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Journal of Systems Science & Complexity 2023年第4期36卷 1423-1442页

作者： hu Jun hu zhibin DONG Hongli LIU Hongjian School of Automation Harbin University of Science and TechnologyHarbin 150080China Department of Mathematics Harbin University of Science and TechnologyHarbin 150080China Heilongjiang Provincial Key Laboratory of Optimization Control and Intelligent Analysis for Complex Systems Harbin University of Science and TechnologyHarbin 150080China Heilongjiang Provincial Key Laboratory of Networking and Intelligent Control Northeast Petroleum UniversityDaqing 163318China School of Mathematics-Physics and Finance Anhui Polytechnic UniversityWuhu 241000China

This paper is concerned with the distributed resilient fusion filtering(DRFF)problem for a class of time-varying multi-sensor nonlinear stochastic systems(MNSSs)with random sensor delays(RSDs).The phenomenon of the RSDs is modeled by a set of random variables with certain statistical *** addition,the nonlinear function is handled via Taylor expansion in order to deal with the nonlinear fusion filtering *** aim of the addressed issue is to propose a DRFF scheme for MNSSs such that,for both RSDs and estimator gain perturbations,certain upper bounds of estimation error covariance(EEC)are given and locally minimized at every sample *** the light of the obtained local filters,a new DRFF algorithm is developed via the matrix-weighted fusion ***,a sufficient condition is presented,which can guarantee that the local upper bound of the EEC is ***,a numerical example is provided,which can show the usefulness of the developed DRFF approach.

关键词： Distributed resilient fusion filtering matrix-weighted fusion nonlinear time-varying systems random sensor delays

Organic Synthesis through Radical Innovation:Frustrated Radical Pairs

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Chinese Journal of Chemistry 2024年第10期42卷 1157-1160页

作者： zhibin hu Zengrui Cheng Ning Jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Shanghai Key Laboratory of Green Chemistry and Chemical Processes East China Normal UniversityShanghai 200062China

Frustrated Lewis Pairs(FLPs)represent a unique class of interactions in Lewis acid-base chemistry,driven by spatial hindrance or incongruent orbital energy levels that hinder the formation of effective coordination *** have received significant attention for their application in activating small molecules and facilitating organic synthesis *** developments have led to the emergence of Frustrated Radical Pairs(FRPs)as an extension of the radical *** are formed from FLPs through Single Electron Transfer(SET)and exhibit the ability to activate a variety of chemical *** research on FLPs is well-established,investigations into FRPs in organic reactions remain *** review highlights the current state of FRPs in organic synthesis,delves into mechanistic insights,explores their potential,and underscores the challenges in this emerging field.

关键词： Radicals Frustrated Lewis Pairs Frustrated Radical Pairs Methodology and reactions Reaction mechanisms

Review on application progress of federated learning model and security hazard protection

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Digital Communications and Networks 2023年第1期9卷 146-158页

作者： Aimin Yang Zezhong Ma Chunying Zhang Yang Han zhibin hu Wei Zhang Xiangdong huang Yafeng Wu Hebei Engineering Research Center for the Intelligentization of Iron Ore Optimization and Ironmaking Raw Materials Preparation Processes North China University of Science and TechnologyTangshanHebeiChina Hebei Key Laboratory of Data Science and Application North China University of Science and TechnologyTangshanHebeiChina The Key Laboratory of Engineering Computing in Tangshan City North China University of Science and TechnologyTangshanHebeiChina Tangshan Intelligent Industry and Image Processing Technology Innovation Center North China University of Science and TechnologyTangshanHebeiChina College of Science North China University of Science and TechnologyTangshanHebeiChina College of Artificial Intelligence North China University of Science and TechnologyTangshanHebeiChina

Federated learning is a new type of distributed learning framework that allows multiple participants to share training results without revealing their data *** data privacy becomes more important,it becomes difficult to collect data from multiple data owners to make machine learning predictions due to the lack of data *** is forced to be stored independently between companies,creating“data silos”.With the goal of safeguarding data privacy and security,the federated learning framework greatly expands the amount of training data,effectively improving the shortcomings of traditional machine learning and deep learning,and bringing AI algorithms closer to our *** the context of the current international data security issues,federated learning is developing rapidly and has gradually moved from the theoretical to the applied *** paper first introduces the federated learning framework,analyzes its advantages,reviews the results of federated learning applications in industries such as communication and healthcare,then analyzes the pitfalls of federated learning and discusses the security issues that should be considered in applications,and finally looks into the future of federated learning and the application layer.

