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Risk Stratification and Prognosis of Pulmonary Arterial Hypertension Associated with Congenital Heart Disease

Congenital Heart Disease 2024年第3期19卷 325-339页

作者： Wenjie Dong zhibin hong Aqian Wang Kaiyu Jiang Hai Zhu Fu zhang Zhaoxia Guo hongling Su Yunshan Cao Department of Cardiology The First People’s Hospital of TianshuiTianshui741000China Department of Cardiology Pulmonary Vascular Disease CenterGansu Provincial HospitalLanzhou730000China Heart Lung and Vessels CenterSichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu610072China

Background:Current guidelines for managing pulmonary arterial hypertension(PAH)recommend a risk strati-fication ***,the applicability and accuracy of these strategies for PAH associated with congenital heart disease(PAH-CHD)require further *** study aims to validate the reliability and predictive accuracy of a simplified stratification strategy for PAH-CHD patients over a three-year ***,new prognostic variables are identified and novel risk stratification methods are developed for assessing and managing PAH-CHD ***:This retrospective study included 126 PAH-CHD *** and biochemical variables across risk groups were assessed using Kruskal-Wallis and Fisher’s exact ***-dent risk factors were identified using ordered logistic regression,while Kaplan-Meier and Cox proportional hazards regression analyses evaluated their impact on all-cause mortality.A new stratification model for the PAH-CHD population was constructed based on these ***:Significant survival differences across stratified risk groups were observed(p<0.001),validating the effectiveness of the simplified risk stratification method in PAH-CHD *** activity was a strong independent predictor of adverse outcomes of PAH-CHD patients(Hazard ratio 0.95,p<0.001,C-index 0.70).A model combining N-terminal pro-brain natriuretic peptide,prothrombin activity,albumin,and right atrial area achieved an area under the curve of 0.89 and a C-index of ***:The simplified risk stratification method is applicable to PAH-CHD *** activity is a strong independent predictor of adverse outcomes.A comprehensive risk stratification approach,incorporating both established and novel biomarkers,enhances accessibility and offers predictive efficacy during follow-up for PAH-CHD patients,comparable to established models.

关键词： Pulmonary hypertension pulmonary arterial hypertension congenital heart disease risk stratification

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NON-LINEAR SPECTRAL IMAGING MICROSCOPY STUDIES OF HUMAN HYPERTROPHIC SCAR

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Journal of Innovative Optical Health Sciences 2009年第1期2卷 61-66页

作者： KECHENG LU SHUANGMU ZHUO zhibin hong GUANNAN CHEN XINGSHAN JIANG LIQIN ZHENG JIANXIN CHEN Institute of Laser and Optoelectronics Technology Fujian Provincial Key Laboratory for Photonics Technology Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education Fujian Normal University Fuzhou 350007 China

Skin scar is unique to humans,the major significant negative outcome sustained after thermal injuries,traumatic injuries,and surgical *** scar in human skin is investigated using non-linear spectral imaging *** high contrast images and spectroscopic intensities of collagen and elastic fibers extracted from the spectral imaging of normal skin tissue,and the normal skin near and far away from the hypertrophic scar tissues in a 10-year-old patient case are *** results show that there are apparent differences in the morphological structure and spectral characteristics of collagen and elastic fibers when comparing the normal skin with the hypertrophic scar *** differences can be good indicators to differentiate the normal skin and hypertrophic scar tissue and demonstrate that non-linear spectral imaging microscopy has potential to noninvasively investigate the pathophysiology of human hypertrophic scar.

关键词： Non-linear spectral imaging microscopy human hypertrophic scar collagen and elastin fibers

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Neurokinin-2 receptor antagonist SR48968 induced necroptosis of myeloid leukemia cells by calcium overload-driven reactive oxygen species accumulation

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Genes & Diseases 2024年第5期11卷 33-35页

作者： zhibin Yan Xiangyu hong Qihao Lin Leijie Wang Gang Shao Chentao Ge Ruilong Xia Caiyun Fu Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhouZhejiang 310018China College of Life Sciences China Jiliang UniversityHangzhouZhejiang 310018China

