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Optoelectronic Date Acquisition System Based on FPGA

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Optoelectronic Date Acquisition System Based on FPGA

A simple and efficient CRISPR/Cas9 system permits ultra-multiplex genome editing in plants

国防光电子论坛第二届新型探测技术及其应用研讨会

作者： Xin LI Chunyang LIU De SONG zhiguo tong Xiangqing LIU School of Science Changchun University of Science and Technology

An optoelectronic date acquisition system is designed based on FPGA. FPGA chip that is EP1C3T144C8 of Cyclone devices from Altera corporation is used as the centre of logic control, XTP2046 chip is used as A/D converter,host computer that communicates with the date acquisition system through RS-232 serial communication interface are used as display device and photo resistance is used as photo sensor. We use Verilog HDL to write logic control code about FPGA. It is proved that timing sequence is correct through the simulation of Model Sim. Test results indicate that this system meets the design requirement, has fast response and stable operation by actual hardware circuit test.

关键词： FPGA XTP2046 Cyclone EP1C3T144C8 photoelectric date acquisition RS-232 serial

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The Crop Journal 2024年第2期12卷 569-582页

作者： Suting Wu Htin Kyaw Zhijun tong Yirong Yang Zhiwei Wang Liying Zhang Lihua Deng zhiguo Zhang Bingguang Xiao William Paul Quick Tiegang Lu Guoying Xiao Guannan Qin Xue'an Cui Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081China Key Laboratory of Genetics Breeding and Multiple Utilization of CropsMinistry of EducationCollege of AgricultureFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Key Laboratory of Biological Breeding for Fujian and Taiwan Crops Ministry of Agriculture and Rural AffairsCollege of AgricultureFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125HunanChina School of Biosciences The University of SheffieldFirth CourtWestern BankSheffield S102TNUK Key Laboratory of Tobacco Biotechnological Breeding National Tobacco Genetic Engineering Research CenterYunnan Academy of Tobacco Agricultural SciencesKunming 650021YunnanChina

The development and maturation of the CRISPR/Cas genome editing system provides a valuable tool for plant functional genomics and genetic *** available genome-editing tools have a limited number of targets,restricting their application in genetic *** this study,we developed a novel CRISPR/Cas9 plant ultra-multiplex genome editing system consisting of two template vectors,eight donor vectors,four destination vectors,and one primer-design software *** combining the advantages of Golden Gate cloning to assemble multiple repetitive fragments and Gateway recombination to assemble large fragments and by changing the structure of the amplicons used to assemble sg RNA expression cassettes,the plant ultra-multiplex genome editing system can assemble a single binary vector targeting more than 40 genomic loci.A rice knockout vector containing 49 sg RNA expression cassettes was assembled and a high co-editing efficiency was *** plant ultra-multiplex genome editing system advances synthetic biology and plant genetic engineering.

关键词： CRISPR/Cas9 Multiplex genome editing Assembly system Plant

An organic free radical generator independent on hydrogen peroxide for chemodynamic and immunotherapy in vivo

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Journal of Materials Science & Technology 2024年第7期174卷 85-94页

作者： Yang Chen Yunpeng Song Chaojie Tang Hong Yang Wu Wang Shiping Yang zhiguo Zhou College of Chemistry and Materials Science International Joint Laboratory on Resource Chemistry of Ministry EducationShanghai Frontiers Science Center of Biomimetic CatalysisShanghai Normal UniversityShanghai 200234China Institute of Diagnostic and Interventional Radiology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China

It is desirable to develop a free radical generator that is neither dependent on hydrogen peroxide nor external stimuli-triggered to achieve effective tumor ***,the free radical genera-tor MNPs-mCPBA was constructed with Zn_(0.4)Co_(0.6)F_(e2)O_(4)@Zn_(0.4)Mn_(0.6)Fe_(2)O_(4)nanoparticles(MNPs)and 3-chloroperbenzoic acid(mCPBA).We believe that the iron(Ⅱ)on the surface of MNPs-mCPBA maybe represent high reactive activity and promote the generation of a large number of organic free radicals(C_(6)H_(4)ClCOOO)in an acidic tumor microenvironment,which realizes the acid-dependent tumor treat-ment strategy independent on the H_(2)O_(2)level in *** addition,the generated organic free radicals(C_(6)H_(4)ClCOOO)effectively induced immunogenic cell death(ICD)and increased T cell ***-der the synergetic treatment with an anti-PD-L1 antibody(α-PD-L1),a favorable anti-tumor effect was achieved.

