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Role of selected criteria and preventive chemotherapy in tumor recurrence after liver transplantation

Hepatobiliary & Pancreatic Diseases International 2020年第4期19卷 378-383页

作者： Mei-Xi Wang Dong Chen yuan-yuan Zhao Bo Yang Ji-Pin Jiang fan-Jun Zeng Lai Wei zhi-Shui Chen Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Key Laboratory of Organ Transplantation Ministry of EducationWuhan 430030China NHC Key Laboratory of Organ Transplantation Wuhan 430030China Key Laboratory of Organ Transplantation Chinese Academy of Medical SciencesWuhan 430030China

Background:Long-term survival after liver transplantation(LT)for hepatocellular carcinoma(HCC)patients remains poor because of tumor *** improve the prognosis of HCC patients after LT,we aimed to identify different transplantation criteria and risk factors related to tumor recurrence and evaluate the effect of preventive chemotherapy in a single ***:In total,data on 20 variables and the survival of 199 patients with primary HCC who underwent LT between 2005 and 2015 were included for *** patients were divided into the following three groups:Group 1,within the Milan and Hangzhou criteria(n=51);Group 2,beyond the Milan but within the Hangzhou criteria(n=36);and Group 3,beyond the Milan and Hangzhou criteria(n=112).Survival probabilities for the three groups were calculated using multivariate Cox regression *** association between preventive therapy and HCC-recurrence after LT was analyzed by multiple logistic regression ***:Child-Pugh stage C and hepatitis B virus(HBV)infection were independent risk factors for patients with tumor recurrence who did not meet the Milan *** overall survival rates of the 199 patients showed statistically significant differences among the three groups(P0.05).Multivariate logistic regression analysis showed that postoperative prophylactic chemotherapy reduced the risk of tumor recurrence in patients who did not meet the Hangzhou and Milan criteria(OR=0.478;95%CI:0.308–0.741;P=0.001).Conclusions:Child-Pugh classification and HBV infection were the independent risk factors of tumor recurrence in HCC patients with *** Hangzhou criteria were effective and analogous compared with the Milan *** chemotherapy significantly reduced the risk of recurrence and prolonged the survival time for HCC patients beyond the Milan and Hangzhou criteria after LT.

关键词： Hepatocellular carcinoma Liver transplantation Preventive chemotherapy Hangzhou criteria

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Constructing an assessment index system for strategic risk management in coal science and technology enterprises

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International Journal of Mining Science and Technology 2016年第4期26卷 653-660页

作者： fan Baoying yuan Yingju School of Management China University of Mining and Technology

Coal occupies a dominant position in China＇s national economy and is an essential energy source for future industrial development. To inform the efficient and sustainable development of the coal industry, this paper analyzes the sources of strategic risk for coal science and technology enterprises using 3 first-class indicators, 10 second-level indicators, and 37 observation points established through the existing research literature and experience. Moreover, in accordance to the obtained initial index data, the selected indicators have been tested and screened using reliability and membership degree analyses to remove redundant variables, avoid juxtaposition of risk factors at different levels, and reduce the influ- ence of some tiny risk factors for enterprise strategic risk. Then, factor analysis of external environment factor sub-scale was carried out. Factors are extracted according to a standard characteristic value greater than 1. Variables with high coefficients are classified into one factor category; and finally, 3 first-class indicators. 8 second-level indicators, and 37 observation noints are reconstructed.

关键词： Coal science and technology enterprises Strategic risk Risk assessment index Constructing

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我们都是“同时代人”——如何建构当代文学价值共同体的反思

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当代文坛 2025年第1期 77-81页

作者：丁帆南京大学文学院

“同时代人”是一个超越年龄、时空的广义内涵的存在,它打破了生理年龄和朝代更迭,以代际划分的“同时代人”的陈见,用一种具有深刻和前瞻意义的理念,聚合成一种具有“当代性”的切分方法,以跨越代际的共同价值观来重塑“同时代人”群体... 详细信息

“同时代人”是一个超越年龄、时空的广义内涵的存在,它打破了生理年龄和朝代更迭,以代际划分的“同时代人”的陈见,用一种具有深刻和前瞻意义的理念,聚合成一种具有“当代性”的切分方法,以跨越代际的共同价值观来重塑“同时代人”群体,以此作为解决创作困囿和批评迷惘的突破口。“我们可以使自己成为这些文本的同时代人”的命题,才是需要正视的最本质的问题所在。当下的“同时代人”,既要以史为鉴,从历史的“同时代人”的思想宝库中,汲取属于我们这个时代的相对统一价值观,同时还要引领更多能够聚合在同一价值观下的“同时代人”,发出对整个世界的批判性哲学诘问,这也是改“未完成的现代性”为“当代性”关键词的理由,希冀由此而触及对当代文学治史观念的一种新观念和新方法,在“同时代人”旗帜下,建构起一种基本的人文价值观和学术守则。

关键词： “同时代人” “当代性” 文学价值共同体 “真理性”

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Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang Nan Mo Le Tong Jianhong Dong Ziwei fan Mengxian Jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

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Sintering densification behavior and kinetic mechanism of nano-tungsten powder prepared by sol-spray drying

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Tungsten 2020年第4期2卷 371-380页

作者： zhi‑yuan Du Yong‑Qi Lv Yong Han Jing‑Lian fan Lei Ye State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China

