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Cardiovascular Innovations and Applications 2017年第B2期2卷 265-271页

作者： Wenbo He zhibing Lu Hong jiang Department of Cardiology Renmin Hospital of Wuhan UniversityWuhan 430060People’s Republic of China

Amlodipine/valsartan(Aml/Val)single-pill combination(SPC)therapy has been widely used and studied in clinical practice in recent *** article reviews the Chinese and English literature on the clinical use of Aml/Val SPC therapy in Chinese hypertensive *** to five studies concerning the efficacy and safety of this treatment,Aml/Val SPC therapy was more efficacious than monotherapy with valsartan,amlodipine,or the nifedipine gastrointestinal therapeutic *** treatment showed greater blood pressure-lowering effects,a higher blood pressure control rate,and a higher response ***/Val SPC treatment was well tolerated,with adverse event rates similar to those of monotherapy with valsartan or amlodipine and significantly rarer adverse events compared with the nifedipine gastrointestinal therapeutic ***/Val SPC is a highly efficacious and well-tolerated antihypertensive treatment in Chinese hypertensive patients.

关键词： hypertension valsartan amlodipine single-pill combination

A Teosinte-derived Allele of a MYB Transcription Repressor Confers Multiple Disease Resistance in Maize.

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Molecular Plant 2021年第11期14卷 1846-1863页

作者： Hongze Wang Jiabao Hou Pei Ye Long Hu Junshi Huang Zhikang Dai Bao Zhang Sha Dai Jiamin Que Haoxuan Min Gengshen Chen Yanbo Wang Min jiang Yan Liang Lin Li Xuecai Zhang zhibing Lai National Key Laboratory of Crop Genetic Improvement WuhanChina Liaoning Academy of Agricultural Sciences ShenyangChina International Maize and Wheat Improvement Center(CIMMYT) EI BatanTexcocoMexico

Natural alleles controlling multiple disease resistances (MDR) are valuable for crop breeding. However, only one MDR gene have been cloned in maize, and molecular mechanisms of MDR are not clear. By map-based cloning, we have cloned a teosinte-derived allele of a resistance gene, Mexicana lesion mimic 1 (ZmMM1), which has a lesion mimic phenotype and confers resistance to northern leaf blight (NLB), gray leaf spot (GLS) and southern corn rust (SCR). Strong MDR conferred by the teosinte allele is linked with the polymorphisms in the 3' untranslated region of the ZmMM1 gene that cause increased accumulation of ZmMM1 protein. ZmMM1 acts as a transcription repressor and negatively regulates transcription of specific target genes including ZmMM1-target gene 3 (ZmMT3), which functions as a negative regulator of plant immunity and associated cell death. The successful isolation of the ZmMM1 resistance gene will help not only in developing broad-spectrum and durable disease resistance but also in understanding the molecular mechanisms underlying MDR.

关键词： Multiple disease resistance ZmMM1 lesion mimic maize teosinte

高气压SF_(6)中毛细管放电等离子体的喷射特性

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高电压技术 2022年第12期48卷 5080-5089页

作者：李晓昂张宁博李志兵蒋攀张然张乔根西安交通大学电力设备电气绝缘国家重点实验室西安710049 中国电力科学研究院有限公司北京100192

毛细管放电等离子体喷射是实现极低工作系数下间隙开关触发导通极具潜力的技术路线,而高气压SF_(6)对等离子体喷射的“抑制效应”直接影响喷射极限和触发特性,亟待开展相关研究。为此构建了高气压SF_(6)中毛细管等离子体喷射实验平台,... 详细信息

毛细管放电等离子体喷射是实现极低工作系数下间隙开关触发导通极具潜力的技术路线,而高气压SF_(6)对等离子体喷射的“抑制效应”直接影响喷射极限和触发特性,亟待开展相关研究。为此构建了高气压SF_(6)中毛细管等离子体喷射实验平台,研究了不同触发能量、毛细管结构和气压对等离子体喷射特性的影响,分析了不同放电次数后的性能劣化过程和机理。结果表明,等离子体喷射发展呈射流状,经过稳定增长到最大高度后迅速消失;提高触发能量可显著提升喷射速度和高度,但存在饱和效应;随着毛细管腔长度增加,喷射速度和高度呈现先增大后减小的趋势,这是消融产气量和寄生体积共同影响所致。SF_(6)气压在0.1~0.5 MPa增加时,等离子体喷射被显著抑制,最大喷射高度从6.3 cm下降至4.3 cm,喷口速度从1710 m/s下降至960 m/s。长期重复放电过程中,等离子体喷射速度和高度均呈现缓慢下降趋势,其主要原因是毛细管材料消融导致微腔形变和寄生体积增大。该研究为高气压SF_(6)中毛细管放电喷射等离子体特性提供了基础数据,对SF_(6)气体间隙开关的性能提升和推广应用具有重要意义。

