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Isolation andapplicationofanibuprofen-degrading bacterium toabiologicalaerated filter forthetreatmentof micro-polluted water

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Frontiers of Environmental Science & Engineering 2018年第5期12卷 1-8页

作者： Bingjie xu Gang xue xing Yang College of Chemistry and Environmental Engineering Jiujiang UniversityJiujiang 332005China College of Environmental Science and Engineering Donghua UniversityShanghai 201620China

Ibuprofen(IBU)is widely used in the world as anti-inflammatory drug,which posed health risk to the environment.A bacterium capable of degrading IBU was isolated from activated sludge in a sewage treatment *** to its morphological,physiologic,and biochemical characteristics,as well as 16S rRNA sequence analysis,the strain was identified as Serratia marcescens BL1(BL1).Degradation of IBU required the presence of primary *** a five-day cultivation with yeast powder at 30℃ and pH 7,the highest degradation(93.47%2.37%)was *** process of BL1 degrading IBU followed first-order reaction *** BL1 strain was applied to a small biological aerated filter(BAF)device to form a biofilm with activated *** removal by the BAF was consistent with the results of static *** removal of IBU was 32.01% to 44.04% higher than for a BAF without *** indigenous bacterial community was able to effectively remove CODMn(permanganate index)and ammonia nitrogen in the presence of BL1.

关键词： Ibuprofen Biological aerated filter Degrading bacterium Serratia marcescens

Facebook and Tencent Data Fit a Cube Law Better than Metcalfe’s Law

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Journal of Computer Science & Technology 2023年第2期38卷 219-227页

作者：张星洲徐志伟 Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Metcalfe’s law states that the value of a network grows as the square of the number of its users(V■N^(2)),which was validated by actual data of Facebook and Tencent in 2013–*** then,the users and the values of Facebook and Tencent have increased *** Metcalfe’s law still valid?This paper leverages the latest data of Facebook and Tencent to fit the network effect laws and makes the following observations:1)actual data of network values fit a cube law(V■N^(3))better than Metcalfe’s law;2)actual data of network costs fit a cube law;3)actual data of network sizes show a growth trend matching the netoid function *** also discuss the underlying factors affecting such observations and the generality of the network effect laws.

关键词： network effect Metcalfe’s law cube law netoid function

Specific CYP450 Genotypes in the Chinese Population Affect Sorafenib Toxicity in HBV/HCV-associated Hepatocellular Carcinoma Patients

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Biomedical and Environmental Sciences 2018年第8期31卷 586-595页

作者： GUO xing Gang WANG zhi Heng DONG Wei HE xu Dong LIU Fu Chen LIU Hui The Third Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Respiratory and Endocrine Department The People's Hospital of Wuwei County

Objective The purpose of this study was to screen for frequencies of different CYP450 genotypes in the Chinese population and explore the relationship between sorafenib toxicity and CYP450 polymorphism. Methods A total of 600 peripheral blood samples were obtained from two groups for this study. The first group of 300 samples were from Chinese patients with HBV/HCV-associated HCC, while the remaining 300 samples were from a healthy population of recruited subjects. Allele-specific PCR and long-fragment gene sequencing was used to identify the frequencies of CYP450 polymorphism. Aflatoxin-induced HCC rat models expressing CYP3A4*1, CYP3A5*3, CYP2C19*2, and CYP2D6*10 were established and treated with sorafenib at certain time points. Hepatic and renal function, along with plasma concentration of sorafenib, were monitored regularly. Results The most common forms of CYP mutations in the Chinese population were identified. The levels of sorafenib plasma concentration, as well as damage to hepatic and renal function in aflatoxin-induced HCC rat models varied significantly across the different CYP genotypes. Conclusion The mutational frequencies of CYP3A5, CYP3A4, CYP2C19, and CYP2D6 genotypes varied among different ethnic groups and populations. Individuals with CYP3A5*3 demonstrated minimal sorafenib metabolism, which led to severe hepatic and renal damage. Inter-individual variability in sorafenib-toxicity may be interpreted by CYP450 genetic polymorphisms, suggesting that identification of CYP polymorphism within a certain population should be considered in sorafenib therapy.

关键词： Sorafenib Hepatocellular carcinoma CYP450 polymorphism Inter-individual adverse events

Exploration of Gas‑Dependent Self‑Adaptive Reconstruction Behavior of Cu_(2)O for Electrochemical CO_(2)Conversion to Multi‑Carbon Products

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Nano-Micro Letters 2025年第3期17卷 280-296页

