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Gravitational waves and primordial black hole productions from gluodynamics by holography

Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 31-42页

作者： Song He li li zhibin li Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin UniversityChangchun 130012China Max Planck Institute for Gravitational Physics(Albert Einstein Institute) Golm 14476Germany CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China

Understanding the nature of quantum chromodynamics(QCD)matter is important but challenging due to the presence of nonperturbative dynamics under extreme conditions.We construct a holographic model describing the gluon sector of QCD at finite temperatures in the non-perturbative regime.The equation of state as a function of temperature is in good accordance with the lattice QCD data.Moreover,the Polyakov loop and the gluon condensation,which are proper order parameters to capture the deconfinement phase transition,also agree quantitatively well with the lattice QCD data.We obtain a strong first-order confinement/deconfinement phase transition at Tc=276.5 Me V that is consistent with the lattice QCD prediction.Based on our model for a pure gluon hidden sector,we compute the stochastic gravitational waves and primordial black hole(PBH)productions from this confinement/deconfinement phase transition in the early Universe.The resulting stochastic gravitational-wave backgrounds are found to be within detectability in the International Pulsar Timing Array and Square Kilometre Array in the near future when the associated productions of PBHs saturate the current observational bounds on the PBH abundances from the liGO-Virgo-Collaboration O3 data.

关键词： AdS/QCD confinement/deconfinement phase transition gravitational wave primordial black hole

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liquid Crystal Based Label-Free Optical Sensors forBiochemical Application

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Photonic Sensors 2024年第2期14卷 57-88页

作者： Jieyuan TANG zhibin li Mengyuan XIE Yunhan LUO Jianhui YU Guojie CHEN Zhe CHEN School of Physics and Optoelectronic Engineering Foshan UniversityFoshan 528225China Guangdong-Hong Kong.Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology Foshan UniversiyFoshan 528225China Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes Jinan UniversityGuangzhou 510632.China Department of Optoelectronic Engineering Jinan UniversityGuangzhou 510632China JiHua Laboratory Foshan 528200China

Biochemical sensors have important applications in biology,chemistry,and medicine.Nevertheless,many biochemical sensors are hampered by intricate techniques,cumbersome procedures,and the need for labeling.In the past two decades,it has been discovered that liquid crystals can be used to achieve the optical amplification of biological interactions.By modifying recognition molecules,a variety of label-free biochemical sensors can be created.Consequently,biochemical sensors based on the amplification of liquid crystals have become one of the most promising sensors.This paper describes in detail the optical sensing principle of liquid crystals,sensing devices,and optical detection technologies.Meanwhile,the latest research findings are elucidated.Finally,the challenges and future research directions are discussed.

关键词： Optical sensor biochemistry liquid crystal label-free

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Insights into the role of RNA m6 A modification in the metabolic process and related diseases

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Genes & Diseases 2024年第4期11卷 270-295页

作者： Haiming Hu zhibin li Xia Xie Qiushi liao Yiyang Hu Chunli Gong Nannan Gao Huan Yang Yufeng Xiao Yang Chen Department of Gastroenterology Xinqiao HospitalArmy Medical UniversityChongqing 400037China

According to the latest consensus,many traditional diseases are considered meta-bolic diseases,such as cancer,type 2 diabetes,obesity,and cardiovascular disease.Currently,metabolic diseases are increasingly prevalent because of the ever-improving living standards and have become the leading threat to human health.Multiple therapy methods have been applied to treat these diseases,which improves the quality of life of many patients,but the overall effect is still unsatisfactory.Therefore,intensive research on the metabolic process and the pathogenesis of metabolic diseases is imperative.N6-methyladenosine(m°A)is an important modification of eukaryotic RNAs.It is a critical regulator of gene expression that is involved in different cellular functions and physiological processes.Many studies have indi-cated that m6A modification regulates the development of many metabolic processes and metabolic diseases.In this review,we summarized recent studies on the role of m6A modifica-tion in different metabolic processes and metabolic diseases.Additionally,we highlighted the potential m6A-targeted therapy for metabolic diseases,expecting to facilitate m6A-targeted strategies in the treatment of metabolic diseases.

关键词： Cancer m6A-targeted therapy Metabolic disease Metabolism N6-methyladenosine

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Numerical Investigation on Heat Transfer Characteristics of Microencapsulated Phase Change Material Slurry in a Rectangular Minichannel

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Journal of Thermal Science 2024年第2期33卷 564-577页

作者： WANG zhibin li Zilong JIA lisi DING Bin CHEN Ying School of Materials and Energy Guangdong University of TechnologyGuangzhou510006China Guangdong Provincial Key Laboratory of Functional Soft Condensed Matter Guangzhou510006China College of New Energy China University of Petroleum(East China)Qingdao266580China

