kupffer cells （KCs） were separated from liver at HS initiation, and the concentrations of se- creted TNF-α, IL-1β3 and IL-6 were measured. RESULTS： Time to HS onset and survival were signif- icantly longer in the XBJ than in the HS group. Moreover, the concentrations of TNF-α, IL-1β, IL-6, ALT and AST were lower and liver injury was milder in the XBJ than in the HS group. Heat-stress in- duced structural changes in KCs and hepatic cells were more severe in the HS than in the XBJ group and the concentrations of TNF-α, IL-1β and IL-6 se- creted by KCs were lower in the XBJ than in the HS group. CONCLUSION： XBJ can alleviate HS-induced sys- temic inflammatory response syndrome and liver injury in rats, and improve outcomes. These protec- tive effects may be due to the ability of XBJ to inhib- it cytokine secretion by KCs.

关键词： Heat stroke Kupffer cells Systemic in-flammatory response syndrome Xuebijing Liver in-jury Inflammatory cytokines

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Numerical study on heat and mass transfer mechanisms of Janus particle sedimentation considering corrosion

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Particuology 2023年第12期83卷 71-90页

作者： zhiguo Xu Zelin Zhao School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai200240China

Janus particle is a research hotspot due to its novelty and settlement in acid liquid during wastewater *** and mass transfer mechanisms of Janus particle sedimentation considering corrosion are numerically investigated based on immersed boundary lattice Boltzmann *** reaction heat ratio,Damkohler number,Peclet number,and particle number effects on temperature field,concentration field,Janus particle mass reduction,position,and velocity are *** uniform particle has an equilibrium position of about 1/4 times the channel width for two corroded uniform particle settlement *** Janus particle horizontal position deviates from the uniform particle equilibrium position due to the force caused by nonuniform buoyancy and particle *** the chemical reaction heat ratio is more than 1,the Janus particle horizontal position is closer to the channel centerline and has a positive ***,the converse trend happens when the chemical reaction heat ratio is less than 1,and the Janus particle horizontal position has a negative *** Janus particle horizontal position deviation magnitude increases with increasing Damkohler number and decreasing Peclet *** horizontal position deviation phenomenon exists for the single corroded Janus particle and two corroded Janus particle settlement processes.

关键词： Janus particle Corrosion Equilibrium position Chemical reaction heat ratio Temperature

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Near-field radiative heat transfer enhancement by multilayers and gratings in the thermophotovoltaic system

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Science China(Technological Sciences) 2023年第10期66卷 2968-2977页

作者： XU zhiguo HU ZhiFang School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

The near-field effect can be used to improve the output power of the near-field thermophotovoltaic device(NTPV).The nearfield radiative heat transfer in the near-field thermophotovoltaic device can be enhanced by the excitation of hyperbolic modes and the coupling of surface plasmon *** this study,we design a two-body near-field thermophotovoltaic system based on hyperbolic *** multilayer structure on the emitter is composed of Ga-doped ZnO(GZO)and hafnium dioxide(HfO2).The gratings are on the InAs photovoltaic *** electrodynamics and rigorous coupled-wave method are employed to calculate radiative heat *** is found that the NTPV system with multiple microstructures performs better than the NTPV system just with single *** NTPV system performs better in a wider vacuum *** output power and efficiency are enhanced by the GZO-HfO2surface plasmon polaritons in multilayer *** gratings can monitor the spectral heat flux to match the cell band gap to enhance the performance of the near-field thermophotovoltaic *** investigation provides a novel approach for improving the output power of a two-body near-field thermophotovoltaic system.

关键词： near-field radiative heat transfer thermophotovoltaics multilayer surface plasmon polariton output power

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Clinical features and treatment outcomes of major depressive disorder with genital symptoms

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Chinese Medical Journal 2024年第5期137卷 622-624页

作者： Xiaohui Wu Yuncheng Zhu Ping Sun Shuo Wang zhiguo Wu Jia Huang Lan Cao Yun Wang Yousong Su Zhijian Yao Zuowei Wang Fan Wang Yong Wang Daihui Peng Jun Chen Yiru Fang Department of Clinical Research Center&Division of Mood Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China Department of Mood Disorders Shanghai Hongkou Mental Health CenterShanghai 200083China Department of Psychiatry Nanjing Medical University Affiliated Brain HospitalNanjingJiangsu 210029China Department of Psychiatry&Affective Disorders Center Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China Shanghai Key Laboratory of Psychotic Disorders Shanghai 200118China

