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An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

Nano-Micro Letters 2025年第1期17卷 548-558页

作者： ying wang Kai Zhang Liping Ding Liyun Wu Songfeng E Qian He Nanyang wang Hui Zuo Zhengyang Zhou Feng Ding Yue Hu Jin Zhang Yagang Yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

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Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi Yang Xuerui Pang Yibing Yan Yue Wu zhi Geng Wenjie Hu Panpan Hu Xingqi Wu Kai wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

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贝伐珠单抗生物类似药与原研药在转移性结直肠癌患者中疗效和安全性的Meta分析

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药物流行病学杂志 2023年第12期32卷 1401-1407页

作者：文恩辉李莹王芝莹龙丽辉西安医学院第一附属医院临床药学室西安710077 西安市精神卫生中心中医科西安710061 西安医学院药学院西安710021

目的系统评价贝伐珠单抗生物类似药对比原研药在转移性结直肠癌患者中的疗效与安全性。方法计算机检索PubMed、Embase、Cochrane Library、CNKI、WanFang Data、VIP和SinoMed数据库,搜集贝伐珠单抗生物类似药对比原研药在转移性结直肠... 详细信息

目的系统评价贝伐珠单抗生物类似药对比原研药在转移性结直肠癌患者中的疗效与安全性。方法计算机检索PubMed、Embase、Cochrane Library、CNKI、WanFang Data、VIP和SinoMed数据库,搜集贝伐珠单抗生物类似药对比原研药在转移性结直肠癌患者中应用的随机对照试验(RCT),检索时限均为建库至2023年6月18日。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,使用Stata 17.0软件进行Meta分析。结果共纳入4个RCT,包括1052例患者。Meta分析结果显示,贝伐珠单抗生物类似药组和原研药组患者的客观缓解率[RD=-0.01,95%CI(-0.06,0.05),P=0.86]、无进展生存期[HR=1.00,95%CI(0.91,1.09),P=0.94]、药品不良反应总发生率[RR=1.05,95%CI(0.85,1.31),P=0.91]、严重不良事件发生率[RR=0.88,95%CI(0.37,2.08),P=0.60]比较,差异均无统计学意义。结论现有证据显示,贝伐珠单抗生物类似药在转移性结直肠癌患者中的疗效及安全性与原研药相似。受纳入研究的数量和质量限制,上述结论尚待更多高质量研究予以验证。

关键词：贝伐珠单抗生物类似药转移性结直肠癌 Meta分析随机对照试验

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庆城县退耕还林区春季土壤纤毛虫群落特征

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西北师范大学学报（自然科学版） 2017年第2期53卷 88-93页

作者：宁应之王婷婷董玟含杨元罡烟郑杰西北师范大学生命科学学院甘肃兰州730070 甘肃省林业职业技术学院甘肃天水741020

为了研究退耕还林对土壤纤毛虫群落特征的影响并对退耕还林后土壤恢复效果进行客观评价.采用非淹没培养皿法、活体观察法和培养直接计数法对甘肃省庆阳市庆城县退耕还林10年后的多树种混交林和单一树种经济林2种模式林地的纤毛虫群落进... 详细信息

为了研究退耕还林对土壤纤毛虫群落特征的影响并对退耕还林后土壤恢复效果进行客观评价.采用非淹没培养皿法、活体观察法和培养直接计数法对甘肃省庆阳市庆城县退耕还林10年后的多树种混交林和单一树种经济林2种模式林地的纤毛虫群落进行调查分析.研究共发现纤毛虫70种,隶属10纲21目30科42属;退耕还林样地的物种分布和农田之间存在明显差异;农田退耕后纤毛虫种类数、密度和物种多样性均呈现增长趋势且以多树种混交林的物种多样性最高;纤毛虫优势类群由农田的篮环目(Cyrtolophosidida)演替为退耕后的尾柱虫目(Urostylida).冗余分析显示,在生态恢复条件下土壤含水量、土壤容重、有机质和总氮含量是影响土壤纤毛虫群落复杂程度的关键因子,表明土壤纤毛虫群落结构可以作为响应退耕还林生态效应的重要标志.

关键词：生态恢复群落结构冗余分析生物学指标

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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu ying wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

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Illuminating Neural Circuits in Alzheimer’s Disease

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Neuroscience Bulletin 2021年第8期37卷 1203-1217页

作者： Yang ying Jian-zhi wang Department of Pathophysiology School of Basic MedicineMinistry of Education Key Laboratory for Neurological DisordersHubei Key Laboratory for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Alzheimer’s disease(AD)is the most common neurodegenerative disorder and there is currently no *** circuit dysfunction is the fundamental mechanism underlying the learning and memory deficits in patients with ***,it is important to understand the structural features and mechanisms underlying the deregulated circuits during AD progression,by which new tools for intervention can be ***,we briefly summarize the most recently established cutting-edge experimental approaches and key techniques that enable neural circuit tracing and manipulation of their *** also discuss the advantages and limitations of these ***,we review the applications of these techniques in the discovery of circuit mechanisms underlyingβ-amyloid and tau pathologies during AD progression,and as well as the strategies for targeted AD treatments.