关键词：毛细管放电 SF_(6) 等离子体喷射触发性能劣化

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增强型等离子体喷射装置及其触发极限

高电压技术 2022年第8期48卷 3334-3343页

作者：郜淦李晓昂张宁博蒋攀李志兵张乔根西安交通大学电力设备电气绝缘国家重点实验室西安710049 中国电力科学研究院有限公司北京100192

江苏-白鹤滩±800 kV特高压混合直流输电工程中,采用可控避雷器实现柔性直流母线的过电压保护,但是当可控避雷器不能满足泄能需求时,亟需超快速动作旁路保护开关在1 ms内将柔性直流母线快速接地,实现对系统的保护。兆伏级SF6气体触发间... 详细信息

江苏-白鹤滩±800 kV特高压混合直流输电工程中,采用可控避雷器实现柔性直流母线的过电压保护,但是当可控避雷器不能满足泄能需求时,亟需超快速动作旁路保护开关在1 ms内将柔性直流母线快速接地,实现对系统的保护。兆伏级SF6气体触发间隙具有高耐压、大通流、经济性好的优点极具工程应用的潜力,但实现其在极低工作系数下的触发导通极为困难。文中首次设计了一种增强型等离子体喷射装置,通过聚四氟乙烯毛细管内金属丝电爆炸的方式产生稠密的热金属等离子体并喷射至间隙中,实现了高气压SF6中等离子体喷射高度的显著提升。并研究了铝丝直径、触发电压和环境介质气压对等离子体喷射特性的影响规律,研究结果表明:铝丝直径越大、触发电压越高、环境介质气压越低,装置的喷射能力越强。当触发电压为-4 kV、铝丝直径为800μm时,等离子体在0.5 MPa SF6中最大喷射高度超过8 cm。最后,通过实验研究了增强型等离子体喷射装置的触发极限,在上电极电压-80 kV(工作系数低至4.22%)时,仍能够可靠触发间隙距离9 cm长的兆伏级SF6气体开关导通,平均导通时延(542±43)μs,满足工程需求。

关键词：气体开关金属丝电爆炸增强型等离子体喷射装置喷射特性触发极限

Permeability and Selectivity of Sulfur Dioxide and Carbon Dioxide in Supported Ionic Liquid Membranes

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Chinese Journal of Chemical Engineering 2009年第4期17卷 594-601页

作者：江滢滢吴有庭王文婷李磊周政张志炳 Key Laboratory of Mesoscopic Chemistry of MOE School of Chemistry and Chemical Engineering Nanjing University Nanjing 210093 China

Permeabilities and selectivities of gases such as carbon dioxide(CO2),sulfur dioxide(SO2),nitrogen(N2)and methane(CH4)in six imidazolium-based ionic liquids([emim][BF4],[bmim][BF4],[bmim][PF6],[hmim][BF4],[bmim][Tf2N]and[emim][CF3SO3])supported on polyethersulfone microfiltration membranes are investigated in a single gas feed system using nitrogen as the environment and reference component at temperature from 25 to 45oC and pressure of N2 from 100 to *** is found that SO2 has the highest permeability in the tested supported ionic liquid membranes,being an order of magnitude higher than that of CO2,and about 2 to 3 orders of magnitude larger than those of N2 and *** observed selectivity of SO2 over the two ordinary gas components is also *** is shown experimentally that the dissolution and transport of gas components in the supported ionic liquid membranes,as well as the nature of ionic liquids play important roles in the gas permeation.A nonlinear increase of permeation rate with temperature and operation pressure is also observed for all sample *** considering the factors that influence the permeabilities and selectivities of CO2 and SO2,it is expected to develop an optimal supported ionic liquid membrane technology for the isolation of acidic gases in the near future.

关键词：离子选择性二氧化硫二氧化碳渗透性离子液体气体成分液膜负载

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盆地内部砂岩型铀矿找矿技术的设计与探讨

地质学报 2022年第6期96卷 2217-2229页

作者：封志兵聂逢君宁媛丽江丽夏菲何剑锋盛洲宁东华理工大学江西省放射性地学大数据技术工程实验室江西南昌330013 东华理工大学核资源与环境国家重点实验室江西南昌330013 核工业航测遥感中心中核集团铀资源地球物理勘查技术中心(重点实验室) 河北石家庄050002 东华理工大学放射性地质与勘探国防重点学科实验室江西南昌330013

长期以来,盆地边缘是砂岩型铀矿找矿与勘探的主要区域。然而,近年在盆地内部也探明了多个铀矿床、矿化点,表明盆地内部同样具有良好的铀矿找矿前景。文章剖析了盆地内部砂岩型铀矿的矿床特征,并据此凝练出“大型中-酸性火成岩隆起+隆起... 详细信息

