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Clinicopathological analysis of small intestinal metastasis from extra-abdominal/extra-pelvic malignancy

World Journal of Gastrointestinal Oncology 2024年第10期16卷 4138-4145页

作者： zhi Zhang Jing Liu Peng-Fei Yu Hai-Rui Yang Jin-Yang Li zhi-wei dong wei Shi Guo-Li Gu Department of General Surgery Anhui Medical University First Affiliated HospitalHefei 230002Anhui ProvinceChina Department of General Surgery Air Force Clinical CollegeChina Medical UniversityBeijing 100142China Department of General Surgery Air Force Medical CenterAir Force Clinical College of China Medical UniversityBeijing 100142China Department of General Surgery Air Force Medical CenterChinese People’s Liberation ArmyFifth Clinical(Air Force Clinical College)of China Medical UniversityBeijing 100142China Department of General Surgery Beijing Changping HospitalBeijing 102200China Department of General Surgery Air Force Medical CenterBeijing 100142China

BACKGROUND The metastatic tumors in the small intestine secondary to extra-abdominal/extrapelvic malignancy are extremely ***,the small intestine metastases are extremely prone to misdiagnosis and missed diagnosis due to the lack of specific clinical manifestations and examination methods,thus delaying its ***,in order to improve clinical diagnosis and treatment capabilities,it is necessary to summarize its clinical pathological characteristics and *** To summarize the clinicopathological characteristics of patients with small intestinal metastases from extra-abdominal/extra-pelvic malignancy,and to improve the clinical capability of diagnosis and treatment for rare metastatic tumors in the small *** The clinical data of patients with small intestinal metastases from extra-abdominal/extra-pelvic malignancy were retrieved and summarized,who admitted to and treated in the Air Force Medical Center,Chinese People’s Liberation *** descriptive statistics were performed on the general conditions,primary tumors,secondary tumors in the small intestine,diagnosis and treatment processes,and *** Totally 11 patients(9 males and 2 females)were enrolled in this study,including 8 cases(72.3%)of primary lung cancer,1 case(9.1%)of malignant lymphoma of the thyroid,1 case(9.1%)of cutaneous malignant melanoma,and 1 case(9.1%)of testicular *** median age at the diagnosis of primary tumors was 57.9 years old,the median age at the diagnosis of metastatic tumors in the small intestine was 58.81 years old,and the average duration from initial diagnosis of primary tumors to definite diagnosis of small intestinal metastases was 9 months(0-36 months).Moreover,small intestinal metastases was identified at the diagnosis of primary tumors in 4 *** small intestinal metastases were distributed in the jejunum and ileum,with such clinical manifestations as hematochezia(5,45.4%)and abdominal pain,vomiting and other obstr

关键词： Small intestinal Metastases Clinicopathological features Prognostic analysis Malignancy

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基于自旋转射流的钻头设计研究

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机械工程与自动化 2024年第1期 33-35页

作者：韦志东安徽理工大学机械工程学院安徽淮南232001

针对煤层气开采效率低的问题,设计了一种用于开采煤层气的自旋转射流钻头。采用Fluent数值模拟和实验相结合的研究方法,对基于自旋转射流的钻头进行了仿真研究。仿真结果表明:中心射流具有最大速度,中部和边部射流速度较小,但具有空间... 详细信息

针对煤层气开采效率低的问题,设计了一种用于开采煤层气的自旋转射流钻头。采用Fluent数值模拟和实验相结合的研究方法,对基于自旋转射流的钻头进行了仿真研究。仿真结果表明:中心射流具有最大速度,中部和边部射流速度较小,但具有空间角。通过对比分析三种类型射流钻头的冲蚀破碎煤岩特征,发现自旋转射流钻头冲孔破岩能力要优于直旋混合和空化射流钻头。研究表明:该自旋转射流钻头具有较好的冲蚀破碎煤岩能力。

关键词：自旋转射流数值模拟钻头冲孔破岩

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Hierarchical BiOBr microspheres with oxygen vacancies synthesized via reactable ionic liquids for dyes removal

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Chinese Chemical Letters 2016年第5期27卷 769-772页

作者： zhi-dong wei Rui Wang School of Environmental Science and Engineering Shandong University

Hierarchical BiOBr microspheres with oxygen vacancies, which can be used for the dyes removal, have been synthesized successfully in the presence of different kinds of ionic liquids. It was revealed that BiOBr prepared by the ionic liquids with short chain length exhibited higher photocatalytic activity in the degradation of methyl orange （MO） under visible light. The experimental results showed that the phenomenon of the photocatalytic degradation of MO can be explained by the photoluminescence spectra.

