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Development of a miniature silicon wafer fuel cell using L-ascorbic acid as fuel

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第7期9卷 955-960页

作者： Jian WU zhi-yong xiao Yi-bin YING Philip C.H. CHAN School of Biosvstems Engineering and Food Science Zhejiang University Hangzhou 310029 China Department of Electrical and Electronic Engineering Hong Kong University of Science and Technology Hong Kong China

In the current studies a miniature silicon wafer fuel cell(FC) using L-ascorbic acid as fuel was developed. The cell employs L-ascorbic acid and air as reactants and a thin polymer electrolyte as a separator. Inductively coupled plasma(ICP) silicon etching was employed to fabricate high aspect-ratio columns on the silicon substrate to increase the surface area. A thin platinum layer deposited directly on the silicon surface by the sputtering was used as the catalyst layer for L-ascorbic acid electro-oxidation. Cyclic voltammetry shows that the oxidation of L-ascorbic acid on the sputtered platinum layer is irreversible and that the onset potentials for the oxidation of L-ascorbic acid are from 0.27 V to 0.35 V versus an Ag/AgCl reference electrode. It is found that at the room temperature,with 1 mol/L L-ascorbic acid/PBS(phosphate buffered solution) solution pumped to the anode at 1 ml/min flow rate and air spontaneously diffusing to the cathode as the oxidant,the maximum output power density of the cell was 1.95 mW/cm2 at a current density of 10 mA/cm2.

关键词： L-ascorbic acid Fuel cell (FC) Silicon wafer

Estimation of the elastic thickness over ancient Mare Moscoviense

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Research in Astronomy and Astrophysics 2019年第12期19卷 318-326页

作者： Zhen Zhong Jian-Guo Yan Teng Zhang zhi-yong xiao Jose Alexis Palmero Rodriguez School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550001China State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhan 430079China Instituto de Astronomiay Ciencias Planetarias de Atacama Universidad de AtacamaCopayapu 485Chile Planetary Science Institute Chinese University of Geosciences(Wuhan)Wuhan 430074China Planetary Science Institute 1700 East Fort Lowell RoadSuite 106TucsonAZ 85719-2395USA

The Moscoviense basin is an atypical lunar impact basin with concentric rings of positive and negative gravity anomalies. This basin can provide insights into the inhomogeneous thermal activities across the farside of the Moon. Based on an updated spherical harmonic thin elastic-shell loading model, we used localized admittance analyses to estimate the elastic thickness as well as other associated selenophysical parameters for the Moscoviense basin. The high precision gravity and topography data employed in our estimation were collected by the Gravity Recovery and Interior Laboratory and the Lunar Orbiter Laser Altimeter missions. Our results indicate that the crust-mantle interface is mainly compensated by the prefilling depth rather than the observed surface topography. The results constrained within two standard deviations yielded a small load ratio(~0.168), a best-fit crustal thickness of 36.2 km, and an optimized crustal density of 3159.5 kg m-3. Such large density approaches the density of olivine-rich mantle materials, implying that the excavation of the Mare Moscoviense occurred during a basin-forming impact. The inversed elastic thickness at Mare Moscoviense was around 18 km, lower than the previous results(~60 km) found over Mare basins on the lunar nearside. These results indicate that extreme thermal activity existed during the Moscoviense basin-forming period such as reheating mechanisms from a double-impact process and mare volcanism.

关键词： Mare Moscoviense localized admittance thin elastic spherical shell elastic thickness

The inner solar system cratering record and the evolution of impactor populations

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Research in Astronomy and Astrophysics 2015年第3期15卷 407-434页

作者： Robert G.Strom Renu Malhotra zhi-yong xiao Takashi Ito Fumi Yoshida Lillian R Ostrach Lunar and Planetary Laboratory The University of Arizona Planetary Science Institute China University of Geosciences(Wuhan) National Astronomical Observatory NASA Goddard Space Flight Center

