检索结果-南通市图书馆

Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang Chen zhifeng Chen Menghua Li Weiwei Guo Shuolong Yuan Liangwei Xu Chang Lin Xi Shi Wei Chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Impact of Oil Shocks on Systemic Risk of the Commodity Markets

引用

Journal of Systems Science & Complexity 2024年第6期37卷 2697-2720页

作者： DAI zhifeng WU Tong College of Mathematics and Statistics Hunan Provincial Key Laboratory of Mathematical Modeling and Analysis in Engineering Changsha University of Science and Technology

This study examines the influence of oil shocks on systemic risk spillover among the commodity markets. Specifically, this paper uses the DCC-GARCH approach combined with the TVP-VAR model to calculate risk connectedness and the GARCH-MIDAS model to explore how oil shocks from different sources affect the risk spillover effects among the commodity markets. The results are the following: First, there are significant risk spillovers among the commodity markets with important time-varying characteristics and with sharp changes in times of crisis. The industrial metals, agriculture, precious metals, and light energy commodity markets are risk recipients, and the energy and livestock commodity markets are risk exporters. Second, oil price shocks, particularly oil aggregate demand shocks, prominently affect the total risk connectedness among the commodity markets. In particular, the impact on the net risk spillover effect of different commodity market differs.

关键词： Commodity markets connectedness GARCH-MIDAS model oil price shocks systemic risk

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Solute-solute interactions and their impacts on solute co-segregation and interfacial cohesion of{1012}twin boundary in zinc

引用

Journal of Materials Science & Technology 2023年第7期138卷 117-128页

作者： zhifeng Huang Jian-Feng Nie Department of Materials Science and Engineering Monash UniversityMelbourneVIC 3800Australia

Interactions of solute atoms in biodegradable zinc alloys and their effect on alloy mechanical properties have been less *** this work,the interactions between the common solutes(Li,Mg,Mn,Cu,and Ag)used in the biodegradable Zn alloys,including a solute-solute pair with the same element or with two different elements,are investigated based on first-principles *** is found that the energetically favorable configuration is the third nearest-neighboring for most solute-solute pairs in the bulk lattice because of the relatively strong electronic interaction between solute and Zn atoms or the relatively small local elastic deformation associated with the *** that interfacial cleavage is a key fracture mode of zinc,the segregation ability of these solutes and their effect on the{1012}twin boundary cohesion are also *** result shows that Li tends to fully occupy its preferred site in the twin boundary,while Mg,Mn,Cu,or Ag has a concentration limitation in the twin *** twin boundary cohesion can be significantly enhanced by the segregation of Mn,followed by Cu and Ag,because of the contribution of their d states close to the Fermi ***,the co-segregation ability of two solute atoms in the twin boundary increases with increasing the binding tendency of these two solute atoms in the *** and Li or Mg show a relatively strong co-segregation ability in the twin *** Mn to Zn-Li or Zn-Mg alloys can significantly enhance the resistance to fracture of twin boundaries.

关键词： Zinc alloys Twin boundary Solute-solute interaction Co-segregation Interfacial fracture

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stable local trace formula

引用

Science China Mathematics 2014年第12期57卷 2509-2518页

作者： PENG zhifeng Department of Mathematics Nanjing University

Langlands program is the central concern of modern number theory. In general, we think that the main tool for studying this program is the trace formula. Arthur-Selberg's trace formula is successful in solving the endoscopic case of Langlands program. Arthur stabilized the geometric side of the local trace formula in the general case, but did not stabilize the general spectral. This paper aims to solve the general case by different method in the Archimedean case, by directly stabilizing the spectral side of the local trace formula, and obtains the stable local trace formula.

