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螺环类农药研究进展

现代农药 2024年第1期23卷 40-50页

作者：袁婷伍思凯吴志兵贵州中医药大学时珍学院贵阳550200 贵州大学绿色农药与农业生物工程教育部重点实验室/国家重点实验室培育基地贵阳550025 贵州师范大学国际教育学院贵阳550001

综述了具有杀虫活性、杀菌活性和抗病毒活性螺环化合物在农药领域的研究进展,总结了具有生物活性的螺环化合物的结构特征,并展望了螺环化合物作为农药先导化合物的研究前景。

关键词：螺环化合物生物活性杀虫剂抗病毒剂杀菌剂

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基于元路径属性融合的异质网络表示学习

山东大学学报（理学版） 2024年第3期59卷 1-13页

作者：王静红吴芝冰黄鹏杨家腾李笔河北师范大学计算机与网络空间安全学院河北石家庄050024 河北省网络与信息安全重点实验室(河北师范大学) 河北石家庄050024 供应链大数据分析与数据安全河北省工程研究中心(河北师范大学) 河北石家庄050024 河北师范大学商学院河北石家庄050024

针对信息网络的表示学习进行研究,提出了一种基于元路径信息融合的异质图神经网络(metapath attribute fusion graph neural network,MAFGNN),通过在异质网络中引入元路径之前将目标节点的邻居信息包括元路径信息融入到节点中,实现目标... 详细信息

针对信息网络的表示学习进行研究,提出了一种基于元路径信息融合的异质图神经网络(metapath attribute fusion graph neural network,MAFGNN),通过在异质网络中引入元路径之前将目标节点的邻居信息包括元路径信息融入到节点中,实现目标节点和邻居信息的融合。该方法首先将不同类型的节点属性特征进行维度转换便于后续的融合操作,通过计算目标节点和邻居节点权重值完成目标节点信息的融合操作。然后根据特定元路径对目标节点进行融合,最后在不同元路径间实现不同语义信息的融合操作。在多个异质信息数据集上进行实验表明,MAFGNN模型在处理异质网络节点嵌入方面相比于最先进的基准实验有最好的性能和更加准确的预测结果。

关键词：元路径异质信息网络异质图嵌入信息融合注意力机制

腹腔镜子宫肌瘤剔除术治疗子宫肌瘤的效果及对机体创伤的影响评价

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中外医疗 2024年第5期43卷 66-69页

作者：张岩陆瑞吴志兵吴苗苗沭阳县中医院妇产科江苏沭阳223600

目的探讨子宫肌瘤患者采用腹腔镜剔除(Laparoscopic Myomectomy,LM)的效果及对机体创伤的影响。方法便利选取2021年7月—2023年6月沭阳县中医院收治的58例子宫肌瘤患者为研究对象,按抽签法随机分为对照组(开腹手术治疗,29例)与干预组(L... 详细信息

目的探讨子宫肌瘤患者采用腹腔镜剔除(Laparoscopic Myomectomy,LM)的效果及对机体创伤的影响。方法便利选取2021年7月—2023年6月沭阳县中医院收治的58例子宫肌瘤患者为研究对象,按抽签法随机分为对照组(开腹手术治疗,29例)与干预组(LM治疗,29例),比较两组疗效、手术指标、卵巢功能与并发症发生率。结果干预组治疗总有效率为96.55%,高于对照组的72.41%,差异有统计学意义(χ^(2)=4.735,P<0.05)。干预组术中出血量、术后肛门首次排气时间、首次下床活动时间、住院时间分别(61.76±5.86)mL、(21.38±4.43)h、(20.11±5.37)h、(5.26±0.56)d,均优于对照组,差异有统计学意义(t=28.943、7.874、5.909、11.717,P均<0.05)。干预组抗缪勒管激素、卵泡刺激素、雌二醇分别(1.93±0.17)ng/mL、(7.38±1.11)U/L、(131.75±6.12)pmol/L,均高于对照组,差异有统计学意义(t=2.535、3.964、17.809,P均<0.05)。干预组并发症发生率为3.45%,低于对照组的27.59%,差异有统计学意义(χ^(2)=4.735,P<0.05)。结论LM治疗子宫肌瘤效果较好,可优化手术指标,提高卵巢功能,降低术后并发症发生率。

关键词：腹腔镜子宫肌瘤剔除术子宫肌瘤临床效果机体创伤

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Microwave triggered multifunctional nanoplatform for targeted photothermal-chemotherapy in castration-resistant prostate cancer

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Nano Research 2023年第7期16卷 9688-9700页

