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Mechanism underlying the effects of exercise against type 2 diabetes:A review on research progress

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World Journal of Diabetes 2024年第8期15卷 1704-1711页

作者： Chen-Jian Peng Shuo Chen Su-Ying Yan Jian-Ning Zhao zhi-wen luo Yuan Qian Guo-Liang Zhao Department of Sports Medicine Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022Jiangsu ProvinceChina Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China Department of Outpatient Nanjing Hospital of Chinese Medicine affiliated to Nanjing University of Chinese MedicineNanjing 210006Jiangsu ProvinceChina

Exercise has emerged as one of the important and effective non-drug therapies used for management of type 2 diabetes(T2D)in certain *** present report summarizes the latest findings from the research on the beneficial effect of exercise on *** objectives were to provide references for the theoretical study and the clinical practice of exercise-based management of T2D,in addition to identify the limitations of the existing literature,thereby provide direction for future research in this field.

关键词： Type 2 diabetes Diabetes Exercise Mechanism Inflammation

Comment on “Outcomes of different minimally invasive surgical treatments for vertebral compression fractures: An observational study”

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World Journal of Clinical Cases 2022年第12期10卷 3966-3968页

作者： Long Ma zhi-wen luo Ya-Ying Sun Department of Orthopedics The First People's Hospital of Pindingshan CityPingdingshan 467000Henan ProvinceChina Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China

Recently we read the article entitled“Outcomes of different minimally invasive surgical treatments for vertebral compression fractures:An observational study”.This was an observational study that reviewed the safety and efficacy of different cement augmentation modalities for vertebral compression fractures under osteoporotic ***,this is a valuable study that can provide a reference for clinical *** the other hand,we also noticed some points in the article and are willing to share our *** studies with a higher level of evidence can add more knowledge regarding relevant concerns.

关键词： Vertebral compression fractures Osteoporosis Study design Observational study Randomize

Physical energy-based ultrasound shifts M1 macrophage differentiation towards M2 state

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World Journal of Stem Cells 2022年第2期14卷 214-218页

作者： Hao-Cheng Qin zhi-wen luo Yu-Lian Zhu Department of Rehabilitation Medicine Huashan HospitalFudan UniversityShanghai 200040China Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China

Recently,we read with interest the article entitled“Unveiling the Morphogenetic Code:A New Path at the Intersection of Physical Energies and Chemical Signaling”.In this paper,the investigation into the systematic and comprehensive bio-effects of physical energies prompted us to reflect on our *** believe that ultrasound,which possesses a special physical energy,also has a certain positive regulatory effect on macrophages,and we have already obtained some preliminary research results that support our hypothesis.

关键词： Ultrasound Macrophages Stem cells Physical energies Inflammation

Management of hip fracture in COVID-19 infected patients

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World Journal of Orthopedics 2022年第6期13卷 544-554页

作者： Hao-Cheng Qin Zhong He zhi-wen luo Yu-Lian Zhu Department of Rehabilitation Medicine Huashan HospitalFudan UniversityShanghai 200040China Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China

Given that the global population of elderly individuals is expanding and the difficulty of recovery,hip fractures will be a huge challenge and a critical health issue for all of *** people have spent more time at home during the coronavirus disease 2019(COVID-19)pandemic,hip fractures show no sign of *** studies have shown that patients with hip fracture and COVID-19 have a multifold increase in mortality compared to those uninfected and a more complex clinical *** present,no detailed research has systematically analyzed the relationship between these two conditions and proposed a comprehensive *** article aims to systematically review the impact of COVID-19 on hip fracture and provide practical *** found that hip fracture patients with COVID-19 have higher mortality rates and more complicated clinical ***,COVID-19 prevents hip fracture patients from receiving regular medical *** regard to the problems we encounter,we provide clinical recommendations based on existing research evidence and a clinical flowchart for the management of hip fracture patients who are COVID-19 *** study will help clinicians adequately prepare in advance when dealing with such patients and optimize treatment decisions.

关键词： Hip fracture COVID-19 Management Adverse impact Comorbidity Treatment

Bone marrow mesenchymal stem cell-derived exosomal microRNAs target PI3K/Akt signaling pathway to promote the activation of fibroblasts

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World Journal of Stem Cells 2023年第4期15卷 248-267页