关键词： Data silos Machine learning Federated learning Privacy protection Learning framework

Genetic susceptibility of cervical cancer

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The Journal of Biomedical Research 2011年第3期25卷 155-164页

作者： Xiaojun Chen Jie Jiang Hongbing Shen zhibin hu Department of Gynecology Tumor Hospital of Nantong Nantong Jiangsu 226000 China Department of Epldemlology and Biostatistics Nanjing Medical University Nanjing Jiangsu 210029 China Section of Clinical Epidemiology Jiangsu Key Lab of Cancer Biomarkers Prevention and Treatment Cancer Center Nanjing Medical University Nanjing Jiangsu 210029 China.

Epidemiological and laboratory-based studies have identified infection with one of 15 high-risk human papillo-mavirus （HPV） types as a necessary but not sufficient cause of cervical cancer. The prevalence of genital HPV in-fections is high in young women, but most of the infections regress without interventions. Host genetic variations in genes involved in immune response pathways may be related to HPV clearance, and HPV E6/E7 oncoproteins interacting or downstream genes, both coding and non-coding, may contribute to the outcome of high risk HPV infection and cervical cancer. Of specific interest for this review has been the selection of genetic variants in genes involved in the above-referred pathways with a summary of their applications in association studies. Because the supportive and opposing data have been reported in different populations, well-designed international collabora-tive studies need to be conducted to define the consistency of the associations, paving the way to better define the patients at high risk of developing cervical cancer.

关键词： cervical cancer genetic human papillomavirus

Outlier-resistant distributed fusion filtering for nonlinear discrete-time singular systems under a dynamic event-triggered scheme

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Frontiers of Information Technology & Electronic Engineering 2024年第2期25卷 237-249页

作者： zhibin hu Jun hu Cai CHEN Hongjian LIU Xiaojian YI Department of Applied Mathematics Harbin University of Science and TechnologyHarbin150080China Heilongjiang Provincial Key Laboratory of Optimization Control and Intelligent Analysis for Complex Systems Harbin University of Science and TechnologyHarbin150080China School of Automation Harbin University of Science and TechnologyHarbin150080China School of Mathematics and Physics Anhui Polytechnic UniversityWuhu241000China School of Mechatronical Engineering Beijing Institute of TechnologyBeijing100081China Yangtze Delta Region Academy of Beijing Institute of Technology Jiaxing314003China Tangshan Research Institute Beijing Institute of TechnologyTangshan063099China

This paper investigates the problem of outlier-resistant distributed fusion filtering(DFF)for a class of multi-sensor nonlinear singular systems(MSNSSs)under a dynamic event-triggered scheme(DETS).To relieve the effect of measurement outliers in data transmission,a self-adaptive saturation function is ***,to further reduce the energy consumption of each sensor node and improve the efficiency of resource utilization,a DETS is adopted to regulate the frequency of data *** the addressed MSNSSs,our purpose is to construct the local outlier-resistant filter under the effects of the measurement outliers and the DETS;the local upper bound(UB)on the filtering error covariance(FEC)is derived by solving the difference equations and minimized by designing proper filter ***,according to the local filters and their UBs,a DFF algorithm is presented in terms of the inverse covariance intersection fusion *** such,the proposed DFF algorithm has the advantages of reducing the frequency of data transmission and the impact of measurement outliers,thereby improving the estimation ***,the uniform boundedness of the filtering error is discussed and a corresponding sufficient condition is ***,the validity of the developed algorithm is checked using a simulation example.

关键词： Distributed fusion filtering Multi-sensor nonlinear singular systems Dynamic event-triggered scheme Outlier-resistant filter Uniform boundedness

Genetic variants in RAN, DICER and HIWI of microRNA biogenesis genes and risk of cervical carcinoma in a Chinese population

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Chinese Journal of Cancer Research 2013年第5期25卷 565-571页

作者： Jiaping Chen Zhenzhen Qin Shandong Pan Jie Jiang Li Liu Jibin Liu Xiaojun Chen zhibin hu Hongbing Shen State Key Laboratory of Reproductive Medicine Department of Epidemiology and BiostatisticsSchool of Public HealthNanjing Medical University Section of Clinical Epidemiology Jiangsu Key Lab of Cancer BiomarkersPrevention and TreatmentCancer CenterNanjing Medical University Tumor Hospital of Nantong City

