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Efficacy and safety of PD-1 blockade plus long-course chemoradiotherapy in locally advanced rectal cancer(NECTAR):a multi-center phase 2 study

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1721-1729页

作者： Zhengyang Yang Jiale Gao Jianyong Zheng Jiagang Han Ang Li Gang Liu Yi Sun Jie Zhang Guangyong Chen Rui Xu Xiao Zhang Yishan Liu zhigang bai Wei Deng Wei He Hongwei Yao Zhongtao Zhang Department of General Surgery Beijing Friendship HospitalCapital Medical UniversityState Key Lab of Digestive HealthNational Clinical Research Center for Digestive DiseasesBeijingChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Air Force Medical UniversityXi'anChina Department of General Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Department of General Surgery Beijing Xuanwu HospitalCapital Medical UniversityBeijingChina Department of General Surgery Tianjin Medical University General HospitalTianjinChina Department of Anorectal Tianjin People's HospitalTianjinChina Department of Radiology Beijing Friendship Hospital Capital Medical UniversityBeijingChina Department of Pathology Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Thoracic Surgery/Institute of Thoracic Oncology West China HospitalSichuan UniversityChengduChina

Adding PD-1 blockade in the neoadjuvant regimens for locally advanced rectal cancer(LARC)patients with microsatellite stable(MsS)/mismatch repair-proficient(pMMR)tumors is an attractive,but debatable *** phase 2,multicenter,prospective,single-arm study enrolled patients from 6 centers from June 2021 to November *** advanced rectal cancer(LARC,cT_(3-4a)N_(0)M_(0) and cT_(1-4a)N_(1-2)M_(0))patients aged≥18 years with the distance from distal border of tumor to anal verge≤10 cm(identified by Magnetic Resonance Imaging)were qualifed for *** patients received long-course radiotherapy(50 Gy/25 fractions,2 Gy/fraction,5 days/week)and three 21-day cycles capecitabine(850-1000 mg/m2,bid,po,day1-14)and three 21-day cycles tislelizumab(200 mg,***,day8)as *** mesorectal excision(TME)was 6-12 weeks after the end of radiotherapy to achieve radical resection.A total of 50 patients were enrolled in this *** pathological complete response rate was 40.0%[20/50,95%confidence interval(CI):27.61-53.82%],while 15(30.0%,95%CI:19.1-43.75%),9(18.0%,95%CI:9.77-30.8%),2(4.0%,95%CI:1.10-13.46%)patients respectively achieved grade 1,2,and 3 tumor ***-related adverse events(TRAEs)occurred in 28(56.0%)LARC patients,including 26(52.0%)with grade I-II and 2(4.0%)with grade II(1 with grade 3 immune-related colitis and 1 with grade 3 rash).PD-1 blockade plus long-course chemoradiotherapy(CRT)showed promising therapeutic effects according to pathological complete response rate and is well-tolerated in LARC patients.A larger randomized controlled study is desired to further validate the above findings.

关键词： rectal cancer phase

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MicroRNAs are implicated in the initiation and progression of gastric cancer

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Chinese Medical Journal 2014年第3期127卷 554-559页

作者： Song Jianning bai zhigang Zhang Zhongtao Department of General Surgery Beijing Friendship Hospital Capital Medical University Beijing 100050 China

Objective Gastric cancer is a genetically heterogeneous disease that progresses via different *** （miRNA） can regulate oncogene expression at the post-translational *** this review,we summarize the most commonly altered miRNAs and their possible roles in cancer initiation and progression in gastric *** sources Most articles were identified by searching PubMed online resources using the key terms of microRNA and gastric *** selection Mainly original milestone articles and critical reviews written by major pioneer investigators in the field were selected,and the 69 most important articles were cited *** A set of miRNAs are consistently deregulated in gastric cancer,although there is no clear miRNA expression profiles,such as miR-21 and miR-17 （～92 clusters）.These deregulated miRNAs play important roles in promoting cell proliferation,tumor metastasis,and chemotherapeutic resistance in gastric cancer by targeting different *** relevance of these deregulated miRNAs is proved to be associated with TNM stages,metastasis,and prognosis of gastric cancer *** addition,circulating miRNAs are promising noninvasive biomarkers for gastric *** miRNAs have produced a novel paradigm in research in gastric *** small molecules play macroroles in gastric cancer initiation and *** results will help us improve management of gastric cancer in future.

