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Pd@Ir-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy

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Nano Research 2024年第1期17卷 270-281页

作者： Zichen Ye Yun Li Jingchao Li Xinyan Hu Jinyang Zheng Gongxin zhang Sijin Xiang Tianbao Zhu zhide Guo Xiaolan Chen State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials and Engineering Research Center for Nano-Preparation Technology of Fujian ProvinceCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen UniversityXiamen 361102China The High Educational Key Laboratory for Biomedical Engineering&Key Laboratory of Fire Retardant Materials of Fujian Province Department of BiomaterialsCollege of MaterialsXiamen UniversityXiamen 361102China

Lactic acid(LA)plays a major role in the occurrence,development,and spread of cancer.Enlightened by its high accumulation in tumor site,a novel lactate oxidase(LOD)conjugated two-dimensional Pd@Ir nanoplatform(Pd@Ir-LOD,PIL)was fabricated to combine cascade reaction with photothermal for tumor therapy.In detail,the overexpressed LA in tumor microenvironment(TME)was a key factor to activate the PIL-based cascade reaction:(1)Plenty of H_(2)O_(2)could be generated from LA by the catalysis of LOD with O_(2);(2)potent·OH was produced from H_(2)O_(2)due to the peroxidase(POD)-like activity of PIL;(3)meantime,PIL’s catalase(CAT)-like activity could decompose part H_(2)O_(2)into O_(2)to achieve the purpose of LA cyclic oxidization.Moreover,the reduced glutathione(GSH)scavenging capability of PIL might protect the produced reactive oxygen species(ROS)from being cleared to further improve the cascade therapeutic effect.More importantly,PIL had excellent photothermal conversion efficiency(37.35%)and manifested a surprising temperature rising effect in tumor.Taken together,the decreasing LA concentration,accumulation of high-toxic ROS,the depletion of GSH together with the higher intra-tumoral temperature potently enhanced in vivo antitumor therapy.Therefore,a promising therapeutic tactic based on PIL integrating endogenous LA consumption,chemodynamic therapy(CDT),and photothermal therapy(PTT)has been put forward.

关键词： lactate oxidase chemodynamic therapy photothermal therapy cascade reaction tumor microenvironment

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新型结核性胸腔积液诊断标志物研究进展

中国感染与化疗杂志 2024年第3期24卷 371-376页

作者：欧阳佩珩胡志德张蕾内蒙古医科大学附属医院检验科呼和浩特010010

胸腔积液在临床极为常见,与多种疾病有关。常见的胸腔积液病因包括结核性胸膜炎、心力衰竭、恶性肿瘤和肺炎等[1]。其中,由结核性胸膜炎引发的胸腔积液又称为结核性胸腔积液(TPE)[2]。在就诊时原因不明的胸腔积液患者中诊断TPE,是采用... 详细信息

胸腔积液在临床极为常见,与多种疾病有关。常见的胸腔积液病因包括结核性胸膜炎、心力衰竭、恶性肿瘤和肺炎等[1]。其中,由结核性胸膜炎引发的胸腔积液又称为结核性胸腔积液(TPE)[2]。在就诊时原因不明的胸腔积液患者中诊断TPE,是采用正规、系统抗痨治疗的前提,也是改善患者预后的关键所在。当前,TPE的诊断金标准包括胸水抗酸染色、胸水结核分枝杆菌培养和胸膜活检[2],但是这些方法都具有一定的局限性。胸水抗酸染色诊断TPE的特异度虽然可达100%,但灵敏度仅为3%[3]。

关键词：结核性胸腔积液诊断生物标志物胸水结核病

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磁流变脂组分对其动态流变性能的影响

重庆大学学报 2024年第5期47卷 37-46页

作者：胡志德张寒松张时豪赵湖钧许春霞蒋昊洋中国人民解放军陆军勤务学院重庆401311 中央军委后勤保障部北京100036

采用原位皂化工艺制备了基于不同类型载液和磁性颗粒的磁流变脂,使用智能磁流变仪分别考察了基础油类型及黏度、磁性颗粒粒径对磁流变脂流变性能的影响,并用自然沉降法考察了基于不同组分的磁流变脂的沉降稳定性。实验结果表明,通过改... 详细信息

采用原位皂化工艺制备了基于不同类型载液和磁性颗粒的磁流变脂,使用智能磁流变仪分别考察了基础油类型及黏度、磁性颗粒粒径对磁流变脂流变性能的影响,并用自然沉降法考察了基于不同组分的磁流变脂的沉降稳定性。实验结果表明,通过改变基础油类型和调节基础油的黏度可控制磁流变脂的内部骨架结构,有效地改善磁流变脂的磁流变性能和沉降稳定性;增大磁性颗粒的粒径可提高磁流变脂的流动性,增大磁场下磁流变脂的结构强度,增强其磁流变效应。