关键词： Langlands program trace formula Arthur-Selberg's trace formula

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Numerical modeling of annular electromagnetic stirring with intercooling in direct chill casting of 7005 aluminum alloy billet

引用

Progress in Natural Science:Materials International 2019年第1期29卷 81-87页

作者： Yajun Luo zhifeng Zhang Department of Mechanical Engineering Hunan Institute of Engineering General Research Institute for Non-Ferrous Metals Hunan Provincial Key Laboratory of Vehicle Power and Transmission System Hunan Institute of Engineering

Uniform direct chill(UDC) casting method was developed by combining annular electromagnetic stirring(AEMS) with intercooling in direct chill casting. In order to investigate effect of UDC on flow patterns, temperature profiles and solidification during the casting, a numerical model of the UDC casting process was developed and used to simulate the UDC casting process for preparing 7005 aluminum alloy billets. The comparison of the calculated results of UDC casting with normal direct chill(NDC) casting indicated that flow patterns, temperature profiles and the sump depth are modified remarkably by the application of annular electromagnetic stirring and intercooling during the direct chill casting. The sump profile and the temperature history during UDC casing were studied, and the mechanism of the casting process were discussed. The comparisons between the simulations and experimental results suggested that the proposed model provides good agreement for the sump profiles and the temperature history within the billets.

关键词： Aluminum alloy Direct chill casting Simulation Electromagnetic stirring Intercooling

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Watershed Ecology and Its Applications

引用

Engineering 2018年第5期4卷 582-583页

作者： zhifeng Yang State Key Laboratory of Water Environment Simulation School of Environment Beijing Normal University Beijing 100875 China

Global climate change and intense human activities greatly alter natural eco-hydrological processes in multi-scale watersheds, resulting in a series of threats to human society and ecosystems that include the increase of extreme climatic events, water quality degradation, and decreases in biodiversity and ecosystem stability. Many theories and approaches on eco- logical restoration for different types of water environments （e.g., rivers, lakes, marshes, and estuaries） have been proposed in the existing research. However, hydrologi-cal connections, mass and energy transports are usually consider- able among the different types of water environments in a watershed, and restoration measures for one component typically affect other components in the same watershed.

关键词：全球气候变化极端气候生物多样性发展现状

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Numerical study of conduction and radiation heat losses from vacuum annulus in parabolic trough receivers

引用

Frontiers in Energy 2022年第6期16卷 1048-1059页

作者： Dongqiang LEI Yucong REN zhifeng WANG Key Laboratory of Solar Thermal Energy and Photovoltaic System Chinese Academy of SciencesBeijing 100190China Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Beijing Engineering Research Center of Solar Thermal Power Beijing 100190China

Parabolic trough receiver is a key component to convert solar energy into thermal energy in the parabolic trough solar *** heat loss of the receiver has an important influence on the thermal efficiency and the operating cost of the power *** this paper,conduction and radiation heat losses are analyzed respectively to identify the heat loss mechanism of the receiver.A 2-D heat transfer model is established by using the direct simulation Monte Carlo method for rarefied gas flow and heat transfer within the annulus of the receiver to predict the conduction heat loss caused by residual *** numerical results conform to the experimental results,and show the temperature of the glass envelope and heat loss for various conditions in *** effects of annulus pressure,gas species,temperature of heat transfer fluid,and annulus size on the conduction and radiation heat losses are systematically ***,the main factors that cause heat loss are analyzed,providing a theoretical basis for guiding the improvement of receiver,as well as the operation and maintenance strategy to reduce heat loss.

关键词： parabolic trough receiver vacuum annulus rarefied gas DSMC(direct simulation Monte Carlo) heat loss

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Magnetic properties of two soil profiles from Yan'an,Shaanxi Province and their implications for paleorainfall reconstruction

引用

Science China Earth Sciences 2014年第4期57卷 719-728页

作者： LIU zhifeng LIU QingSong State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of Sciences Graduate University of Chinese Academy of Sciences

