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Association of plant-based diets with the risk of upper gastrointestinal tract cancers:A systematic review and meta-analysis

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Journal of Nutritional Oncology 2023年第4期8卷 183-195页

作者： Shan-Rui Ma Yue-Ying Zhang zhi-yuan fan Fei-fan He Wen-Qiang Wei National Cancer Center Beijing 100021China National Clinical Research Center for Cancer Beijing 100021 China Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Background:Diets rich in red or processed meat have been linked to an increased risk of cancers within the digestive *** has been suggested that a plant-based diet may have protective effects against digestive system *** study aimed to determine the association between plant-based diets and upper gastrointestinal tract cancers(UGTC).Methods:We conducted a systematic review and meta-analysis of observational *** searched the PubMed,Medline,Embase,and Web of Science databases for articles published up to September 30,*** pooled the risk ratios(RR)with the corresponding 95%confi-dence intervals(CI)using fixed or random-effects ***:Our meta-analysis included 16 studies(30 results).The data revealed a strong inverse association between a high intake of plant-based diets and UGTC(RR=0.60,95%CI=0.49-0.72),specifically gastric cancer(GC,RR=0.53,95%CI=0.42-0.67)and esophageal can-cer(EC,RR=0.63,95%CI=0.42-0.96).This relationship was not significant for gastric cardia cancer(GCA)or esophagogastric junctional cancer(EGJC,RR=0.76,95%CI=0.47-1.22).A subgroup analysis showed the association was significant in studies from Asia and Europe,as well as in studies utilizing indices such as a vegetarian diet,Mediterranean diet,the plant-based diet index,and principal component analy-sis(PCA)dietary *** was no indication of publication bias among the analyzed ***:This meta-analysis highlights the potential health benefits of plant-based diets in preventing UGTC,particularly regarding esophageal squamous cell carcinoma(ESCC)and ***,additional research is required to validate these results and explore the un-derlying mechanisms.

关键词： upper gastrointestinal tract cancers plant-based diets meta-analysis

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Association of plant-based diets with risk of upper gastrointestinal tract cancers:A systematic review and meta-analysis

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Journal of Nutritional Oncology 2023年第4期 159-168页

作者： Shan-Rui Ma Yue-Ying Zhang zhi-yuan fan Fei-fan He Wen-Qiang Wei National Cancer Center National Clinical Research Center for Cancerand Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College

Background:Diets rich in red or processed meat have been linked to an increased risk of cancers within the digestive *** has been suggested that a plant-based diet may have protective effects against digestive system *** study aimed to determine the association between plant-based diets and upper gastrointestinal tract cancers(UGTCs).Methods:We conducted a systematic review and meta-analysis of observational *** searched the PubMed,MEDLINE,Embase,and Web of Science databases for articles published up to September 30,*** pooled the risk ratios(RRs) with the corresponding95% confidence intervals(CIs) using fixed-or random-effects ***:Our meta-analysis included 16 studies(30 results).The data revealed a strong inverse association between a high intake of plant-based diets and UGTC(RR=0.60,95% CI=0.49-0.72),specifically gastric cancer(GC,RR=0.53,95% CI=0.42-0.67) and esophageal cancer(EC,RR=0.63,95% CI=0.42-0.96).This relationship was not significant for gastric cardia cancer(GCA) or esophagogastric junctional cancer(EGJC,RR=0.76,95% CI=0.47-1.22).A subgroup analysis showed the association was significant in studies from Asia and Europe,as well as in studies utilizing indices such as a vegetarian diet,Mediterranean diet,the Plant-Based Diet Index,and principal component analysis dietary *** was no indication of publication bias among the analyzed ***:This meta-analysis highlights the potential health benefits of plant-based diets in preventing UGTC,particularly regarding esophageal squamous cell carcinoma(ESCC) and ***,additional research is required to validate these results and explore the underlying mechanisms.

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Static coarsening behavior of equiaxed α phase in Ti-8Al-1Mo-1V alloy

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Transactions of Nonferrous Metals Society of China 2021年第6期31卷 1628-1640页

作者： Xiao-hui SHI Zu-han CAO zhi-yuan fan Jürgen ECKERT Jun-wei QIAO College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Erich Schmid Institute of Materials Science Austrian Academy of SciencesLeobenA-8700Austria Department of Materials Science Chair of Materials PhysicsMontanuniversität LeobenLeobenA-8700Austria

To get a deep understanding of the evolution behavior of equiaxedαphase in Ti−8Al−1Mo−1V alloy during annealing,its static coarsening mechanism was studied based on the calculations of coarsening exponent n and the activation energy forαboundary *** result of n=6 indicates a special coarsening mechanism of equiaxedα*** activation energy forαboundary migration is calculated to be 138 kJ/mol,which is close to the activation energy for grain growth of pureα-*** is revealed that the coarsening of equiaxedαcan be mainly attributed to the self-diffusion of Ti atoms across theα/α*** on the experimental findings,a static coarsening kinetics model of equiaxedαgrains in theα+βfield is *** last,the effects of the coarsening behavior of equiaxedαon tensile properties were studied.