We review previously published and newly obtained crater size-frequency distributions in the inner solar system. These data indicate that the Moon and the ter- restrial planets have been bombarded by two populations of objects. Population 1, dominating at early times, had nearly the same size distribution as the present-day asteroid belt, and produced heavily cratered surfaces with a complex, multi-sloped crater size-frequency distribution. Population 2, dominating since about 3.8-3.7 Gyr, had the same size distribution as near-Earth objects （NEOs） and a much lower im- pact flux, and produced a crater size distribution characterized by a differential -3 single-slope power law in the crater diameter range 0.02 km to 100 km. Taken to- gether with the results from a large body of work on age-dating of lunar and meteorite samples and theoretical work in solar system dynamics, a plausible interpretation of these data is as follows. The NEO population is the source of Population 2 and it has been in near-steady state over the past ～ 3.7-3.8 Gyr; these objects are derived from the main asteroid belt by size-dependent non-gravitational effects that favor the ejection of smaller asteroids. However, Population 1 was composed of main belt as- teroids ejected from their source region in a size-independent manner, possibly by means of gravitational resonance sweeping during orbit migration of giant planets; this caused the so-called Late Heavy Bombardment （LHB）. The LHB began some time before ～3.9 Gyr, peaked and declined rapidly over the next ～ 100 to 300 Myr, and possibly more slowly from about 3.8-3.7 Gyr to ～2 Gyr. A third crater population （Population S） consisted of secondary impact craters that can dominate the cratering record at small diameters.

关键词： solar system: formation -- minor planets asteroids -- Earth -- Moon

Synthesis and Cytotoxic Activity of Novel Water-soluble Prodrugs of Combretastatin A-4

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Chinese Chemical Letters 2006年第1期17卷 23-26页

作者： zhi Quart yong xiao Ping XU Ying Chun CHEN Xu BAO Ling Ling WENG Hu ZHENG Department of Medicinal Chemistry West China School of Pharmacy Sichuan University Chengdu 610041

Novel water-soluble prodrugs of combretastatin A-4 （5-8） were synthesized and evaluated for their in vitro cytotoxicity against lung carcinoma A549. Compound 5, bearing phosphoryl choline （PC） moiety, showed 90% inhibition at 32 ktg/mL concentration after 24 h. The findings showed the PC derivative would be a promising candidate for the development of new water-soluble prodrug of cytotoxic combretastatin A-4,

关键词： Combretastafin A-4 cytotoxicity phosphoryl choline water-soluble prodrug.

Efficacy and safety of acupuncture for polycystic ovary syndrome:An overview of systematic reviews

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Journal of Integrative Medicine 2023年第2期21卷 136-148页

作者： Han Yang zhi-yong xiao Zi-han Yin Zheng Yu Jia-jia Liu Yan-qun xiao Yao Zhou Juan Li Jie Yang Fan-rong Liang Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina College of Medical Information and Engineering Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina Traditional Chinese Medicine Department Chengdu Xinan Gynecological HospitalChengdu 610051Sichuan ProvinceChina Infertility Clinic Chengdu Xinan Gynecological HospitalChengdu 610051Sichuan ProvinceChina Health Preservation and Rehabilitation School Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina

Background:Polycystic ovary syndrome(PCOS)is the primary cause of anovulatory infertility,bringing serious harm to women’s physical and mental *** may be an effective treatment for ***,systematic reviews(SRs)on the efficacy and safety of acupuncture for PCOS have reported inconsistent results,and the quality of these studies has not been adequately ***:To summarize and evaluate the current evidence on the efficacy and safety of acupuncture for PCOS,as well as to assess the quality and risks of bias of the available *** strategy:Nine electronic databases(Cochrane Library,MEDLINE,Embase,PsycINFO,CINAHL,Chinese National Knowledge Infrastructure,Wanfang Data,Chongqing VIP Chinese Science and Technology Periodical Database,and China Biology Medicine disc)were searched from their establishment to July 27,*** on the principle of combining subject words with text words,the search strategy was constructed around search terms for“acupuncture,”“polycystic ovary syndrome,”and“systematic review.”Inclusion criteria:SRs of randomized controlled trials that explored the efficacy and(or)safety of acupuncture for treating patients with PCOS were *** extraction and analysis:Two authors independently extracted study data according to a predesigned *** for evaluating the methodological quality,risk of bias,reporting quality,and confidence in study outcomes,including A Measurement Tool to Assess Systematic Reviews 2(AMSTAR 2),Risk of Bias in Systematic Reviews(ROBIS),Preferred Reporting Items for Systematic Reviews and Metaanalyses for Acupuncture(PRISMA-A),and the Grading of Recommendations Assessment,Development and Evaluation(GRADE),were used to score the included ***:A total of 885 studies were retrieved,and 11 eligible SRs were finally included in this *** methodological quality of 2 SRs(18.18%)was low,while the other 9 SRs(81.82%)were scored as extremely *** SRs(36.36%)were considered to be of

