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Multiparameter magnetic resonance imaging-based radiomics model for the prediction of rectal cancer metachronous liver metastasis

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 62-72页

作者： zhi-Da Long Xiao Yu zhi-xiang xing Rui Wang Department of Hepatobiliary and Pancreaticosplenic Surgery Jingzhou Hospital Affiliated to Yangtze UniversityJingzhou 434100Hubei ProvinceChina

BACKGROUND The liver,as the main target organ for hematogenous metastasis of colorectal cancer,early and accurate prediction of liver metastasis is crucial for the diagnosis and treatment of ***,this study aims to investigate the application value of a combined machine learning(ML)based model based on the multiparameter magnetic resonance imaging for prediction of rectal metachronous liver metastasis(MLM).AIM To investigate the efficacy of radiomics based on multiparametric magnetic resonance imaging images of preoperative first diagnosed rectal cancer in predicting MLM from rectal *** We retrospectively analyzed 301 patients with rectal cancer confirmed by surgical pathology at Jingzhou Central Hospital from January 2017 to December *** participants were randomly assigned to the training or validation queue in a 7:3 *** first apply generalized linear regression model(GLRM)and random forest model(RFM)algorithm to construct an MLM prediction model in the training queue,and evaluate the discriminative power of the MLM prediction model using area under curve(AUC)and decision curve analysis(DCA).Then,the robustness and generalizability of the MLM prediction model were evaluated based on the internal validation set between the validation queue *** Among the 301 patients included in the study,16.28%were ultimately diagnosed with MLM through pathological *** analysis showed that carcinoembryonic antigen,and magnetic resonance imaging radiomics were independent predictors of ***,the GLRM prediction model was developed with a comprehensive nomogram to achieve satisfactory *** prediction performance of GLRM in the training and validation queue was 0.765[95%confidence interval(CI):0.710-0.820]and 0.767(95%CI:0.712-0.822),*** with GLRM,RFM achieved superior performance with AUC of 0.919(95%CI:0.868-0.970)and 0.901(95%CI:0.850-0.952)in the training and validation queue,respect

关键词： Rectal cancer Metachronous liver metastases Magnetic resonance imaging Radiomics Machine learning

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Development and validation of a postoperative pulmonary infection prediction model for patients with primary hepatic carcinoma

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World Journal of Gastrointestinal Oncology 2023年第7期15卷 1241-1252页

作者： Chao Lu zhi-xiang xing Xi-Gang Xia zhi-Da Long Bo Chen Peng Zhou Rui Wang Department of Hepatobiliary&Pancreaticospleen Surgery Yangtze UniversityJing Zhou hospitalJingzhou 434020Hubei ProvinceChina

BACKGROUND There are factors that significantly increase the risk of postoperative pulmonary infections in patients with primary hepatic carcinoma(PHC).Previous reports have shown that over 10%of patients with PHC experience postoperative pulmonary ***,it is crucial to prioritize the prevention and treatment of postoperative pulmonary infections in patients with *** To identify the risk factors for postoperative pulmonary infection in patients with PHC and develop a prediction model to aid in postoperative *** We retrospectively collected data from 505 patients who underwent hepatobiliary surgery between January 2015 and February 2023 in the Department of Hepatobiliary and Pancreaticospleen *** data were selected for statistical analysis,and clinical pathological parameters and imaging data were included in the screening database as candidate predictive *** then developed a pulmonary infection prediction model using three different models:An artificial neural network model;a random forest model;and a generalized linear regression ***,we evaluated the accuracy and robustness of the prediction model using the receiver operating characteristic curve and decision curve *** Among the 505 patients,86 developed a postoperative pulmonary infection,resulting in an incidence rate of 17.03%.Based on the gray-level co-occurrence matrix,we identified 14 categories of radiomic data for variable screening of pulmonary infection prediction *** these,energy,contrast,the sum of squares(SOS),the inverse difference(IND),mean sum(MES),sum variance(SUV),sum entropy(SUE),and entropy were independent risk factors for pulmonary infection after hepatectomy and were listed as candidate variables of machine learning prediction *** random forest model algorithm,in combination with IND,SOS,MES,SUE,SUV,and entropy,demonstrated the highest prediction efficiency in both the training and internal verificatio

关键词： Primary hepatic carcinoma Pulmonary infection Gray-level co-occurrence matrix Machine learning Prediction

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Personal predictive model based on systemic inflammation markers for estimation of postoperative pancreatic fistula following pancreaticoduodenectomy

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World Journal of Gastrointestinal Surgery 2022年第9期14卷 963-975页