关键词： Neural circuit Alzheimer’s disease Single cell RNA sequencing Neural circuit tracing Optogenetics Chemogenetics

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吉林省教育学院2010年度科研工作发展报告

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吉林省教育学院学报 2011年第5期27卷 149-154页

作者：吴群志孟昕颖王文霞吉林省教育学院科研处吉林长春130022

在部门总结和调查研究基础上,从基础教育教学研究、教师教育研究、职业技术教育教学研究、基础理论研究、课题研究和工作问题及改进措施等六个方面全面总结和分析了2010年度我院科研工作的发展情况。

关键词：吉林省教育学院科研工作发展报告

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Bo’s abdominal acupuncture treatment for adult-onset Still's disease:A case report

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World Journal of Clinical Cases 2025年第8期13卷 41-48页

作者： Jia-Min Yang Yu wang Yu-Qing Zhang Hong-Lin Zhang zhi-Yun Bo College for People's Livelihood and Well-being Beijing Vocational College of Labor and Social SecurityBeijing 100029China College of Acupuncture and Moxibustion Beijing University of Chinese MedicineBeijing 100029China Guang'Anmen Hospital China Academy of Traditional Chinese MedicineBeijing 100053China Beijing zhiyuntang Traditional Chinese Medicine Clinic Beijing Bo’s Abdominal Acupuncture Research InstituteBeijing 100122China

BACKGROUND Adult-onset Still's disease(AOSD)is a rare autoinflammatory disease charac-terized by nonspecific symptoms such as fever,rash,sore throat and *** paper reports a clinical case of AOSD successfully treated with Bo’s abdo-minal acupuncture(BAA).CASE SUMMARY We report a 20-year-old man who suffered from cold exposure,presenting with high fever,rash,sore throat,arthralgia,and elevated erythrocyte sedimentation rate,leukocytosis with neutrophilic predominance,elevated ferritin,elevated C-reactive protein,and negative rheumatoid *** was diagnosed with AOSD based on the Yamaguchi *** treatment with traditional Chinese medi-cine(TCM)decoction and prednisone acetate tablets,there was some alleviation of sore throat,joint and muscle pain,and fever,but he still had persistent low-grade fever,rash,sore throat and *** went to the TCM acupuncture outpatient department to receive *** acupoints Zhongwan(CV12),Xiawan(CV10),0.5 cm below Xiawan(CV10),Qihai(CV6),Guanyuan(CV4),bilateral Qixue(KI13),bilateral Huaroumen(ST24),bilateral Shangfengshidian(AB1)and bilateral Daheng(SP15)were *** 3 months treatment,all symptoms disappeared,and the laboratory examination returned to normal *** did not take glucocorticoids or nonsteroidal anti-inflammatory drugs afterwards,and no relapse was observed during the 3-year follow-up *** BAA can be used as a complementary medical approach for treatment of AOSD.

关键词： Adult-onset Still’s disease Bo’s abdominal acupuncture Traditional Chinese medicine Complementary medicine Case report

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负责任的社会科学数据治理的内涵、特征与层次

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现代情报 2025年第1期45卷 124-134页

作者：王英卢国强湖北大学历史文化学院湖北武汉430062 吉林大学商学与管理学院吉林长春130012

[目的/意义]“十四五”国家哲学社会科学发展规划的背景下,负责任的数据治理成为促进社会科学数据开放共享、推进社会科学研究与创新的重要驱动力,亟须探索负责任的社会科学数据治理的基础理论。[方法/过程]运用主题分析法,探寻负责任... 详细信息

[目的/意义]“十四五”国家哲学社会科学发展规划的背景下,负责任的数据治理成为促进社会科学数据开放共享、推进社会科学研究与创新的重要驱动力,亟须探索负责任的社会科学数据治理的基础理论。[方法/过程]运用主题分析法,探寻负责任的数据治理的概念要素及维度,按照国际标准ISO704:2009的概念关系,结合社会科学数据的特性,阐释负责任的社会科学数据治理的内涵及其与相关概念的关系、特征、层次与内容,旨在构建一个较为全面且系统的概念体系。[结果/结论]负责任的社会科学数据治理是多元主体在现有的数据治理环境之下,运用相应的治理机制和手段,将负责任的研究与创新的理念和原则融入社会科学数据全生命周期,以确保所有涉及社会科学数据的流程和成果的责任性的过程,具有责任性、反思性、前瞻性、开放性和工具性特征,可划分为战略层、数据层和活动层。

关键词：社会科学数据负责任的数据治理数据治理

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眼底病常见病征中医治疗浅析

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山东中医杂志 2003年第2期22卷 69-72页

作者：李志英王燕詹敏叶笑妮广州中医药大学第一附属医院广东广州510405

目的 :论述眼底病常见病征中医治疗的规律 ,以提高中医治疗眼底病的疗效。方法 :综合中医理、法、方、药的基础理论知识 ,分别阐述血管扩张、出血、血管阻塞、微血管瘤、水肿、渗出物、组织增生、变性等眼底病常见病征中医治疗规律。结... 详细信息

目的 :论述眼底病常见病征中医治疗的规律 ,以提高中医治疗眼底病的疗效。方法 :综合中医理、法、方、药的基础理论知识 ,分别阐述血管扩张、出血、血管阻塞、微血管瘤、水肿、渗出物、组织增生、变性等眼底病常见病征中医治疗规律。结果 :眼底病常见病征的中医辨证治疗具有一定规律 ,理气法、理血法、化痰法、祛湿法是其主要治法。结论

关键词：眼底病中医治疗辨治规律

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