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Engineering lattice defects in 2D nanomaterials for enhancing biomedical performances

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Particuology 2022年第5期20卷 121-133页

作者： zhi Qi Li Li zhi Ping xu Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQLD 4072Australia

2D nanomaterials are widely investigated for biomedical applications,attributed to their large specific surface area,high therapeutic loading capacity,and unique optical,thermal,and/or electronic *** defects affect the theranostic performance of 2D nanomaterials significantly by altering their electronic properties and chemical *** investigations have shown that defect-rich 2D nanomaterials are capable of enhancing tumor treatment through efficient drug delivery,photothermal and photodynamic therapies(PTT and PDT),and improving diagnostics via computed tomography(CT),photoacoustic and magnetic resonance *** review summarizes recent progresses,including synthesis,characterization approach,and applications of defect-engineered 2D nanomaterials that are potentially useful in cancer *** expert opinions are also proposed as the conclusion.

关键词： 2D nanomaterials Engineering lattice defects Cancer theranostics Phototherapy

Deploy Efficiency Driven k-Barrier Construction Scheme Based on Target Circle in Directional Sensor Network

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Journal of Computer Science & Technology 2020年第3期35卷 647-664页

作者： xing-Gang Fan zhi-Cong Che Feng-Dan Hu Tao Liu Jin-Shan xu Xiao-Long Zhou College of zhijiang Zhejiang University of TechnologyShaoxing 312030China College of Computer Science and Technology Zhejiang University of TechnologyHangzhou 310023China College of Electrical and Information Engineering Quzhou UniversityQuzhou 324000China

With the increasing demand for security,building strong barrier coverage in directional sensor networks is important for effectively detecting un-authorized *** this paper,we propose an efficient scheme to form the strong barrier coverage by adding the mobile nodes one by one into the *** first present the concept of target circle which determines the appropriate residence region and working direction of any candidate node to be *** we select the optimal relay sensor to be added into the current barrier based on its input-output ratio(barrier weight)which reflects the extension of barrier *** strategy looses the demand of minimal required sensor nodes(maximal gain of each sensor)or maximal lifetime of one single barrier,leading to an augmentation of sensors to be *** simulation results show that,compared with the available schemes,the proposed method significantly reduces the minimal deploy density required to establish k-barrier,and increases the total service lifetime with a high deploy efficiency.

关键词： directional sensor network barrier coverage target circle deploy efficiency

Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： Qing He Zhen Wang Yuchen Wang Mengjie Zhu zhile Liang Kanghong Zhang Yuge xu Gong Chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming

Hunting problems of multi-quadrotor systems via bearing-based hybrid protocols with hierarchical network

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Chinese Physics B 2020年第5期29卷 194-202页

作者： Zhen xu Xin-zhi Liu Qing-Wei Chen Zi-xing Wu School of Automation Nanjing University of Science and TechnologyNanjing 210094China Department of Applied Mathematics University of WaterlooWaterloo N2L 3G1Canada

Bearing-based hunting protocols commonly adopt a leaderless consensus method,which requests an entire state of the target for each agent and ignores the necessity of collision *** investigate a hunting problem of multi-quadrotor systems with hybrid bearing protocols,where the quadrotor systems are divided into master and slave groups for reducing the onboard loads and collision *** masters obtain the entire state of the target,whose hybrid protocols are based on the displacement and bearing constraints to maintain formation and to avoid the collision in the hunting ***,the slaves’protocols merely depend on the part state of the masters to reduce loads of data *** also investigate the feasibility of receiving the bearing state from machine *** simulation results are given to illustrate the effectiveness of the proposed hybrid bearing protocols.