关键词： Acupuncture Polycystic ovary syndrome Systematic review Meta-analysis

Effects of somatostatin analog on splanchnic hemodynamics and plasma glucagon level in portal hypertensive rats

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World Journal of Gastroenterology 1997年第4期3卷 20-22页

作者： WU zhiyong, ZHANG xiaoJie, JIAO Zhe, CHEN zhiPing and KUANG YaoLing

IM To investigate the effects of somatostatin analog on splanchnic hemodynamics and plasma glucagon level in portal hypertensive rats.METHODS Twentyeight male SpragueDawley rats were divided into two groups: intrahepatic portal hypertension (IHPH, n=14) by injection of CCl4 and prehepatic portal hypertension (PHPH, n=14) by stenosis of the portal vein. Animals of each group were divided into two subgroups: injection of octreotide and injection of normal saline. Seven agematched normal rats served as controls. The mean systemic arterial pressure (MSAP) and free portal venous pressure (FPP) were measured. The splanchnic blood flow was detected by injection of toad blood red cell labelled with 51Cr and 125I·T3. The concentration of plasma glucagon was determined by radioimmunoassay.RESULTS Octreotide significantly decreased both the splanchnic blood flow and FPP in portal hypertensive rats, and markedly increased splanchnic vascular and portal venous resistance. Octreotide did not significantly lower the plasma glucagon levels in both the peripheral and the portal veins.CONCLUSION The decreased splanchnic blood flow induced by octreotide in portal hypertensive rats results mainly from direct vasoconstriction but less from decreased plasma glucagon level.

关键词： portal hypertension octreotide glucagon splanchnic hemodynamics somatostatin analog

Graft-verse-host disease after liver transplantation:A report of two cases and review of literature

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World Journal of Gastroenterology 2008年第6期14卷 974-979页

作者： zhi-yong Guo xiao-Shun He Lin-Wei Wu xiao-Feng Zhu Wei-Qiang Ju Dong-Ping Wang Shen You Yi Ha Guo-Dong Wang Jie-Fu Huang Organ Transplantation center First Affiliated Hospital Sun Yat-Scn University Guangzhou 510080 Guangdong Province China

Graft-verse-host disease (GVHD) is an uncommon fatal complication following liver transplantation (LTx). In China's Mainland, only six cases have been reported with a morbidity rate up to 1%-2%. Definitive diagnosis was achieved by molecular techniques (HLA typing or PCR-STR) in only two cases and the remaining cases were diagnosed based on typical clinical features with exclusion of other possible causes. All patients died of septic shock or multiple organ failure even after administration of increased corticosteroids and supportive therapy, and reduced immunosuppressive agents. In our center, two cases of GVHD were found among 128 (1.56%) patients. One case was diagnosed by detecting lymphocyte macrochimerism through DNA-STR. Both of them died even after aggressive treatment. In China, the incidence of GVHD is similar to that reported by foreign centers except for an extremely bad prognosis. Rapid diagnosis is crucial for a better prognosis. In China, only 37.5% of cases are diagnosed by molecular methods. We recommend detecting lymphocyte macrochimerism through DNA-STR to get a rapid diagnosis, and interleukin 2-receptor antibody (basiliximab or daclizumab) therapy seems to be a good choice for the disease.

关键词： Graft-versus-host disease Liver transplantation Prognosis Diagnosis Treatment

Addition of tanshinone IIA to UW solution decreases skeletal muscle ischemia-reperfusion injury

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Acta Pharmacologica Sinica 2006年第8期27卷 991-999页

作者： Hong-gang WANG zhi-yong LI xiao-lin LIU~2 Department of Orthopaedics & Microsurgery,the First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,China Department of Orthopaedics & Microsurgery the First Affiliated Hospital of Sun Yat-Sen University Guangzhou China