关键词： microRNA gastric cancer

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Vascular endothelial growth inhibitor affects the invasion, apoptosis and vascularisation in breast cancer cell line MDA-MB-231

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Chinese Medical Journal 2014年第10期127卷 1947-1953页

作者： Gao Yinguang Ge Zhicheng Zhang Zhongtao bai zhigang Ma Xuemei Wang Yu Department of General Surgery Beijing Friendship Hospital CapitalMedical University Beijing 100050 China

Background Breast cancer is one of the most common malignant female diseases *** is a significant threat to every woman＇s *** endothelial growth inhibitor （VEGI） is known to be abundant in endothelial *** to previous literature,overexpression of VEGI has been shown to inhibit tumor neovascularisation and progression in cellular and animal models,but there has been limited research on the significance of VEGI in the breast *** In our study,cell lines MDA-MB-231 were first constructed in which VEGI mediated by lentivirus *** effects of VEGI over-expression on MDA-MB-231 cells were investigated both in vitro and in *** expression of VEGI in the MDA-MB-231 cells after infection of lentivirus was analyzed using real-time PCR and Western *** effect of the biological characteristics of MDA-MB-231 cells was assessed by growth,invasion,adhesion,and migration assay with subcutaneous tumor-bearing nude mice *** the growth curves of the subcutaneous tumors were *** of VEGI,CD31 and CD34 in the tumors were analyzed by immunohistochemistry and apoptosis was detected by flow cytometry and *** Infection of MDA-MB-231 cells within the lentivirus resulted in approximately a 1 000-fold increase in the expression of *** can be seen in the invasion,adhesion and migration assay,the over-expression of VEGI can inhibit the ability of MDA-MB-231 cells during migration,adhesion and *** volume of the subcutaneous tumor in the over-expression group was distinctly and significantly less than that of the control *** analysis of the tumor biopsies cleady showed the expression of VEGI in the over-expression group increased while CD31 and CD34 decreased *** vitro and in vivo,the early apoptosis rate and the apoptosis index were increased within the VEGI over-expression group as compared with the control *** Taken to

关键词： breast cancer lentivirus MDA-MB-231 apotosis

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老年血液透析患者跌倒恐惧的影响因素及干预研究进展

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中华现代护理杂志 2024年第15期30卷 2071-2077页

作者：张涛刘洋白志刚李韵健陈熠蔓沙丽艳大连医科大学附属第二医院护理部大连116023

老年血液透析患者跌倒发生率较高,伴随跌倒恐惧心理也呈现较高水平。跌倒恐惧可造成身心损害和生活质量降低,是老年患者发生死亡的一项重要危险因素。本文对老年血液透析患者跌倒恐惧的概述、对患者的影响、发生现状、影响因素及干预措... 详细信息

老年血液透析患者跌倒发生率较高,伴随跌倒恐惧心理也呈现较高水平。跌倒恐惧可造成身心损害和生活质量降低,是老年患者发生死亡的一项重要危险因素。本文对老年血液透析患者跌倒恐惧的概述、对患者的影响、发生现状、影响因素及干预措施进行综述,以期为制订针对老年血液透析患者跌倒恐惧有效干预策略提供科学依据。

关键词：综述老年人血液透析跌倒恐惧影响因素

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感知学习风格理论在护理教育领域的应用进展

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全科护理 2024年第12期22卷 2234-2237页

作者：陈熠蔓沙丽艳何洋张涛白志刚李韵健大连医科大学附属第二医院 116023 大连医科大学 116044

通过回顾感知学习风格理论的发展历程,概括了其在护理高等教育、护士在职教育、病人健康教育中的应用现状,并剖析其在护理教育界应用的前景,旨在为护理教育者推广应用感知学习风格理论提供参考。

