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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan Jiao Lingyan Meng Kang du Xuezhi Li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein

Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang Chen zhifeng Chen Menghua Li Weiwei Guo Shuolong Yuan Liangwei Xu Chang Lin Xi Shi Wei Chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

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排球运动员发球技巧类型与应对方式研究

体育科技文献通报 2020年第3期28卷 25-26页

作者：杜志峰陈鹏广西师范大学体育学院广西桂林541006

发球往往是发起进攻的一个重要方式,破坏对方进攻战术,甚至是直接得分,由此需要准确把握发球类型,预知对方发球技战术,从而采取针对性的应对措施。基于此,文章在简要阐述排球运动员发球技巧类型的基础上,系统分析了其攻击性特征,据此提... 详细信息

发球往往是发起进攻的一个重要方式,破坏对方进攻战术,甚至是直接得分,由此需要准确把握发球类型,预知对方发球技战术,从而采取针对性的应对措施。基于此,文章在简要阐述排球运动员发球技巧类型的基础上,系统分析了其攻击性特征,据此提出针对性的应对方式。这一方面深化对排球发球技巧特征的认识,另一方面为排球训练提供必要的指导,增强运动员对于发球的应对能力。

关键词：发球技巧类型发球攻击性特征发球应对方式

NPR锚索支护下相交隧道围岩变形规律及破坏机理

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煤炭学报 2023年第S2期48卷 473-484页

作者：陶志刚杜志锋刘凇源郭爱鹏毛亚东曹诗定中国矿业大学(北京)深部岩土力学与地下工程国家重点实验室北京100083 中国矿业大学(北京)力学与建筑工程学院北京100083

城市交通逐渐向地下发展,地下立交中相交隧道数量日益增加。为探究复杂地质条件下相交隧道的变形规律,以深圳南龙地下立交隧道相交隧道段为工程背景,通过物理模型试验探索相交隧道在开挖支护及超载状态下的变形机理。首先自主设计三维... 详细信息

城市交通逐渐向地下发展,地下立交中相交隧道数量日益增加。为探究复杂地质条件下相交隧道的变形规律,以深圳南龙地下立交隧道相交隧道段为工程背景,通过物理模型试验探索相交隧道在开挖支护及超载状态下的变形机理。首先自主设计三维模型试验系统,并通过相似理论计算,进行了多种岩样及支护材料的配制;其次在模型搭建完成后,基于开挖补偿理论,利用缩尺NPR(Negative Poisson’s Ratio)锚索对相交隧道进行开挖支护。通过对隧道应变、位移及NPR锚索轴力的分析,得到隧道开挖状态下的应力重分布特征;最后,对隧道进行超载试验,结合数据及现象分析,揭示了相交隧道合建结构的围岩破坏机理。研究结果表明:相交隧道在开挖贯通时,合建区域岩体因隧道开挖产生应力损失,会对已经开挖支护完的隧道造成轻微影响。隧道贯通加载时,相交隧道的破坏分为3个阶段:拱顶应力集中区沉降阶段、合建结构的破坏阶段和隧道洞口破坏阶段。具体表现:首先是上层隧道合建区域拱顶开始出现沉降,然后下层隧道出现底鼓,最后应力传播至边界,使得洞口上方垮塌。试验中采用NPR锚索对相交隧道进行支护,现象和数据表明,开挖阶段隧道合建区的沉降影响到NPR支护段,由于NPR锚索的高应力补偿特点,支护段并未出现明显沉降。试验验证了NPR锚索在相交隧道的支护效果,可为类似工程支护提供一种新的思路。

关键词： NPR锚索相交隧道围岩变形规律应力补偿破坏机理

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依达拉奉注射液联合血栓通冻干粉治疗老年脑梗死患者的效果分析

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首都食品与医药 2024年第7期31卷 65-67页

作者：杜志锋张艳军陕西省志丹县人民医院陕西延安717500 陕西省神木市中医医院陕西榆林719300

目的探讨依达拉奉注射液联合血栓通冻干粉治疗老年脑梗死患者的应用价值。方法选取志丹县人民医院2022年1月-2023年1月收治的老年脑梗死患者80例,按随机法分为实验组与对照组,每组40例。对照组采用血栓通冻干粉治疗,实验组在其基础上加... 详细信息

目的探讨依达拉奉注射液联合血栓通冻干粉治疗老年脑梗死患者的应用价值。方法选取志丹县人民医院2022年1月-2023年1月收治的老年脑梗死患者80例,按随机法分为实验组与对照组,每组40例。对照组采用血栓通冻干粉治疗,实验组在其基础上加用依达拉奉注射液。对比两组临床疗效、美国国立卫生研究院脑卒中量表(NIHSS)评分、日常生活活动能力量表(ADL)评分、白细胞介素-6(IL-6)水平、超敏C反应蛋白(hs-CRP)水平、一氧化氮(NO)水平、内皮型NO合成酶(eNOS)水平及不良反应发生率。结果实验组总有效率为95.00%,高于对照组的80.00%(P<0.05);治疗后,实验组NIHSS评分低于对照组,ADL评分高于对照组(P<0.05);治疗后,实验组IL-6、hs-CRP水平低于对照组(P<0.05);治疗后,实验组NO、eNOS水平高于对照组(P<0.05);实验组不良反应发生率为5.00%,低于对照组的20.00%(P<0.05)。结论老年脑梗死患者应用血栓通冻干粉联合依达拉奉注射液治疗可提高临床疗效,改善神经缺损程度、生活自理能力及血管内皮功能,缓解炎症,用药安全性较高,值得临床推广应用。