关键词： BiOBr Dyes removal Photocatalytic Ionic liquids Oxygen vacancies

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Protein Content and Amino Acid Composition in Grains of Wheat-Related Species

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Agricultural Sciences in China 2008年第3期7卷 272-279页

作者： JIANG Xiao-ling TIAN Ji-chun HAO zhi ZHANG wei-dong State Key Laboratory of Crop Biology/Group of Quality Wheat Breeding Shandong Agricultural University Tai＇an 271018 P.R. China

The protein content and amino acid composition for 17 wheat-related species （WRS） and three common wheats （control） were determined and analyzed, and the essential amino acids （EAAs） in WRS were evaluated according to FAO/WHO amino acid recommendations. The results showed that the mean protein content for WRS was 16.67%, which was 23.21% higher than that for the control. The mean contents （g 100 g^-1 protein） of most amino acids for WRS were lysine 2.74%, threonine 2.83%, phenylalanine 4.17%, isoleucine 3.42%, valine 3.90%, histidine 2.81%, glutamic acid 29.96%, proline 9.12%, glycine 3.59%, alanine 3.37%, and cysteine 1.57%, which were higher than those for the control. The contents of the other 6 amino acids for WRS were lower than those for the control. The materials （Triticum monococcum L., Triticum carthlicum Nevski, and Triticum turgidum L.） contained relatively high concentration of the most deficient EAAs （lysine, threonine, and methionine）. Comparing with FAO/WHO amino acid recommendations, the amino acid scores （AAS） of lysine （49.8%）, threonine （70.7%）, and sulfur-containing amino acids （74.8%） were the lowest, which were considered as the main limiting amino acids in WRS. It was observed that the materials with Triticum urartu Turn. （AA） and Aegilops speltoides Tausch. （SS） genomes had relatively high contents of protein and EAA. The contents of protein （16.91%）, phenylalanine （4.78%）, isoleucine （3.53%）, leucine （6.16%）, and valine （4.09%） for the diploid materials were higher than those for the other materials. These results will provide some information for selecting parents in breeding about nutrient quality and utilization of fine gene in wheat.

关键词： wheat-related species protein content amino acid composition amino acid score

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Detection and analysis of common pathogenic germline mutations in Peutz-Jeghers syndrome

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World Journal of Gastroenterology 2021年第39期27卷 6631-6646页

作者： Guo-Li Gu zhi Zhang Yu-Hui Zhang Peng-Fei Yu zhi-wei dong Hai-Rui Yang Ying Yuan Department of General Surgery Air Force Medical CenterChinese People's Liberation ArmyBeijing 100142China Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Department of Medical Oncology Cancer InstituteThe Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina

Different types of pathogenic mutations may produce different clinical phenotypes,but a correlation between Peutz-Jeghers syndrome(PJS)genotype and clinical phenotype has not been *** all patients with PJS have detectable mutations of the STK11/LKB1 gene,what is the genetic basis of clinical phenotypic heterogeneity of PJS?Do PJS cases without STK11/LKB1 mutations have other pathogenic genes?Those are clinical problems that perplex *** The aim was to investigate the specific gene mutation of PJS,and the correlation between the genotype and clinical phenotype of *** A total of 24 patients with PJS admitted to the Air Force Medical Center,PLA(formerly the Air Force General Hospital,PLA)from November 1994 to January 2020 were randomly selected for inclusion in the *** hundred thirty-nine common hereditary tumor-related genes including STK11/LKB1 were screened and analyzed for pathogenic germline mutations by high-throughput nextgeneration sequencing(NGS).The mutation status of the genes and their relationship with clinical phenotypes of PJS were *** Twenty of the 24 PJS patients in this group(83.3%)had STK11/LKB1 gene mutations,90%of which were pathogenic mutations,and ten had new mutation *** mutations in exon 7 of STK11/LKB1 gene were significantly lower than in other *** mutations are more common in exons 1 and 4 of STK11/LKB1,and their pathogenicity was significantly higher than that of missense *** also found SLX4 gene mutations in PJS *** PJS has a relatively complicated genetic *** in the sites responsible for coding functional proteins in exon 1 and exon 4 of STK11/LKB1 may be one of the main causes of *** of the SLX4 gene may be a cause of genetic heterogeneity in PJS.