Objective：Recent evidence indicates that dysregulation of microRNA （miRNA） biogenesis is implicated in cancer development and *** on the important role of miRNA biogenesis genes in carcinogenesis,we hypothesized that genetic variations of the miRNA biogenesis genes may modulate susceptibility to cervical ***：We identified three single nucleotide polymorphisms （SNPs） located in the 3＇-untranslated regions （3＇-UTR） of of miRNA biogenesis key genes （rs1057035 in DICER,rs3803012 in RAN and rs10773771 in HIWI） and genotyped these SNPs in a case-control study of 1,486 cervical cancer cases and 1,549 cancer-free controls in Chinese ***：Logistic regression analyses showed that no significant associations were observed between the three SNPs and cervical cancer risk [rs3803012 in RAN AG/GG *** adjusted OR =1.104,95 ％ confidence interval （CI）：0.859-1.419; rs1057035 in DICER CT/CC *** adjusted OR =0.962,95％ CI：0.805-1.149;rs10773771 in HIWICT/CC *** adjusted OR =0.963,95％ CI：0.826-1.122].Conclusions：The findings did not suggest that genetic variants in the 3＇-UTR of RAN,DICER and HIWI of miRNA biogenesis genes were associated with the risk of cervical cancer in this Chinese population.

关键词： miRNA biogenesis gene genetic variant cervical cancer

Association of long non-coding RNA HOTAIR and MALAT1 variants with cervical cancer risk in Han Chinese women

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The Journal of Biomedical Research 2019年第5期33卷 308-316页

作者： Meiqun Jia Lulu Ren Lingmin hu Hongxia Ma Guangfu Jin Dake Li Ni Li zhibin hu Dong Hang Department of Epidemiology School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Gynecologic Oncology the Affiliated Tumor Hospital of Nantong University(Nantong Tumor Hospital)NantongJiangsu 226361China Department of Reproduction the Affiliated Changzhou Maternity and Child Health Care Hospital of Nanjing Medical UniversityChangzhouJiangsu 213003China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer MedicineNanjing Medical UniversityNanjing 211166China Department of Gynecologic Oncology Nanjing Maternity and Child Health HospitalNanjingJiangsu 210004China Program Office for Cancer Screening in Urban China National Cancer Centre/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Reproductive Medicine Nanjing Medical UniversityNanjingJiangsu 211166China

Long noncoding RNA(lncRNA) HOTAIR and MALAT1 are implicated in the development of multiple cancers. Genetic variants within HOTAIR and MALAT1 may affect the gene expression, thereby modifying genetic susceptibility to cervical cancer. A case-control study was designed, including 1 486 cervical cancer patients and 1 536 healthy controls. Based on RegulomeDB database, 11 SNPs were selected and genotyped by using Sequenom’s Mass ARRAY. Univariate and multivariate logistic regression models were used to calculate the odds ratio(OR) and 95% confidence interval(CI). We found that the A allele of rs35643724 in HOTAIR was associated with increased risk of cervical cancer, while the C allele of rs1787666 in MALAT1 was associated with decreased risk. Compared to individuals with 0–1 unfavorable allele, those with 3–4 unfavorable alleles showed18% increased odds of having cervical cancer. Our findings suggest that HOTAIR rs35643724 and MALAT1 rs1787666 might represent potential biomarkers for cervical cancer susceptibility.

关键词： cervical cancer variant long noncoding RNA HOTAIR MALAT1

Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing,China

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Science China(Life Sciences) 2020年第5期63卷 706-711页

作者： Zhiliang hu Ci Song Chuanjun Xu Guangfu Jin Yaling Chen Xin Xu Hongxia Ma Wei Chen Yuan Lin Yishan Zheng Jianming Wang zhibin hu Yongxiang Yi Hongbing Shen Nanjing Infectious Disease Center the Second Hospital of NanjingNanjing University of Chinese MedicineNanjing 210003China Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166China State Key Laboratory of Reproductive Medicine Nanjing Medical UniversityNanjing 211166China Department of Radiology the Second Hospital of NanjingNanjing University of Chinese MedicineNanjing 210003China Department of Clinical Research Center the Second Hospital of NanjingNanjing University of Chinese MedicineNanjing 210003China Department of Maternal Child and Adolescent HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166China Department of Critical Medicine the Second Hospital of NanjingNanjing University of Chinese MedicineNanjing 210003China