关键词： static coarsening kinetics model tensile properties Ti−8Al−1Mo−1V

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Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease

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World Journal of Gastroenterology 2025年第3期31卷 62-72页

作者： Hao Ding yuan-yuan fang Wen-Jie fan Chen-Yu Zhang Shao-Fei Wang Jing Hu Wei Han Qiao Mei Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Radiation Oncology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Gastroenterology Suzhou First People's HospitalSuzhou 234099Anhui ProvinceChina

BACKGROUND Mucosal healing(MH)is the major therapeutic target for Crohn's disease(CD).As the most commonly involved intestinal segment,small bowel(SB)assessment is crucial for CD ***,it poses a significant challenge due to its limited accessibility through conventional endoscopic *** To establish a noninvasive radiomic model based on computed tomography enterography(CTE)for MH assessment in SBCD *** Seventy-three patients diagnosed with SBCD were included and divided into a training cohort(n=55)and a test cohort(n=18).Radiomic features were obtained from CTE images to establish a radiomic *** demographics were analysed to establish a clinical model.A radiomic-clinical nomogram was constructed by combining significant clinical and radiomic *** diagnostic efficacy and clinical benefit were evaluated via receiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA),*** Of the 73 patients enrolled,25 patients achieved *** radiomic-clinical nomogram had an area under the ROC curve of 0.961(95%confidence interval:0.886-1.000)in the training cohort and 0.958(0.877-1.000)in the test cohort and provided superior clinical benefit to either the clinical or radiomic models alone,as demonstrated by *** These results indicate that the CTE-based radiomic-clinical nomogram is a promising imaging biomarker for MH and serves as a potential noninvasive alternative to enteroscopy for MH assessment in SBCD patients.

关键词： Crohn’s disease Computed tomography enterography Mucosal healing Nomogram Radiomics

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Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑yuan Yu Jing Wu Guang Yin fan‑Zhen Jiao Zhong‑Zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

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超高强Ti-15Mo-2.7Nb-3Al-0.2Si钛合金的强化行为及模型

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Transactions of Nonferrous Metals Society of China 2024年第4期34卷 1136-1149页

作者：石晓辉张琪荆镇范智渊刘江林乔珺威太原理工大学材料科学与工程学院太原030024 太原理工大学机械与运载工程学院太原030024

基于XRD、OM、SEM和TEM分析,研究超高强Ti-15Mo-2.7Nb-3Al-0.2Si钛合金的组织演变及强化行为。结果表明,位错强化和析出强化效应对该合金的屈服强度影响较大。冷轧+再结晶+冷轧+双时效组合工艺可获得1518 MPa的最高屈服强度,这主要归因... 详细信息

基于XRD、OM、SEM和TEM分析,研究超高强Ti-15Mo-2.7Nb-3Al-0.2Si钛合金的组织演变及强化行为。结果表明,位错强化和析出强化效应对该合金的屈服强度影响较大。冷轧+再结晶+冷轧+双时效组合工艺可获得1518 MPa的最高屈服强度,这主要归因于显微组织中的高密度残存位错及密集而细小的次生α相。建立复合强化模型,其预测误差在16.6%以内。此外,研究发现次生α相体积分数的增加可以不断强化晶内区域,这使得沿晶断裂开始出现并逐渐占据整个断裂面。

关键词：强化模型超高强强化行为钛合金 Ti-15Mo-2.7Nb-3Al-0.2Si

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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-Lian Wang Yun-Feng Wang fan Yang Jian-Qin Liu Jie Chen zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

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Soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

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Neural Regeneration Research 2025年第9期20卷 2585-2586页

作者： Andrew Gregory Chengyun Tang fan fan Department of Physiology Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词： Alzheimer population drug

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术中超声定位技术在颅内深部肿瘤切除中的应用

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中国现代药物应用 2016年第13期10卷 24-25页

作者：赖瑾瑜袁志帆于超东莞市人民医院超声科 523000

目的探讨超声定位技术在颅内深部肿瘤切除中的临床应用。方法 23例颅内深部肿瘤患者,随机分为超声定位组12例和传统CT及MR定位组11例,分别给予相应定位治疗,比较两组的手术时间及疗效的差异。结果超声定位组平均手术时间(125±10)min短... 详细信息

目的探讨超声定位技术在颅内深部肿瘤切除中的临床应用。方法 23例颅内深部肿瘤患者,随机分为超声定位组12例和传统CT及MR定位组11例,分别给予相应定位治疗,比较两组的手术时间及疗效的差异。结果超声定位组平均手术时间(125±10)min短于传统CT及MR定位组(245±30)min(P<0.05);超声定位组治愈率优于传统CT及MR定位组(P<0.05)。结论术中超声定位技术在颅内深部肿瘤切除中有着明显的优势,以其准确性及实时性为临床所接受,值得在颅脑外科深部肿瘤的切除中推广应用。

关键词：颅内深部肿瘤术中超声介入性

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利用折射率衡量蔗糖水解反应的进程

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物理实验 2017年第8期37卷 48-50,53页

作者：种晴袁志峰范婷石河子大学理学院新疆石河子832000 石河子大学机械电气工程学院新疆石河子832000

利用旋光性溶液的折射率与旋光度的线性关联,研究了不同浓度的蔗糖溶液经盐酸水解过程中旋光度和折射率随时间的变化.实验结果表明:在室温环境下,0.20g/mL和0.15g/mL的蔗糖水解溶液分别经120min和145min的反应时间,折射率和旋光度同时... 详细信息

利用旋光性溶液的折射率与旋光度的线性关联,研究了不同浓度的蔗糖溶液经盐酸水解过程中旋光度和折射率随时间的变化.实验结果表明:在室温环境下,0.20g/mL和0.15g/mL的蔗糖水解溶液分别经120min和145min的反应时间,折射率和旋光度同时趋于稳定.实验验证了反应过程中,酸水解蔗糖溶液的折射率随旋光度的变化成线性关系.因此,利用水解过程中折射率或旋光度随时间的变化关系可判定水解反应的进程.

关键词：蔗糖酸水解旋光度折射率反应进程

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