To the Editor:Major depressive disorder(MDD)is a mood disorder characterized by complex patterns of emotional,cognitive,and behavioral symptomology and deficits in daily *** symptoms,including a reduction in libido and menstrual disturbances,have been considered to be a classic symptom of MDD for many *** evidence has reached a broad consensus that the incidence of genital symptoms is higher in patients with MDD than in the general population.A systematic review and meta-analysis found a bidirectional association between MDD and genital symptoms,with patients with MDD showing a 50–70%increased risk of developing genital symptoms,while individuals with genital symptoms had a 130–210%increased risk of developing MDD.^([1])As previously reported,50–70%of people with MDD experience sexual dysfunction.^([2])To date,few studies have focused on the comparison of clinical features between patients with MDD with and without genital symptoms,and the longitudinal prognosis.

关键词： symptoms Clinical features

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Two New Coordination Complexes Based on 2,2'-H2biimidazole: Synthesis, Structure, Luminescent Property and Theoretical Calculation

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Chinese Journal of Structural Chemistry 2020年第8期39卷 1451-1457,1359页

作者： ZHANG Hua XU tongtong XING Tianyi WANG Xueying ZUO Jiamei KONG zhiguo Key Laboratory of Preparation and Applications of Environmental Friendly Materials Jilin Normal UniversityMinistry of EducationChangchun 130103China Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of Education Jilin Normal UniversityMinistry of EducationChangchun 130103China Department of Chemistry Jilin Normal UniversitySiping 136000China

Two new coordination complexes[Cd(L)2(1,2,3-HBTC)]·3H2O(1)and{[Zn(L)(1,2-BDC)]-H2O}n(2)were synthesized under hydrothermal conditions(1,2,3-H3 BTC=1,2,3-tricarboxybenzene,1,2-H2 BDC=1,2-dicarboxybenzene and L=2,2’-H2 biimidazole).1 crystallizes in monoclinic,space group P21/c with a=12.256(5),b=11.620(5),c=17.479(5)A,β=95.548(5)°,V=2477.6(16)A^3,Z=4,C21H22N8 O9 Cd,Mr=642.86,Dc=1.724 g/cm^3,F(000)=1296,μ(MoKa)=0.950 mm^-1,R=0.0546 and wR=0.1724.2 belongs to the monoclinic system,space group P21/c with a=7.408(4),b=20.743(10),c=10.194(5)A,β=95.648(6)°,V=1477.3(12)A^3,Z=4,C14H12N4 O5 Zn,Mr=381.65,Dc=1.716 g/cm3,F(000)=776,μ(MoKa)=1.698 mm^-1,R=0.0574 and wR=*** central Cd(Ⅱ)ion in 1 is coordinated with five atoms,forming a slightly distorted square-pyramidal *** central Zn(Ⅱ)ion in 2 is four-coordinated by two nitrogen atoms from one L ligand and two oxygen atoms from two different 1,2-BDC *** addition,luminescent property of 1 has been investigated,and natural bond orbital(NBO)analysis of 2 has been calculated by the B3LYP/LANL2DZ method.

关键词： structure coordination complex 2,2'-H_(2)biimidazole luminescent property

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全身免疫炎症指数及躯体化症状评分对首发心梗PCI术后发生院内主要不良心血管事件的预测价值

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上海交通大学学报（医学版） 2024年第3期44卷 334-341页

作者：郑梦奕毛家亮邹治国张瑞雷张厚李世光蚌埠医科大学研究生院蚌埠233030 上海交通大学医学院附属仁济医院心内科上海200127 安徽省第二人民医院心内科合肥230041