Microencapsulation phase change material slurry(MEPCMS) becomes a potential working fluid for cooling high energy density miniaturized components,thanks to the latent heat absorption of particles in the heat transfer process.In this work,the Discrete Phase Model(DPM) based on the Euler-Lagrangian method is used to numerically investigate the convective heat transfer characteristics of MEPCMS flowing through a rectangular minichannel with constant heat flux.The results show that particles of MEPCMS are mainly subjected to drag force during the flow.Even so,they can migrate from the high-temperature region to the low-temperature region driven by the thermophoretic force,affecting the particle distribution and phase change process.Moreover,the Nux of the MEPCMS fluctuates due to particle phase change with varying specific heat capacities.Specifically,the value increases first,then decreases,and eventually increases again until it approaches the fully developed value of the pure base fluid as the particles gradually melt.Furthermore,the heat transfer performance of the MEPCMS is influenced by the combination of fluid inlet temperature fluid inlet velocity(v),and mass concentration(c_(m)) of MEPCM particles.The result shows that the maximum reduction of the maximum bottom wall temperature difference(ΔT_(w)) is 23.98% at T_(in)=293.15 K,v=0.15 m·s^(-1),c_(m)=10%.

关键词： Microencapsulated Phase Change Material Slurry(MPCMS) Discrete Phase Model(DPM) particle-fluid interaction force minichannel heat sink thermophoresis

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Finite Element Method for Transient Electric Field by Using Indirect Laplace Transform with High Accuracy

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 401-411页

作者： Teng Wen Xiang Cui Xuebao li Sijia liu zhibin Zhao State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China China Electric Power Planning&Engineering Institute Beijing 100120China

This paper focuses on the finite element method in the complex frequency domain(CFD-FEM)for the transient electric field.First,the initial value and boundary value problem of the transient electric field under the electroquasistatic field in the complex frequency domain is given.In addition,the finite element equation and the constrained electric field equation on the boundary are derived.Secondly,the indirect algorithm of the numerical inverse Laplace transform is introduced.Based on it,the calculation procedures of the CFD-FEM are illustrated in detail.Thirdly,the step response,zero-state response under the positive periodic square waveform(PPSW)voltage,and the zero-input response by the CFD-FEM with direct algorithm and indirect algorithm are compared.Finally,the reason for the numerical oscillations of the zero-state response under the PPSW voltage is analyzed,and the method to reduce oscillations is proposed.The results show that the numerical accuracy of the indirect algorithm of the CFD-FEM is more than an order of magnitude higher than that of the direct algorithm when calculating the step response of the transient electric field.The proposed method can significantly reduce the numerical oscillations of the zero-state response under the PPSW voltage.The proposed method is helpful for the calculation of the transient electric field,especially in the case of frequency-dependent parameters.

关键词： Electroquasistatic field transient electric field finite element method complex frequency domain numerical Laplace transform

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Experts’Consensus on the Management of Respiratory Disease Syndemic

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China CDC weekly 2024年第8期6卷 131-138页

作者： Weizhong Yang Zhongjie li Ting Yang Yanming li Zhengde Xie Luzhao Feng zhibin Peng Jue liu School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina State Key Laboratory of Respiratory Health and Multimorbidity BeijingChina Key Laboratory of Pathogen Infection Prevention and Control Peking Union Medical CollegeMinistry of EducationBeijingChina National Center for Respiratory Diseases State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesDepartment of Pulmonary and Critical Care MedicineCenter of Respiratory MedicineChina-Japan Friendship HospitalBeijingChina Department of Pulmonary and Critical Care Medicine National Center of GerontologyBeijing HospitalInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016National Key Discipline of Pediatrics(Capital Medical University)Beijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijingChina Chinese Center for Disease Control and Prevention BeijingChina Department of Epidemiology and Biostatistics School of PublicHealthKey Laboratory of Epidemiology of Major DiseasesMinistry of EducationPeking University Health Science Center-Weifang Joint Research Center for Maternal and Child HealthPeking UniversityBeijingChina

The global burden of respiratory diseases is a significant and increasing threat to individuals worldwide.In 2017,there were 544.9 million cases of chronic respiratory diseases,a 39.8%increase since 1990(1).These diseases were the third leading cause of global mortality in 2017,accounting for 7.0%of all deaths,an 18.0%increase compared to 1990.

关键词： diseases respiratory mortality

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c-myb is involved in CML progression and is a therapeutic target in the zebrafish CML model

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Animal Models and Experimental Medicine 2024年第2期7卷 136-144页

作者： Yin Ye Xiaojun Yang Feifei li Wei liu Wenqing Zhang zhibin Huang Division of Cell Developmental and Integrative BiologySchool of MedicineSouth China University of TechnologyGuangzhouChina