作者： Pengyuan Liu Yajun wu Xiaogang Xu Xudong Fan Chuan Sun Xiaojie Chen Jindan Xia Shiting Bai Li Qu Huasong Lu Jing wu Jun Chen Ji-Gang Piao zhibing wu Department of Oncology Affiliated Zhejiang HospitalZhejiang University School of MedicineHangzhou 310013China School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Department of Radiation Oncology Affiliated Zhejiang HospitalZhejiang University School of MedicineHangzhou 310013China Geriatrics Institute of Zhejiang Province Department of GeriatricsAffiliated Zhejiang HospitalZhejiang University School of MedicineHangzhou 310030China Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology Life Sciences InstituteZhejiang UniversityHangzhou 310058China TCM Dispensary Affiliated Zhejiang HospitalZhejiang University School of MedicineHangzhou 310013China Department of Breast Surgery Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China

Lacking a precise targeting strategy,castration-resistant prostate cancer(CRPC)is still hard to be treat *** treatment options that can accurately target CPRC is an important issue with urgent *** this study,a novel nanotechnologybased strategy had been developed for the precise target treatment of *** combining microwaves and photothermal therapy(PTT),this nanoplatform,cmHSP70-PL-AuNC-DOX,targets tumor tissues with outstanding precision and achieves better anti-tumor activity by simultaneously eliciting photothermal and chemotherapeutic *** nanotechnology,cmHSP70-modified and thermo-sensitive liposome-coated AuNC-DOX were prepared and used for CRPC-targeted photothermal ablation and ***(DOX)was selected as the chemotherapeutic agent for *** terms of the curative scheme,prostate tissues were firstly pre-treated with microwaves to induce the expression of heat shock protein 70(HSP70)and its migration to the cell membrane,which was then targeted by HSP70 antibody(cmHSP70)coated on the nanoparticles to achieve accurate drug *** nanoplatform then achieved precise ablation and controlled release of DOX under external near-infrared(NIR)*** the implementation,the targeting,cell killing,and safety of this therapeutical strategy had been verified in vivo and in *** work establishes an accurate,controllable,efficient,non-invasive,and safe treatment platform for targeting CRPC,provides a rational design for CRPC’s PTT,and offers new prospects for nanomedicines with great precision.

关键词： castration-resistant prostate cancer gold nanocage heat shock protein 70 targeted drug delivery photothermalchemotherapy

自拟补肾安胎饮联合穴位贴敷治疗肾虚型先兆流产临床疗效及对患者血清β-HCG、孕酮的影响

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实用妇科内分泌电子杂志 2024年第3期11卷 44-46页

作者：董其虎陆瑞郭红霞李文清吴志兵南京中医药大学沭阳附属医院妇科江苏沭阳223600

目的探讨自拟补肾安胎饮联合穴位贴敷治疗肾虚型先兆流产临床疗效及对患者血清β-人绒毛膜促性腺激素(β-HCG)、孕酮的影响。方法选取62例肾虚型先兆流产患者,按照随机数字表法分为两组,每组31例,对照组予以常规西医方案治疗,观察组在... 详细信息

目的探讨自拟补肾安胎饮联合穴位贴敷治疗肾虚型先兆流产临床疗效及对患者血清β-人绒毛膜促性腺激素(β-HCG)、孕酮的影响。方法选取62例肾虚型先兆流产患者,按照随机数字表法分为两组,每组31例,对照组予以常规西医方案治疗,观察组在对照组的基础上,联合应用自拟补肾安胎饮和穴位贴敷治疗。比较两组患者治疗后血清性激素水平、炎性细胞因子水平及临床疗效。结果治疗后,观察组性激素水平、炎性细胞因子水平优于对照组,差异有统计学意义(P<0.05)。试验组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论肾虚型先兆流产患者临床治疗中应用自拟补肾安胎饮联合穴位贴敷治疗的疗效显著,可调节患者血清β-HCG、孕酮水平,具有进一步推广与应用的价值。

关键词：自拟补肾安胎饮穴位贴敷肾虚型先兆流产

Stability Investigation and Improvement for DC Cascade Systems with Simplified Impedance-based Stability Criterion

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1044-1052页

作者： Junbin Fang Zhikang Shuai Yang Li zhibing Wang Xiangyang wu Xia Shen Z.John Shen College of Electrical and Information Engineering Hunan UniversityChangsha 410082China Renewable Energy Department of China Electric Power Research Institute Beijing 100192China Department of Electrical and Computer Engineering Illinois Institute of TechnologyChicagoIL 60616USA IEEE