关键词：学习风格理论感知型 VARK 护理教育综述

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缺氧后处理通过piRNA-005854调控衰老心肌细胞自噬发挥保护心肌作用

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中国组织工程研究 2024年第13期28卷 2054-2060页

作者：迟宏扬杨慧霞郝银菊杨安宁白志刚焦运熊建团马胜超姜怡邓宁夏医科大学临床医学院宁夏回族自治区银川市750004 宁夏医科大学国家卫生健康委代谢性心血管疾病研究重点实验室宁夏回族自治区银川市750004 宁夏医科大学药学院宁夏回族自治区银川市750004 宁夏医科大学基础医学院宁夏回族自治区银川市750004 宁夏回族自治区人民医院宁夏回族自治区银川市750004 宁夏医科大学总医院感染科宁夏回族自治区银川市750004

背景:缺血后处理是减轻缺血再灌注损伤的有效方式之一,近年来被越来越广泛地应用于临床实践,但其具体分子机制还有待研究。目的:探讨piRNA-005854在衰老心肌细胞缺氧后处理中的作用及机制。方法:体外给予心肌细胞8 mg/mL D-半乳糖9 d诱... 详细信息

背景:缺血后处理是减轻缺血再灌注损伤的有效方式之一,近年来被越来越广泛地应用于临床实践,但其具体分子机制还有待研究。目的:探讨piRNA-005854在衰老心肌细胞缺氧后处理中的作用及机制。方法:体外给予心肌细胞8 mg/mL D-半乳糖9 d诱导其衰老,β-半乳糖苷酶染色观察心肌细胞的衰老情况;衰老后细胞给予缺氧/复氧处理和缺氧后处理,ELISA检测心肌损伤标志物肌酸激酶同工酶MB以及乳酸脱氢酶水平;Western blot检测衰老心肌细胞中自噬相关蛋白LC3Ⅱ、p62和ULK1及其磷酸化ULK1的表达;qRT-PCR检测piRNA-005854的表达水平;进一步用piRNA-005854 inhibitor及piRNA-005854 mimics转染衰老心肌细胞并进行缺氧后处理,Western blot检测LC3Ⅱ、p62和ULK1及其磷酸化ULK1的表达。结果与结论:①D-半乳糖诱导9 d后心肌细胞出现明显衰老;②与正常氧组比较,缺氧/复氧组肌酸激酶同工酶MB以及乳酸脱氢酶水平增加(P<0.01);LC3Ⅱ/Ⅰ表达升高、p62表达降低、ULK1磷酸化水平升高、piRNA-005854表达升高(P<0.01);③与缺氧/复氧组比较,缺氧后处理组肌酸激酶同工酶MB以及乳酸脱氢酶水平明显减少(P<0.01);LC3Ⅱ/Ⅰ表达明显降低(P<0.05)、p62表达升高(P<0.01)、ULK1磷酸化水平降低(P<0.05)、piRNA-005854表达降低(P<0.01);④转染piRNA-005854 inhibitor后,LC3Ⅱ/Ⅰ表达降低(P<0.01),p62表达明显升高(P<0.05),ULK1磷酸化水平明显降低(P<0.01);转染piRNA-005854 mimics后,LC3Ⅱ/Ⅰ表达显著升高,p62表达降低,ULK1磷酸化水平明显增加(P<0.01);⑤结果表明,piRNA-005854介导的ULK1依赖性自噬水平降低是衰老心肌细胞缺氧后处理发挥保护作用的可能机制。

关键词： piRNA 自噬衰老心肌细胞缺血再灌注损伤缺氧/复氧缺氧后处理

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下肢力线不良解剖危险因素与非接触性前交叉韧带损伤

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国际骨科学杂志 2024年第4期45卷 238-241页

作者：奥其高晓宇白志钢新苏雅拉图内蒙古医科大学鄂尔多斯临床医学院 017000

前交叉韧带(ACL)是维持人体活动的重要组织之一,下肢力线不良会导致运动中非接触性ACL损伤。导致下肢力线不良的解剖因素包括骨性因素与非骨性因素,骨性因素主要包括胫骨因素、股骨髁因素、股骨近端及髌骨与足踝因素等,非骨性因素主要... 详细信息