关键词： hunting problem multi-quadrotor system bearing constraint hierarchical network

Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei Li Xiaoxiao xu xuan Wu Jiarui Li Shiling Chen Danyang Chen Gaigai Li Zhouping Tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

Research on the Dynamic Compressibility of Polyurethane Microcellular Elastomer and its Application for Impact Resistance

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Chinese Journal of Polymer Science 2024年第8期42卷 1185-1197页

作者： zhi-Ying Zhao Hao Jiang Xiao-Dong Li xu-Dong Zhang xing Su Mei-Shuai Zou School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China

The packaging materials with cushioning performance are used to prevent the internal contents from being damaged by the impact and vibration of external *** polyurethane microcellular elastomers(PUMEs)can absorb energy through cell collapse and molecular chain *** this study,PUMEs with different densities were investigated by scanning electron microscopy,dynamic mechanical analysis and dynamic compression *** exhibited significant im pact resistance and the maximum peak stress attenuation ratio reached 73.33%.The protective equipment was made by PUME with the optimal density of 600 kg/m^(3),and then the acceleration sensing device installed with the same protective equipment fell from a height of 3,5 and 10 m to evaluate the energy-absorbing property and reusability of *** results showed that PUMEs equipment reduced the peak acceleration of the device by 93.84%,with a maximum deviation of 9%between actual test and simulation,and shortened the impact time of first landing by 57.39%.In addition,the equipment PUMEs equipment could effectively reduce the stress on the protected items.

关键词： Polyurethane microcellular elastomer Impact velocity Stress attenuation ratio Impact resistance

Peripheral blood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy

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Neural Regeneration Research 2025年第6期20卷 1764-1775页

作者： Zhenzhong Zheng Jialin Chen Jinghong xu Bin Jiang Lei Li Yawei Li Yuliang Dai Bing Wang Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse *** numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical *** study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic *** analysis identified 128 differentially expressed genes that were enriched in patients with neurological *** least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,*** of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%*** results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.

关键词： biomarkers candidate genes degenerative cervical myelopathy gene expression analysis immune cell types neurological disabilities peripheral blood RNA profiles spinal cord injury

Two-Colour Effect on the Ionization and Harmonic Generation of One-Dimensional He^(+)

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Chinese Physics Letters 2001年第8期18卷 1047-1049页

作者： QU Wei-xing GAN Ming-Long XIA Yu-xing LI Ru-Xin xu zhi-Zhan Laboratory for High Intensity Optics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800 Department of Computer Scinece and Technology Shanghai Jiao Tong UniversityShanghai 200030 Department of Applied Physics Shanghai Jiao Tong UniversityShanghai 200030

Using the one-demensional ion mode,We theoretically investigate the dynamics ionization process and the high-order harmonic generation of the He^(+)subject to different kinds of two-colour laser pulse with the same fundamental frequency but various harmonic *** is found that from the results calculated by numerically solving the time-dependent Schrödinger equation,the two-colour laser pulse with the fundamental frequency and harmonic frequency enables the power spectrum of high-order harmonic generation to increase by a few orders of magnitude and the yield of He^(+)to enhance significantly when the harmonic frequency of laser pulse is close to the energy interval between the ground state and the first excited state of He^(+);even the harmonic field added into the pulse is much weaker than the fundamental one.

关键词： harmonic fundamental excited

Temporal Behaviour of Harmonics from One-Dimensional H+2 in an Ultrashort Laser Pulse

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Chinese Physics Letters 2001年第8期18卷 1050-1052页

作者： QU Wei-xing XIA Yu-xing GAN Ming-Long LI Ru-Xin xu zhi-Zhan Laboratory for High Intensity Optics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800 Applied Physics Department Shanghai Jiao Tong UniversityShanghai 200030 Department of Computer Science and Technology Shanghai Jiao Tong UniversityShanghai 200030

With the method of wavelet transform,we consider the temporal behaviour of high-order harmonic generation from one-dimensional H+2 exposed to an ultrashort laser pulse with a duration of tens of *** results,which are calculated by numerically solving the corresponding time-dependent Schrödinger equation with the split-operator method in the non-Born-Oppenheimer approach,show that:(1)The high-order harmonics in the cut-off range emitted as a train of pulses have better coherence than those in the plateau.(2)The harmonics are emitted early in time when the intensity of laser pulse increases.

关键词： pulse ultrashort harmonics