作者： Fang-Qi Li wen-Bo Chen zhi-wen luo Yi-Sheng Chen Ya-Ying Sun Xiao-Ping Su Jun-Ming Sun Shi-Yi Chen Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Laboratory Animal Center Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Fibroblast plays a major role in tendon-bone *** derived from bone marrow mesenchymal stem cells(BMSCs)can activate fibroblasts and promote tendon-bone healing via the contained microRNAs(miRNAs).However,the underlying mechanism is not comprehensively ***,this study aimed to identify overlapped BMSC-derived exosomal miRNAs in three GSE datasets,and to verify their effects as well as mechanisms on *** To identify overlapped BMSC-derived exosomal miRNAs in three GSE datasets and verify their effects as well as mechanisms on *** BMSC-derived exosomal miRNAs data(GSE71241,GSE153752,and GSE85341)were downloaded from the Gene Expression Omnibus(GEO)*** candidate miRNAs were obtained by the intersection of three data *** was used to predict potential target genes for the candidate *** and pathway analyses were conducted using the Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)databases,respectively,by processing data with the *** interconnected genes in the protein-protein interaction(PPI)network were analyzed using Cytoscape ***,wound healing assay,collagen contraction assay and the expression of COL I andα-smooth muscle actin positive were applied to investigate the cell proliferation,migration and collagen *** real-time reverse transcription polymerase chain reaction was applied to determine the cell fibroblastic,tenogenic,and chondrogenic *** Bioinformatics analyses found two BMSC-derived exosomal miRNAs,has-miR-144-3p and hasmiR-23b-3p,were overlapped in three GSE *** network analysis and functional enrichment analyses in the GO and KEGG databases indicated that both miRNAs regulated the PI3K/Akt signaling pathway by targeting phosphatase and tensin homolog(PTEN).In vitro experiments confirmed that miR-144-3p and miR-23b-3p stimulated proliferation,migration and collagen sy

关键词： Exosome MicroRNA Fibroblast Mesenchymal stem cell Tendon-bone healing

Combination of diketone and PAO to achieve macroscale oil-based superlubricity at relative high contact pressures

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Friction 2024年第5期12卷 869-883页

作者： Shaonan DU Chenhui ZHANG zhi luo State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing100084China Beijing National Laboratory of Molecular Sciences CAS Key Laboratory of Engineering PlasticsInstitute of ChemistryChinese Academy of SciencesBeijing100190China

1-(4-ethylphenyl)-nonane-1,3-dione(0206)is an oil-soluble liquid molecule with rod-like *** this study,the chelate(0206-Fe)with octahedral structure was prepared by the reaction of ferric chloride and 1,*** experimental results show that when using 0206 and a mixed solution containing 60%0206-Fe and 40%0206(0206-Fe(60%))as lubricants of the steel friction pairs,superlubricity can be achieved(0.007,0.006).But their wear scar diameters(WSD)were very large(532µm,370µm),which resulted in the pressure of only 44.3 and 61.8 MPa in the contact areas of the friction *** 0206-Fe(60%)was mixed with PAO6,it was found that the friction coefficient(COF)decreased with increase of 0206-Fe(60%)in the *** the ratio of 0206-Fe(60%)to PAO6 was 8:2(PAO6(20%)),it exhibited better comprehensive tribological properties(232.3 MPa).Subsequent studies have shown that reducing the viscosity of the base oil in the mixed solution helped to reduce COF and increased *** the COF,contact pressure,and running-in time,it was found that the mixed lubricant(Oil3(20%))prepared by the base oil with a viscosity of 19.7 mPa·s(Oil3)and 0206-Fe(60%)exhibited the best tribological properties(0.007,161.4 MPa,3,100 s).

关键词： diketone oil-based lubricants chelate superlubricity

Reducing Operation Emissions and Improving Work Efficiency Using a Pure Electric Wheel Drive Tractor

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Engineering 2024年第6期37卷 230-245页

作者： Chang-Kai wen wen Ren Qing-Zhen Zhu Chun-Jiang Zhao Zhen-Hao luo Sheng-Li Zhang Bin Xie zhi-Jun Meng Research Center of Intelligent Equipment Beijing Academy of Agriculture and Forestry SciencesBeijing 100097China State Key Laboratory of Intelligent Agricultural Power Equipment Beijing 100097China BYD Company Limited Shenzhen 518118China College of Agricultural Engineering Jiangsu UniversityZhenjiang 212013China College of Engineering China Agricultural UniversityBeijing 100083China

In response to the problems of excessive greenhouse-gas and particulate emissions and the low traction efficiency of conventional diesel tractors in the field,a purely electric wheel-side drive tractor was studied,including an electric motor drive system,a battery ballast system,and an electro–hydraulic suspension *** paper develops a dynamics model of an electric tractor-ploughing unit under complex soil conditions,leading to the proposal of an active control method for drive wheel torque and a joint control method for the traction force of the suspension system and the front-and rear-axle loads of a ***,the tractor is prototyped and assembled,and ploughing tests are carried *** ploughing results show that the active torque-distribution control method proposed in this study reduces the tractor slip by 14.83%and increases the traction efficiency by 10.28%compared with the average torquedistribution *** with the conventional traction control mode,the joint control method for traction and ballast proposed in this paper results in a 3.7%increase in traction efficiency,a 15.05%decrease in slip,and a 4.9%reduction in total drive motor energy *** study will help to improve the operation quality and traction efficiency of electric tractors in complex soil conditions.

