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Turán Number of the Family Consisting of a Blow-up of a Cycle and a Blow-up of a Star

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Acta Mathematica Sinica,English Series 2023年第10期39卷 1980-1988页

作者： zhi wei wu Li Ying KANG Department of Mathematics Shanghai UniversityShanghai 200444P.R.China

Let F={H_(1),...,H_(k)}(k≥1)be a family of graphs.The Tur´an number of the family F is the maximum number of edges in an n-vertex{H_(1),...,H_(k)}-free graph,denoted by ex(n,F)or ex(n,{H_(1),H_(2),...,H_(k)}).The blow-up of a graph H is the graph obtained from H by replacing each edge in H by a clique of the same size where the new vertices of the cliques are all different.In this paper we determine the Tur´an number of the family consisting of a blow-up of a cycle and a blow-up of a star in terms of the Tur´an number of the family consisting of a cycle,a star and linear forests with k edges.

关键词： Tur´an number extremal graph blow-up cycle star

Optimal Formula of Angelica sinensis Ameliorates Memory Deficits in β-amyloid Protein-induced Alzheimer's Disease Rat Model

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Current Medical Science 2022年第1期42卷 39-47页

作者： Hu-ping WANG Hong-yan wu Chun-lin MA Qing-tao ZENG Kai-min ZHU Shu-mei CUI Hai-long LI Guo-tai wu zhi-wei wu Jian-zheng HE Basic Medicine College Gansu University of Chinese MedicineLanzhou 730000 Clinical Medicine College Gansu University of Chinese MedicineLanzhou 730000 Pharmacy College Gansu University of Chinese MedicineLanzhou 730000

Objective:Angelica(A.)sinensis is used as a traditional medical herb for the treatment of neurodegeneration,aging,and inflammation in Asia.A.sinensis optimal formula(AOF)is the best combination in A.sinensis that has been screened to rescue the cognitive ability in P-amyloid peptide(Ap25-35)-treated Alzheimer’s disease(AD)rats.The objective of this study was to investigate the effect of AOF on the learning and memory of AD rats as well as to explore the underlying mechanisms.

关键词： optimal formula of Angelica sinensis Alzheimer's disease amyloid P aggregation oxidative stress neuroinflammation

Effect of deep cryogenic treatment on martensitic lath refinement and nano-twins formation of low carbon bearing steel

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Journal of Iron and Steel Research(International) 2020年第1期27卷 105-113页

作者： Xin-yang Lü zhi-wei wu Xiao He Jun Li Shao-hong Li Mao-sheng Yang Kun-yu Zhao Faculty of Material Science and Engineering Kunming University of Science and TechnologyKunming 650093YunanChina Institute for Special Steels Central Iron and Steel Research InstituteBeijing 100081China

The effect of heat treatment and deep cryogenic treatment on microstructural evolution of low carbon martensitic bearing steel was investigated.The experimental results showed that the lath martensite was obtained by quenching and a few twins as substructures formed in some martensitic laths.The rudiment of sub-interfaces of martensitic lath was formed in the highdensity dislocation regions after deep cryogenic treatment;meanwhile,the number of twins increased,especially in the highdensity dislocation regions.This phenomenon is due to the increase in internal stress caused by cryogenic treatment.After tempering,the rudiment of sub-interface further evolved into the martensitic lath boundary,and thus the original martensitic laths were refined.The twins formed by cryogenic treatment did not disappear after tempering.In addition,small quantities of annealing twins formed in tempering process.Martensitic laths morphology and substructures in different stages of the heat and deep cryogenic treatment were observed by tninsmission electron microscopy.

关键词： Low carbon bearing steel-Deep cryogenic treatment Internal stress Sub-interface Nano-twin

Novel intergenic KIF5B-MET fusion variant in a patient with gastric cancer: A case report

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World Journal of Clinical Cases 2021年第14期9卷 3350-3355页

作者： zhi-wei wu Yu Sha Qing Chen Juan Hou Yan Sun Wang-Kun Lu Jing Chen Li-Jiang Yu Department of Oncology The Seventh Affiliated Hospital of Yangzhou UniversityJingjiang People's HospitalJingjiang 214500Jiangsu ProvinceChina Department of Pathology The Seventh Affiliated Hospital of Yangzhou UniversityJingjiang People's HospitalJingjiang 214500Jiangsu ProvinceChina

BACKGROUND MET fusion is a key driver mutation,but it is rare in gastric cancer(GC).Several MET(hepatocyte growth factor receptor)inhibitors have been approved for the treatment of MET-positive patients,but the tumor response is heterogeneous.With the development of next-generation sequencing,diverse MET fusion partner genes have been identified.We herein report a fusion variant involving KIF5BMET in GC.CASE SUMMARY After thoracoscopic inferior lobectomy plus lymph node dissection under general anesthesia,a“tumor within a tumor”was found in the lung tumor tissue of a 64-year-old non-smoking male patient.Combining the medical history and the results of enzyme labeling,the focal area was considered to be GC.To seek potential therapeutic regimens,an intergenic region between KIF5B and MET fusion was identified.This fusion contains a MET kinase domain and coil-coiled domains encoded by KIF5B exons 1-25,which might drive the oncogenesis.CONCLUSION Our finding could extend the spectrum and genomic landscape of MET fusions in GC and favor the development of personalized therapy.