Previous studies have showed clinical characteristics of patients with the 2019 novel coronavirus disease(COVID-19)and the evidence of person-to-person *** data are available for asymptomatic *** study aims to present the clinical characteristics of 24 cases with asymptomatic infection screened from close contacts and to show the transmission potential of asymptomatic COVID-19 virus *** investigations were conducted among all close contacts of COVID-19 patients(or suspected patients)in Nanjing,Jiangsu Province,China,from Jan 28 to Feb 9,2020,both in clinic and in *** carriers were laboratory-confirmed positive for the COVID-19 virus by testing the nucleic acid of the pharyngeal swab *** clinical records,laboratory assessments,and chest CT scans were *** a result,none of the 24 asymptomatic cases presented any obvious symptoms while nucleic acid *** cases(20.8%)developed symptoms(fever,cough,fatigue,etc.)during ***(50.0%)cases showed typical CT images of ground-glass chest and 5(20.8%)presented stripe shadowing in the *** remaining 7(29.2%)cases showed normal CT image and had no symptoms during *** 7 cases were younger(median age:14.0 years;P=0.012)than the *** of the 24 cases developed severe COVID-19 pneumonia or *** median communicable period,defined as the interval from the first day of positive nucleic acid tests to the first day of continuous negative tests,was 9.5 days(up to 21 days among the 24 asymptomatic cases).Through epidemiological investigation,we observed a typical asymptomatic transmission to the cohabiting family members,which even caused severe COVID-19 ***,the asymptomatic carriers identified from close contacts were prone to be mildly ill during ***,the communicable period could be up to three weeks and the communicated patients could develop severe ***

关键词： COVID-19 asymptomatic infections close contact China

Analysis on the Development of Lushan （Xingzi） Hot Spring Health Tourism Products from the Perspective of Product Integrated Marketing

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International English Education Research 2014年第9期 88-90页

作者： Fenglian Zou zhibin hu Xinyu University XinyuJiangxi338004 China

Through the development of more than 60 years, the hot spring tourism industry in China will confront with a situation of ＂innovative competition, standard development, and secondary upgrade＂. In this paper, from the perspective of product integrated marketing theory, by taking Lushan （Xingzi） hot spring as an example, the authors carry out an analysis on some problems in the development of Xingzi hot spring tourism products, propose the framework and model of the integrated development of hot spring health tourism products, and also provide some suggestions for the design of Xingzi hot spring health tourism routes.

关键词： Product Integration, Health Preservation by Hot Spring Route Design

Association of microRNA polymorphisms with the risk of head and neck squamous cell carcinoma in a Chinese population:a case-control study

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Chinese Journal of Cancer 2016年第11期35卷 596-603页

作者： Limin Miao Lihua Wang Longbiao Zhu Jiangbo Du Xun Zhu Yuming Niu Ruixia Wang zhibin hu Ning Chen Hongbing Shen Hongxia Ma Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical University Department of Stomatology and Center for Evidence-Based Medicine and Clinical Research Taihe HospitalHubei University of Medicine Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical University

Background:MicroRNA(miRNA) polymorphisms may alter miRNA-related processes,and they likely contribute to cancer *** studies have investigated the associations between genetic variants in several key miRNAs and the risk of human cancers;however,few studies have focused on head and neck squamous cell carcinoma(HNSCC) *** study aimed to evaluate the associations between several key miRNA polymorphisms and HNSCC risk in a Chinese ***:In this study,we genotyped five common single-nucleotide polymorphisms(SNPs) in several key miRNAs(miR-149 rs2292832,miR-146 a rs2910164,miR-605 rs2043556,miR-608 rs4919510,and miR-196a2 rs11614913) and evaluated the associations between these SNPs and HNSCC risk according to cancer site with a case-control study including 576 cases and 1552 controls,which were matched by age and sex in a Chinese ***:The results revealed that miR-605 rs2043556[dominant model:adjusted odds ratio(OR) 0.71,95%confidence interval(CI) 0.58-0.88;additive model:adjusted OR 0.74,95%CI 0.62-0.89]and miR-196a2 rs11614913(dominant model:adjusted OR 1.36,95%C11.08-1.72;additive model:adjusted OR 1.28,95%C11.10-1.48) were significantly associated with the risk of oral squamous cell carcinoma(OSCC).Furthermore,when these two loci were evaluated together based on the number of putative risk alleles(rs2043556 A and rs11614913 G),a significant locus-dosage effect was noted on the risk of OSCC(P_(trend) < 0.001).However,no significant association was detected between the other three SNPs(miR-149 rs2292832,miR- 146 a rs2910164,and miR-608 rs4919510) and HNSCC ***:Our study provided the evidence that miR-605 rs2043556 and miR-196a2 rs11614913 may have an impact on genetic susceptibility to OSCC in Chinese population.

关键词： Head and neck cancer microRNA Polymorphism Squamous cell carcinoma Susceptibility