长期以来,盆地边缘是砂岩型铀矿找矿与勘探的主要区域。然而,近年在盆地内部也探明了多个铀矿床、矿化点,表明盆地内部同样具有良好的铀矿找矿前景。文章剖析了盆地内部砂岩型铀矿的矿床特征,并据此凝练出“大型中-酸性火成岩隆起+隆起区翼部深大断裂”的关键控铀成矿要素。结合砂岩型铀矿成矿理论,设计了一套相适应的找矿方法组合。该找矿方法组合可分为2个步骤:(1)勘探靶区初筛。根据区域重、磁、放射性、遥感等资料查明盆地内部基底起伏和埋深、识别岩性和划分断裂,将岩性为中-酸性火成岩且发育断裂的隆起区圈定为潜在勘探靶区。结合含矿目的层产出特征、隆起区翼部坡度和隆起区面积等因素来初筛勘探靶区;(2)勘探靶区优选。在初筛的勘探靶区深大断裂位置沿隆起区方向布置并实施钻探。通过对地下水“补-径-排”体系、含矿目的层供铀和聚铀能力以及氧化-还原带发育情况等的评价来优选勘探靶区,为下一步铀矿勘探工作的布置与实施提供有益指导。该方法充分利用区域地球物理数据和公开可下载的资料,可极大地降低勘探成本。着眼于关键控铀成矿要素,优选相适应的地质、地球物理等方法,可有效提高盆地内部砂岩型铀矿找矿与勘探的效率。

关键词：砂岩型铀矿盆地内部隆起区地球物理方法中-酸性火成岩

Off-pump versus on-pump coronary artery bypass surgery for the treatment of left main with triple coronary artery disease

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Journal of Nanjing Medical University 2008年第3期22卷 159-163页

作者： zhibing Qiu Xin Chen Ming Xu Kaihu Shi Yinshuo jiang Liqiong Xiao Department of Cardiothoracic Surgery the Nanjing First Hospital Affiliated to Nanjing Medical University Nanjing 210006 Jiangsu Province China

Objective：To obtain early results of off-pump coronarE~ artery bypass grafting（OPCAB） in patients with significant left main coronary artery（LMCA） and triple vessels stenosis by comparing with those of a similar group undergoing conventional coronary artery bypass surgery（CCAB）. Methods：Data for patients with significant LMCA and triple vessels stenosis who underwent CCAB or OPCAB were collected retrospectively between January 1999 and May 2006. Non-randomized, retrospective data analysis included demo- graphic and preoperative risk factors, operative details, clinical outcome and early follow-up. Results： The number of distal anastomo- sis and grafts varied from 3 to 6. The average number per patient was similar in the two groups （OPCAB group：3.76 ± 0.98, CCAB group：3.81 ± 1.02）. Thirty-day mortality occurred to one patient in the OPCAB group whereas two early deaths were observed in the CCAB group but did not reach statistical significance （P 〉 0.05）. The frequency of atrial fibrillation （AF）, IABP usage, mediastinitis, re-operation for bleeding （or tamponade） were similar in the two groups （P 〉 0.05）. Postoperative inotropic requirements, peak CKMB, ventilation time, blood loss, FFP, RBC transfusion need and the length of ICU-stay were all significantly lower in the OPCAB group compared with CCAB group（P 〈 0.05）.Conclusion： Significant LMCA and triple-vessel stenosis can safely and effectively undergo myocardial revascularization using OPCAB surgery. LMCA should no longer be seen as a contraindication to perform OPCAB grafting.

关键词： left main coronary artery triple-vessel stenosis off-pump coronary artery bypass grafting

Off-pump Coronary Endarterectomy and Bypass Grafting in Patients With Diffuse Coronary Artery Disease

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South China Journal of Cardiology 2006年第2期7卷 104-107,72页

作者： Chen Xin Xu Ming jiang Yinshuo Sui Kaihu Qiu zhibing Wang Liming Liu Peisheng Department of Thoracic and Cardiovascular Surgery Nanjing First HospitalNanjing Heart Institute Nanjing Medical University Nanjing 210006 China