关键词： Electric tractor Ploughing unit Torque distribution Active ballast Traction performance

Long head of biceps tendon transposition for massive and irreparable rotator cuff tears:A systematic review and meta-analysis

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World Journal of Orthopedics 2023年第11期14卷 813-826页

作者： Ren-wen Wan zhi-wen luo Yi-Meng Yang Han-Li Zhang Jia-Ni Chen Shi-Yi Chen Xi-Liang Shang Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China

BACKGROUND Superior capsular reconstruction(SCR)with long head of biceps tendon(LHBT)transposition was developed to massive and irreparable rotator cuff tears(MIRCTs);however,the outcomes of this technique remain *** To perform a systematic review of biomechanical outcomes and a meta-analysis of clinical outcomes after LHBT transposition for *** We performed a systematic electronic database search on PubMed,EMBASE,and Cochrane *** of SCR with LHBT transposition were included according to the inclusion and exclusion *** studies were assessed for main results and *** clinical studies were evaluated for quality of *** including study characteristics,cohort demographics,and outcomes were extracted.A meta-analysis was conducted of the clinical *** According to our inclusion and exclusion criteria,a total of six biomechanical studies were identified and reported an overall improvement in subacromial contact pressures and prevention of superior humeral migration without limiting range of motion(ROM)after LHBT transposition for MIRCTs.A total of five clinical studies were included in the meta-analysis of LHBT transposition outcomes,consisting of 253 *** results indicated that compared to other surgical methods for MIRCTs,LHBT transposition had advantages of more significant improvement in ROM(forward flexion mean difference[MD]=6.54,95%confidence interval[CI]:3.07-10.01;external rotation[MD=5.15,95%CI:1.59-8.17];the acromiohumeral distance[AHD][MD=0.90,95%CI:0.21-1.59])and reducing retear rate(odds ratio=0.27,95%CI:0.15-0.48).No significant difference in American Shoulder and Elbow Surgeons score,visual analogue scale score,and University of California at Los Angles score was demonstrated between these two groups for *** In general,SCR with LHBT transposition was a reliable and economical technique for treating MIRCTs,both in terms of biomechanical and clinica

关键词： Massive and irreparable rotator cuff tears Long head of biceps tendon transposition Rotator cuff repair Superior capsular reconstruction

Bayesian network-based survival prediction model for patients having undergone post-transjugular intrahepatic portosystemic shunt for portal hypertension

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World Journal of Gastroenterology 2024年第13期30卷 1859-1870页

作者： Rong Chen Ling luo Yun-zhi Zhang Zhen Liu An-Lin Liu Yi-wen Zhang Department of Infectious Diseases Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Portal hypertension(PHT),primarily induced by cirrhosis,manifests severe symptoms impacting patient *** transjugular intrahepatic portosystemic shunt(TIPS)is a critical intervention for managing PHT,it carries risks like hepatic encephalopathy,thus affecting patient survival *** our knowledge,existing prognostic models for post-TIPS survival in patients with PHT fail to account for the interplay among and collective impact of various prognostic factors on ***,the development of an innovative modeling approach is essential to address this *** To develop and validate a Bayesian network(BN)-based survival prediction model for patients with cirrhosis-induced PHT having undergone *** The clinical data of 393 patients with cirrhosis-induced PHT who underwent TIPS surgery at the Second Affiliated Hospital of Chongqing Medical University between January 2015 and May 2022 were retrospectively *** were selected using Cox and least absolute shrinkage and selection operator regression methods,and a BN-based model was established and evaluated to predict survival in patients having undergone TIPS surgery for *** Variable selection revealed the following as key factors impacting survival:age,ascites,hypertension,indications for TIPS,postoperative portal vein pressure(post-PVP),aspartate aminotransferase,alkaline phosphatase,total bilirubin,prealbumin,the Child-Pugh grade,and the model for end-stage liver disease(MELD)*** on the above-mentioned variables,a BN-based 2-year survival prognostic prediction model was constructed,which identified the following factors to be directly linked to the survival time:age,ascites,indications for TIPS,concurrent hypertension,post-PVP,the Child-Pugh grade,and the MELD *** Bayesian information criterion was 3589.04,and 10-fold cross-validation indicated an average log-likelihood loss of 5.55 with a standard deviation of *** model’s acc

关键词： Bayesian network Cirrhosis Portal hypertension Transjugular intrahepatic portosystemic shunt Survival prediction model