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Prognostic and immunological roles of heat shock protein A4 in lung adenocarcinoma

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World Journal of Clinical Oncology 2024年第1期15卷 45-61页

作者： xuan Wu Shen-Ying Yang Yi-Hua Zhang Jin-Zhou Fang Shuai Wang zhi-wei xu Xiao-Ju Zhang Department of Respiratory and Critical Care Medicine Zhengzhou University People’s HospitalZhengzhou 450008Henan ProvinceChina Graduate School Xinxiang Medical UniversityXinxiang 453003Henan ProvinceChina Department of Pulmonary and Critical Care Medicine Zhengzhou University People’s HospitalZhengzhou 450008Henan ProvinceChina

BACKGROUND Heat shock protein A4(HSPA4)belongs to molecular chaperone protein family which plays important roles within variable cellular activities,including cancer initiation and ***,the prognostic and immunological significance of HSPA4 in lung adenocarcinoma(LUAD)has not been revealed *** To explore the prognostic and immunological roles of HSPA4 to identify a novel prognostic biomarker and therapeutic target for *** We assessed the prognostic and immunological significance of HSPA4 in LUAD using data from The Cancer Genome Atlas *** association between HSPA4 expression and clinical-pathological features was assessed through Kruskal-Wallis and Wilcoxon signed-rank ***/multivariate Cox regression analyses and Kaplan-Meier curves were employed to evaluate prognostic factors,including HSPA4,in *** set enrichment analysis(GSEA)was conducted to identify the key signaling pathways associated with *** correlation between HSPA4 expression and cancer immune infiltration was evaluated using single-sample gene set enrichment analysis(ssGSEA).RESULTS Overexpressing HSPA4 was significantly related to advanced pathologic TNM stage,advanced pathologic stage,progression disease status of primary therapy outcome and female subgroups with *** addition,increased HSPA4 expression was found to be related to worse disease-specific survival and overall *** analysis indicated a significant correlation between HSPA4 and cell cycle regulation and immune response,particularly through diminishing the function of cytotoxicity cells and CD8 T *** ssGSEA algorithm showed a positive correlation between HSPA4 expression and infiltrating levels of Th2 cells,while a negative correlation was observed with cytotoxic cell infiltration *** Our findings indicate HSPA4 is related to prognosis and immune cell infiltrates and may act as a novel prognostic biomarker and therapeutic target for LUAD.

关键词： Heat shock protein A4 Lung adenocarcinoma Tumor-infiltration Prognosis T helper cells

STRNet:Triple-stream Spatiotemporal Relation Network for Action Recognition

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International Journal of Automation and computing 2021年第5期18卷 718-730页

作者： zhi-wei xu Xiao-Jun Wu Josef Kittler School of Artificial Intelligence and Computer Science Jiangnan UniversityWuxi 214122China Jiangsu Provincial Engineering Laboratory of Pattern Recognition and Computational Intelligence Wuxi 214122China Centre for Vision Speech and Signal ProcessingUniversity of SurreyGuildfordGU27XHUK

Learning comprehensive spatiotemporal features is crucial for human action recognition. Existing methods tend to model the spatiotemporal feature blocks in an integrate-separate-integrate form, such as appearance-and-relation network(ARTNet) and spatiotemporal and motion network(STM). However, with blocks stacking up, the rear part of the network has poor interpretability. To avoid this problem, we propose a novel architecture called spatial temporal relation network(STRNet), which can learn explicit information of appearance, motion and especially the temporal relation information. Specifically, our STRNet is constructed by three branches,which separates the features into 1) appearance pathway, to obtain spatial semantics, 2) motion pathway, to reinforce the spatiotemporal feature representation, and 3) relation pathway, to focus on capturing temporal relation details of successive frames and to explore long-term representation dependency. In addition, our STRNet does not just simply merge the multi-branch information, but we apply a flexible and effective strategy to fuse the complementary information from multiple pathways. We evaluate our network on four major action recognition benchmarks: Kinetics-400, UCF-101, HMDB-51, and Something-Something v1, demonstrating that the performance of our STRNet achieves the state-of-the-art result on the UCF-101 and HMDB-51 datasets, as well as a comparable accuracy with the state-of-the-art method on Something-Something v1 and Kinetics-400.

关键词： Action recognition spatiotemporal relation multi-branch fusion long-term representation video classification

Post-exascale supercomputing:research opportunities abound

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Frontiers of Information Technology & Electronic Engineering 2018年第10期19卷 1203-1208页

作者： Zuo-ning CHEN Jack DONGARRA zhi-wei xu Chinese Academy of Engineering Electrical Engineering and Computer Science Department University of Tennessee Institute of Computing Technology Chinese Academy of Sciences

Exascale supercomputing refers to the scientific research efforts and activities to build and use supercomputers that can perform scientific computing at the speed of exaflops,or 10^(18) floating-point(64-bit)operatio... 详细信息

关键词：计算研究机科学研究浮点操作

An Inverse Electromagnetic Scattering Method for One-Dimensional Inhomogeneous Media

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Chinese Physics Letters 2011年第1期28卷 82-85页

作者： LIN zhi-wei xu Xin ZHANG Xiao-Juan FANG Guang-You Key Laboratory for Electromagnetic Radiation and Detection Technology Institute of Electronics Chinese Academy of Sciences Beijing 100190

A frequency-domain inversion scheme for reconstructing the permittivity profile of one-dimensional inhomoge- neous media is proposed. The generalized reflection coefficients and the generalized transmission coefficients of the inhomogeneous media are used as the input data of the inverse model. A Newton-like iterative algorithm known as the generalized pulse-spectrum technique with the Tikhonov regularization is applied to solve the in- verse problem. Novel boundary conditions are proposed for the inverse problem and therefore the permittivity at the boundary of the inhomogeneous media is not required as prior knowledge. The choice of frequency points of the frequency-domain method is also investigated. Numerical examples are carried out to validate the inversion technique. Good agreements between the reconstructed profiles and the true profiles are shown.