目的·探讨全身免疫炎症指数(systemic immune inflammation index,SII)及躯体化症状评分(somatic symptom scale-China,SSS-CN)对首发急性心肌梗死(acute myocardial infarction,AMI)患者接受经皮冠状动脉介入治疗术(percutaneous coronary intervention,PCI)后发生院内主要不良心血管事件(major adverse cardiovascular event,MACE)的预测价值。方法·连续纳入2021年9月至2023年9月就诊于安徽省第二人民医院心内科并接受PCI治疗的首发AMI患者305例。根据患者住院期间是否发生MACE相关事件分为MACEs组(n=203)与非MACEs组(n=102)。对2组患者的性别、年龄、实验室检查结果等资料进行描述性统计分析,并根据分析结果对有统计学意义的项目进行二元Logistic回归检验;进一步绘制受试者操作特征(receiver operating characteristic,ROC)曲线,评估SII及SSS-CN预测院内MACE发生的价值。在此基础上联合冠状动脉syntax评分(syntax score,SS),评价三者联合的预测效能,根据最大约登指数确定诊断的最佳cut-off值。结果·共有203例患者发生MACE事件,其中179例(88.1%)患者发生心力衰竭,16例(7.9%)患者发生严重心律失常,4例(2.0%)患者发生休克,2例(1.0%)患者发生再发心肌梗死,2例(1.0%)患者死亡。与非MACE组相比,MACEs组SII及SSS-CN评分显著升高(1925.86 vs 934.23,38.57 vs 23.30;均P<0.05);二元Logistic回归分析结果提示两者均为MACE发生的独立危险因素。ROC曲线显示:当SII≥952时预测效能最佳,敏感度达64.0%,特异度达62.7%(AUC 0.675,95%CI 0.612~0.737);SSS-CN≥28.5分时预测效能最佳,敏感度达80.7%,特异度达77.5%(AUC 0.840,95%CI 0.794~0.886);联合SS后,三者对MACE的预测效能进一步提高(AUC 0.898,95%CI 0.862~0.933)。结论·首发AMI患者的入院SII及SSS-CN分值为此类患者行PCI术后住院期间发生MACE的独立危险因素,早期监测首发AMI患者PCI术后SII变化,或对有明显躯体化症状的患者及时进行SSS-CN评分能帮助识别院内MACE发生的高危患者。

关键词：全身免疫炎症指数躯体化症状评分首发急性心肌梗死主要不良心血管事件经皮冠状动脉介入治疗术

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Numerical and Experimental Investigation on Photothermal Performance of Polyimide/High-Electrical-Performance-Coating Composite Films Considering Surface Roughness

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Journal of Thermal Science 2022年第4期31卷 1206-1219页

作者： JING Peng ZHOU Xiao XU Zhengyang XU zhiguo School of Mechanical Engineering Shanghai Jiao tong University Shanghai 200240 China Sunman(Zhenjiang)Co. LtdZhenjiang 212000China

Polyimide(PI)films are the common and important components on spacecraft for thermal *** parameter design accuracy has an important impact on the spacecraft thermal balance but there are few studies focusing on the effect of film surface *** the present study,photothermal properties of composite films made of PI films and germanium/indium tin oxide/aluminum coatings are obtained by UV-VIS-NIR *** film surface morphology of composite films is obtained by the atomic force *** present study creatively introduces surface roughness into modeling from the perspective of finite-difference time-domain(FDTD)*** FDTD method considering surface roughness is used to present a comprehensive investigation on the coating effect on the photothermal properties including transmittance and reflectance of composite *** on the random rough surface generated by root-mean-square(RMS)roughness and correlation length,the FDTD method is applied to characterize the electromagnetic field of composite *** has been found that the numerical accuracy is greatly improved and the numerical results agree well with the experimental data when surface roughness is *** results also show that coating material and thickness have remarkable impacts on photothermal properties of the composite films.

关键词： FDTD composite film surface roughness photothermal property coating material

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Tribo-informatics approaches in tribology research:A review

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Friction 2023年第1期11卷 1-22页

作者： Nian YIN zhiguo XING Ke HE Zhinan ZHANG State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China National Key Laboratory for Remanufacturing Army Academy of Armored ForcesBeijing 100072China

Tribology research mainly focuses on the friction,wear,and lubrication between interacting *** the continuous increase in the industrialization of human society,tribology research objects have become increasingly *** research methods have also gone through the stages of empirical science based on phenomena,theoretical science based on models,and computational science based on *** research has a strong engineering *** to the intense coupling characteristics of tribology,tribological information includes subject information related to mathematics,physics,chemistry,materials,machinery,*** emerging data and models are the basis for the development of *** development of information technology has provided new and more efficient methods for generating,collecting,processing,and analyzing tribological *** a result,the concept of"tribo-informatics(triboinformatics)"has been *** this paper,guided by the framework of tribo-informatics,the application of tribo-informatics methods in tribology is *** article aims to provide helpful guidance for efficient and scientific tribology research using tribo-informatics approaches.