前交叉韧带(ACL)是维持人体活动的重要组织之一,下肢力线不良会导致运动中非接触性ACL损伤。导致下肢力线不良的解剖因素包括骨性因素与非骨性因素,骨性因素主要包括胫骨因素、股骨髁因素、股骨近端及髌骨与足踝因素等,非骨性因素主要包括神经型因素、股骨机械轴周围因素、胫骨机械轴周围因素等。运动导致的非接触性ACL损伤大多由于下肢生物力线不良而影响膝关节正常负重,造成ACL力学环境异常,而ACL损伤修复或重建术后移植物失效的病例中也存在下肢力线不良的情况。因此,在临床中准确评估并纠正下肢力线不良,对于预防非接触性ACL损伤和ACL重建术后移植物失效有着重要意义。

关键词：下肢力线不良前交叉韧带非接触性损伤解剖因素

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Burden of colorectal cancer in China, 1990-2017: Findings from the Global Burden of Disease Study 2017

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Chinese Journal of Cancer Research 2019年第3期31卷 489-498页

作者： Jie Yin zhigang bai Jun Zhang Zhi Zheng Hongwei Yao Pengpeng Ye Jun Li Xin Gao Zhongtao Zhang Department of General Surgery Beijing Friendship HospitalCapital Medical UniversityBeijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive DiseasesBeijing 100050China National Center for Chronic and Noncommunicable Disease Control and Prevention (NCNCD) Chinese Center for Disease Control and Prevention (CDC)Beijing 100050China

Objective: Our goal is to analyze the trend of colorectal cancer(CRC) regarding the death, incidence and prevalence rates over time, and to provide epidemiological knowledge basis for health policy revision by comparing data about fatal outcomes of CRC in 2017 to those data in 1990, which was extracted from the Global Burden of Disease(GBD).Methods: The time trend and changes of CRC burden from 1990 to 2017 were measured by using the methods and results from the Institute for Health Metrics and Evaluation(IHME) GBD 2017, based on the rates of death,incidence and ***: The death rate of CRC is 13.24/100,000, accounting for 1.79% of total deaths in China in 2017. In1990, CRC ranked 21 st in all causes of death in China compared to its 11 th ranking in 2017. The death, incidence and prevalence rate of CRC were standardized by the age scale of the global population in 2010, the change of standardized death rate of CRC was not significant, from 9.33/100,000 in 1990 to 10.10/100,000 in 2017. The standardized incidence rate of CRC significantly increased from 12.18/100,000 in 1990 to 22.42/100,000 in *** standardized prevalence rate of CRC significantly increased from 44.55/100,000 in 1990 to 118.40/100,000 in2017. The trend of the prevalence rate in both genders grow higher in 2017 compared to the 1990, resulting in141.6%, 209.8% and 189.0% for the studied three age groups(15-49, 50-69 and 70+ years old), respectively. The death rate increased in the age groups of 50-69 and 70+ years in both genders(8.6% and 31.0% respectively), in contrast to a decrease of death rate in the age group of 15-49 years old(-10.8%).Conclusions: China experienced a stunning increase in terms of incidence and prevalence rate of CRC from1990 to 2017. To decrease the burden of CRC, prevention and management of known risk factors should be promoted through national polices.

关键词： Colorectal cancer death incidence prevalence epidemiology

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LncRNA SNHG1在同型半胱氨酸致足细胞焦亡中的作用

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实用医学杂志 2024年第4期40卷 476-482页

作者：张正皓马芳张晴夏童童刘虹麟白志刚卢冠军张竞文彭红建姜怡邓马胜超宁夏医科大学基础医学院银川750004 国家卫生健康委员会代谢性心血管疾病研究重点实验室银川750004 宁夏医科大学检验学院银川750004 宁夏回族自治区人民医院银川750004 宁夏医科大学总医院银川750004 中南大学化学化工学院长沙410083