关键词： KIF5B MET Gastric cancer Non-small cell lung cancer Tumor within a tumor Case report

Transcutaneous electroacupuncture alleviates postoperative ileus after gastrectomy: A randomized clinical trial

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World Journal of Gastrointestinal Surgery 2018年第2期10卷 13-20页

作者： Kai-Bo Chen Yi-Qiao Lu Jian-De Chen Di-Ke Shi zhi-Hui Huang Yi-Xiong Zheng Xiao-Li Jin Zhe-Fang Wang wei-Dong Zhang Yi Huang zhi-wei wu Guo-Ping Zhang Hang Zhang Ying-Hao Jiang Li Chen Department of General Surgery Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Obstetrics and Gynecology Women’s HospitalZhejiang University School of MedicineHangzhou 310006Zhejiang ProvinceChina Division of Gastroenterology and Hepatology Johns Hopkins University School of MedicineBaltimoreMD 21224United States Department of Gastroenterology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016Zhejiang ProvinceChina Department of General Visceral and Cancer SurgeryUniversity of CologneCologne 50937Germany Department of Thyroid Surgery Ningbo No.2 HospitalNingbo 315000Zhejiang ProvinceChina Department of Chinese Medicine Rehabilitation Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of General Surgery First People’s Hospital of WenlingTaizhou 317500Zhejiang ProvinceChina

AIM To investigate the efficacy and safety of transcutaneouselectroacupuncture(TEA) to alleviate postoperative ileus(POI) after gastrectomy.METHODS From April 2014 to February 2017, 63 gastric cancer patients were recruited from the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. After gastrectomy, the patients were randomly allocated to the TEA(n = 33) or control(n = 30) group. The patients in the TEA group received 1 h TEA on Neiguan(ST36) and Zusanli(PC6) twice daily in the morning and afternoon until they passed flatus. The main outcomes were hours to the first flatus or bowel movement, time to nasogastric tube removal, time to liquid and semi-liquid diet, and hospital stay. The secondary outcomes included postoperative symptom assessment and complications.RESULTS Time to first flatus in the TEA group was significantly shorter than in the control group(73.19 ± 15.61 vs 82.82 ± 20.25 h, P = 0.038), especially for open gastrectomy(76.53 ± 14.29 vs 87.23 ± 20.75 h, P = 0.048). Bowel sounds on day 2 in the TEA group were significantly greater than in the control group(2.30 ± 2.61/min vs 1.05 ± 1.26/min, P = 0.017). Time to nasogastric tube removal in the TEA group was earlier than in the control group(4.22 ± 1.01 vs 4.97 ± 1.67 d, P = 0.049), as well as the time to liquid diet(5.0 ± 1.34 vs 5.83 ± 2.10 d, P = 0.039). Hospital stay in the TEA group was significantly shorter than in the control group(8.06 ± 1.75 vs 9.40 ± 3.09 d, P = 0.041). No significant differences in postoperative symptom assessment and complications were found between the groups. There were no severe adverse events related to TEA.CONCLUSION TEA accelerated bowel movements and alleviated POI after open gastrectomy and shortened hospital stay.

关键词： Transcutaneous electroacupuncture Gastrectomy Postoperative ileus

M_(23)C_(6)precipitation and Si segregation promoted by deep cryogenic treatment aggravating pitting corrosion of supermartensitic stainless steel

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Journal of Iron and Steel Research(International) 2021年第5期28卷 629-640页

作者： Xiao He Xin-yang Lu zhi-wei wu Shao-hong Li Qi-long Yong Jian-xiong Liang Jie Su Lie-xing Zhou Jun Li Kun-yu Zhao Faculty of Material Science and Engineering Kunming University of Science and TechnologyKunming 650093YunnanChina Institute for Special Steels Central Iron and Steel Research InstituteBeijing 100081China Research Center for Analysis and Measurement Kunming University of Science and TechnologyKunming 650093YunnanChina

The microstructure evolution and the pitting corrosion resistance of a supermartensitic stainless steel after deep cryogenic treatment process were clarified through X-ray diffraction,field emission scanning electron microscopy,transmission electron microscopy(TEM)and electrochemical methods.The results showed that the microstructure of supermartensitic stainless steel mainly consisted of reversed austenite,tempered martensite,and M_(23)C_(6)carbides after tempering.The deep cryogenic treatment promoted the refinement of the martensite laths and the precipitation of the carbides in comparison with the traditional process.TEM analysis indicated that the segregation of Si atoms at the boundary was found at the interface between carbide and martensite.The pitting corrosion potential of the specimens subjected to deep cryogenic treatment decreased with the elevated tempering temperature,and the lowest pitting corrosion potential was found at the tempering temperature of 650℃.The sensitivity of the pitting corrosion potential was attributed to the precipitation of M_(23)C_(6)carbides and Si atoms segregation.Si atoms segregation engendered the formation of Cr-depleted zone near M_(23)C_(6)and impeded the recovery of Cr-depleted zone.