关键词： Peutz-Jeghers syndrome Genotype Phenotype STK11 Mutation

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Genome size of 14 species of fireflies (Insecta, Coleoptera, Lampyridae)

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Zoological Research 2017年第6期38卷 449-458页

作者： Gui-Chun Liu zhi-wei dong Jin-Wu He Ruo-Ping Zhao Wen Wang Xue-Yan Li State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan 650223 China University of Chinese Academy of Sciences Beijing 100049 China Center for Ecological and Environmental Sciences Key Laboratory for Space Bioscience & Biotechnology Northwestern Polytechnical University Xi'an Shaanxi 710072 China

Eukaryotic genome size data are important both as the basis for comparative research into genome evolution and as estimators of the cost and difficulty of genome sequencing programs for non-model organisms. In this study, the genome size of 14 species of fireflies （Lampyridae）（two genera in Lampyrinae, three genera in Luciolinae, and one genus in subfamily incertae sedis） were estimated by propidium iodide （PI）-based flow cytometry. The haploid genome sizes of Lampyridae ranged from 0.42 to 1.31 pg, a 3.1-fold span. Genome sizes of the fireflies varied within the tested subfamilies and genera. Lamprigera and Pyrocoelia species had large and small genome sizes, respectively. No correlation was found between genome size and morphological traits such as body length, body width, eye width, and antennal length. Our data provide additional information on genome size estimation of the firefly family Lampyridae. Furthermore, this study will help clarify the cost and difficulty of genome sequencing programs for non-model organisms and will help promote studies on firefly genome evolution.

关键词： Haploid genome size Firefly Flow cytometry Evolution

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Diffuse invasive signet ring cell carcinoma in total colorectum caused by ulcerative colitis:A case report and review of literature

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World Journal of Clinical Cases 2022年第5期10卷 1729-1737页

作者： zhi Zhang Peng-Fei Yu Guo-Li Gu Yu-Hui Zhang Yu-Ming Wang zhi-wei dong Hai-Rui Yang Department of General Surgery Air Force Medical CenterChinese People's Liberation ArmyBeijing 100142China Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Health Team 93656 Troop of Chinese People's Liberation ArmyBeijing 101113China

BACKGROUND Diffuse invasive signet ring cell carcinoma of the colorectum is extremely rare *** type of colorectal cancer has certain clinical,pathological and biological characteristics that are different from ordinary colorectal *** SUMMARY A 31-year-old young woman was admitted to the hospital for nearly 1 wk due to recurrent symptoms of mucopurulent bloody stools and abdominal *** colonoscopy showed a ring-shaped intestinal wall mass 10 cm from the rectum to the *** pieces of tumor tissue were removed for *** pathological results showed rectal mucinous *** patient underwent laparoscopic exploration under general anesthesia,and then laparoscopic total colorectal resection,ileal pouch–anal anastomosis and ileostomy were *** patient was switched to a FOLFOX+cetuximab *** the fifth cycle,the patient was unable to tolerate further treatment due to tumor progression and multiple organ dysfunction,and died at the end of May *** survival was 7 *** Carcinogenesis of ulcerative colitis is different from sporadic colon cancer,and the overall prognosis is extremely poor.

关键词： Ulcerative colitis Colorectal cancer Signet ring cell carcinoma Case report

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Cystic fibrosis transmembrane conductance regulator prevents ischemia/reperfusion induced intestinal apoptosis via inhibiting PI3K/AKT/NF-κB pathway

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World Journal of Gastroenterology 2022年第9期28卷 918-932页

作者： zhi-wei dong Hui Liu Fei-Fei Su Xiao-Zhou Fan Yong Zhang Peng Liu Department of General Surgery Air Force Medical CenterBeijing 100000China Department of Gastroenterology Second Affiliated Hospital of Dalian Medical UniversityDalian 116023Liaoning ProvinceChina Department of Cardiology Air Force Medical CenterBeijing 100000China Department of Ultrasound Air Force Medical CenterBeijing 100000China School of Chemistry and Biological Engineering University of Science and TechnologyBeijing 100000China Research Laboratory of Aero-Medical Support Air Force Medical CenterBeijing 100000China