Objectives preliminary experience on endarterectomy and To summarize our off-pump coronary bypass grafting in patients with diffuse coronary artery disease. Methods Over a 3year period, 53 patients （41 male） with diffuse coronary artery disease underwent off-pump coronary endarterectomy and bypass grafting at our institution. Patients＇ age ranged from 55 to 79 years. Prior to surgery, 70% of patients were in CCS angina class 2 （n=5） or 3 （n=32）, and nearly half of them （26/53） had history of myocardial infarction. Most patients （n= 50） had triple vessel lesions, with left main stem involvement in 9. Their left ventricular ejection fraction ranged from 26% to 65% （mean 52%）. At the end of operation, a flow-meter was routinely applied to measure the perfusion flow of each postendarterectomy graft. Results In total, 70 endarterectomies were performed in 53 patients, including 38 in left anterior descending artery （LAD）, 8 in circumflex artery and 24 in right coronary artery. Four operations were emergency or urgent in nature. Five patients received on-lay venous patch after endarterectomy in LAD, followed by left internal mammary artery （LIMA） grafting on the patch. The graft conduits included 53 LIMAs and 2 radial arteries, and saphenous veins in others. Mean number of grafts per patient was 3.75. The overall index of complet-eness of revascularization reached 1.03±0.07. There was no death in this group of patients during their post-operative hospital stay （mean duration = 9 days）. Intra-operatively, 63 （90%） out of the 70 grafts after coronary endarterectomy showed satisfactory flow. Two patients had perioperative neither experienced signifi myocardial infarctions but cant hemodynamic deteriations. Conclusions Off-pump coronary endarterectomy with bypass grafting is technically feasible and can be coronary improve zation. performed safely in patients with diffuse artery disease. This strategy may help to the completeness of myocardial revasculariation.

关键词： Coronary endarterectomy Off-pumpCoronary artery bypass grafting Diffuse coronaryartery disease

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舰载机自动着舰引导与控制综述

南京航空航天大学学报 2018年第6期50卷 734-744页

作者：张志冰甄子洋江驹薛艺璇南京航空航天大学自动化学院南京211106 沈阳飞机设计研究所沈阳110035

引导与控制是舰载机自动着舰的关键技术,为此本文对该技术进行综述。给出了舰载机进场航线和几种着舰工作模式,概述了基于跟踪雷达的着舰引导系统和基于卫星的着舰引导系统的工作原理及关键技术,着重分析了自动着舰的几种控制技术,包括... 详细信息

引导与控制是舰载机自动着舰的关键技术,为此本文对该技术进行综述。给出了舰载机进场航线和几种着舰工作模式,概述了基于跟踪雷达的着舰引导系统和基于卫星的着舰引导系统的工作原理及关键技术,着重分析了自动着舰的几种控制技术,包括控制律设计技术、直接力控制技术、推力矢量控制技术、甲板运动预估与补偿技术、舰尾气流抑制技术、动力补偿技术以及着舰安全控制技术。最后,从多系统集成着舰控制技术、多体制融合着舰引导技术两方面对自动着舰引导与控制技术进行了展望。

关键词：舰载机自动着舰系统引导飞行控制

带蒂皮瓣在四肢躯干软组织恶性肿瘤切除后创面修复中的应用

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中国肿瘤临床 2022年第4期49卷 179-183页

作者：戴志兵孙亚超麦尔旦江·麦合木提江仁兵新疆医科大学附属肿瘤医院骨与软组织科乌鲁木齐市830000

目的:回顾性分析带蒂皮瓣在四肢躯干软组织恶性肿瘤切除后创面修复的应用。方法:回顾性选取2019年1月至2021年1月于新疆医科大学附属肿瘤医院收治的15例软组织恶性肿瘤患者临床病理资料,其中多形性未分化肉瘤3例、滑膜肉瘤2例、平滑肌肉... 详细信息

目的:回顾性分析带蒂皮瓣在四肢躯干软组织恶性肿瘤切除后创面修复的应用。方法:回顾性选取2019年1月至2021年1月于新疆医科大学附属肿瘤医院收治的15例软组织恶性肿瘤患者临床病理资料,其中多形性未分化肉瘤3例、滑膜肉瘤2例、平滑肌肉瘤2例、脂肪肉瘤2例、上皮样肉瘤2例、皮肤鳞癌2例、足跟恶性黑色素瘤2例,均参照指南行肿瘤广泛切除术,因切除后软组织缺损大,无法直接缝合或植皮,根据肿瘤切除后创面缺损的位置,选择适合的带血管蒂皮瓣修复。结果:1例足跟部鳞癌行逆行腓肠神经营养皮瓣修复者因皮瓣远端发生坏死行二次清创局部任意旋转皮瓣加植皮后愈合,1例逆行缝匠肌肌皮瓣术后2天出现皮瓣局部发黑,术后1周发现整个皮瓣完全坏死,经清创局部任意旋转皮瓣加植皮后愈合,其余皮瓣术后均一期愈合,随访6~24个月,4例患者因多处转移死亡,余患者均生存,随访期间局部无肿瘤复发。结论:四肢躯干软组织恶性肿瘤往往需保证足够的切除范围,范围及深度均需要达到安全外科边界,广泛切除后皮肤缺损及残腔较大,应用带血管蒂皮瓣可有效填充覆盖创面,降低感染风险,促进创面早期愈合,减少术后并发症,有利于术后功能恢复。

关键词：恶性肿瘤广泛切除带蒂皮瓣创面修复