Due to its excellent mechanical and radiation resistance performance,fine-grained tungsten becomes an ideal plasma facing material in fusion ***,the preparation of fine-grained tungsten by ultrafine powder is faced with some problems,such as low density,coarse grain and not suitable for engineering *** this paper,nano-tungsten powders prepared by“sol-spray drying-calcination-hydrogen thermal reduction”process were sintered by non-isothermal ordinary pressureless sintering,and the densification behavior and kinetic mechanism were *** results show that there exists two stages during sintering process,namely significant densification process at low temperature(1300-1700℃)and grain growth stage at high temperature(1700-2000℃).Finally,bulk tungsten material with the relative density of 96.9%and average grain size of 2-6μm was prepared at 1900℃.Moreover,electron backscatter diffraction results show the grain size is uniform and *** mathematical calculation,the nanocrystallization of tungsten powder significantly reduces the sintering activation energy and promotes the densification of tungsten powder at low *** diffusion is the main transport mechanism in grain growth *** is easy to find that the hardness of material increased with the sintering temperature increasing,at the end of sintering densification(>1700℃),TEM observation revealed that the inner pores formed by particle combine were gradually eliminated through grain boundary diffusion with the sintering temperature increasing,resulting in the intra-crystal densification to increase the hardness of tungsten material.

关键词： Nano-tungsten powder Sintering densification Electron backscatter diffraction Kinetics Nanoindentation hardness

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Identification of neutron-rich isotope ^(197)Os

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Nuclear Science and Techniques 2004年第5期15卷 265-267页

作者： YANGWei-fan yuanShuang-Gui XUYan-Bing XIAOYong-Hou ZHAOLi-Min WANGPing-zhi LIHeng-yuan InstituteofModernPhysics.theChineseAcademyofSciences Lanzhou730000

A new neutron-rich isotope 197Os was produced in the198Pt(n, 2p) reaction by irradiating natural Pt targets with 14 MeV neutrons. The γ(X) singles spectrum and coincidence spectrum measurements were performed using two HPGe γ-ray detectors. Ten unknown γ-rays at 41.2, 50.7, 196.8, 199.6, 223.9, 233.1, 250.2, 342.1, 403.6, and 460.4 keV attributed to the decay of 197Os were observed in the experiments. The half-life of 197Os was found to be (2.8 ± 0.6) min. A partial decay scheme of 197Os was proposed on the basis of decay and coincidence relations. The half-life was compared with the values expected by different theoretical models.

关键词： Os 半衰期同时测量法重同位素衰减图解

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Wide area measurements based fault detection and location method for transmission lines

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Protection and Control of Modern Power Systems 2019年第1期4卷 53-64页

作者： Wen fan yuan Liao Department of Electrical and Computer Engineering University of KentuckyLexingtonKY40506USA

Electric power grids are critical infrastructure for delivering energy from generation stations to load centers. To maximize utilization of assets, it is desirable to increase the power transferred over transmission systems. Reliable protection of transmission systems is essential for safeguarding the integrity and reliability of the power grid. Distance protection is the most widely used scheme for protecting transmission lines. Most existing protection systems use local measurements to make a decision while pilot protection is used in some circumstances. Distance protection may fail under stressed operating conditions, which could lead to cascading faults. This paper proposes a system integrity protection scheme by utilizing wide area measurements. The scheme partitions the system into subnetworks or protection zones and employs current measurements to derive a fault identification vector indicating the faulted zone. Then the fault location is pinpointed based on wide area measurements and network data. The proposed method is able to deal with multiple, simultaneous faults, and is applicable to both transposed and untransposed lines. Evaluation studies based on simulation studies are presented.

关键词： System integrity protection scheme Fault location Transmission systems

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Analysis and Verification of the Relationship between the Maximum Mass Sensitivity of Quartz Crystal Microbalance and Electrode Parameters

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Chinese Physics Letters 2019年第7期36卷 23-26页

作者： Wei Pan Xian-He Huang Qiao Chen zhi-Chao fan yuan Xu School of Automation Engineering University of Electronic Science and Technology of China

We analyze the effect of electrode diameter and thickness on the mass sensitivity. Through the theoretical approximate calculation, we find that the mass sensitivity does not change monotonically with electrode diameter and there is a maximum point. The optimum electrode diameter corresponding to the maximum mass sensitivity varies with the electrode thickness. For a particular electrode diameter, a quartz crystal microbalance(QCM)with thick electrode has a higher mass sensitivity. A proper plating experiment using 35 QCMs with different electrode diameters and thicknesses verifies this finding. The present study further reveals how electrode size affects mass sensitivity and is helpful for QCM design.

关键词： effect of electrode mass sensitivity QCM design

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Enhanced cooperative MAC for wireless local area networks

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The Journal of China Universities of Posts and Telecommunications 2011年第5期18卷 7-14页

作者： JIANG fan fan Jiu-lun CHANG zhi-xian School of Communications and Information Engineering Xi＇an University of Posts and Telecommunications Xi＇an 710121 China

A novel network protocol, enhanced cooperative medium access control （ECoop MAC）, is present in this article. Its function is to guarantee the quality of service （QoS） in wireless local area networks. For the sake of supporting different application scenarios, two proposed schemes, namely E-scheme I for lower priority traffic and E-scheme II for higher priority traffic can be adopted independently or in combination. ECoop MAC takes into account request failure problems, and utilizes cooperative protocol information to boost the system performance as well as to effectively cut control packets overhead. Simulation results show that the proposed algorithm can not only improve network throughput, but also lead to reduced network delays for individual packets.

关键词： MAC protocols cooperative communication game theory QoS

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Rheological Properties of Electrorheological Fluids Beyond and in the Original Transition Zone

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Chinese Physics Letters 2002年第9期19卷 1309-1311页

作者： fan zhi-Kang, Liang Shu-Hua School of Material Science and Engineering Xi\'an University of Technology Xi\'an 710048

We find a nonlinear relationship between the shear stress and shear rate of electrorheological (ER) fluids with aluminosilicate suspension in the original zone corresponding to low shear rates. Beyond the original zon... 详细信息

关键词： Electrorheological fluids

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