关键词：智能材料磁流变脂基础油流变性能沉降稳定性

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等带宽间作模式下不同玉米花生行比对花生光合特性和系统产量的影响

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四川农业大学学报 2024年第1期42卷 39-45页

作者：梁满沈一刘永惠沈悦张旭尧陈志德江苏省农业科学院经济作物研究所南京210014

【目的】明确相同带宽条件下不同玉米花生种植行比对花生光合特性和系统产量的影响,为构建适宜行比的玉米花生带状间作模式提供理论参考和技术支持。【方法】以玉米花生带状间作系统为对象,设置玉米单作,花生单作,玉米花生间作(3.6 m的... 详细信息

【目的】明确相同带宽条件下不同玉米花生种植行比对花生光合特性和系统产量的影响,为构建适宜行比的玉米花生带状间作模式提供理论参考和技术支持。【方法】以玉米花生带状间作系统为对象,设置玉米单作,花生单作,玉米花生间作(3.6 m的总带宽,行比分别为2∶6、4∶4、6∶2),研究不同行比对间作花生干物质积累、叶面积指数、叶片光合参数、产量构成和玉米花生系统产量的影响。【结果】3种间作模式的干物质量和叶面积指数均小于单作,其中2∶6种植模式在花生生育后期的叶面积指数较4∶4和6∶2分别提高30.07%和44.19%,等带宽间作体系下相对较少的玉米行比可以增加间作花生的叶绿素含量和光合速率,保持花生叶片较高的光合能力,从而获得产量优势。间作显著降低了玉米的穗数、穗粒数和百粒重以及花生的单株饱果数和百果重,系统产量以2行玉米6行花生的种植模式最高,为13749.9 kg/hm^(2),3种间作模式的土地当量比均大于1,且综合产量均显著高于单作玉米和单作花生。【结论】在玉米花生等带宽间作模式下,花生行比的增加缓解了玉米的荫蔽效应,改善了花生的光合能力,同时提高土地利用率,实现稳粮增油、均衡生产。

关键词：间作花生行比光合特性系统产量

Enhanced Mechanical Properties of AA5083 Matrix Composite via Introducing Al_(0.5)CoCrFeNi Particles and Cryorolling

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Acta Metallurgica Sinica(English Letters) 2022年第6期35卷 879-889页

作者： Hao Gu zhide Li Kaiguang Luo Laxman Bhatta Hanqing Xiong Yun zhang Charlie Kong Hailiang Yu State Key Laboratory of High Performance Complex Manufacturing Central South UniversityChangsha 410083China College of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China Mark Wainwright Analytical Center University of New South WalesSydneyNSW 2052Australia Light Alloys Research Institute Central South UniversityChangsha 410083China

High-entropy alloy particles(HEAPs)can markedly enhance the mechanical properties of metal matrix composites(MMCs).In this study,AA5083/Al_(0.5) CoCrFeNi HEAPs MMCs with diff erent HEAPs contents(0,1,and 3 wt%)were prepared via a stir-casting,and then these MMCs sheets were hot rolled(573 K)and cryorolled(77 K),respectively.The mechanical properties of the MMCs sheets were measured by tensile testing and microhardness test.Additionally,their microstructures were analyzed by scanning electron microscopy and transmission electron microscopy.Results revealed that the ultimate tensile strength(UTS)of the as-cast AA5083/Al_(0.5) CoC rF eN i HEAPs MMCs were improved from 203 to 257 MPa by adding 3 wt%HEAPs.And the mechanical properties of the MMCs sheets were improved after cryorolling.After cryorolling with 50%rolling reduction ratio,the MMCs with 1 wt%HEAPs had an UTS of 382 MPa,which was 1.9 times that of the MMCs before rolling.Finally,the strengthening mechanisms of HEAPs and cryorolling on the AA5083/HEAPs MMCs were discussed.