BACKGROUND Intestinal ischemia/reperfusion(I/R)injury is a fatal syndrome that occurs under many clinical *** apoptosis of intestinal cells caused by ischemia can cause cell damage and provoke systemic dysfunction during ***,the mechanism of I/R-induced apoptosis remains *** fibrosis transmembrane conductance regulator(CFTR)is a cAMP-activated chloride *** researchers have paid attention to its role in intestinal I/R injury,or the relationship between CFTR and intestinal apoptosis induced by hypoxia/reoxygenation(H/R).AIM To investigate the effects of CFTR on I/R-induced intestinal apoptosis and its underlying molecular *** An intestinal I/R injury model was established in mice with superior mesenteric artery occlusion, and Caco2 cells were subjected to H/R for the simulation of I/R in *** results suggested that CFTR overexpression significantly increased the Caco2 cell viability anddecreased cell apoptosis induced by the H/R. Interestingly, we found that the translocation of p65,an NF-κB member, from the cytoplasm to the nucleus after H/R treatment can be reversed by theoverexpression of CFTR, the NF-κB P65 would return from the nucleus to the cytoplasm asdetermined by immunostaining. We also discovered that CFTR inhibited cell apoptosis in theH/R-treated cells, and this effect was significantly curbed by the NF-κB activator BA, AKTinhibitor GSK690693 and the PI3K inhibitor LY294002. Moreover, we demonstrated that CFTRoverexpression could reverse the decreased PI3K/AKT expression induced by the I/R treatment invivo or H/R treatment in *** results of the present study indicate that the overexpression of CFTR protects Caco2 cells fromH/R-induced apoptosis;furthermore, it also inhibits H/R-induced apoptosis through thePI3K/AKT/NF-κB signaling pathway in H/R-treated Caco2 cells and intestinal tissues.

关键词： Apoptosis Cystic fibrosis transmembrane conductance regulator Intestinal ischemia-reperfusion injury PI3K/AKT/NF-κB Hypoxia/reoxygenation Caco2 cells

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Ion-focused propagation of a relativistic electron beam in the self-generated plasma in atmosphere

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Chinese Physics B 2022年第6期31卷 334-341页

作者： Jian-Hong Hao Bi-Xi Xue Qiang Zhao Fang Zhang Jie-Qing Fan zhi-wei dong School of Electrical and Electronic Engineering Department North China Electric Power UniversityBeijing 102206China Institute of Applied Physics and Computational Mathematics Beijing 100094 China

It is known that ion-focused regime(IFR)can effectively suppress expansion of a relativistic electron beam(REB).Using the particle-in-cell Monte Carlo collision(PIC-MCC)method,we numerically investigate the propagation of an REB in neutral *** results demonstrate that the beam body is charge neutralization and a stable IFR can be *** a result,the beam transverse dimensions and longitudinal velocities keep close to the initial *** also calculate the charge and current neutralization factors of the *** with envelope equations,we obtain the variations of beam envelopes,which agree well with the PIC ***,both the energy loss and instabilities of the REB may lead to a low transport efficiency during long-range *** is proved that decreasing the initial pulse length of the REB can avoid the influence of electron *** parts of REB pulses to build a long-distance IFR in advance can improve the beam quality of subsequent ***,a long-distance IFR may contribute to the implementation of long-range propagation of the REB in space environment.

关键词： ion-focused regime(IFR) charge neutralization electron avalanche relativistic electron beam(REB) particle-in-cell Monte Carlo collision(PIC-MCC)

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Physical properties of relativistic electron beam during long-range propagation in space plasma environment

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Chinese Physics B 2021年第10期30卷 283-291页

作者： Bi-Xi Xue Jian-Hong Hao Qiang Zhao Fang Zhang Jie-Qing Fan zhi-wei dong School of Electrical and Electronic Engineering Department North China Electric Power UniversityBeijing 102206China Institute of Applied Physics and Computational Mathematics Beijing 100094China

It is known that ion channel can effectively limit the radial expansion of an artificial electron beam during its longrange propagation in the space plasma *** prior studies discussed the focusing characteristics of the beam in the ion channel,but the establishment process and transient properties of the ion channel itself,which also plays a crucial role during the propagation of the relativistic electron beam in the plasma environment,were commonly *** this study,a series of two-dimensional(2D)particle-in-cell simulations is performed and an analytical model of ion channel oscillation is constructed according to the single-particle *** results showed that when the beam density is higher than the density of plasma environment,ion channel can be established and always continues to oscillate periodically over the entire *** factors,including the beam electron density,initial beam radius,and the plasma density can affect the oscillation properties of ion *** velocity of the beam oscillates synchronously with the ion channel and this phenomenon will finally develop into a two-stream instability which can seriously affect the effective transport for relativistic electron *** appropriate beam parameters based on various plasma environments may contribute to the improvement of the stability of ion ***,radial expansion of the beam can be limited by ion channel and a stable long-range propagation in terrestrial atmosphere may be achieved.

关键词： ion channel space plasma environment long-range propagation particle-in-cell(PIC)simulation

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