Background:Despite the success of tyrosine kinase inhibitors in chronic myeloid leukemia(CML)therapy,CML still faces the challenges of drug resistance and progression to blast crisis.Twenty-five percent of patients have imatinib resistance and treatment difficulties due to heterogeneity after progression,but little is known about the mechanism.A key transcription factor in hematopoiesis,MYB,has been reported to increase abnormally in several types of aggressive blood disorders including CML.Methods:This study used a zebrafish model to explore the relationship between BCR/ABL1 and c-myb in CML progression.A CML zebrafish model was crossed with a c-myb hyperactivity transgenic line.Results:It was found that both exogenous BCR/ABL1 and c-myb could up-regulate the expression of neutrophil-related genes.More seriously,neutrophil accumulation was observed when BCR/ABL1 was combined with c-myb overexpression.Further studies showed that c-myb may be one of the downstream targets of BCR/ABL1 and the effect of BCR/ABL1 on neutrophils was c-myb dependent.Taking advantage of this inheritable in vivo model,it was shown that a combination of imatinib and flavopiridol,a cyclin-dependent kinase inhibitor targeting MYB,could more effectively alleviate the aggressive phenotype of the double transgene line.Conclusion:In summary,this study suggests that c-myb acts downstream of BCR/ABL1 and is involved in CML progression and is therefore a risk factor and a valuable target for the treatment of CML progression.The model used in the study could be helpful in high-throughput drug screening in CML transformation.

关键词： chronic myeloid leukemia c-myb flavopiridol zebrafish model

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On group structures of strategic-form games

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Fundamental Research 2024年第3期4卷 540-549页

作者： Zhigang Cao Guopeng li zhibin Tan Xiaoguang Yang School of Economics and Management Beijing Jiaotong UniversityBeijing 100044China School of Economics Huazhong University of Science and TechnologyWuhan 430074China University of Chinese Academy of Sciences Beijing 100049China MADIS Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100049China

There are two recognized classes of strategic-form symmetric games,both of which can be conveniently defined through the corresponding player symmetry groups.We investigate the basic properties of these groups and several related concepts.We generalize the notion of coveringness and adapt their results to characterize these player symmetry groups.We study the relationships between the coveringnesses of various symmetry groups.Our results demonstrate that these symmetry groups have rich mathematical structures that are of game theoretical and economic interests.

关键词： Noncooperativegames Strategic-form games Symmetricgames Symmetry groups Covering groups

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Masting promotes transformation from predation to mutualism in an oak-weevil-rodent system

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Science China(life Sciences) 2024年第7期67卷 1514-1524页

作者： Hongmao Zhang Hongyu Niu Michael ASteele liqing Peng Huimin He Aoqiang li Xianfeng Yi Hongjun li zhibin Zhang Institute of Evolution and Ecology School of Life SciencesCentral China Normal UniversityWuhan 430079China State Key Laboratory of Integrated Management of Pest Insects and Rodents in Agriculture Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Biology Wilkes UniversityWilkes-Barre 18766USA School of life Sciences Qufu Normal UniversityQufu 273165China

The significance of ecological non-monotonicity(a function whose first derivative changes signs)in shaping the structure and functions of the ecosystem has recently been recognized,but such studies involving high-order interactions are rare.Here,we have proposed a threetrophic conceptual diagram on interactions among trees,rodents,and insects in mast and non-mast years and tested the hypothesis that oak(Quercus wutaishanica)masting could result in increased mutualism and less predation in an oak-weevil-rodent system in a warm temperate forest of China.Our 14-year dataset revealed that mast years coincided with a relatively low rodent abundance but a high weevil abundance.Masting not only benefited seedling recruitment of oaks through increased dispersal by rodents but also a decrease in predation by rodents and weevils,as well as an increase in the overwintering survival of rodents.Masting appeared to have increased weevil survival by reducing predation of infested acorns by rodents.These results suggest that masting benefits all participants in the plant-insect-rodent system by increasing mutualism and reducing predation behavior(i.e.,a non-monotonic function).Our study highlights the significance of masting in maintaining the diversity and function of the forest ecosystem by facilitating the transformation from predation to mutualism among trophic species.

关键词： antagonism ecological non-monotonicity mutualism seed-weevil-rodent system seedling recruitment rodent overwintering survival weevil survival

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A Peridynamics-Based Finite Element Method(PeriFEM)for Quasi-Static Fracture Analysis

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Acta Mechanica Solida Sinica 2022年第3期35卷 446-460页

作者： Fei Han zhibin li State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering MechanicsDalian University of TechnologyDalian 116023China

In this paper,a peridynamics-based finite element method(PeriFEM)is proposed for the quasi-static fracture analysis,which is of the consistent computational framework with the classical finite element method(FEM).First,the integral domain of peridynamics is reconstructed,and a new type of element called peridynamic element(PE)is defined.Although PEs are generated by the continuous elements(CEs)of classical FEM,they do not affect each other.Then,spatial discretization is performed based on PEs and CEs,and the linear equations about nodal displacement are established according to the principle of minimum potential energy.Besides,cracks are characterized as degradation of the mechanical properties of PEs.Finally,the validity of the proposed method is demonstrated through numerical examples.

关键词： Peridynamics Finite element method Fracture Damage

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