关键词： Organic free radicals Immunogenic cell death Immunotherapy Chemodynamic therapy

树儿里煤业8204工作面开采方式及液压支架选型设计

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山东煤炭科技 2022年第6期40卷 153-155页

作者：仝志国大同煤矿集团同生树儿里煤业有限公司山西大同037100

以树儿里煤业8204工作面地质条件为依据,设计了单一走向长壁后退式采煤方法和开采参数,通过支架强度、工作阻力参数的计算确定采用ZF8400/20.5/38型放顶煤液压支架。

关键词：开采方式液压支架选型

厘清课堂对话误区,提升语文教学效益——“对话式教学”误区及改进策略刍议

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湖北招生考试 2020年第3期 52-56页

作者：童志国安徽省铜陵市义安区第二中学安徽铜陵244121

"对话式教学"对"满堂灌"的教学模式确实起到了一定程度的纠偏作用,但也很容易滑向另一个极端——"满堂问"。针对"对话式教学"存在的诸如窄化对话的多维向度、强化教师话语霸权和弱化对话思维品质等误区,语文阅读教学中可以从三个方面发... 详细信息

"对话式教学"对"满堂灌"的教学模式确实起到了一定程度的纠偏作用,但也很容易滑向另一个极端——"满堂问"。针对"对话式教学"存在的诸如窄化对话的多维向度、强化教师话语霸权和弱化对话思维品质等误区,语文阅读教学中可以从三个方面发力:力求做一个"明师";拓宽对话的范围;教会学生阅读的策略,用"真问题"催生真对话,这样似可走出"伪对话"的泥淖,从而回归课堂对话教学的本真——思维的碰撞、观点的交锋以及阅读能力的提升。

关键词： “对话式教学” 三大误区改进策略注意事项

First-line camrelizumab(a PD-1 inhibitor)plus apatinib(an VEGFR-2 inhibitor)and chemotherapy for advanced gastric cancer(SPACE):a phase 1 study

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1760-1767页

作者： Xiaofeng Chen Hao Xu Xiaobing Chen tongpeng Xu Yitong Tian Deqiang Wang Fen Guo Kangxin Wang Guangfu Jin Xiao Li Rong Wang Fengyuan Li Yongbin Ding Jie Tang Yueyu Fang Jing Zhao Liang Liu Ling Ma Lijuan Meng zhiguo Hou Rongrong Zheng Yang Liu Ni Guan Bei Zhang Shuang tong Shiqing Chen Xing Li Yongqian Shu Department of Oncology The First Affiliated Hospital with Nanjing Medical UniversityNanjingChina Gusu School Nanjing medical UniversitySuzhouChina Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingChina Department of General surgery The First Affiliated Hospital with Nanjing Medical UniversityNanjingChina Department of Oncology Henan Cancer Hospital Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhouChina Henan Engineering Research Center of Precision Therapy of Gastrointestinal Cancer&Zhengzhou Key Laboratory for Precision Therapy of Gastrointestinal Cancer ZhengzhouChina Department of Oncology Digestive Disease Institute&Cancer Institute of Jiangsu UniversityAffiliated Hospital of Jiangsu UniversityZhenjiangChina Department of Oncology Suzhou Hospital of Nanjing Medical UniversitySuzhouChina Department of Oncology Nanjing PuKou People’s HospitalNanjingChina Department of Epidemiology School of Public HealthNanjing Medical UniversityNanjingChina Department of Pathology The First Affiliated Hospital with Nanjing Medical UniversityNanjingChina Department of general surgery Jurong Branch hospital of Jiangsu Province People HospitalJurongChina Department of Medical Oncology Liyang People’s HospitalLiyangChina Department of radiology Nanjing PuKou People’s HospitalNanjingChina Jiangsu Hengrui Pharmaceuticals ShanghaiChina Department of Medical Affairs 3D Medicines Inc.ShanghaiChina Shanghai OrigiMed Co. Ltd.ShanghaiChina

Patients with advanced gastric cancer typically face a grim *** phase 1a(dose escalation)and phase 1b(dose expansion)study investigated safety and efficacy of first-line camrelizumab plus apatinib and chemotherapyfor advanced gastric or gastroesophageal junction *** primary endpoints included maximum tolerated dose(MTD)in phase 1a and objective response rate(ORR)across phase 1a and *** 1a tested three dose regimens of camrelizumab,apatinib,oxaliplatin,and *** regimen 1:camrelizumab 200 mg on day 1,apatinib 250 mg every other day,oxaliplatin 100 mg/m^(2) on day 1,and S-140 mg twice a day on days *** regimen 2:same as dose regimen 1,but oxaliplatin 130mg/*** regimen3:same as dose regimen 2,but apatinib 250 mg ***-four patients were included(9 in phase 1a,25 in phase 1b).No dose-limiting toxicities occurred so no MTD was *** 3 was set for the recommended phase 2 doses and administered in phase *** confrmed ORR was 76.5%(95%CI 58.8-89.3).The median progression-free survival was 8.4 months(95%CI 5.9-not evaluable[NE]),and the median overall survival(OS)was not mature(11.6-NE).Ten patients underwent surgery after treatment and the multidisciplinary team *** 24 patients without surgery,the median OS was 19.6 months(7.8-NE).Eighteen patients(52.9%)developed grade≥3 treatment-emergent adverse *** plus apatinib and chemotherapy showed favorable clinical outcomes and manageable safety for untreated advanced gastric cancer(ChiCTR2000034109).