Aim:To investigate whether tanshinone ⅡA could improve the effect of UWsolution for skeletal muscle preservation and to determine the dose range oftanshinone ⅡA providing optimal protection during ischemia and ***:Ischemic rat limbs were perfused with UW solution or UW plus tanshinoneⅡA (UW+T,0.05,0.1,or 0.2 mg/mL) for 0.5h before reperfusion;controls (I/R)received no *** creatine phosphokinase (CPK),aspartate aminotrans-ferase (AST),and lactate dehydrogenase (LDH) were measured pre-ischemia andafter reperfusion (2-h,4-h,and 6-h).Muscle water content,superoxide dismutase(SOD),malondialdehyde (MDA),adenosine triphosphatase (ATPase) were as-sessed pre-reperfusion and after 6-h *** adhesion molecule-1(ICAM-1) and apoptosis were detected after 6-h *** bloodflow was monitored during reperfusion ***:UW and UW+T pre-vented luxury perfusion during reperfusion and inhibited ICAM-1 expression andapoptosis after 6-h *** CPK,AST,and LDH levels in UW ratswere significantly less than those in controls after 2-h reperfusion (no difference,4-h or 6-h reperfusion).After 4-h ischemia,there were significant differences inwater content,MDA,SOD,and ATPase between UW and controls,but no differ-ence after 6-h *** tests with UW+T rats were significantly differentfrom control results at corresponding *** tanshinone doses im-proved ***:UW plus tanshinone ⅡA increased protection againstI/R injury,suggesting that tanshinone ⅡA has clinical value.

关键词： UW solution tanshinone IIA ischemia-reperfusion skeletal muscle

Application of neuroendoscopic surgical techniques in the assessment and treatment of cerebral ventricular infection

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Neural Regeneration Research 2019年第12期14卷 2095-2103页

作者： Feng Guan Wei-Cheng Peng Hui Huang Zu-Yuan Ren Zhen-Yu Wang Ji-Di Fu Ying-Bin Li Feng-Qi Cui Bin Dai Guang-Tong Zhu zhi-yong xiao Bei-Bei Mao zhi-Qiang Hu Department of Neurosurgery Beijing Shijitan Hospital Capital Medical University Beijing China Department of Neurosurgery Peking Union Medical College Hospital Beijing China Department of Neurosurgery Peking University Third Hospital Peking University Beijing China Department of Neurosurgery Beijing Tongren Hospital Capital Medical University Beijing China Department of Neurosurgery the Second Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu Province China Department of Neurosurgery Beijing Liangxiang Hospital Beijing China

Cerebral ventricular infection (CVI) is one of the most dangerous complications in neurosurgery because of its high mortality and disability rates. Few studies have examined the application of neuroendoscopic surgical techniques (NESTs) to assess and treat CVI. This multicenter, retrospective study was conducted using clinical data of 32 patients with CVI who were assessed and treated by NESTs in China. The patients included 20 men and 12 women with a mean age of 42.97 years. NESTs were used to obliterate intraventricular debris and pus, fenestrate or incise the intraventricular compartment and reconstruct cerebrospinal fluid circulation, and remove artificial material. Intraventricular irrigation with antibiotic saline was applied after neuroendoscopic surgery (NES). Secondary hydrocephalus was treated by endoscopic third ventriculostomy or a ventriculoperitoneal shunt. Neuroendoscopic findings of CVI were used to classify patients into Grade Ⅰ(n = 3), Grade Ⅱ(n = 13), Grade Ⅲ(n = 10), and Grade Ⅳ(n = 6) CVI. The three patients with grade ⅠCVI underwent one NES, the 23 patients with grade Ⅱ/Ⅲ CVI underwent two NESs, and patients with grade Ⅳ CVI underwent two (n = 3) or three (n = 3) NESs. The imaging features and grades of neuroendoscopy results were positively related to the number of neurosurgical endoscopic procedures. Two patients died of multiple organ failure and the other 30 patients fully recovered. Among the 26 patients with secondary hydrocephalus, 18 received ventriculoperitoneal shunt and 8 underwent endoscopic third ventriculostomy. There were no recurrences of CVI during the 6- to 76-month follow-up after NES. Application of NESTs is an innovative method to assess and treat CVI, and its neuroendoscopic classification provides an objective, comprehensive assessment of CVI. The study trial was approved by the Institutional Review Board of Beijing Shijitan Hospital, Capital Medical University, China.

关键词： nerve regeneration neuroendoscopy surgery cerebral ventricular infection assessment treatment hydrocephalus irrigation neural regeneration