关键词： Mathematical physics Accelerators beams and electromagnetism

Electromagnetic Scattering and Inverse Scattering of Layered Media with a Slightly Rough Surface

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Chinese Physics Letters 2011年第1期28卷 86-89页

作者： LIN zhi-wei xu Xin ZHANG Xiao-Juan FANG Guang-You Key Laboratory for Electromagnetic Radiation and Sen ~ing Technology Institute o1 Electronics Chinese Academy ot Sciences Beijing 100190

An electromagnetic （EA1） scattering model for layered media covered by a 3D infinite rough surface and the corresponding inversion technique are investigated. The work aims at remote sensing the surface roughness and dielectric constant for different depths of bear soil through radar measurement data. The forward problem is carried out by the wave decomposition method. The small perturbation method （SPM） and EM boundary conditions are employed to solve the integral equations introduced by the wave decomposition method. The second-order SPM solution of the scatteringfield is involved in the computation of the forward problem for the first time. The backseattering coefficients of multiple frequencies, multiple angles and multiple polarizations are employed to create a nonlinear optimization problem. A genetic algorithm is introduced to help the inversion procedure approaeh to the global minimum of the cost function. Examples are carried out to validate the inversion technique. The inverion results show good agreement with the forward problem with given parameters and pose good tolerance to the input data with the additive white Gaussian noise.

关键词： Broadcasting Technology Data Degradation Measurement Methods

Disaggregated Datacenters for Future Cloud Computing

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Journal of Computer Science & Technology 2023年第5期38卷 947-948页

作者：徐志伟 Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China Great Bay UniversityDongguan 523000China

Datacenters are warehouse-scale computers providing compute,storage and network *** are engines of cloud computing and have seen rapid progress in the past two decades.A recent research trend is disaggregated datacent... 详细信息

关键词： computer Data centers

Extended Object Model for Product Configuration Design

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International Journal of Automation and computing 2010年第3期7卷 289-294页

作者： zhi-wei xu Ze-Zhong Liang Zhong-Qi Sheng School of Mechanical Engineering and Automation Northeastern University Shenyang 110004 PRC

This paper presents an extended object model for case-based reasoning （CBR） in product configuration design. In the extended object model, a few methods of knowledge expression are adopted, such as constraints, rules, objects, etc. On the basis of extended object model, case representation model for CBR is applied to product configuration design system. The product configuration knowledge can be represented by the extended object. The model can support all the processes of CBR in product configuration design, such as case representation, indexing, retrieving, and case revising. The presented model is an extension of the traditional object-oriented model by including the relationship class used to express the relation between the cases, constraints class used in the product configuration knowledge representation, index class used in ease retrieving, and solution class used in case revising. Therefore, the product configuration knowledge used in the product configuration design can be represented by using this model. In the end, a metering pump product configuration design system is developed on the basis of the proposed product configuration model to support customized products.

关键词： Mass customization product configuration case-based reasoning (CBR) object-oriented modeling case representation.

Pd-Catalyzed Transfer of Difluorocarbene for Three Component Cross-Coupling

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Chinese Journal of Chemistry 2020年第12期38卷 1647-1650页

作者： zhi-wei xu wei Zhang Jin-Hong Lin Chuan-Ming Jin Ji-Chang Xiao Hubei Key Laboratory of Pollutant Analysis and Reuse Technology College of Chemistry and Chemical EngineeringHubei Normal UniversityHuangshiHubei 435002China Key Laboratory of Organofluorine Chemistry Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of Sciences345 Lingling RoadShanghai 200032China

Summary of main observation and conclusion Outstanding accomplishments have been achieved in the chemistry of difluorocarbene,but transitionmetal-catalyzed transfer of difluorocarbene for coupling remains a challenging ***,we describe a Pd-catalyzed coupling of difluorocarbene with two aryl carbon centers to give difluoromethylenation products,which cannot be obtained by any previous difluorocarbene-transformation method.

关键词： method. carbene catalyzed

Structure and Biological Activities of Novel Triazole Compounds Containing 1,3,4-Oxadiazole Ring

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Chemical Research in Chinese Universities 2008年第3期24卷 299-302页

作者： xu Liang-zhong BI Wen-zhao SHANG Yu-qing ZHAI zhi-wei YI xu College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 P R. China

Eighteen novel triazole compounds containing 1,3,4-oxadiazole groups were synthesized from 2-（1H-1,2,4-triazol-1-yl）acetohydrazide and carbon disulfide by several step reactions. The target compounds were characterized by elemental analysis, 1H NMR, 13C NMR, IR, MS, and X-ray crystallography. The results of preliminary biological tests show that all the compounds exhibit certain fungicidal activities.

关键词： 1H-1,2,4-Triazole 1,3,4-Oxadiazole Biological activity Crystal structure