关键词： regimen cancer doses

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齿轮传动式百分表示值误差的分析

计量与测试技术 2017年第6期44卷 35-37页

作者：童治国刘红陈萍萍解放军国防科学技术大学湖南长沙410000

百分表是利用精密齿条齿轮机构制成的表式通用长度测量工具,由于使用频繁易发生示值超差不合格,本文通过分析设计结构和齿轮变形等几方面值确定误差的几个方面:齿形误差、齿轮偏心误差、刻度盘偏心误差和齿轮周节的累积误差。

关键词：百分表齿轮传动偏心变形误差分析

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胃神经内分泌癌的临床病理特征及预后分析

中国肿瘤临床 2023年第21期50卷 1098-1105页

作者：尚峰进谭胜武卫鹏矫健李璐璐张浩然仝志国连长红长治医学院附属和平医院胃肠外科山西省长治市046000 长治医学院第一临床学院长沙市望城区人民医院普通外科

目的:探讨胃神经内分泌癌(gastric neuroendocrine carcinoma,G-NEC)、胃混合性腺-神经内分泌癌(gastric mixed adenoendocrine carcinoma,G-MANEC)的临床病理特征及预后因素。方法:回顾性收集2015年5月至2023年5月于长治医学院附属和平医院就诊并行手术治疗的67例G-NEC、G-MANEC患者的临床资料,并分析其病理特征。结果:与胃腺癌相比,G-NEC、GMANEC患者好发于男性的贲门部、确诊时年龄更大、肿瘤直径更大、术前更易发生贫血、低白蛋白、更易侵犯神经和脉管、肿瘤浸润深度更深、淋巴结转移数更多、TNM分期更晚、术后更易发生远处转移。G-NEC、G-MANEC患者的预后较胃腺癌差(P=0.001),而G-NEC和G-MANEC在病理特征(P>0.05)及预后分析(P=0.212)差异均无统计学意义。单因素生存分析显示:年龄、术前白蛋白、术前CEA、淋巴结转移数、TNM分期和术后远处转移是影响患者总生存期(overall survival,OS)的危险因素;多因素分析显示:年龄、术前白蛋白、TNM分期和术后远处转移是影响OS的独立危险因素。结论:G-NEC、G-MANEC与胃腺癌的临床特征存在显著性差异,且确诊时多处于进展期,术后易发生远处转移。年龄>60岁、术前白蛋白<40 g/L、TNM分期Ⅱ/Ⅲ期、术后发生远处转移的患者预后较差。

关键词：胃神经内分泌肿瘤腺癌病理特征预后分析

胶质瘤患者外周血 DNA 修复基因甲基化与蛋白表达的相关性

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实用肿瘤学杂志 2014年第3期28卷 198-201页

作者：刘楠佟志国周敏祝继原戚基萍哈尔滨医科大学附属第一医院病理科哈尔滨150001 哈尔滨医科大学附属第四医院普外科

目的：探讨胶质瘤患者O6-甲基鸟嘌呤-DNA-甲基转移酶（ O6-Methylguanine -DNA methyltransferase，MGMT）及人类错配修复基因 MSH2（Human mutS homolog2，hMSH2）蛋白表达与外周血相应基因启动子甲基化的相关性。方法分别采用免疫组... 详细信息

目的：探讨胶质瘤患者O6-甲基鸟嘌呤-DNA-甲基转移酶（ O6-Methylguanine -DNA methyltransferase，MGMT）及人类错配修复基因 MSH2（Human mutS homolog2，hMSH2）蛋白表达与外周血相应基因启动子甲基化的相关性。方法分别采用免疫组化法及甲基化特异性PCR （ MSP ）检测275例胶质瘤患者肿瘤组织MGMT、hMSH2蛋白的表达及外周血中这两个基因启动子甲基化情况。结果脑胶质瘤患者肿瘤组织MGMT和hMSH2蛋白阴性表达率分别为47．2％和62．5％；基因启动子区甲基化阳性率分别为41．8％和22．4％。统计学分析显示外周血MGMT基因启动子甲基化与肿瘤组织蛋白阴性表达相关（P＜0．05）。 hMSH2基因启动子甲基化与肿瘤组织hMSH2蛋白表达不具有相关性（P＞0．05）。结论 MGMT基因甲基化是脑胶质瘤发生过程中常见的分子事件，可能与胶质瘤的发生有关；而hMSH2基因启动子甲基化可能并不是胶质瘤hMSH2蛋白失活的主要原因，可能存在其他重要因素影响其表达。

关键词：胶质瘤甲基化甲基化特异性PCR O6-甲基鸟嘌呤-DNA-甲基转移酶人类错配修复基因MSH2