Increasing evidence highlight tachykinin receptors as a prominent player in hematological *** previously revealed the proto-oncogenic role of neurokinin-1 receptor(NK-1R)in acute myeloid leukemia(AML),1 whereas the role of neurokinin-2 receptor(NK-2R)has not been ***,we found NK-2R was significantly up-regulated in AML patients in The Cancer Genome Atlas *** result was further confirmed in blood from AML patients and a range of human leukemia ***,we verified that blocking NK-2R by SR48968 markedly promoted cell death in human myeloid leukemia without cytotoxicity to normal ***,we uncovered that SR48968 induced cytotoxicity through necroptosis mediated by calcium overload-driven reactive oxygen species(ROS)*** summary,our results propose that NK-2R antagonist SR48968 may be used as a new therapeutic approach for myeloid leukemia.

关键词： myeloid antagonist markedly

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Gravitational waves and primordial black hole productions from gluodynamics by holography

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 31-42页

作者： Song He Li Li zhibin Li Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin UniversityChangchun 130012China Max Planck Institute for Gravitational Physics(Albert Einstein Institute) Golm 14476Germany CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China

Understanding the nature of quantum chromodynamics(QCD)matter is important but challenging due to the presence of nonperturbative dynamics under extreme *** construct a holographic model describing the gluon sector of QCD at finite temperatures in the non-perturbative *** equation of state as a function of temperature is in good accordance with the lattice QCD ***,the Polyakov loop and the gluon condensation,which are proper order parameters to capture the deconfinement phase transition,also agree quantitatively well with the lattice QCD *** obtain a strong first-order confinement/deconfinement phase transition at Tc=276.5 Me V that is consistent with the lattice QCD *** on our model for a pure gluon hidden sector,we compute the stochastic gravitational waves and primordial black hole(PBH)productions from this confinement/deconfinement phase transition in the early *** resulting stochastic gravitational-wave backgrounds are found to be within detectability in the International Pulsar Timing Array and Square Kilometre Array in the near future when the associated productions of PBHs saturate the current observational bounds on the PBH abundances from the LIGO-Virgo-Collaboration O3 data.

关键词： AdS/QCD confinement/deconfinement phase transition gravitational wave primordial black hole

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Organic Synthesis through Radical Innovation:Frustrated Radical Pairs

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Chinese Journal of Chemistry 2024年第10期42卷 1157-1160页

作者： zhibin Hu Zengrui Cheng Ning Jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Shanghai Key Laboratory of Green Chemistry and Chemical Processes East China Normal UniversityShanghai 200062China

Frustrated Lewis Pairs(FLPs)represent a unique class of interactions in Lewis acid-base chemistry,driven by spatial hindrance or incongruent orbital energy levels that hinder the formation of effective coordination *** have received significant attention for their application in activating small molecules and facilitating organic synthesis *** developments have led to the emergence of Frustrated Radical Pairs(FRPs)as an extension of the radical *** are formed from FLPs through Single Electron Transfer(SET)and exhibit the ability to activate a variety of chemical *** research on FLPs is well-established,investigations into FRPs in organic reactions remain *** review highlights the current state of FRPs in organic synthesis,delves into mechanistic insights,explores their potential,and underscores the challenges in this emerging field.

关键词： Radicals Frustrated Lewis Pairs Frustrated Radical Pairs Methodology and reactions Reaction mechanisms

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Numerical Investigation on Heat Transfer Characteristics of Microencapsulated Phase Change Material Slurry in a Rectangular Minichannel

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Journal of Thermal Science 2024年第2期33卷 564-577页

作者： WANG zhibin LI Zilong JIA Lisi DING Bin CHEN Ying School of Materials and Energy Guangdong University of TechnologyGuangzhou510006China Guangdong Provincial Key Laboratory of Functional Soft Condensed Matter Guangzhou510006China College of New Energy China University of Petroleum(East China)Qingdao266580China