The physical and chemical properties of soils are closely controlled by the climate factors and thus are significant for paleoclimate reconstruction. In this study, two adjacent soil profiles （LP and LPM） with different slopes from Yah＇an, Shaanxi Province, were investigated using magnetic methods to determine the impact of topography on magnetic properties of soil. Our results show that although LP and LPM have similar magnetic minerals and grain size distribution, both the average and max- imum magnetic susceptibility （Z） of LP are almost doubled compared to those of LPM. In addition, the ratios of susceptibility enhancement to the background （Ez） for LP and LPM are 2.27 and 2.04, respectively; the ratios of saturation isothermal rem- nant magnetization （SIRM） enhancement （EsIRM） for these two profiles are 1.80 and 1.86, respectively. The slopes of the linear regression trends between frequency-dependent susceptibility （ZFD） and ＂hard＂ isothermal remnant magnetization （HIRM）（ZFD/HIRM）, Anhysteretic remnant magnetization （ARM） and HIRM （ARM/HIRM）, are almost free from the effect of parent material. XFD/HIRMs for LP and LPM are 28.7×10 5 and 28.9×10 5 A m^-1, respectively; ARM/HIRMs are 0.35 and 0.33 for LP and LPM, respectively. These results demonstrate that parameters, ZFD/HIRM, ARM/HIRM, Ez and ESIRM, are affected less by parent material and topography, which are better than the Z for bulk samples to indicate the paleoclimatic conditions （e.g., the paleorainfall） in a large-scale region.

关键词： soil profile slope magnetic properties paleorainfall reconstruction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Investigation on 3D flow field induced by a plasma actuator with serrated electrode

引用

Science Bulletin 2016年第6期61卷 481-487页

作者： zhifeng Liu Mingming Zhang Lianze Wang School of Aerospace Engineering Tsinghua University Institute of Engineering Thermophysics Chinese Academy of Sciences

This paper presents an experimental investigation on flow field induced by a dielectric barrier discharge(DBD) plasma actuator with serrated electrodes in still air to further improve its flow control effectiveness. For comparison, the actuator with widely used linear electrodes was also studied. Experiments were carried out using 2D particle image velocimetry. Particular attention was given to the flow topology, discharge phenomenon, and vortex formation mechanism. Results showed that a 2D wall jet was induced by the linear actuators, whereas the plasma actuators with serrated electrode introduced a series of streamwise vorticities, which might benefit flow control(e.g., enhancing the momentum transport in the separated boundary flow). In addition, the mechanism of 3D flow topology induced by the serrated DBD actuator was analyzed in detail.

关键词： Plasma actuator Serrated electrode Vortex dynamics Particle image velocimetry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

YN2 monolayer： Novel p-state Dirac half metal for high-speed spintronics

引用

Nano Research 2017年第6期10卷 1972-1979页

作者： zhifeng Liu Junyan Liu Jijun Zhao School of Physical Science and Technology Inner Mongolia University Hohhot 010021 China Beijing Computational Science Research Center Beijing 100094 China Key Laboratory of Materials Modification by Laser Ion and Electron Beams Dalian University of Technology Dalian 116024 China

In spintronics, it is highly desirable to find new materials that can simultaneously possess complete spin-polarization, high-speed conduction electrons, large Curie temperature, and robust ferromagnetic ground states. Using first-principles calculations, we demonstrate that the stable YN2 monolayer with octahedral coordination is a novel p-state Dirac half metal （DHM）, which not only has a fully spin-polarized Dirac state, but also the highest Fermi velocity （3.74×10^5 m/s） of the DHMs reported to date. In addition, its half-metallic gap of 1.53 eV is large enough to prevent the spin-flip transition. Because of the strong nonlocal p orbitals of N atoms （N-p） direct exchange interaction, the Curie temperature reaches over 332 K. Moreover, its ferromagnetic ground state can be well preserved under carrier doping or external strain. Therefore, the YN2 monolayer is a promising DHM for high-speed spintronic devices and would lead to new opportunities in designing other p-state DHMs.

关键词： spintronics Dirac half metalYN2 monolayer ferromagnetism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：