关键词： 15Cr supermartensitic stainless steel Deep cryogenic treatment Si segregation Pitting corrosion Microstructure

Mechanism Design for Ancillary Service Market Considering Social Welfare and Fairness

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1000-1010页

作者： zhi wu Yuanxi wu wei Gu Zheng Xu Shu Zheng Jingtao Zhao School of Electrical Engineering Southeast UniversityNanjing 210096China NARI Technology Co. Ltd.Nanjing 211106China IEEE CSEE

Increasing penetration of distributed energy resources in the distribution network(DN)is threatening safe operation of the DN,which necessitates setup of the ancillary service market in the DN.In the ancillary service market,distribution system operator(DSO)is responsible for safety of the DN by procuring available capacities of aggregators.Unlike existing studies,this paper proposes a novel market mechanism composed of two parts:choice rule and payment rule.The proposed choice rule simultaneously considers social welfare and fairness,encouraging risk-averse aggregators to participate in the ancillary service market.It is then formulated as a linear programming problem,and a distributed solution using the multi-cut Benders decomposition is presented.Moreover,successful implementation of the choice rule depends on each aggregator’s truthful adoption of private parameters.Therefore,a payment rule is also designed,which is proved to possess two properties:incentive compatibility and individual rationality.Simulation results demonstrate effectiveness of the proposed choice rule on improving fairness and verify properties of the payment rule.

关键词： Aggregator ancillary service market distributed mechanism fairness mechanism design

Gene therapy for monogenic disorders: challenges, strategies, and perspectives

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Journal of Genetics and Genomics 2024年第2期51卷 133-143页

作者： Yi Zhang zhi-Ying wu Department of Medical Genetics and Center for Rare Diseases Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Key Laboratory of Medical Neurobiology of Zhejiang Province HangzhouZhejiang 310009China

Monogenic disorders refer to a group of human diseases caused by mutations in single genes. While disease-modifying therapies have offered some relief from symptoms and delayed progression for some monogenic diseases, most of these diseases still lack effective treatments. In recent decades, gene therapy has emerged as a promising therapeutic strategy for genetic disorders. Researchers have developed various gene manipulation tools and gene delivery systems to treat monogenic diseases. Despite this progress, concerns about inefficient delivery, persistent expression, immunogenicity, toxicity, capacity limitation, genomic integration, and limited tissue specificity still need to be addressed. This review gives an overview of commonly used gene therapy and delivery tools, along with the challenges they face and potential strategies to counter them.

关键词： Gene therapy Monogenic diseases Geneediting Genedelivery Challenges

Single-atom Ag-loaded carbon nitride photocatalysts for efficient degradation of acetaminophen:The role of Ag-atom and O_(2)

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Journal of Environmental Sciences 2024年第5期139卷 12-22页

作者： Yi Yuan Wen-Long Wang zhi-wei Wang Jin Wang Qian-Yuan wu Key Laboratory of Microorganism Application and Risk Control of Shenzhen Guangdong Provincial Engineering Research Center for Urban Water Recycling and Environmental SafetyInstitute of Environment and EcologyShenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Shenzhen Environmental Science and New Energy Technology Engineering Laboratory Tsinghua-Berkeley Shenzhen InstituteShenzhen 518055China College of Materials Science and Engineering Shenzhen UniversityShenzhen 518071China

Carbon nitride has been extensively used as a visible-light photocatalyst,but it has the disadvantages of a low specific surface area,rapid electron-hole recombination,and relatively low light absorbance.In this study,single-atom Ag was successfully anchored on ultrathin carbon nitride(UTCN)via thermal polymerization,the catalyst obtained is called AgUTCN.The Ag hardly changed the carbon nitride's layered and porous physical *** exhibited efficient visible-light photocatalytic performances in the degradation of various recalcitrant pollutants,eliminations of 85% were achieved by visible-light irradiation for 1hr.Doping with Ag improved the photocatalytic performance of UTCN by narrowing the forbidden band gap from 2.49 to 2.36 e V and suppressing electron-hole pair recombination.In addition,Ag doping facilitated O_(2) adsorption on UTCN by decreasing the adsorption energy from -0.2 to -2.22 e V and favored the formation of O_(2)^(·-).Electron spin resonance and radical-quenching experiments showed that O_(2)^(·-)was the major reactive species in the degradation of Acetaminophen(paracetamol,APAP).

关键词： Ag single atom Carbon nitride Photocatalysis Visible light Adsorption energy Reactive species