关键词： tribo-informatics data-driven artificial intelligence information technology machine learning

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Numerical Investigation on Pool Boiling Mechanism of Hybrid Structures with Metal Foam and Square Column by LBM

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Journal of Thermal Science 2022年第6期31卷 2293-2308页

作者： LIU Zhongyi QIN Jie WU Ziheng YUE Sijia XU zhiguo School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

In the present study, pool boiling heat transfer performance and bubble behaviors of hybrid structures with metal foam and square column are investigated by lattice Boltzmann method. By using the vapor-liquid phase change model of Gong-Cheng and Peng-Robinson equation of state, the effects of structural parameters, including metal foam thickness, porosity, column height and ratio of column width(W) to gap spacing(D) are investigated in details. The results show that hybrid structure performs better than pure columnar structure in pool boiling heat transfer. The hybrid structure accelerates bubble growth by fluid disturbance while metal skeletons prevent the bubble escaping. The optimum ratio of column width to gap spacing decreases with the increase of heat flux and HTC(heat transfer coefficient) can achieve an increase up to 25% when W/D change from 5/3 to 1/3. The increase of column height enhances heat transfer by expanding surface area and providing space for bubble motion. The metal foam thickness and porosity have a little influence on pool boiling heat transfer performance, but they have an important effect on bubble motion in the regime.

关键词： hybrid structure metal foam square column pool boiling heat transfer lattice Boltzmann method

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肉鸭对糖渣和酱油渣养分利用率评定

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中国畜牧兽医 2024年第11期51卷 4833-4841页

作者：吴占月郭艳红庄蕾王宁鹿震涛任雯雯徐彤王岐蒙牛志力曹俊婷吴永保吴森闻治国青海大学畜牧兽医科学院西宁810016 中国农业科学院饲料研究所农业农村部饲料生物技术重点实验室北京100081

【目的】试验旨在对糖渣和酱油渣进行营养价值评定,测定其在肉鸭中的营养物质消化率、代谢能和回肠氨基酸消化率。【方法】代谢能及养分消化率采用排空-强饲法测定,共选取24只肉鸭,随机分为糖渣组和酱油渣组,每组12个重复,每重复1只鸭,... 详细信息

【目的】试验旨在对糖渣和酱油渣进行营养价值评定,测定其在肉鸭中的营养物质消化率、代谢能和回肠氨基酸消化率。【方法】代谢能及养分消化率采用排空-强饲法测定,共选取24只肉鸭,随机分为糖渣组和酱油渣组,每组12个重复,每重复1只鸭,强饲量为60 g,排空和集粪时间均为48 h,收集肉鸭粪便样品,测定干物质、粗蛋白质、粗脂肪、粗纤维、中性洗涤纤维、酸性洗涤纤维含量和总能。使用无氮饲粮法和回肠末端法测定回肠氨基酸消化率,选取60只肉鸭,随机分为糖渣组、糖渣无氮饲粮组、酱油渣组和酱油渣无氮饲粮组,每组5个重复,每重复3只鸭,适应期3 d后分别饲喂试验饲料,4 h后统一屠宰取回肠内容物,测定氨基酸含量。【结果】糖渣中干物质含量为89.70%、粗蛋白质为21.98%、总能为26.47 MJ/kg;酱油渣中干物质含量为89.53%,粗蛋白质含量为26.65%,总能为24.06 MJ/kg。代谢试验结果表明,糖渣和酱油渣在肉鸭中的表观代谢能分别为18.09和8.59 MJ/kg,干物质消化率分别为57.46%和44.61%,粗脂肪消化率分别为84.88%和84.43%。回肠氨基酸消化率结果显示,糖渣和酱油渣试验中表观回肠消化率最高的是赖氨酸,分别为92.75%和55.60%。【结论】糖渣和酱油渣粗蛋白质含量高,氨基酸含量和组成丰富,肉鸭对粗脂肪和粗蛋白质利用率较高,可以开发作为肉鸭饲料原料应用在生产中。

关键词：糖渣酱油渣肉鸭氨基酸回肠消化率非常规饲料原料

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