作者： zhi-Da Long Chao Lu Xi-Gang Xia Bo Chen zhi-xiang xing Lei Bie Peng Zhou Zhong-Lin Ma Rui Wang Department of Hepatobiliary and Pancreaticosplenic Surgery Jingzhou HospitalYangtze UniversityJingzhou 434020Hubei ProvinceChina Department of Hepatobiliary Surgery Lu’an Hospital of AnHui Medical UniversityHefei 237006Anhui ProvinceChina

BACKGROUND Postoperative pancreatic fistula(PF)is a serious life-threatening complication after pancreaticoduodenectomy(PD).Our research aimed to develop a machine learning(ML)-aided model for PF risk *** To develop an ML-aided model for PF risk *** We retrospectively collected 618 patients who underwent PD from two tertiary medical centers between January 2012 and August *** used an ML algorithm to build predictive models,and subject prediction index,that is,decision curve analysis,area under operating characteristic curve(AUC)and clinical impact curve to assess the predictive efficiency of each *** A total of 29 variables were used to build the ML predictive *** them,the best predictive model was random forest classifier(RFC),the AUC was[0.897,95%confidence interval(CI):0.370–1.424],while the AUC of the artificial neural network,eXtreme gradient boosting,support vector machine,and decision tree were between 0.726(95%CI:0.191–1.261)and 0.882(95%CI:0.321–1.443).CONCLUSION Fluctuating serological inflammatory markers and prognostic nutritional index can be used to predict postoperative PF.

关键词： Pancreatoduodenectomy Pancreatic fistula Machine learning algorithm Systemic inflammatory biomarker Risk prediction

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Unraveling the therapeutic potential of Calculus Bovis in liver cancer:A novel step for targeted cancer treatment

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World Journal of Gastroenterology 2025年第3期31卷 127-129页

作者： xing-Yu Chen xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

Hepatocellular carcinoma is one of the leading causes of cancer-related deaths globally,and effective treatments are urgently *** present study aimed to investigate the inhibitory effect of Calculus Bovis(CB)on liver cancer and the underlying *** inhibited M2 tumor-associated macrophage polarization and modulated the Wnt/β-catenin signaling pathway,thereby suppressing the proliferation of liver cancer *** inhibitory effect on liver cancer growth was confirmed by both in vivo and in vitro experiments(detailed by Huang et al).The present study provides a theoretical basis for the application of CB for the treatment of liver cancer,providing new avenues for liver cancer treatment.

关键词： Calculus Bovis Liver cancer M2 tumor-associated macrophage polarization Wnt/β-catenin Pathway Tumor microenvironment

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桥梁断面三分力系数的雷诺数效应

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同济大学学报（自然科学版） 2004年第10期32卷 1328-1333页

作者：李加武林志兴项海帆同济大学桥梁工程系上海200092

在TJ- 2风洞中 ,测量了近 2个数量级的雷诺数范围内不同宽高比的 2类桥梁断面的三分力 ;研究了桥梁断面三分力系数雷诺数效应、宽高比对断面三分力系数雷诺数效应的影响 .近流线型桥梁断面的阻力系数、升力系数都有明显的雷诺数效应 ;... 详细信息

在TJ- 2风洞中 ,测量了近 2个数量级的雷诺数范围内不同宽高比的 2类桥梁断面的三分力 ;研究了桥梁断面三分力系数雷诺数效应、宽高比对断面三分力系数雷诺数效应的影响 .近流线型桥梁断面的阻力系数、升力系数都有明显的雷诺数效应 ;Π型断面阻力系数雷诺数效应与近流线型断面规律相反 ,升力矩及升力系数雷诺数效应不明显 ;宽高比对三分力系数雷诺数效应有明显的影响 ;

关键词：桥梁工程桥梁断面雷诺数效应紊流度三分力系数

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地花鼓与花灯的特征探析

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贵州工业大学学报（社会科学版） 2006年第2期8卷 108-109,112页

作者：向智星湖南女子大学艺术系湖南长沙410000

通过对地花鼓、花灯的客观现实性、较强的地域性和鲜明的形象性三个特征详细阐述,意在说明这一民间艺术的内在规律和表现方式,为继承和发扬这一民间艺术有着重要意义。

关键词：地花鼓花灯特征探讨现实

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民族性与时代性:东方舞蹈艺术发展的基石

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吉首大学学报（社会科学版） 2006年第3期27卷 85-86页