关键词： Metal matrix composite Cryorolling Mechanical properties High-entropy alloy particle

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伤口治疗师职业倦怠现状及影响因素分析

中华现代护理杂志 2024年第5期30卷 632-636页

作者：麦智德于淼张建霞丁炎明北京大学第一医院急诊科北京100034 北京大学第一医院护理部北京100034

目的调查我国伤口治疗师职业倦怠现状水平及其影响因素,为伤口治疗师的成长和发展提供支持。方法于2022年9月—2023年3月,采用便利抽样法选取全国235名经过伤口治疗师认证的专科护士作为研究对象,使用伤口治疗师一般资料调查表、个人-... 详细信息

目的调查我国伤口治疗师职业倦怠现状水平及其影响因素,为伤口治疗师的成长和发展提供支持。方法于2022年9月—2023年3月,采用便利抽样法选取全国235名经过伤口治疗师认证的专科护士作为研究对象,使用伤口治疗师一般资料调查表、个人-工作匹配量表、专科护士工作投入量表和马氏职业倦怠量表-服务行业版对其进行问卷调查。采用二项Logistic回归分析探讨伤口治疗师职业倦怠的影响因素。结果本研究共发放问卷235份,回收有效问卷219份,问卷有效问卷回收率为93.2%。219名伤口治疗师中职业倦怠阳性人数为125名(57.1%)。二项Logistic回归分析结果显示,职称、工作负荷、团队氛围和工作价值是伤口治疗师职业倦怠的影响因素(P<0.05)。结论伤口治疗师的职业倦怠检出率较高,职称、工作负荷、团队氛围和工作价值影响其职业倦怠,提示护理管理者应采用相对应的措施改善伤口治疗师职业环境,降低其职业倦怠。

关键词：护士伤口治疗师职业倦怠个人-工作匹配工作投入影响因素

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联盟链下的高效车联网数据安全共享研究

情报探索 2024年第7期 49-55页

作者：彭贻希金燚陈志德唐敏张章学福建省交通信息通信与应急处置中心福建福州350001 福建师范大学计算机与网络空间安全学院福建福州350117 福建省海峡信息技术有限公司福建福州350003

[目的/意义]旨在解决现有的车联网数据共享方案中计算开销大、共享效率低、安全性不足等问题。[方法/过程]设计了一个车联网高效数据安全共享方案,采用基于线性秘密共享(LSSS)的密文策略属性加密(CP-ABE)算法和基于联盟区块链群组技术,... 详细信息

[目的/意义]旨在解决现有的车联网数据共享方案中计算开销大、共享效率低、安全性不足等问题。[方法/过程]设计了一个车联网高效数据安全共享方案,采用基于线性秘密共享(LSSS)的密文策略属性加密(CP-ABE)算法和基于联盟区块链群组技术,实现了车联网高效数据共享,减少数据冗余,并通过共识机制的优化,进一步提高时间效率,同时确保车辆实体的数据安全性和隐私性。[结果/结论]该方案能够适应车联网快速移动、动态变化的复杂特性,可实现灵活访问控制和高自由度的数据共享,满足车联网场景需求。

关键词：区块链车联网密文策略属性加密(CP-ABE) 线性秘密共享(LSSS) 群组管理数据共享

Dependence of sperm structural and functional integrity on testicular calcineurin isoform PPP3R2 expression

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Journal of Molecular Cell Biology 2020年第7期12卷 515-529页

作者： Yue Liu Chujun zhang Shiyao Wang Yanqin Hu Jia Jing Luyao Ye Ran Jing zhide Ding Department of Histology EmbryologyGenetics and Developmental BiologyShanghai Key Laboratory for Reproductive MedicineShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Clinical Medicine Shanghai Jiao Tong University School of MedicineShanghai 200025China

After leaving the testis,mammalian sperm undergo a sequential maturation process in the epididymis followed by capacitation during their movement through the female reproductive tract.These phenotypic changes are associated with modification of protein phosphorylation and membrane remodeling,which is requisite for sperm to acquire forward motility and induce fertilization.However,the molecular mechanisms underlying sperm maturation and capacitation are still not fully understood.Herein,we show that PPP3R2,a testis-specific regulatory subunit of protein phosphatase 3(an isoform of calcineurin in the testis),is essential for sperm maturation and capacitation.Knockout of Ppp3r2 in mice leads to male sterility due to sperm motility impairment and morphological defects.One very noteworthy change includes increases in sperm membrane stiffness.Moreover,PPP3R2 regulates sperm maturation and capacitation via(i)modulation of membrane diffusion barrier function at the annulus and(ii)facilitation of cholesterol efflux during sperm capacitation.Taken together,PPP3R2 plays a critical role in modulating cholesterol efflux and mediating the dynamic control of membrane remodeling during sperm maturation and capacitation.

关键词： cholesterol metabolism Ppp3r2 sperm deformity sperm motility sperm maturation

High-fidelity Wide Frequency Processing Techniques for Seismic Data Acquired by Digital Geophones

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石油地球物理勘探 2012年第A2期47卷 7-19页

作者： Chen zhide Guan Xin Li Ling zhang Jing Exploration and Development Research Institute of Daqing Oilfield Company Daqing Heilongjiang 163712 China