关键词：脑梗死老年依达拉奉注射液血栓通冻干粉

综采工作面风速与瓦斯浓度分布规律实测与分析

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煤炭科学技术 2018年第S1期46卷 127-130页

作者：刘光文杜志锋周秋娟程志恒广东水利电力职业技术学院广东广州510925 华晋焦煤有限责任公司沙曲二矿山西柳林033300 煤炭科学技术研究院有限公司安全分院北京100013 煤炭资源高效开采与洁净利用国家重点实验室(煤炭科学研究总院) 北京100013

为了得到风速与瓦斯浓度在综采工作面巷道三维空间上的分布规律,采用现场实测与理论分析相结合的研究方法,以沙曲煤矿14205综采工作面为研究对象,分别对检修班期间与生产班期间综采工作面瓦斯浓度与风速进行实测,分别对综采工作面内风... 详细信息

为了得到风速与瓦斯浓度在综采工作面巷道三维空间上的分布规律,采用现场实测与理论分析相结合的研究方法,以沙曲煤矿14205综采工作面为研究对象,分别对检修班期间与生产班期间综采工作面瓦斯浓度与风速进行实测,分别对综采工作面内风速与瓦斯浓度从工作面巷道走向方向、工作面推进方向及垂直于工作面底板方向3个空间方向上的分布规律进行了分析,研究表明:靠近煤壁的巷道断面区域为综采工作面定点测风最佳位置,综采工作面前半段工作面长度范围内靠近煤壁且处于下部的巷道断面区域和综采工作面后半段工作面长度范围内靠近采空区且处于上部的巷道断面区域为瓦斯浓度重点监测区域,研究结果对综采工作面瓦斯浓度监测监控工作具有指导意义。

关键词：综采工作面瓦斯浓度风速工作面巷道

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杜雨茂教授运用八味肾气丸治疗高血压的经验

陕西中医学院学报 2011年第3期34卷 15-16页

作者：李惠林杜治锋深圳市中医院广东深圳518033 咸阳雨茂医院陕西咸阳712000

肾阴阳两虚型高血压病在临床辨证论治过程中常常被忽视,杜雨茂教授运用经方仲景八味肾气丸双补阴阳治疗肾阴阳两虚型高血压病经验丰富,临床疗效显著。

关键词：高血压头晕八味肾气丸阴阳两虚

Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang Liu Xiang Li Shen du Ming Gao Yanbin Yin Jiongming Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

during the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

Effect of lamellarization on the microstructure and mechanical properties of marine 10Ni5CrMoV steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 402-413页

作者： Tao Zou Yanwu Dong Zhouhua Jiang Shuyang du Yushuo Li School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Key Laboratory for Ecological Metallurgy of Multimetallic Ores(Ministry of Education) Northeastern UniversityShenyang 110819China

Multistage heat treatment involving quenching(Q),lamellarizing(L),and tempering(T)is applied to marine 10Ni5CrMoV *** microstructure and mechanical properties were studied by multiscale characterizations,and the kinetics of reverse austenite transformation,strain hardening behavior,and toughening mechanism were further *** lamellarized specimens possess low yield strength but high toughness,especially cryogenic *** leads to the development of film-like reversed austenite at the martensite block and lath boundaries,refining the martensite structure and lowering the equivalent grain *** analysis of austenite reversion based on the JMAK model shows that the isothermal transformation is dominated by the growth of reversed austenite,and the maximum transformation of reversed austenite is reached at the peak temperature(750℃).The strain hardening behavior based on the modified Crussard-Jaoul analysis indicates that the reversed austenite obtained from lamellarization reduces the proportion of martensite,significantly hindering crack propagation via martensitic transformation during the *** a consequence,the QLT specimens exhibit high machinability and low yield *** with the QT specimen,the ductile-brittle transition temperature of the QLT specimens decreases from-116 to-130℃due to the low equivalent grain size and reversed austenite,which increases the cleavage force required for crack propagation and absorbs the energy of external load,*** work provides an idea to improve the cryogenic toughness of marine 10Ni5CrMoV steel and lays a theoretical foundation for its industrial application and comprehensive performance improvement.

关键词： 10Ni5CrMoV steel lamellarizing reversed austenite cryogenic toughness ductile-brittle transition temperature

Preparation of FeCoNi medium entropy alloy from Fe^(3+)-Co^(2+)-Ni^(2+)solution system

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 92-101页

作者： Zongyou Cheng Qing Zhao Mengjie Tao Jijun du Xingxi Huang Chengjun Liu Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking(Ministry of Education) Shenyang 110819China

In recent years,medium entropy alloys have become a research hotspot due to their excellent physical and chemical *** controlling reasonable elemental composition and processing parameters,the medium entropy alloys can exhibit similar properties to high entropy alloys and have lower *** this paper,a FeCoNi medium entropy alloy precursor was prepared via sol-gel and coprecipitation methods,respectively,and FeCoNi medium entropy alloys were prepared by carbothermal and hydrogen *** phases and magnetic properties of FeCoNi medium entropy alloy were *** showed that FeCoNi medium entropy alloy was produced by carbothermal and hydrogen reduction at 1500℃.Some carbon was detected in the FeCoNi medium entropy alloy prepared by carbothermal *** alloy prepared by hydrogen reduction was uniform and showed a relatively high ***,the hydrogen reduction product exhibited better saturation magnetization and lower coercivity.

关键词： medium entropy alloy sol-gel co-precipitation carbothermal hydrogen reduction