Microencapsulation phase change material slurry(MEPCMS) becomes a potential working fluid for cooling high energy density miniaturized components,thanks to the latent heat absorption of particles in the heat transfer *** this work,the Discrete Phase Model(DPM) based on the Euler-Lagrangian method is used to numerically investigate the convective heat transfer characteristics of MEPCMS flowing through a rectangular minichannel with constant heat *** results show that particles of MEPCMS are mainly subjected to drag force during the *** so,they can migrate from the high-temperature region to the low-temperature region driven by the thermophoretic force,affecting the particle distribution and phase change ***,the Nux of the MEPCMS fluctuates due to particle phase change with varying specific heat ***,the value increases first,then decreases,and eventually increases again until it approaches the fully developed value of the pure base fluid as the particles gradually ***,the heat transfer performance of the MEPCMS is influenced by the combination of fluid inlet temperature fluid inlet velocity(v),and mass concentration(c_(m)) of MEPCM *** result shows that the maximum reduction of the maximum bottom wall temperature difference(ΔT_(w)) is 23.98% at T_(in)=293.15 K,v=0.15 m·s^(-1),c_(m)=10%.

关键词： Microencapsulated Phase Change Material Slurry(MPCMS) Discrete Phase Model(DPM) particle-fluid interaction force minichannel heat sink thermophoresis

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Finite Element Method for Transient Electric Field by Using Indirect Laplace Transform with High Accuracy

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 401-411页

作者： Teng Wen Xiang Cui Xuebao Li Sijia Liu zhibin Zhao State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China China Electric Power Planning&Engineering Institute Beijing 100120China

This paper focuses on the finite element method in the complex frequency domain(CFD-FEM)for the transient electric ***,the initial value and boundary value problem of the transient electric field under the electroquasistatic field in the complex frequency domain is *** addition,the finite element equation and the constrained electric field equation on the boundary are ***,the indirect algorithm of the numerical inverse Laplace transform is *** on it,the calculation procedures of the CFD-FEM are illustrated in ***,the step response,zero-state response under the positive periodic square waveform(PPSW)voltage,and the zero-input response by the CFD-FEM with direct algorithm and indirect algorithm are ***,the reason for the numerical oscillations of the zero-state response under the PPSW voltage is analyzed,and the method to reduce oscillations is *** results show that the numerical accuracy of the indirect algorithm of the CFD-FEM is more than an order of magnitude higher than that of the direct algorithm when calculating the step response of the transient electric *** proposed method can significantly reduce the numerical oscillations of the zero-state response under the PPSW *** proposed method is helpful for the calculation of the transient electric field,especially in the case of frequency-dependent parameters.

关键词： Electroquasistatic field transient electric field finite element method complex frequency domain numerical Laplace transform

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ELABELA-derived peptide ELA13 attenuates kidney fibrosis by inhibiting the Smad and ERK signaling pathways

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 341-353页

作者： zhibin YAN Ying SHI Runling YANG Jijun XUE Caiyun FU Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhou310018China State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou University Lanzhou 730000China Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences&Research Unit of Peptide ScienceChinese Academy of Medical Sciences2019RU066Lanzhou UniversityLanzhou 730000China

Kidney fibrosis is an inevitable result of various chronic kidney diseases(CKDs)and significantly contributes to end-stage renal ***,there is no specific treatment available for renal ***13(amino acid sequence:RRCMPLHSRVPFP)is a conserved region of ELABELA in all vertebrates;however,its biological activity has been very little *** the present study,we evaluated the therapeutic effect of ELA13 on transforming growth factor-β1(TGF-β1)-treated NRK-52E cells and unilateral ureteral occlusion(UUO)*** results demonstrated that ELA13 could improve renal function by reducing creatinine and urea nitrogen content in serum,and reduce the expression of fibrosis biomarkers confirmed by Masson staining,immunohistochemistry,real-time polymerase chain reaction(RT-PCR),and western *** biomarkers were increased after UUO and decreased by administration of ***,we found that the levels of essential molecules in the mothers against decapentaplegic(Smad)and extracellular signal-regulated kinase(ERK)pathways were reduced by ELA13 treatment in vivo and in *** conclusion,ELA13 protected against kidney fibrosis through inhibiting the Smad and ERK signaling pathways and could thus be a promising candidate for anti-renal fibrosis treatment.