作者： Chaoran Zhang Yichuan Gu Qu Jiang Ziyang Sheng Ruohan Feng Sihong Wang Haoyue Zhang Qianqing xu Zijian Yuan Fang Song State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Structural reconstruction of electrocatalysts plays a pivotal role in catalytic performances for CO_(2)reduction reaction(CO_(2)RR),whereas the behavior is by far superficially ***,we report that CO_(2)accessibility results in a universal self-adaptive structural reconstruction from Cu_(2)O to Cu@CuxO composites,ending with feeding gas-dependent microstructures and catalytic *** CO_(2)-rich atmosphere favors reconstruction for CO_(2)RR,whereas the CO_(2)-deficient one prefers that for hydrogen evolution *** the assistance of spectroscopic analysis and theoretical calculations,we uncover a CO_(2)-induced passivation behavior by identifying a reductionresistant but catalytic active Cu(I)-rich amorphous layer stabilized by*CO ***,we find extra CO production is indispensable for the robust production of *** inverse correlation between durability and FECO/FEC2H4 is disclosed,suggesting that the selfstabilization process involving the absorption of*CO intermediates on Cu(I)sites is essential for durable *** by this insight,we design hollow Cu_(2)O nanospheres for durable and selective CO_(2)RR electrolysis in producing *** work recognizes the previously overlooked passivation reconstruction and self-stabilizing behavior and highlights the critical role of the local atmosphere in modulating reconstruction and catalytic processes.

关键词： CO_(2)reduction reaction Electrocatalysts Cu_(2)O Reconstruction Self-adaptive electrocatalysis

Arsenic Trioxide Combining Leflunomide Activates Nrf2-ARE-HO-1 Signaling Pathway and Protects Heart Xenografts

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Chinese Journal of Integrative Medicine 2021年第10期27卷 760-766页

作者： WANG Teng-da xu Song-lin YU Zheng-yi Nl Shao-bin ZHANG Cheng JIAO zhi-xing Department of Urology The First Affiliated Hospital of Harbin Medical UniversityHarbin(150000)China

Objective:To investigate the molecular mechanisms underlying the effects of arsenic trioxide(As_(2)0_(3))in combination with leflunomide on the hamster-to-rat heart ***:Transplantation of LVG hamster hearts to Lewis rats was performed by anastomosis of vessels in the neck using end-to-end anastomosis with a non-suture cuff *** groups of recipient rats(n=6 in each)were treated with normal saline(control),As_(2)0_(3)[5 mg/(kg*day)intraperitoneally],leflunomide[5 mg/(kg*d)orally],or leflunomide[5 mg/(kg.d)+As_(2)0_(3)5 mg/(kg.d)]in *** hearts and/or rat spleens were harvested and analyzed 4 days after *** reverse-transcription polymerase chain reaction and Western blot analysis were performed to detect the expression of the nuclear factor erythroid-derived factor 2-related factor(Nrf2)and its target gene heme oxygenase-1(HO-1),Treg cell marker fork-head Box P3(FOXP3),apoptosis-associated proteins Bcl-2,Bax,and cleaved *** staining was used to detect the levels of inflammatory natural killer cell and macrophage infiltration,intercellular cell adhesion molecule-1(ICAM-1)and complement ***:Expression of Nrf2-ARE-HO-1 signaling pathway was upregulated in heart xenografts in rats treated with As_(2)0_(3) plus leflunomide compared with control rats or rats treated with either drug alone(P<0.01),and this was accompanied by an increased Treg cells in the recipient rat spleen(P<0.01).In contrast,the expressions of Bax,cleaved caspase-3,ICAM-1,and complement C3,and infiltration of inflammatory cells in the xenografts were inhibited by As_(2)0_(3) plus leflunomide treatment(P<0.01).Conclusion:Combination treatment with As_(2)0_(3) and leflunomide protected hamster heart-xenografts in recipient rats.

关键词： arsenic trioxide leflunomide Nrf2-ARE-HO-1 signaling pathway inflammation infiltration xenotransplantation

Fatty acid-binding protein gene is indispensable for molting process in Heortia vitessoides(Lepidoptera:Crambidae)

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Journal of Integrative Agriculture 2023年第2期22卷 495-504页

作者： YE Qing-ya LI zhi-xing CHEN Qing-ling SUN Ming-xu YIN Ming-liang LIN Tong College of Forestry and Landscape Architecture South China Agricultural UniversityGuangzhou 510642P.R.China

As intracellular fatty acid(FA) carriers,FA-binding proteins(FABPs) widely participate in the absorption,transport,and metabolism of *** is a key protein in insect lipid metabolism and plays an important role in various physiological activities of *** FABP gene(HvFABP) was cloned from the transcriptional library of Heortia vitessoides Moore(Lepidoptera:Crambidae),and its expression patterns were determined using reverse transcription quantitative PCR(RTqPCR).Stage-and tissue-specific expression profiles indicated that HvFABP highly expressed from prepupal to adult stages and in larval midgut and adult *** expression may be induced through starvation,mRNA expression was downregulated at 24 and 48 h and upregulated at 72 h after ***,20-hydroxyecdysone can induce the upregulation of its *** interference-mediated silencing of Hv FABP significantly inhibited HvFABP expression,resulting in delayed development,abnormal molting or lethal phenotypes,and a significantly reduced survival *** results indicate that HvFABP plays a key role in the molting of ***.