作者：向智星湖南女子大学艺术系湖南长沙410000

东方舞蹈艺术必须背靠着民族文化的坚实基石,并坚持用时代精神、民族精神建构我们本土的现代舞蹈艺术,才能使东方舞蹈艺术立于世界舞蹈艺术之林。

关键词：民族性时代性东方舞蹈

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Laparoscopic liver resection utilizing the ventral avascular area of the inferior vena cava:A retrospective cohort study

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World Journal of Gastroenterology 2025年第1期31卷 42-57页

作者： Kun Huang Zhu Chen Heng Xiao Hai-Yang Hu xing-Yu Chen Cheng-You Du xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400000China Department of General Surgery Mianyang Hospital of Traditional Chinese MedicineMianyang 621000Sichuan ProvinceChina

BACKGROUND Laparoscopic liver resection(LLR)can be challenging due to the difficulty of establishing a retrohepatic tunnel under *** the third hepatic hilum before parenchymal transection often leads to significant liver mobilization,tumor compression,and bleeding from the short hepatic veins(SHVs).This study introduces a novel technique utilizing the ventral avascular area of the inferior vena cava(IVC),allowing SHVs to be addressed after parenchymal transection,thereby reducing surgical complexity and improving outcomes in in situ *** To introduce and evaluate a novel LLR technique using the ventral avascular area of the IVC and compare its short-term outcomes with conventional *** The clinical cohort data of patients with pathologically confirmed hepatocellular carcinoma or intrahepatic cholangiocarcinoma who underwent conventional LLR and novel LLR between July 2021 and July 2023 at the First Affiliated Hospital of Chongqing Medical University were retrospectively *** novel LLR,we initially separated the caudate lobe from the IVC using dissecting forceps along the ventral avascular area of the ***,we transected the parenchyma of the left and right caudate lobes from the caudal side to the cephalic side using the avascular area as a ***,we addressed the SHVs and finally dissected the root of the right hepatic vein or left hepatic *** short-term postoperative outcomes and oncological results of the two approaches were evaluated and *** A total of 256 patients were included,with 150(58.59%)undergoing conventional LLR and 106(41.41%)undergoing novel *** novel technique resulted in significantly larger tumor resections(6.47±2.96 cm vs 4.01±2.33 cm,P<0.001),shorter operative times(199.57±60.37 minutes vs 262.33±83.90 minutes,P<0.001),less intraoperative blood loss(206.92±37.09 mL vs 363.34±131.27 mL,P<0.001),and greater resection volume(345.11±31.40 mL vs 264.38±31.98 mL,P<0.001)comp

关键词： Laparoscopic liver resection Inferior vena cava Retrohepatic tunnel Short hepatic veins Complex liver tumors Intraoperative bleeding control

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Thrombolysis and extracorporeal cardiopulmonary resuscitation for cardiac arrest due to pulmonary embolism:A case report

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World Journal of Critical Care Medicine 2025年第1期14卷 111-117页

作者： Guan-xing Yuan zhi-Ping Zhang Jia Zhou Department of Emergency Wuhan Asia General HospitalWuhan 430056Hubei ProvinceChina Department of Neurosurgery Central Theater Command General HospitalWuhan 430000Hubei ProvinceChina

BACKGROUND Cardiac arrest caused by acute pulmonary embolism(PE)is the most serious clinical circumstance,necessitating rapid identification,immediate cardiopulmonary resuscitation(CPR),and systemic thrombolytic *** CPR(ECPR)is typically employed as a rescue therapy for selected patients when conventional CPR is failing in settings where it can be *** SUMMARY We present a case of a 69-year-old male who experienced a prolonged cardiac arrest in an ambulance with pulseless electrical *** arrival at the emergency department with ongoing manual chest compressions,bedside pointof-care ultrasound revealed an enlarged right ventricle without *** PE was suspected as the cause of cardiac arrest,and intravenous thrombolytic therapy with 50 mg tissue plasminogen activator was administered during mechanical chest *** 31 minutes of CPR,return of spontaneous circulation was not achieved until 8 minutes after initiation of Veno-arterial extracorporeal membrane oxygenation(ECMO)*** ECMO support,the hemodynamic status and myocardial contractility significantly ***,the patient ultimately did not survive due to intracerebral hemorrhagic complications,leading to death a few days later in the *** This case illustrates the potential of combining systemic thrombolysis with ECPR for refractory cardiac arrest caused by acute PE,but it also highlights the increased risk of significant bleeding complications,including fatal intracranial hemorrhage.

关键词： Pulmonary embolism Cardiac arrest Thrombolytic therapy Cardiopulmonary resuscitation Extracorporeal membrane oxygenation Intracranial hemorrhage Case report

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Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le Wang Wenwu Zhang Gang Li xing Cheng Peiqiang Su Yong Wan xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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