In DC distributed power systems(DPSs),the complex impedance interactions possibly lead to DC bus voltage oscillation or *** previous research,the stability analysis of DPSs is implemented based on mathematical analysis in control *** specific mechanisms of the instability of the cascade system have not been intuitively *** this paper,the stability analysis of DPSs based on the traditional Nyquist criterion is simplified to the resonance analysis of the seriesconnected port impedance(Z=R+jX)of source and load *** reveals that the essential reason for impedance instability of a DC cascade system is that the negative damping characteristic(R<0)of the port the overall impedance amplifies the internal resonance source at reactance zero-crossing *** simplified stability criterion for DC cascade systems can be concluded as:in the negative damping frequency ranges(R<0),there exists no zero-crossing point of the reactance component(i.e.,X=0).According to the proposed stability criterion,the oscillation modes of cascade systems are classified.A typical one is the internal impedance instability excited by the negative damping,and the other one is that the external disturbance amplified by negativity in a low stability ***,the impedance reshaping method for stability improvement of the system can be further *** validity of the simplified criterion is verified theoretically and experimentally by a positive damping reshaping method.

关键词： DC cascaded system,impedance model impedance reconstruction stability criterion

Top(ological-operon) secret behind the long-range transcriptional coupling

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Signal Transduction and Targeted Therapy 2022年第11期7卷 3998-4000页

作者： Lei Zhang zhibing wu Huasong Lu Department of Orthopaedic Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang325000China Department of Oncology Affiliated Zhejiang HospitalZhejiang University School of MedicineHangzhouZhejiang310013China Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology Life Sciences InstituteZhejiang UniversityHangzhouZhejiang310058China

In a recent study published in Nature,Levo et *** that paralogous genes separated by long distances are regulated by specialized DNA stretches called tethering elements,which enable their physical associations and co-... 详细信息

关键词： transcriptional coupling embryogenesis.

Antiviral and Antibacterial Activities of N-（4-Substituted phenyl） Acetamide Derivatives Bearing 1,3,4-Oxadiazole Moiety

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Chinese Journal of Chemistry 2016年第12期34卷 1236-1244页

作者： Ling Chen Peiyi Wang Zhenxing Li Lei Zhou zhibing wu Baoan Song Song Yang State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education Center for R&D of Fine Chemicals of Guizhou University Guiyang Guizhou 550025 China College of Pharmacy East China University of Science & Technology Shanghai 550025 China

In this paper, a series of N-（4-substituted phenyl） acetamide derivatives bearing 1,3,4-oxadiazole moiety were synthesised. Preliminary bioassays revealed that these compounds not only exhibited favourable antiviral activities toward tobacco mosaic virus （TMV） but also demonstrated sustained inhibition activities against plant pathogenic bacteria, including Xanthomonas oryzae pv. oryzae, Ralstonia solanacearum, and Xanthomonas axonopodis pv. cit- ri. Among the derivatives, TC8 and TC20 exerted the strongest curative activities against TMV, with half-maximal effective concentration （EC50） values of 239.5 and 236.2μg/mL, respectively, which were comparable to that of ningnanmycin （EC50=273.2μg/mL）. Given their simple synthesis, the target compounds can serve as alternative antiviral candidates.

关键词： 1,3,4-oxadiazole acetamide synthesis antiviral antibacterial

热疗联合免疫检查点抑制剂的基础研究和临床应用进展

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中华放射肿瘤学杂志 2022年第5期31卷 483-487页

作者：刘鹏远吴亚军吴稚冰浙江中医药大学第二临床医学院杭州310053 浙江大学医学院附属浙江医院中药房杭州310030 浙江大学医学院附属浙江医院肿瘤科杭州310030

恶性肿瘤传统治疗方法对晚期转移患者疗效欠佳。近年来免疫检查点抑制剂治疗发展迅速,极具潜力,但整体临床有效率不高。肿瘤通过多种机制改变肿瘤微环境,产生免疫耐药,从而大大降低了免疫检查点抑制剂的疗效。热疗不仅可发挥热效应的抗... 详细信息

恶性肿瘤传统治疗方法对晚期转移患者疗效欠佳。近年来免疫检查点抑制剂治疗发展迅速,极具潜力,但整体临床有效率不高。肿瘤通过多种机制改变肿瘤微环境,产生免疫耐药,从而大大降低了免疫检查点抑制剂的疗效。热疗不仅可发挥热效应的抗肿瘤优势,还可通过多种途径起到直接和间接免疫增敏作用,将"冷肿瘤"转变为"热肿瘤",从而多方面起到增强免疫检查点抑制剂疗效的作用。大量基础实验证明,在小鼠体内进行热疗联合免疫检查点抑制剂已取得较好效果。目前,部分正在开展的热疗联合免疫检查点抑制剂临床试验也已取得较好进展。本文从免疫检查点抑制剂、热疗、热疗联合免疫检查点抑制剂3个层面分析了联用优势,并展望了未来热疗联合免疫检查点抑制剂治疗的重点研究方向。

关键词：热疗免疫检查点抑制剂免疫增敏