关键词： fatty acid-binding protein starvation 20-hydroxyecdysone RNA interference Heortia vitessoides Moore

Interfacial Zn2+-solvation regulator towards reversible and stable Zn anode

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Journal of Energy Chemistry 2025年第1期100卷 684-692页

作者： Miao Zhou Xiongbin Luo Hang Li Shan Guo Zhuang Tong Xiaotao Zhou xu Li Zhaohui Hou Shuquan Liang Guozhao Fang College of Mechanical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and Technology School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South University College of Materials and Metallurgy Guizhou University National Energy Metal Resources and New Materials Key Laboratory Central South University

Aqueous zinc-ion batteries （AZIBs） are fundamentally challenged by the instability of the electrode/electrolyte interface,predominantly due to irreversible zinc （Zn） deposition and hydrogen ***,the intricate mechanisms behind the electrochemical discrepancies induced by interfacial Zn2+-solvation and deposition behavior demand comprehensive *** molecules endowed with special functional groups （such as hydroxyl,carboxyl,etc.） have the potential to significantly optimize the solvation structure of Zn2+and regulate the interfacial electric double layer （EDL）.By increasing nucleation overpotential and decreasing interfacial free energy,these functional groups facilitate a lower critical nucleation radius,thereby forming an asymptotic nucleation model to promote uniform Zn ***,this study presents a pioneering approach by introducing trace amounts of n-butanol as solvation regulators to engineer the homogenized Zn （H-Zn） anode with a uniform and dense *** interfacial reaction and structure evolution are explored by in/ex-situ experimental techniques,indicating that the H-Zn anode exhibits dendrite-free growth,no by-products,and weak hydrogen evolution,in sharp contrast to the bare ***,the H-Zn anode achieves a remarkable Zn utilization rate of approximately 20% and simultaneously sustains a prolonged cycle life exceeding 500 ***,the H-Zn//NH4V4O10（NVO） full battery showcases exceptional cycle stability,retaining 95.04%capacity retention after 400 cycles at a large current density of 5 A *** study enlightens solvation-regulated additives to develop Zn anode with superior utilization efficiency and extended operational lifespan.

关键词： Solvation

A Series of Variable Separation Solutions and New Soliton Structures of （2＋1）-Dimensional Korteweg-de Vries Equation

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Communications in Theoretical Physics 2006年第3X期46卷 403-406页

作者： xu Chang-zhi Department of Physics Jinhua Education College Jinhua 321000 China

Variable separation approach is introduced to solve the （2＋1）-dimensional KdV equation. A series of variable separation solutions is derived with arbitrary functions in system. We present a new soliton excitation model （24）. Based on this excitation, new soliton structures such as the multi-lump soliton and periodic soliton are revealed by selecting the arbitrary function appropriately.

关键词： variable separation approach (2+1)-dimensional KdV equation new soliton excitation

Alreration of nuclear matrix-intermediate filament system and differential expression of nuclear matrix proteins during human hepatocarcinoma cell differentiation

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World Journal of Gastroenterology 2007年第20期13卷 2791-2797页

作者： Jian Tang Jing-Wen Niu Dong-Hui xu zhi-xing Li Qi-Fu Li Jin-An Chen The Key Laboratory of Chinese Ministry of Education for Cell Biology and Tumor Cell Engineering School of Life Sciences Xiamen University Xiamen 361005 Fujian Province China Department of Hepatic Biliary Pancreatic Vascular Surgery 1st Hospitalof Xiamen Fujian Medical University Xiamen 361003 Fujian Province China

AIM： To investigate the association between the configurational and compositional changes of nuclear matrix and the differentiation of carcinoma cells. METHODS： Cells cultured with or without 5 × 10^-3 mmol/L of hexamethylene bisacetamide （HMBA） on Nickel grids were treated by selective extraction and prepared for whole mount observation under electron microscopy. The samples were examined under transmission electron microscope. Nuclear matrix proteins were selectively extracted and subjected to subcellular proteomics study. The protein expression patterns were analyzed by PDQuest software. Spots of differentially expressed nuclear matrix proteins were excised and subjected to in situ digestion with trypsin. The peptides were analyzed by matrix-assisted laser- desorption/ionization time of flight mass spectrometry （MALDI-TOF-MS）. Data were submitted for database searching using Mascot tool （***）. RESULTS： The nuclear matrix （NM） and intermediate filament （IF） in SMMC-7721 hepatocarcinoma cells were found relatively sparse and arranged irregularly. The nuclear lamina was non-uniform, and two kinds of filaments were not tightly connected. After induction for differentiation by HMBA, the NM-IF filaments were concentrated and distributed uniformly. The heterogeneous population of filaments, including highly branched utrathin filaments could also be seen in the regular meshwork. The connection between the two kinds of filaments and the relatively thin, condensed and sharply demarcated lamina composed of intermediate- sized filaments was relatively fastened. Meanwhile, 21 NM proteins changed remarkably during SMMC-7721 cell differentiation. Four proteins, i.e. mutant Pystl, hypothetical protein, nucleophosminl, and LBP were downregulated, whereas four other proteins, eIF6, p44 subunit, 13-tubulin, and SIN3B were upregulated with the last one, SR2/ASF found only in the differentiated SMMC-7721 cells. CONCLUSION： The induced differentiation of SMMC-7

关键词： Nuclear matix-intermediate filament system Nuclear matrix protein Hexamethylamine bisacetamide SMMC-7721 cells Cell differentiation