目的探讨lncRNA SNHG1在同型半胱氨酸诱导足细胞焦亡中的作用。方法选取Cbs^(+/-)小鼠随机分成2组,设置正常饮食组(ND)和高蛋氨酸饮食组(HMD),Western blot检测Caspase-1、Cleaved Caspase-1和NLRP3的蛋白表达水平。体外培养小鼠肾小球... 详细信息

目的探讨lncRNA SNHG1在同型半胱氨酸诱导足细胞焦亡中的作用。方法选取Cbs^(+/-)小鼠随机分成2组,设置正常饮食组(ND)和高蛋氨酸饮食组(HMD),Western blot检测Caspase-1、Cleaved Caspase-1和NLRP3的蛋白表达水平。体外培养小鼠肾小球足细胞,设置对照组(Control,0μmol/L Hcy)和同型半胱氨酸干预组(Hcy,80μmol/L Hcy);足细胞转染慢病毒后设置lncSNHG1过表达阴性对照组(OE-NC)和lncSNHG1过表达组(OE-SNHG1);lncSNHG1过表达阴性对照+同型半胱氨酸干预组(OE-NC+Hcy)和lncSNHG1过表达+同型半胱氨酸干预组(OE-SNHG1+Hcy),干预细胞48 h后,实时荧光定量PCR检测Hcy干预的足细胞中lncSNHG1表达水平;Western blot和免疫荧光技术检测足细胞中焦亡相关蛋白Caspase-1、Cleaved Caspase-1、NLRP3及GSDMD和GSDMD-N表达水平;ELISA检测足细胞中焦亡介导的炎症相关因子IL-1β和IL-18含量。结果(1)动物实验中:与正常饮食组(ND)相比,高蛋氨酸饮食组(HMD)中焦亡相关蛋白Caspase-1、Cleaved Caspase-1和NLRP3及GSDMD、GSDMD-N表达水平增高;(2)细胞实验中:与对照组(Control)相比,同型半胱氨酸干预组(Hcy)中焦亡相关蛋白Caspase-1、Cleaved Caspase-1和NLRP3及GSDMD、GSDMD-N表达水平增高,焦亡介导炎症因子IL-1β和IL-18含量增高;(3)细胞实验中:与对照组(Control)相比,同型半胱氨酸干预组(Hcy)中lncSNHG1表达水平增高;足细胞转染lncSNHG1慢病毒后,与Control组及OE-NC组相比,OE-SNHG1组lncSNHG1表达水平增高;(4)细胞实验中:与OE-NC+Hcy组相比,OE-SNHG1+Hcy组中焦亡相关蛋白Caspase-1、Cleaved Caspase-1和NLRP3及GSDMD、GSDMD-N表达水平增高,焦亡介导炎症因子IL-1β和IL-18含量增高。结论lncRNA SNHG1在Hcy诱导的足细胞焦亡过程中起到促进作用。

关键词：同型半胱氨酸足细胞核仁小RNA宿主基因1 焦亡

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中果型西瓜新品种‘夏爽’的选育

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中国果菜 2024年第7期44卷 68-73页

作者：胡启星张扬栋刘帅孙巨龙刘为胜伍琦白志刚崔爱花江西省经济作物研究所江西九江332105 湖北华泰先行农业科技有限公司湖北武汉430200

为丰富西瓜品种类型,满足生产和市场的需求,引进了适于长江流域气候、易坐果、品质优良的中果型西瓜品种‘夏爽’。‘夏爽’是以‘X198’为母本、‘S2018’为父本杂交而成的中果型中熟西瓜品种,全生育期约99 d,果实发育期32 d,中心可溶... 详细信息

为丰富西瓜品种类型,满足生产和市场的需求,引进了适于长江流域气候、易坐果、品质优良的中果型西瓜品种‘夏爽’。‘夏爽’是以‘X198’为母本、‘S2018’为父本杂交而成的中果型中熟西瓜品种,全生育期约99 d,果实发育期32 d,中心可溶性固形物含量12.3%,每667 m2产量约5600 kg,适宜在江西、湖北、湖南等地种植。

关键词：西瓜新品种 ‘夏爽’ 中果型

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