关键词： ELA13 Kidney fibrosis Inflammation Smad Extracllular signal-regulated kinase(ERK)

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Effect of surfactant frequently used in soil flushing on oxygen mass transfer in micro-nano-bubble aeration system

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Chinese Journal of Chemical Engineering 2024年第3期67卷 174-181页

作者： Mei Bai zhibin Liu Zhu Liu Chenfei He Zhanhuang Fan Miaoxin Yuan Jiangsu Key Laboratory of Urban Underground Engineering and Environmental Safety Southeast UniversityNanjing 211189China CECEP DADI(Hangzhou)Environmental Remediation Co. Ltd.Hangzhou 310020China

In-site soil flushing and aeration are the typical synergetic remediation technology for contaminated *** surfactant present in flushing solutions is bound to affect the aeration *** purpose of this study is to evaluate the effect of surfactant frequently used in soil flushing on the oxygen mass transfer in micro-nano-bubble(MNB)aeration ***,bio-surfactants and chemical surfactants were used to investigate their effects on Sauter mean diameter of bubble(dBS),gas holdup(ε),volumetric mass-transfer coefficient(kLa)and liquid-side mass-transfer coefficient(kL)in the MNB aeration ***,based upon the experimental results,the Sardeing's and Frossling's models were modified to describe the effect of surfactant on kL in the MNB *** results showed that,for the twenty aqueous surfactant solutions,with the increase in surfactant concentration,the value of dBS,kLa and kL decreased,while the value ofεand gas-liquid interfacial area(a)*** phenomena were mainly attributed to the synergistic effects of immobile bubble surface and the suppression of coalescence in the surfactant *** addition,with the presence of electric charge,MNBs in anionic surfactant solutions were smaller and higher in number than in non-ionic surfactant ***,the accumulation of surfactant on the gas-liquid interface was more conspicuous for small MNB,so the reduction of kL in anionic surfactant solutions was larger than that in non-ionic surfactant ***,the modified Frossling's model predicted the effect of surfactant on kL in MNB aeration system with reasonable accuracy.

关键词： Soil flushing Micro-nano-bubble aeration Bio-surfactant Mass transfer coefficient

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Temperature trends and its elevation-dependent warming over the Qilian Mountains

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Journal of Mountain Science 2024年第2期21卷 500-510页

作者： ZHAO Peng HE zhibin MA Dengke WANG Wen QIAN Lihui School of Computer Science Huainan Normal UniversityHuainan 232038China Linze Inland River Basin Research Station Key Laboratory of Inland River Basin ScienceNorthwest Institute of Eco-Environment and ResourceChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China

Understanding temperature variability especially elevation dependent warming(EDW)in high-elevation mountain regions is critical for assessing the impacts of climate change on water resources including glacier melt,degradation of soils,and active layer *** means that temperature is warming faster with the increase of *** this study,we used observed temperature data during 1979-2017 from 23 meteorological stations in the Qilian Mountains(QLM)to analyze temperature trend with Mann-Kendall(MK)test and Sen’s slope *** showed that the warming trends for the annual temperature followed the order of T_min>T_mean>T_max and with a shift both occurred in *** and summer temperature have a higher increasing trend than that in autumn and winter.T_mean shifts occurred in 1996 for spring and summer,in 1997 for autumn and winter.T_max shifts occurred in 1997 for spring and 1996 for summer.T_min shifts occurred in 1997 for spring,summer and winter as well as in 1999 for *** mean diurnal temperature range(DTR)shows a significant decreasing trend(-0.18°C/10a)from 1979 to *** mean DTR shows a significant decreasing trend(-0.26°C/10a)from 1979 to 2017 with a shift occurred in *** removing longitude and latitude factors,we can learn that the warming enhancement rate of average annual temperature is 0.0673°C/km/10a,indicating that the temperature warming trend is accelerating with the continuous increase of *** increase rate of elevation temperature is 0.0371°C/km/10a in spring,0.0457°C/km/10a in summer,0.0707°C/km/10a in autumn,and 0.0606°C/km/10a in winter,which indicates that there is a clear EDW in the *** main causes of warming in the Qilian Mountains are human activities,cloudiness,ice-snow feedback and El Nino phenomenon.

关键词： Climate change Qilian Mountains Warming rates DTR Elevation-dependent warming

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